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WO/1998/000376A1 |
The present invention provides several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. The present invention also provides novel compositions of matter comprising ...
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WO/1997/045397A1 |
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase...
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WO/1997/043358A1 |
Aromatic esters of polyalkylphenoxyalkanols having formula (I), or a fuel soluble salt thereof, wherein R is hydroxy, nitro or -(CH2)x-NR5R6, wherein R5 and R6 are independently hydrogen or lower alkyl having 1 to 6 carbon atoms and x is...
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WO/1997/042154A1 |
The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
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WO/1997/041109A1 |
This invention relates to calicheamicinone and related compounds, and processes for the preparation of these compounds and derivatives or analogs thereof. Many of the products that can be synthesized using these compounds have antibiotic...
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WO/1997/040006A2 |
An analogue of a biologically active compound whose activity within a cell is regulated by phosphorylation of said compound, wherein said analogue comprises a di- or tri-phosphate mimic at the site of phosphorylation, said mimic being a ...
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WO/1997/039064A1 |
The family of dyes of the invention are fluoresceins and rhodols that are directly substituted on one or more aromatic carbons by fluorine. These fluorine-substituted fluorescent dyes possess greater photostability and have lower sensiti...
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WO/1997/039005A1 |
The present invention provides novel aryl diphosphines having formula (I) wherein X, Y, R1-18, m, m' and n are defined herein, and which can be complexed with a transition metal to form a novel catalyst useful in such applications as hyd...
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WO/1997/036860A1 |
The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (I), and methods of selectively inhibiting or ant...
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WO/1997/036862A1 |
The present invention relates to a class of compounds represented by Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting o...
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WO/1997/035824A1 |
A process for the preparation of fluorinated dicarbonyl compounds of general formula (2), comprising reacting dicarbonyl compounds of general formula (1) with fluorine gas without any solvent in the presence of one or more acids selected...
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WO/1997/034885A1 |
The present invention relates to novel benzopyran derivatives of formula (I), wherein A is an oxygen or sulfur atom or a methylene group; B and C are: a) when B is a benzofused heterocycle (a) wherein U is an O, S or N atom, Z-Y are two ...
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WO/1997/033846A1 |
The invention concerns a process for preparing nitrobiphenylene of formula (I) wherein m stands for 1 or 2, R means halogen, R' or OR', R' being a C-organic group which can carry groups which are inert in the reaction conditions, n stand...
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WO/1997/032832A1 |
The production of fluorinated aromatic compounds of general formula (I), in which W, X, Z, R1 and R2 have the meanings given in the description, from corresponding C1 or Br-containing compounds with fluorides, e.g. KF, with halogen excha...
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WO/1997/032853A1 |
(4-oxy-3-(aryl)phenyl-azaryl or -arylcarbonyloxy compounds, in free or acid addition salt form, are useful as pharmaceuticals for treatment and prophylaxis of inflammation, particularly inflammatory or obstructive diseases of the airways...
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WO/1997/028122A2 |
The invention relates to a process for preparing compounds of formula (I), wherein R2 is lower alkyl; or phenyl optionally substituted by from one to five groups which may be the same or different selected from lower alkyl, lower haloalk...
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WO/1997/027846A1 |
Compounds of formula (I), wherein R5 is an [A]-CH3, -[A]-C(OH)ZZ' or -[A]-C(O)Z" grouping where -[A]- is an alkylene, alkenylene or alkynylene radical or a single bond, and Z, Z' and Z" are a hydrogen atom or an optionally substituted al...
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WO/1997/027748A1 |
Metal chelates of herbicidal dione compounds of formula (I) are chemically stable for long periods of time under normal as well as extreme temperature conditions. Chemically stable liquid herbicidal formulations containing metal chelates...
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WO/1997/026240A1 |
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure (I) or (IA) or (IB) including pharmaceutically acceptable sa...
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WO/1997/024118A1 |
The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula (I) herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical co...
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WO/1997/024331A1 |
The present invention relates to novel naphthalene quinolines of formula (I), wherein the substituent containing A is bound to the 6- or 7-position of the 2-naphthol system; -R1, R2, R6 are independently hydrogen, fluorine, chlorine, bro...
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WO/1997/022590A1 |
A method of nitrating electron-deficient carbocyclic or heterocyclic aromatic compounds such as pyridines, diazines and triazines and benzenoid aromatics having electron-withdrawing substituents involves first reacting the aromatic speci...
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WO/1997/021658A1 |
The present invention relates to the use as pesticides and in particular as fungicides of diaryl acetylene ketones of the general formula (I), in which Ar1 is optionally substituted phenyl, and Ar2 is optionally substituted phenyl or opt...
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WO/1997/019917A1 |
A novel method for preparing (+)compactin and (+)mevinolin analog compounds having a 'beta'-hydroxy-'delta'-lactone grouping is disclosed. The method for preparing said compounds uses novel reaction intermediates. Said reaction intermedi...
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WO/1997/019040A2 |
The invention relates to compounds of general formula (1), their optically active isomers and salts wherein Ar = alycyclic, aromatic or one or more heteroatom containing heterocyclic moiety, optionally substituted by one or more alkoxy-,...
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WO/1997/017316A1 |
4-Phenyl-4-oxo-butenoic acid derivatives for use in the treatment of the human or animal body by therapy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the ...
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WO/1997/017317A1 |
4-phenyl-4-oxo-butanoic acid derivatives for use in the treatment of the human or animal body by therepy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the ...
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WO/1997/016729A1 |
Combinatorial libraries are disclosed which are represented by Formula (I), wherein S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of Formula (II) ...
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WO/1997/016569A1 |
A lawn assay is described for determining compounds that affect enzyme activity or that bind to target molecules. Compounds to be screened are cleaved, and diffused from solid supports into a colloidal matrix. Enzymatic catalysis or bind...
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WO/1997/010830A1 |
What is described herein is the reaction product of arginine and p-aminobenzoic acid (PABA), cosmetic and human and animal health compositions thereof, useful for treating wounds (small or large animals and humans), burns (small or large...
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WO/1997/010199A1 |
A process for the preparation of a compound of general formula (I) wherein R1 is hydrogen or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl (any of which may optionally be substituted with one or more substituents selected from halogen and ...
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WO/1997/010200A1 |
A process for the purification of a compound of general formula (I), wherein R1 is hydrogen or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl (any of which may optionally be substituted with one or more substituents selected from halogen an...
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WO/1997/003946A1 |
The invention relates to the production of organic nitrogen compounds, especially aminoalkanes, alkyloximes, alkylnitrons or mixtures thereof having only one nitrogen-functional grouping and no alcoholic hydroxyl groups in the molecule, ...
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WO/1997/000848A1 |
A process for the preparation of an ester, especially fluorinated esters R1O.OC-CFR2-CO.OR3.R1 and R3 are each independently selected from alkyl, cycloalkyl and aryl. R2 is selected from hydrogen, alkyl, cycloalkyl. The method includes t...
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WO/1997/000235A1 |
The invention concerns fullerene C70 bis-adducts of formula (I) which can be obtained by successive cyclopropanation of C70 with two different 'alpha'-halo-CH acid compounds. The two additions occur at different hemispheres. The fulleren...
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WO/1996/038399A1 |
Compositions and methods for inhibiting vinyl aromatic monomer polymerization during processing are disclosed. The compositions are combinations of a dinitrosalicylic acid derivative and a hydroxylamine compound and are added to the mono...
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WO/1996/038150A1 |
The present invention relates to novel 4.4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhib...
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WO/1996/037456A1 |
Compounds of formula (I), wherein R1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R2 is -A-R4, wherein A is branched or straight chain C1-9 alkylene and R4 is carboxy or 5-tetrazolyl, R5 or CO-R5, wherei...
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WO/1996/037454A1 |
The object of the invention is a method for preparing 3-carboxy-4-hydroxybenzaldehydes and derivatives thereof from phenol compounds bearing formyl and/or hydroxymethyl groups in positions 2 and 4. Another object of the invention is the ...
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WO/1996/036587A1 |
A solvent free process for the nitration of an aromatic compound using an aluminosilicate catalyst which has been treated with nitric acid and an acid anhydride. The process enables nitrated aromatic compounds to be produced in high yiel...
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WO/1996/035655A1 |
An aromatic ether acylation process is described, particularly a process for acylating a substituted aromatic ether and more particularly veratrol. The method of the invention includes reacting the ether with an acylation agent in the pr...
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WO/1996/035656A1 |
An aromatic ether acylation process is described, particularly a process for acylating an unsubstituted aromatic ether and more particularly anisol. The process of the invention includes reacting the ether with an acylation agent in the ...
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WO/1996/030347A1 |
The invention relates to certain 4-(substitutedphenylamino)quinazoline derivatives of formula (I), their produgs and pharmaceutically acceptable salts wherein R1, R2, R3, R4, m and n are described in said formula. The compounds of formul...
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WO/1996/029304A1 |
The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neura...
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WO/1996/028403A1 |
Tetracyclic compounds having structure (1) are described, wherein R1-R10 are as defined. The tetracyclic compounds are capable of potent effects on steroid sensitive tissues and have demonstrated increased uterine weight, antiovolatory e...
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WO/1996/027575A1 |
A process for the reduction of carbonyl compounds comprises mixing the carbonyl compound and an alcoholic reagent, and bringing the mixture to a temperature above 200 �C. The temperature may be higher than the critical temperature of t...
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WO/1996/023770A1 |
The present invention provides processes having practical utility for preparing 2-oxindoles, N-hydroxy-2-oxindoles, or mixtures thereof comprising: catalytically hydrogenating a 2-nitroarylmalonate diester to produce a 2-(N-hydroxyamino)...
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WO/1996/023754A1 |
This invention relates to a method for preparing difluoromethyl ethers, thiols and amines without using chlorofluorocarbon gases. The intermediates prepared by this method can be used to make certain compounds which act as PDE IV inhibit...
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WO/1996/022957A1 |
A process for preparing a compound of formula (I), where R1, R2, R3, R4, R5 and R6 are independently hydrogen or C1-6 alkyl; R7 is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R8, R9 and ...
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WO/1996/022958A1 |
A process for preparing a compound of formula (I), where R1, R2, R3, R4, R5 and R6 are independently hydrogen or C1-6 alkyl; R7 is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R8, R9 and ...
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