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WO/2001/030734A1 |
The present invention is directed to a procedure for making an enantiomerically enriched compound containing a hydronaphthalene ring structure. The process involves reacting oxabenzonorbornadienes with nucleophiles using rhodium as a cat...
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WO/2001/028974A2 |
The invention concerns novel nitroaromatic compounds of general formula (I') wherein: R, R'¿1?, R¿2?, Z and n are as defined in Claim 38. The invention also concerns a method for preparing nitroaromatic compounds nitrated in position 4...
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WO/2001/026807A1 |
A supported catalyst comprises a cationic rhodium (I) complex of formula (1) wherein R?1¿ and R?2¿ are the same or different hydrocarbon groups of up to 30 C atoms, or R?1¿ and R?2¿ are linked to form a ring, and a heterogeneous supp...
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WO/2001/027068A1 |
The present invention relates to compounds of formula (I) and to their pharmaceutically acceptable salts. Compounds of formula (I) exhibit activity as serotonin, norepinephrine, and dopanine reuptake inhibitors and can be used in the tre...
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WO/2001/023347A1 |
The present invention relates to novel compounds of general formula (I), pharmaceutical formulations comprising these compounds, the use of these compounds as medicaments, the use of these medicaments in the treatment of and/or preventio...
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WO/2001/021575A1 |
The present invention relates to compounds of the general formula: NO¿2?-A-B wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 carbon atoms and B is (CH¿2?)¿n?(COOH)¿m? in which n is an integer from 0 to 2 and m is a...
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WO/2001/021172A1 |
The present invention relates to pharmaceutical compositions comprising, as an anti-cancer agent: (a) one or more compounds having the formula NO¿2?-A-B, wherein A is a saturated or unsaturated hydrocarbon chain of 14-26 double bonds, a...
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WO/2001/017962A1 |
A process for the preparation of tricyclic amino alcohol derivatives including 2-[N-[2-(9H-carbazol-2-yloxy)ethyl]]-amino-1-[(3-methylsulfo
nylamino)phenyl]ethanol useful in the treatment of diabetes, obesity, hyperlipemia and so on; and...
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WO/2001/016057A1 |
The invention relates to a process for the preparation of biphenyls or aromatic olefins by means of coupling reactions of the Suzuki coupling and Heck coupling types using allylpalladium catalysts of the $g(m)-halo(tri-tert-butylphosphin...
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WO/2001/014303A1 |
Triketone compounds represented by general formula (I) or salts thereof wherein W represents oxygen or sulfur; y is from 1 to 6; A represents an optionally alkylated 5- or 6-membered saturated heterocycle having 1 or 2 oxygen or sulfur a...
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WO/2001/012577A1 |
Disclosed is a method of fluorinating a substrate having general formulae (I) or (II) where each R is independently selected from halogen, alkyl from C¿1? to C¿12?, aryl from C¿6? to C¿12?, alkoxide from C¿1? to C¿12?, aryloxide fr...
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WO/2001/010815A1 |
Bis(4-hydroxy-3-nitro-5-perfluoroalkylphenyl)fluoro-alkanes represented by general formula (1): wherein Rf?1¿, Rf?2¿ and Rf?3¿ are each independently straight, branched or cyclic C¿1?-C¿10? perfluoroalkyl, or alternatively Rf?2¿ an...
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WO/2001/010806A2 |
The present invention relates to a process for preparing acylated 1,3-dicarbonyl compounds by rearrangement of corresponding enol esters. The invention also relates to the preparation of the corresponding tautomer compounds of the acylat...
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WO/2001/009065A2 |
The invention relates to a novel method for the nitration of organic compounds, preferably of aromatics and heteroaromatics, using known and novel types of nitration reagents.
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WO/2001/009071A1 |
The present invention relates to the preparation of substituted or unsubstituted 1,2-bis(4-hydroxyphenyl)-hydroxyaliphatics such as 1,2-bis(4-hydroxyphenyl)-2-hydroxypropanes by reacting substituted or unsubstituted 1,2-bis(4-hydroxyphen...
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WO/2001/002320A1 |
The invention concerns the use of aliphatic nitriles with relatively high molecular weight, as polar aprotic solvents, in particular in nucleophilic substitution reactions of the aromatic type. Said nitriles have a molecular mass more 79...
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WO/2001/000558A1 |
The invention relates to methods for preparing substituted cyclopentene compounds, their intermediates and use as neuraminidase inhibitors.
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WO/2000/078768A1 |
Compounds having formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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WO/2000/076951A1 |
The invention relates to a method for producing 2-halo-6-nitrobenzoic acids by the oxidation of 2-halo-6-nitrobenzyl alcohols and/or their esters and/or ethers with nitric acid at high temperatures. The invention also relates to a method...
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WO/2000/076662A2 |
A chemical process to obtain products of higher purity or in shorter time is provided by performing chemical reactions in a reactions volume less than 1 microliter. The advantages of this process are due to better mixing or heat exchanch...
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WO/2000/075094A2 |
The present invention provides a method for producing a specific acetophenone which is useful as an intermediate for pharmaceuticals or agricultural chemicals, i.e. a method for producing a halogenated acetophenone, which comprises react...
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WO/2000/073288A1 |
The invention provides a method for the preparation of 5-substituted oxazoles in high yield using inexpensive, widely available reagents. The method is particularly useful in the preparation of intermediates necessary in the synthesis of...
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WO/2000/071520A2 |
Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof aryloxyalkylamines and arylthioalkylamines, including pyridyloxylalky...
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WO/2000/069803A1 |
A process for the preparation of nitro compounds by reacting an organic substrate with nitrogen dioxide either in the presence of oxygen or under such conditions that the nitrogen dioxide/organic substrate ratio is less than 1 by mole. T...
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WO/2000/069800A2 |
The invention relates to a process for preparing compounds of formula (I), wherein R?1¿ and R?2¿ are as defined in the description.
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WO/2000/069823A1 |
The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds represented by general Formula (I) and a pharmaceutically acceptable salt or an ...
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WO/2000/066525A1 |
Bicycloheptene compounds represented by general formula (1) and being useful as intermediates for the production of agricultural chemicals or drugs (wherein X is hydroxycarbonyl, hydroxymethyl, halogenomethyl, nitromethyl, or methylthiom...
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WO/2000/066524A1 |
A D-mannitol derivative selected from the group consisting of a compound of formula (I) pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R¿1?, R¿2?, ...
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WO/2000/061536A2 |
The invention relates to novel anthracene compounds useful in the treatment of allergic, inflammatory conditions, tumor conditions and therapeutic compositions containing such compounds. The compounds of the present invention are 9-acylo...
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WO/2000/061538A1 |
Methods for preparing substituted aromatic carboxylic acid esters are described. In particular, the invention relates a method for preparing a nitro-substituted aromatic carboxylic acid ester of Formula (A). Additionally the invention re...
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WO/2000/061531A1 |
The invention relates to a method of producing mono-, bi- and/or polyfunctional biaryls of the general formula (I) Ar-Ar' by reacting halogenated aromatics of the general formula (II) Ar-X with boron compounds of the general formula (III...
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WO/2000/059883A2 |
The invention relates to a method for producing N-aryl-aza-heterocycles of general formula (I) in which: R1, R2, R3, R4 and R5 are the same or different and represent a hydrogen atom, a nitro group, a cyano group, an alkoxycarbonyl group...
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WO/2000/058215A1 |
The invention relates to a method for activating mineral fluoride in an organic medium. The inventive method is characterized in that said fluoride is subjected to the action of microwaves in the presence of an advantageously cationic ph...
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WO/2000/058240A1 |
The invention relates to a method for carrying out an SNAr-type nucleophilic substitution on an aromatic substrate, characterized in that an aromatic substrate of general formula (I), wherein A represents an aromatic residue motif, X rep...
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WO/2000/053567A1 |
Disclosed is a method for preparing serinol (2-amino-1,3-proanediol). From nitromethane, para-formaldehyde and sodium hydroxide, 1-nitro-1,3-propanediol sodium salt is prepared as a medical intermediate. In a fixed bed, this intermediate...
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WO2000002887B1 |
One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and car...
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WO/2000/040555A1 |
The invention relates to a method for producing (2S,4R,9S)-octahydro-1H-indole-2-carboxylic acid. The invention is characterised in that a. a compound of the formula (I) (R?1¿O)¿2?CH-CH¿2?-CH(OR?2¿)¿2?, wherein R?1¿ and R?2¿ are e...
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WO/2000/039074A1 |
The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, ben...
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WO/2000/037422A2 |
The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK¿Ca?, IK¿Ca? and BK¿Ca? channels. I...
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WO/2000/037423A1 |
New compounds of formula (I) are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders, where a reduction in the O-methylation of catecholami...
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WO/2000/034223A1 |
A method of preparing dinitromethane salts usable as intermediate products and starting material for production of explosives and propellants. Substituted 1,2-diazoles, 1,2,4-triazoles or 1,3-diazines, such as barbituric acid, are nitrat...
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WO/2000/031020A1 |
The instant invention is improved gamma amino butyric acid analogs, processes for their preparation, and methods of using them as agents for treating epilepsy and other neurodegenerative disorders, depression, anxiety, panic, pain, neuro...
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WO/2000/027790A1 |
A compound of formula (IA) or (IB): in which R?1¿ is R?A¿(CH¿2?)¿n?O(CH¿2?)¿m?, R?A¿(CH¿2?)¿p?, Formula (II) or in which R is a spiro-fused mono- or bi-cyclic ring containing one or two basic nitrogen atoms; and X?1¿ and X?2¿,...
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WO/2000/024743A1 |
The present invention provides novel compounds of formula (I) which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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WO/2000/023435A1 |
Metal complexes which serve as catalysts in various chemical reactions or as materials in the information-electronics industry, exhibit peroxidase-like activities or high hydrolytic activities for phosphoric diesters, and can easily hybr...
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WO/2000/021922A2 |
(57) Abstract The invention relates to a process for the preparation of a compound of formula (I): wherein, R?1¿ represents C¿1-4 ?alkoxy; fluorine, chlorine or bromine; and R?2¿ represents hydrogen or C¿1-4 ?alkoxy; which process co...
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WO/2000/021487A2 |
A method is disclosed for the preparation of optically pure isomers of formoterol and polymorphs of the novel $i(L)-tartrate salt of $i(R,R)-formoterol. Pharmaceutical compositions of the polymorphs and salts are also described.
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WO/2000/017132A1 |
Olefins containing aromatic substituents are synthesized without the addition of phosphonium salts or phosphanes with the aid of a Pd-II compound as a catalyst in the presence of nitrogen-containing additives such as N,N-dimethylglycine ...
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WO/2000/017133A2 |
The invention concerns LTA¿4? hydrolase inhibiting compounds of formula (I). It also concerns their therapeutic, in particular anti-inflammatory, applications.
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WO/2000/015625A2 |
The present invention relates to methods of making dihydropyrone HIV protease inhibitors.
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