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WO/1994/008978A1 |
Compounds having the structural formula (I), wherein R can be the same or different and is halogen, hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C7-C9 aralkyl, phenyl, nitro, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfiny...
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WO/1994/007832A1 |
A phenethyl alcohol derivative represented by general formula (I), which is used as a stabilizer for storing colored images in a thermal recording material and is particularly improved in plasticizer resistance. Y represents a group of g...
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WO/1994/007500A1 |
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntingt...
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WO/1994/008051A1 |
Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produc...
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WO/1994/006782A1 |
The invention provides novel compounds of formula (I) having nematicidal, insecticidal, acaricidal and fungicidal properties, compositions comprising them and processes and intermediates for their preparation, wherein X is oxygen or sulp...
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WO/1994/006433A1 |
The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives, substituted in the 1-position with halo, methyl, hydroxyl, nitro, amino, amido, azido, oxime, cyano, thiol, ether or thioether groups, e.g...
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WO/1994/006751A1 |
Process for preparing dinitrotoluene by reacting toluene with concentrated nitric acid. The process reacts toluene with a large excess of concentrated nitric acid at selected conditions to produce a product which has substantially reduce...
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WO/1994/006748A1 |
Anthrone derivatives (A) and anthracene derivatives (B) of formulae (A) and (B), with the significance of the constituents given in the description, may be used to prevent and treat hyper-proliferatively caused dermatitis, especially pso...
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WO/1994/005619A1 |
An optically active compound represented by general formula (I), a mixture thereof, and a carcinostatic and osteogenesis promoter each containing the same as the active ingredient, wherein Y represents hydrogen or halogen; A represents h...
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WO/1994/004483A1 |
New chromoionophores of formula (IV) wherein a = 0-3, b = 0 or 1, c = 0 or 1, x = 0 or 1, y = 0 or 1, z = 0 or 1; R\', which may be the same or different in each aryl group, is H, halogen, hydrocarbyl, aryl, hydrocarbylaryl or a substitu...
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WO/1994/004502A1 |
A process for the preparation of halobenzoic acids, comprising the step of reacting a halonitrobenzene with a pyridinium salt to form an intermediate of formula (I), wherein R is selected from the group consisting of hydrogen, alkyl, ary...
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WO/1994/002465A1 |
This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation an...
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WO/1994/001436A1 |
The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof; wherein R50 is hydrogen or C1-4 alkyl, A51 is oxygen, sulphur or a group of the formula -NR52- wherein R52 is hydrogen or C1-4 alkyl; A50 com...
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WO/1994/001383A1 |
The present invention relates to a perfluoroalkylation reagent and to a method for using such reagent in order to replace a halogen or pseudo-halogen by a perfluoroalkyl group. This reagent is characterized in that it is comprised of the...
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WO/1994/001391A1 |
A process for the preparation of halonitroalkanes, e.g. bromonitromethane, is disclosed in which a nitroalkane is reacted with an alkali metal base or an alkaline earth metal base, and the resulting nitroalkane salt is halogenated to for...
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WO/1993/025503A1 |
This invention relates to a process for nitrating toluene to produce dinitrotoluene characterized by a liquid phase nitration characterized in that reaction of anhydrous nitric acid with toluene in a reactor at a reaction temperature of ...
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WO/1993/025512A1 |
Described is a method of preparing 5-alkoxy-2,4-dinitroalkylbenzene compounds of general formula (I), in which R?1¿ is C¿1?-C¿4? alkyl and R is C¿1?-C¿6? alkyl, C¿2?-C¿4? hydroxyalkyl or C¿3?-C¿4? dihydroxyalkyl. The method call...
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WO/1993/023378A1 |
This invention relates to novel substituted 1,2,3,4-tetrahydroisoquinolines which are useful in the treatment of vascular restenosis, various disorders of the central nervous system, in the regulation of female reproductive functions, in...
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WO/1993/023357A1 |
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such ...
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WO/1993/023352A1 |
The invention relates to a new nitration system, comprising dinitrogen pentoxide dissolved in liquid sulphur dioxide. The invention also relates to a process for nitrating aromatic compounds, where the nitration agent used is dinitrogen ...
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WO/1993/022476A1 |
Azeotrope-like compositions comprising 1,1,2,3,3-pentafluoropropane and methanol or ethanol and optionally nitromethane are stable and have utility as degreasing agents and as solvents in a variety of industrial cleaning applications inc...
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WO/1993/022272A1 |
Carbon clusters, such as C60 and C70 fullerenes are separated by means of a recognition selector having formula (I), wherein R1 is (a), wherein R2 is O, S or NR12 wherein R12 is independently hydrogen or P=O with the proviso that when R1...
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WO/1993/022261A1 |
This invention relates to a vinyl aromatic, especially styrene, polymerization inhibitor system comprising a reaction product of an alkyl phenol with sulfuric acid and nitric acid and optionally an aryl-substituted phenylenediamine. The ...
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WO/1993/022396A1 |
Fluorine-containing liquid crystal compounds are provided. The compounds comprise a fluorocarbon terminal portion having at least one catenary ether oxygen and a hydrocarbon terminal portion, the terminal portion being connected by a cen...
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WO/1993/021145A1 |
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographica...
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WO/1993/021144A1 |
A method for forming cascade polymers specifically utilizing the amine monomer of formula (I). The monomer is made by initially reacting nitromethane and CH2=CHCO2-TBu by nucleophilic addition to form the triester nitrotrialkanoate of fo...
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WO/1993/019034A1 |
Production of chlorine-substituted olefine compounds of formula (I), wherein: R?1¿ represents a C-organic rest; R?2¿ represents -CN, -CO-R?3¿, -CO-S-R?3¿, -CO-O-R?3¿, -CO-N(R?4¿, R?5¿); R?3¿ represents a C-organic rest; R?4¿, R?...
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WO/1993/017994A1 |
Novel substituted cis-1,2-dihydroxy-cyclohexadiene compounds, useful as intermediates in the production of compounds for use as intermediates in the production of agrochemicals and pharmaceuticals, and a microbial process for the prepara...
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WO/1993/014065A1 |
Compounds of formula (I) wherein R1 is hydrogen, alkyl, halogen, nitro or alkyl or aromatic sulfonyl, x is an integer from 1 to 4, when x is greater than 1, The R1 substituents on any one or all of positions 2, 3, 5 and 6 and can be the ...
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WO/1993/014053A1 |
Novel 4-substituted acetophenone anils and methods for preparing 1,3,5-tris(4'-hydroxyphenyl)benzenes from 4-substituted acetophenones such as 4-hydroxyacetophenones or, from substituted 4-hydroxyacetophenone-anils such as 4-hydroxyaceto...
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WO/1993/012775A1 |
The invention relates to two phase pharmaceutical compositions comprising as active ingredient an MAO inhibitor and an uptake inhibitor together with usual pharmaceutical auxiliaries. The compositions can be used for the treatment of neu...
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WO/1993/013045A1 |
The invention relates to a polymeric optical amplifier doped with lanthanide ions, which are present in the amplifier in the form of a complex. The invention also relates to novel electrically neutral lanthanide complexes which can be ap...
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WO/1993/013099A1 |
Heterocyclic compound of the formula: R1-A-CO-X-Y-R2, in which R1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, R2 is optionally substituted aralkyl, X is optionally substituted arylene, Y is -O- or (a), wherein R6 is hydrogen...
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WO/1993/011760A1 |
Compounds of the formulae (I, II or III) wherein: R1, R2, R3 and R4 which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or to...
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WO/1993/011098A1 |
New compounds are described typically having the formula CH3C(CH2R)3 or ZCH2C(CH2R)3 where R is a fluorohydrocarbon or perfluorocarbon group preferably containing 4-16 carbon atoms and more F atoms than H atoms. Z is a hydrophilic group ...
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WO/1993/009077A2 |
A process for the preparation of 2-chloro-4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid as well as synthetic intermediates useful in and prepared according thereto, comprising reacting a nitrobenzene having formula (II), where...
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WO/1993/007128A1 |
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral...
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WO/1993/007127A1 |
New derivatives of fluoro quinoline carboxylic-3 acid having general formula (I), wherein R is a hydrogen atom or an alkyl radical and Hal is a halogen atom, as well as salts thereof, when they exist, preparation thereof and utilization ...
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WO/1993/006074A1 |
A 2-propanol compound represented by general formula (I), which is used as a preservative for colored images in heat-sensitive recording material and particularly improved in plasticizer resistance, wherein Y represents a group of genera...
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WO/1993/005012A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid of general formula (I), methods for their preparation, novel pharmaceutical compositions and the use thereof for inhibiting the enzyme 3-hydroxyanthranilate ...
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WO/1993/005043A1 |
A compound having formula (I), wherein R?4¿ and R?5¿ independently are hydrogen, halogen, CF¿3?, CN, NO¿2? or SO¿2?NR?1¿R?2¿ wherein R?1¿ is hydrogen or straight, C¿1-6?-alkyl which may be branched or cyclic, R?2¿ is hydrogen o...
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WO/1993/005025A1 |
The invention provides compounds of general formula (I) or a plysiologically acceptable salt, solvate (e.g. hydrate) or a metabolically labile ester thereof in which R1 represents a hydrogen atom or a group selected from C1-6alkyl or C2-...
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WO/1993/002999A1 |
A novel phenylalkanoic acid derivative represented by general formulae (I) or (II), a process for the production thereof, a method of separating optical isomers thereof, and an anti-inflammatory, analgesic or external preparation contain...
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WO/1993/002030A1 |
A novel method for preparing 2-phenyl substituted-1,3-propanediols, useful intermediates in the synthesis of pharmaceutical preparations is disclosed.
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WO/1993/001173A1 |
Aromatic olefins are produced by catalytic vinylation of aryl chlorides in the presence of a base and of a palladium complex catalyst of the formula: [R6R7P(CH2)nPR8R9]2 Pd wherein n is 3 or 4 and R6 to R9 are selected from hydrogen, alk...
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WO/1993/000323A1 |
A method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde by reacting 4-hydroxy-3-methoxy-5-nitrobenzaldehyde with a strong nucleophilic agent which may be created by reacting an aromatic mercapto compound with a strong organic o...
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WO/1992/022520A1 |
A compound represented by formula (I) Ar1-O-M-O-Ar2 wherein Ar1 and Ar2 are independently substituted phenyl or substituted pyridinyl, the substituents on said phenyl or pyridinyl being independently selected from one, two or three of (C...
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WO/1992/021641A1 |
Certain dihydroxyindanone compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g. cancer, atherosclerosis).
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WO/1992/021660A1 |
Certain tricyclic polyhydroxylic compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).
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WO/1992/017449A1 |
Novel processes are disclosed for the stereoselective preparation of substituted piperidine derivatives of formulae (IV) and (I) wherein R1 and R2 are defined as below.
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