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WO/1995/021174A1 |
Compounds of formula (I): wherein R is C1-C6alkyl, C1-C6haloalkyl, C3-C6alkenyl, C3-C6alkynyl, C1-C4alkoxy or C3-C6cycloalkyl; R1 is halogen; R2 and R3 are each independently of the other C1-C4alkyl; R4 is halogen or a group of the formu...
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WO/1995/020578A1 |
This invention is directed to compounds of formula (I), wherein R1 is an optionally substituted lower alkyl group; R2 is an optionally substituted oxaaliphatic group; R3 is an optionally substituted aryl group or an optionally substitute...
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WO/1995/019974A2 |
Calixarene-based compounds are described which have biological activity, particularly anti-bacterial, anti-fungal, anti-cancer and anti-viral activity. Some compounds have been found to have anti-HIV activity. The compounds are calixaren...
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WO/1995/019222A1 |
Porous microcomposites have been prepared from "NAFION" ion-exchange polymer and metal oxides such as silica using the sol-gel process. Such microcomposites possess high surface area and exhibit extremely high catalytic activity.
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WO/1995/018848A1 |
The invention describes liquid crystal compounds of formula (I) which are suitable for use in liquid crystal devices including those devices which exploit the electroclinic effect, wherein X may be CN, NO2, CF3, CF2H, CFH2, halogen, hydr...
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WO/1995/018607A1 |
Pharmaceutical compositions which are useful for the treatment of cancer or illnesses which arise due to an abnormally elevated cell proliferation comprise acyl derivatives of aromatic aldehydes, especially arylidene diesters and 'alpha'...
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WO/1995/017372A1 |
The present invention relates to a method of cleaving arylethers such as arylethers represented by formula (I), wherein R is hydrogen, C1-C6 alkyl, cycloalkyl, phenyl, substituted phenyl or CH=CH2; each A is independently NO2, hydroxy, h...
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WO/1995/017375A1 |
A method of producing 4,6-diaminoresorcinol comprising: a) reducing a dinitroarylether of formula (I), wherein R is hydrogen, C1-C6 alkyl, cycloalkyl or CH=CH2, R' is hydrogen or CH2-R, each A is independently Cl, Br, or l, and n is 0, 1...
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WO/1995/016649A1 |
According to the present invention there is provided a process for the selective introduction of one or more fluorine atoms into a disubstituted aromatic compound in an acid medium with fluorine gas characterised in that the acid medium ...
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WO/1995/015944A1 |
The invention describes compounds of formula (I), where A is an oxygen atom or a NH group; B is the radical -Zm-(CHQ)p-(CH=CH)q-(CH2)r-P, where Z is a -CO- group or -SO2-group, m is 0 or 1, p is 0, 1 or 2, q is 0, 1 or 2, r is 0, 1 or 2,...
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WO/1995/015366A1 |
Polyalkyl nitro and amino aromatic esters having formula (I): wherein A1 is nitro, amino, N-alkylamino wherein the alkyl group contains 1 to 6 carbon atoms, or N,N-dialkylamino wherein each alkyl group independently contains 1 to 6 carbo...
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WO/1995/013262A1 |
Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q(CO2R6 or OH), -CN, -C(R7)=NOR8, NO2, -O(lower alkyl)R9, -CC-R10, -CR11=C(R12)(R13), -C(=O)CH2C(=O)CO2H, -CO(R14), alkylthio, alkylsulphinyl, alkylsulphonyl, c...
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WO/1995/011215A1 |
Non-steroidal compounds of formulae (I) or (II), wherein the variables are as defined in the description, which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods fo...
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WO/1995/007896A1 |
Novel hydroxy ethyl azolyl derivatives of formula (I), in which: X is hydrogen, halogen, alkyl with 1 to 4 carbon atoms or alkoxy with 1 to 4 carbon atoms; Z is halogen, alkyl with 1 to 4 carbon atoms, halogen alkyl with 1 to 4 carbon at...
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WO/1995/007253A1 |
This application relates to 3-substituted and 4-substituted cis-diols. Specifically, there are provided 3-substituted diols of formula (II) and 4-substituted cis-diols having (1S, 2R) and (1R, 2S) absolute configurations of formulae (III...
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WO/1995/005805A1 |
The present invention relates to a process for providing a stable crystallinic form to a fine-grained substance or a substance mixture, which can be produced, stored and used while maintaining the aerodynamic properties required for inha...
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WO/1995/004118A1 |
Fuel compositions containing a major amount of hydrocarbons boiling in the gasoline or diesel range and an effective deposit-controlling amount of a poly(oxyalkylene) aromatic ester having formula (I) where A1 is nitro, amino, N-alkylami...
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WO/1995/003266A1 |
Therapeutic compositions comprising 1,8-dihydroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammator...
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WO/1995/003033A1 |
An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if nee...
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WO/1995/003259A1 |
Novel methods for biodegrading nitroaromatic compounds present as contaminants in soil or water using microorganisms are disclosed. Water is treatable directly; dry soil (22) is first converted into a fluid medium by addition of water. T...
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WO/1995/000473A1 |
A novel calix[4]arene compound, application of the compounds as an active component in a calcium sensitive sensor, and a calcium sensitive sensor containing the compound. The calix[4]arene compound has general formula (I). The sensor is ...
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WO/1995/000136A1 |
A method for the topical or systemic treatment of hyperkeratosis or disorders mediated by proteases that includes the administration of an effective amount of N-acetylcysteine or a pharmaceutically acceptable salt or derivative thereof, ...
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WO/1995/000467A1 |
Substituted phenethanol ethers are prepared by the etherification of corresponding substituted phenethyl alcohols with an aliphatic primary alcohol. The etherification is carried out by reacting a substituted phenethyl alcohol with an al...
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WO/1994/028886A1 |
Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 ...
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WO/1994/029329A1 |
Novel tethered hapten intermediates and related conjugates based on 3-phenyl-1-adamantaneacetic acid, as well as methods for making and using such conjugates. Haptens based on the above core structure may be substituted at any position o...
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WO/1994/027584A2 |
Various arylating agents having activity in the treatment of cancer and viral infection are disclosed. The active compounds include an aromatic ring having at least one labile leaving group and at least one electrophilic group. Preferred...
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WO/1994/026689A1 |
A process for preparing ferrous picrate is disclosed. The process includes the step of reacting under substantially non-oxidising conditions ferrous carbonate substantially free from ferric compounds with a substantially water-free solut...
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WO/1994/026730A2 |
Unsubstituted or substituted halo nitro and nitroso compounds and their metabolites are potent, selective and non-toxic inhibitors and supressants of cancer growth and viral infections in a mammalian host. The compounds are particularly ...
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WO/1994/026726A1 |
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or ary...
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WO/1994/025442A1 |
The invention concerns 3-(Hetero)aryl carboxylic acid derivatives of formula (I) in which R is a formyl group, a CO2H group or a group which can be hydrolysed to give a COOH group and the other substituents are as follows: R2 and R3 are ...
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WO/1994/025424A1 |
Described are fullerene derivatives of the formula (I) in which the symbols are as defined as follows: F is a fullerene unit of the formula C(20+2m) in which m = 20, 25, 28 or 29; E1 and E2, when they are the same or different, are COOH,...
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WO/1994/024080A1 |
Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographica...
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WO/1994/024090A1 |
A compound of formula (I) or a salt, ester or amide thereof, or a solvate thereof, wherein, R0 represents a substituted or unsubstituted aryl group; R1 represents hydrogen or an alkyl group; R2 represents a moiety of formula (a), wherein...
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WO/1994/021248A1 |
The invention pertains to the use of compounds of formula (I) wherein R1 and R2 stand for the constituents indicated in the description, and of their pharmacologically tolerable salts in the preparation of medicines for the treatment of ...
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WO/1994/019315A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, ...
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WO/1994/019310A1 |
The present invention provides a process for the nitration of aromatic substrates. In one process, an aromatic substrate is reacted with a silicate, optionally modified with a metal nitrate, in the presence of an acid anhydride and an or...
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WO/1994/019316A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different...
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WO/1994/017018A1 |
A fullerene derivate has formula (I), in which the symbols and indexes have the following meaning: F is a fullerene residue having the formula (C20+2m), in which m equals 1 to 50; R1 to R8 are the same or different and represent H, CO2R9...
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WO/1994/015258A1 |
A polymer has at least one photoactive site and more than one perfluorocyclobutane group. New monomers containing photoactive sites or photoactive precursors and at least one perfluorovinyl group are useful for making such polymers. Proc...
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WO/1994/014751A1 |
There are provided novel, therapeutically active 4-(4-hydroxy-3-nitrophenyl)-4-oxo-(2E)-butenoic acid and 4-(4-hydroxy-3-nitrophenyl)-4-oxo-(2Z)-butenoic acid of formula (I), as well as their salts formed with H2 receptor antagonists, pr...
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WO/1994/013619A1 |
The invention concerns compounds of formula (I) in which n is 0 to 6; X represents halogen, CN, OCN, SCN, C2-C4 alkinyl or CHR5R6, R5 and R6, independently of each other, being CN, NO2, formyl, optionally halo-substituted (C1-C4 alkyl)ca...
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WO/1994/012461A1 |
This invention relates to 4-substituted catechol diether compounds which are selective inhibitors of phosphodiesterase (PDE) type IV. The compounds of the present invention are useful in inhibiting PDEIV and in the treatment of AIDS, ast...
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WO/1994/012577A2 |
A process for the preparation of a polycyclic dye of formula (1) by reacting a compound of formula (2) with a compound of formula (3), wherein Ring A is unsubstituted or is substituted by from 1 to 5 groups; Ring B is unsubstituted or is...
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WO/1994/011334A1 |
Compounds of general formula (I) in which the index and the constituents have the meanings below: n: 0, 1, 2, 3 or 4; X: CHOCH3, CHCH3 or NOCH3; Y: O or NH; R1: nitro, cyano, halogen, alkyl, alkyl halide, alkoxy, alkoxy halide, alkylthio...
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WO/1994/011344A1 |
Described are substituted 3,4,5,6-tetrahydrophthalimides of formula (I) in which R1 = H or C1-C6 alkyl; R2 = H or halogen; R3 = H, halogen, NO2, CN, CH3, CH3 substituted with 1 to 3 halogen atoms, OCH3 or OCH3 substituted with 1 to 3 hal...
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WO/1994/010106A2 |
The present invention provides an acid catalyst complex comprising an organosulfonic acid having at least one covalent carbon-fluorine bond or one covalent carbon-phosphorus bond provided by a phosphono radical which has been contacted w...
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WO/1994/010118A1 |
Compounds are described in formula (1), wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; R2 is an optionally substituted cycloalkyl or cycloalkenyl group; R3 is a monocyclic or bicyclic aryl...
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WO/1994/010128A1 |
Photoremovable protecting groups for the creation of large scale chemical diversity are disclosed. Orthonitrobenzyl groups containing various phenyl-ring substituents, benzylic carbon substituents, and benzylic carbon extensions protect ...
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WO/1994/010120A1 |
An industrial process for producing a fluorinated dicarbonyl compound in a high yield, wherein a dicarbonyl compound represented by the general formula R1COCHR2COR3 (wherein R1 represents hydrogen, halogen, or (un)substituted alkyl or ar...
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WO/1994/008978A1 |
Compounds having the structural formula (I), wherein R can be the same or different and is halogen, hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, C3-C6 cycloalkyl, C7-C9 aralkyl, phenyl, nitro, C1-C6 alkoxy, C1-C6 alkylthio, C1-C6 alkylsulfiny...
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