| Document |
Document Title |
|
WO/1995/033739A1 |
New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy and Rb is hydrogen or Ra and Rb form toget...
|
|
WO/1995/028923A1 |
Stable pharmaceutical composition having a high concentration of an active taxoid class ingredient such as docetaxel or docetaxel derivatives. The pharmaceutical composition is characterized in that it comprises a therapeutic taxoid clas...
|
|
WO/1995/027707A1 |
A process for separating non-oxidizable compounds from a mixture containing at least one oxidizable compound. The mixture is contacted with ozone to oxidize oxidizable compounds to form oxidized compounds which are then converted to wate...
|
|
WO/1995/027708A1 |
The present invention relates to a process for converting purified, partially purified or crude taxane mixtures into a protected precursor of 10-deacetylbaccatin III and into 10-deacetylbaccatin III. The process comprises three steps, th...
|
|
WO/1995/026967A1 |
Process for preparing 7-trialkylsilyl baccatin III from 10-deacetyl baccatin III.
|
|
WO/1995/026961A1 |
Process for the preparation of 7-hydroxy taxanes of general formula (I) from 7-trialkylsilyl taxanes of general formula (II), wherein R1 is hydrogen, alkoxy, acyloxy or alkoxyacetoxy, and Z is a hydrogen atom or a radical of general form...
|
|
WO/1995/025755A1 |
The invention relates to copolymers of: a) 1 to 65 mol% of at least one diketen of the general formula (I) in which R1 and R2 are mutually independently hydrogen or C1-C30 alkyl; b) 30 to 70 mol% of at least one ethylenically unsaturated...
|
|
WO/1995/025728A1 |
Taxane derivatives of formula (I) are disclosed, characterized by the presence at position 2' and/or 7 of the taxane structure of an alkylating residue, optionally with a spacer consisting of an amino acid or a peptide residue. These com...
|
|
WO/1995/024402A1 |
Compounds having formula (I), wherein -OR1 comprises alkanoyl or the C-13 side-chain of paclitaxel; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the prepara...
|
|
WO/1995/023795A2 |
This invention concerns a process for the preparation of polyfluorooxetanes by the reaction of fluoroketones of fluoroepoxides with haloethylenes in the presence of a Lewis acid catalyst. Polyfluorooxetanes are useful as solvents and pla...
|
|
WO/1995/020582A1 |
This invention provides 7-deoxy-'DELTA'12,13-iso-taxol analogs of formula (I). The compounds of formula (I) are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast ca...
|
|
WO/1995/018613A1 |
Onium salts of taxo-diterpenoid-Cn,2-O-aza-arenes form water soluble self-assembling nanostructures above a critical aggregation concentration. The onium salt of aza-arene includes a delocalized charge which renders derivatized taxo-dite...
|
|
WO/1995/018798A1 |
Cyclic chemical switching method is employed for solubilizing and desolubilizing taxo-diterpenoids with respect to aqueous solvents. 2-halogenated onium salts of aza-arenes are employed to derivatize taxo-diterpenoids so as to alter thei...
|
|
WO/1995/017395A1 |
A method for extracting and isolating 10-deacetylbaccatine III (tetraol) from yew leaves, comprising a first step of yew leaf extraction using a suitable protic solvent to obtain an aqueous extract which has optionally been subjected to ...
|
|
WO/1995/013271A1 |
Novel taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I), Ar is an aryl, alkyl, alkenyl, cycloalkyl or cycloalkenyl radical; R is a hydrogen atom or an alkanoyl, alky...
|
|
WO/1995/013270A1 |
Novel taxicine derivatives of general formula (I), their preparation and pharmaceutical compositions containing them wherein Ar is an aryl, alkyl, alkenyl, cycloalkyl or cycloalkenyl radical, R is a benzoyl radical or a radical of genera...
|
|
WO/1995/012567A1 |
The present invention provides three basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediate...
|
|
WO/1995/012445A1 |
The invention pertains to a process and device for separating a mixture having at least two components, wherein a separation phase is impacted by the mixture to be separated and then the separation phase loaded with the mixture is eluted...
|
|
WO/1995/011247A1 |
Novel taxoids have general formula (I), wherein Ar is an aryl radical, R is an optionally substituted benzoyl radical, furoyl or thenoyl or a radical having the formula R1-O-CO-, wherein R1 is an optionally substituted alkyl radical, alk...
|
|
WO/1995/011241A1 |
Novel taxoids of general formula (I) wherein one of the symbols R1 or R2 is a hydrogen atom and the other is a hydroxy radical, R3 is a hydrogen atom or a radical of general formula (II) wherein: Ar is an aryl radical and R4 is a benzoyl...
|
|
WO/1995/011020A1 |
2'- and/or 7'- substituted taxoid derivatives having improved water-solubility and/or enhanced therapeutic activity and methods of making the same are disclosed.
|
|
WO/1995/009163A1 |
Method of preparing taxoids of general formula (I) by electrochemical reduction of a taxan derivative of general formula (III). The products of general formula (I) in which R1 is a radical of general formula (II) have remarkable anti-tum...
|
|
WO/1995/007900A1 |
The invention relates to pharmaceutical compositions comprising an effective cytotoxic amount of formula (I), wherein R represents Ac or H; R' represents (a) or (b) or (c) or OH; and R'' represents (d) or (e). These new compounds demonst...
|
|
WO/1995/003795A1 |
The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particuclar, it is a method of preventing or reducing atherosclerosis or restenosis after arter...
|
|
WO/1995/003265A1 |
Process for the synthesis of taxol and other tricyclic and tetracyclic taxanes.
|
|
WO/1995/003036A1 |
The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and taxol...
|
|
WO/1995/002576A1 |
Process for the preparation of N-carbonylarylimines of general formula (I) by desulphonating a sulphone of general formula (II). The N-carbonylarylimines of general formula (I) are particularly useful for the preparation of therapeutical...
|
|
WO/1995/002400A1 |
A compound or prodrug thereof having formula (II), wherein -OR1 comprises the C-13 side-chain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R", -CH=NR', -CH=NOR', -CH=NNR'R", -CH(OH)SO3Na, -CH2OPO3...
|
|
WO/1995/001969A1 |
Novel taxoids of general formula (I), preparation thereof and pharmaceutical compositions containing same. The novel taxoids have remarkable antitumor properties. In general formula (I), Ar is an aryl radical; R1 is an alkyl, alkenyl, cy...
|
|
WO/1994/028715A1 |
Quarternary ammonium compounds, compositions incorporating such compounds and waterproofers are provided.
|
|
WO/1994/029284A1 |
A method for preparing an oxazolidinecarboxylic acid of general formula (I), which is useful for preparing therapeutically active taxoids of general formula (III), from an oxazolidinecarboxylic acid of general formula (II). In formulae (...
|
|
WO/1994/029288A1 |
This invention provides 7-deoxy-DELTA6,7-taxol and 7-deoxy-DELTA6,7-taxol analogs of formula (I). The compounds of formula (I) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast ...
|
|
WO/1994/029299A1 |
Certain novel imidazole derivatives having the ability to inhibit the lipoxygenase enzyme and having formula (I), wherein Y is hydrogen, C1-C8 alkyl, halosubstituted C1-C4 alkyl, phenyl, substituted phenyl, C7-C14 phenylalkyl, C7-C14 (su...
|
|
WO/1994/027984A1 |
The present invention relates to a new taxane having the structure (1), which is isolatable from root bark of plants of the Taxus genus. The compound (1) is endowed with antitumor activity higher than the one of taxol, the former being a...
|
|
WO/1994/025449A1 |
Antineoplastic taxol derivatives are derived by selective oxidation of the alkene portion of the side chain of cephalomannine. The derivative displays high activity in promoting assembly of microtubulin and also displays cytotoxic activi...
|
|
WO/1994/025020A1 |
Use of taxol or a pharmaceutically active and ophthalmologically acceptable derivative thereof for manufacturing an intraocular composition for preventing secondary cataract after extracapsular cataract extraction with or without intraoc...
|
|
WO/1994/022813A1 |
Method for the preparation of beta-phenylisoserine derivatives of general formula (I) involving the action of an anhydride and hydrogen with a product of general formula (II). The products of general formula (I) are especially useful in ...
|
|
WO/1994/022856A1 |
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (I...
|
|
WO/1994/021622A1 |
A method for purifying taxoids (Taxot�re, 10-deacetylbaccatin III) by centrifugal partition chromatography.
|
|
WO/1994/021651A1 |
Taxane derivatives having a C13 side chain which includes a furyl or thienyl substituent.
|
|
WO/1994/021251A1 |
Taxanes having side-chain substituted by a group CONX8X10 wherein X8 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterosubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, and X10 is alkyl, alkenyl, alkynyl, aryl, hetero...
|
|
WO/1994/021252A1 |
Taxane derivatives having a pyridyl substituted C13 side-chain.
|
|
WO/1994/021623A1 |
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which an ammonium alkoxide is reacted with a beta-lactam.
|
|
WO/1994/021250A1 |
Taxane derivatives having a C13 side chain which includes an N-substituted group and the formula of the group is -COOX10 wherein X10 is alkyl, alkenyl or aryl. The taxane derivatives are useful antileukemia and anticancer agents.
|
|
WO/1994/020453A1 |
Polyalkylene oxide conjugated beta-amides are disclosed, as well as the polyalkylene oxide conjugates of taxol, taxol analogues and intermediates prepared therefrom. Processes for preparing the polyalkylene oxide conjugated beta-amides a...
|
|
WO/1994/020484A1 |
Novel taxoids of general formula (I), preparation thereof and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical, R is a hydrogen atom or an acetyl or alkoxyacetyl radical, R1 is a benzoyl radical ...
|
|
WO/1994/020486A1 |
Method and apparatus are described for isolating taxoids from taxoid containing source materials. The method and apparatus isolate taxoids from waxes and other constituents of the ornamental yew tree needle with the use of critical or ne...
|
|
WO/1994/020089A1 |
Taxol-based compositions are disclosed based on the formation of 7 carbamates. In certain aspects of the invention, the compositions include polyethylene glycol and have prolonged circulating lives in mammals, are highly water soluble an...
|
|
WO/1994/020088A1 |
Taxane derivatives, useful as anti-tumor and anti-leukemia agents, having alternative C9 substituents wherein the substituents are selected from a group consisting of hydrogen, hydroxy, protected hydroxy and acyloxy.
|
|
WO/1994/020485A1 |
Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin I...
|
