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Matches 701 - 750 out of 7,631

Document Document Title
WO/2004/052876A1
Urea-containing, substituted 4-phenyl-[1,3]-dioxanes, methods of manufacturing them, compositions containing them, and methods of using them to treat, for example, obesity or a sleep/wake disorder mediated by orexin-2 are described.  
WO/2004/050613A2
This invention provides 2-substituted-propenamide derivatives and their compositions for the treament of hepatitis B virus and/or hepatitis D virus.  
WO2004018414A3
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...  
WO/2004/048320A1
Biguanide and dihydrotriazine derivatives, preferably substituted asymmetrical imidodicarbonimidic diamides derived from hydroxylamines, and compositions containing biguanide and dihydrotriazine derivatives are disclosed. In addition, me...  
WO/2004/048329A1
The present invention provides antitumor compounds of the formula (I); and antitumor methods.  
WO/2004/046105A2
Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihy...  
WO/2004/046074A1
Di(ketene acetals) are prepared by photoisomerizing the corresponding di(vinyl acetals).  
WO/2004/041161A2
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine...  
WO/2004/041787A1
A novel process for producing a quinolinecarbaldehyde (IV) which comprises reacting an aminobenzophenone compound (I) with a β-ketoaldehyde derivative (II) in the presence of an acid to obtain a quinolinecarbaldehyde derivative (III) an...  
WO/2004/039794A1
It is intended to provide a cell activator which has a high biocompatibility and activates cells of mammals including humans without showing any species-specificity, a process for producing the cell activator and an apparatus therefor. A...  
WO/2004/039768A1
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...  
WO2003040096A3
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...  
WO/2004/037773A1
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of...  
WO/2004/037807A2
The present invention relates to novel compounds of formula (I), and salts, solvates and physiologically acceptable derivatives thereof, to a process for their manufacture, to pharmaceutical compositions containing them, and to their use...  
WO/2004/037806A1
The present invention relates to a compound of the formula (I) : in which T, A, R, B Xi, Yi and n are as defined in Claim 1, and to the pharmaceutically usable derivatives, solvates and stereoisomers thereof, comprising a mixture thereof...  
WO/2004/032630A1
An agent for controlling protist and/or a harmful substance which comprises a material prepared through firing a shell powder containing calcium carbonate as a primary component in the presence of a metal component. The agent exhibits hi...  
WO2003041728A9
The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 a...  
WO2004020430A3
The invention relates to a compound having general formula (I), wherein R1 denotes a phenyl or naphthalenyl group which is optionally substituted by one or more halogen atoms or groups hydroxy, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, trif...  
WO2003083063A3
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affi...  
WO2004020378A3
The present invention provides a method of producing glycol ethers, which are also commonly known as glymes. The method according to the invention includes contacting a glycol with a monohydric alcohol in the presence of a polyperfluoros...  
WO2003059874A3
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula (I) and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeuticall...  
WO2004005478A3
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA cons...  
WO2003099284B1
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2004/026292A1
Antitussives containing as the active ingredient compounds represented by the general formula (I) or salts thereof: (I) (wherein A is alkoxycarbonylalkyl or the like and R is optionally protected hydroxyl, or A and R may be united to for...  
WO2003004480A3
A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are us...  
WO2003041728A8
The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 a...  
WO/2004/024661A1
The invention relates to a method for producing aldehydes by means of hydroformylation catalysed by metals of groups eight to ten of the periodic table in the presence of cyclic carbonic acid esters.  
WO/2004/024677A1
An N-hydroxyformamidine derivative represented by the formula (I) wherein R1 represents hydrogen, C1-4 alkyl, C1-4 alkoxy, or halogeno; A represents C1-10 alkylene or a group represented by the formula (II) (wherein m, n, and p each is a...  
WO/2004/022552A1
A compound of the following structure: wherein R1 is H, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, or a halogen atom; R2 is H, an alkyl group, an aryl group, a benzyl group, a trityl group, -SiRaRbRc, CH2ORd, or C...  
WO/2004/022523A2
The present invention relates to compounds of formula (AA), (I) and (X), useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment ...  
WO2003002524A3
The present invention relates to compounds of the formula I, in which R<1>, R<2>, R<4>, R<5>, D1, D2, X1, X2, X3, A and B have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active com...  
WO/2004/020380A1
The invention relates to a method for the production of aldehydes by catalysed hydroformylation of metals in the 8th 10th groups of the periodic table of elements of olefinically unsaturated compounds in the presence of cyclic carbonic a...  
WO2003078420A3
A process for a stereoselective preparation of novel chiral nitrogen mustard derivatives useful in synthesizing optically active 1,4-disubstituted piperazines of formula (I) wherein R, Ar, and Q are defined as set forth herein, and inter...  
WO/2004/020430A2
The invention relates to a compound having general formula (I), wherein R1 denotes a phenyl or naphthalenyl group which is optionally substituted by one or more halogen atoms or groups hydroxy, cyano, nitro, C1-3-alkyl, C1-3-alkoxy, trif...  
WO/2004/020378A2
The present invention provides a method of producing glycol ethers, which are also commonly known as glymes. The method according to the invention includes contacting a glycol with a monohydric alcohol in the presence of a polyperfluoros...  
WO/2004/020414A1
This invention relates to compounds of formula (I).  
WO/2004/018446A1
A process for producing high-purity &gammad -keto acetals in high yield by a simple and easy means, as represented by the following scheme: (I) wherein Ar is aryl; X is halogeno; Ra and Rb are each alkyl or the like; and W is alkylene.  
WO/2004/018414A2
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...  
WO/2004/016213A2
The present invention relates to solid phase or solution phase combinatorial libraries of autoinducer analogs. The present invention also relates to autoinducer agonists and antagonists. In addition, the present invention relates to meth...  
WO/2004/014966A1
The invention relates to a method for producing optionally coupled, non-blocked polymers based on conjugated dienes or optionally coupled, non-blocked copolymers based on conjugated dienes and vinyl aromatic compounds by anionic polymeri...  
WO/2004/014871A1
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes,...  
WO/2004/014899A1
The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.  
WO/2004/014890A1
It is intended to provide a method of purifying lactide whereby crude lactide can be purified while consuming less energy and causing no heat denaturation to thereby give D- or L-lactide having a high optical purity. In a method of purif...  
WO/2004/013121A2
The present invention relates to preparing lactic acid derivatives that are useful as odorants and monomers for polymer synthesis.  
WO2003049702A3
Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.  
WO/2004/011420A1
A process by which an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-ylacetic acid derivative useful as an intermediate for medicines can be easily produced through short steps from an inexpensive, easily available material. The proce...  
WO/2004/011451A1
A process for easily and safely producing from inexpensive materials an optically active 1,4-benzodioxane derivative useful as an intermediate for medicines, etc. The process comprises sulfonylating an optically active triol compound (5)...  
WO/2004/011418A1
Disclosed are novel compounds of the formula (I)or a pharmaceutically acceptable salt or solvate thereof. Also disclosed is the treatment of chemokine-mediated diseases using compounds of the formula (II)  
WO2003044065A3
Disclosed is a method for the production of optionally coupled, non-blocking polymers based on conjugated dienes and optionally monovinyl aromatic compounds by anionic polmerization in an inert organic solvent in the presence of a lithiu...  
WO/2004/006878A1
The use is described of merocyanine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C22alkyl; cyclo-C3C8alkyl; or unsubstituted or C1-C5alkyl- or C1-C5alkoxy-substituted C6-C20aryl; orl; or ...  

Matches 701 - 750 out of 7,631