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WO/2023/177253A1 |
The present application provides: a variant polypeptide having an activity of aspartate 1-dicarboxylase; a microorganism including same; a composition for producing beta-alanine or beta-alanine-derived compounds, the composition comprisi...
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WO/2023/177254A1 |
The present application provides: a microorganism with enhanced activity of aspartate 1-decarboxylase derived from Tribolium castaneum; a composition for producing beta-alanine and/or a beta-alanine-derived compound, the composition comp...
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WO/2023/158175A9 |
The present invention relates to a novel transport protein variant and a method for producing an L-aromatic amino acid using same. The transport protein variant has changed protein activity through substitution of at least one amino acid...
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WO/2023/176487A1 |
The production method according to the present invention is characterized in that a D-amino acid oxidase used in step 2 in the scheme shown below is a polypeptide selected from the below-mentioned polypeptides (a) to (c). According to th...
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WO/2023/177160A1 |
The present application relates to an L-amino acid-producing microorganism having weakened carbamoyl phosphate synthase activity, and an L-amino acid production method using same.
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WO/2023/174511A1 |
The present invention relates in a first aspect to an enzymatic method for the production of an L-glufosinate P-ester. This method is characterized by a step (c) in which an L-glufosinate P-ester carbamoylate is reacted to give the corre...
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WO/2023/178318A2 |
The invention provides a method for producing in vitro a beta-hydroxy non- standard amino acid (0-OH-nsAA). The in vitro method comprises incubating L- threonine, an aldehyde and an L-threonine transaldolase (TTA). Also provided is a met...
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WO/2023/177161A1 |
The present application relates to a carbamoyl-phosphate synthetase large subunit variant, a polynucleotide for coding the variant, a microorganism comprising the variant or the polynucleotide, and an L-ornithine production method using ...
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WO/2023/142861A9 |
The present invention provides a method for constructing a threonine-producing engineered bacterium. According to the present invention, a 2-formyl-citrate synthase 1-inactivated strain (corynebacterium) is applied to the production of t...
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WO/2023/171996A1 |
The present application relates to a variant L-threonine export protein and a method for producing L-threonine using same.
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WO/2023/169168A1 |
The present invention relates to the field of microorganisms, in particular to a method for producing vitamin B5 by means of high-activity aspartate decarboxylase. L-aspartate α-decarboxylase (PanD) derived from Bacillus licheniformis i...
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WO/2023/171997A1 |
The present application relates to a mutant L-threonine-releasing protein and a method for producing L-threonine using same.
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WO/2023/169176A1 |
Escherichia coli for expressing aspartate dehydrogenase gene (aspDH) and a method for using same for fermentation production of vitamin B5 (VB5). By comparing the fermentation yield of VB5, it is found that overexpressing the aspDH gene ...
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WO/2023/167563A1 |
The present invention relates to a method for biosynthesizing N-carbamyl-L-glutamic acid and a novel use thereof for the prevention or treatment of inflammatory diseases. The invention also relates to a composition for the prevention, am...
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WO/2023/165684A1 |
The invention relates to a microorganism strain with a deregulated cysteine biosynthetic pathway, said strain thus being suitable for the fermentative production of at least one substance selected from L-cysteine, L-cystine, and thiazoli...
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WO/2023/167314A1 |
This method for hydrolyzing nylon involves monomerizing nylon using nylon hydrolase, and comprises: a step for dissolving nylon in an organic solvent in which nylon is soluble so as to prepare a nylon solution; a step for preparing a nyl...
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WO/2023/161296A1 |
Described herein are methods for conjugating moieties of interest, such as pharmaceutically active molecules, to targeting molecules such as antibodies using transglutaminase-based processes.
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WO/2023/159794A1 |
Provided is a 2,4-diaminopyrimidine oxide preparation method. The preparation method comprises the following steps: carrying out a cyclization reaction on 3-oxopropionitrile and guanidine under an oxidation condition to produce 2,4-diami...
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WO/2023/158030A1 |
The present invention relates to a novel zinc-binding dehydrogenase variant and a method for producing L-aromatic amino acid using same. The zinc-binding dehydrogenase variant has modified enzyme activity due to the substitution of one o...
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WO/2023/158029A1 |
The present invention relates to a novel ATP synthase variant and a method for producing L-aromatic amino acid using same. The ATP synthase variant has modified enzyme activity due to the substitution of one or more amino acids in the am...
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WO/2023/158722A2 |
The present disclosure encompasses a process for chiral resolution of racemic amines, particularly ethyl 2-(4-((tert-butoxycarbonyl)amino)phenyl)piperidine-3-carboxy
late, into its desired isomer, ethyl (2R,3S)-2-(4-((tert-butoxycarbonyl...
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WO/2023/151407A1 |
Provided in the present invention is a construction method for a threonine-producing strain. The present invention performs superimposed modification on a plurality of enzymes related to threonine synthesis and redox capacity supplement,...
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WO/2023/151412A1 |
Provided are a modified Corynebacterium microorganism, a construction method therefor, and a use thereof in production of threonine. The modified Corynebacterium microorganism provided is a Corynebacterium having inactive or activity-red...
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WO/2023/151411A1 |
The present invention relates to the technical field of microbial engineering, in particular to a recombinant microorganism for producing threonine, and a construction method therefor and the use thereof. In the present invention, an ace...
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WO/2023/151406A1 |
Provided in the present invention is a method for constructing a threonine-producing strain. By means of performing overlay modification on a plurality of enzymes related to the synthesis of threonine, including aspartate aminotransferas...
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WO/2023/151409A1 |
The present invention provides a method for constructing high-yield engineered bacteria for threonine. According to the present invention, strains of which the activities of aspartate aminotransferase, aspartokinase, homoserine dehydroge...
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WO/2023/151421A1 |
Provided are a modified Corynebacterium microorganism, a construction method therefor, and the use thereof in the production of threonine. The modified Corynebacterium microorganism has a weakened or inactivated expression of Cgl0978 gen...
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WO/2023/151408A1 |
Provided in the present invention is a construction method for a strain with high-yield production of threonine. In the present invention, the expression of one or more of aspartate aminotransferase, aspartokinase and threonine synthase ...
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WO/2023/149514A1 |
The present invention relates to a method for producing a dicarboxylic acid compound and/or a diamine compound and optionally a dehydration-condensation product of a dicarboxylic acid compound and a diamine compound (i.e., a dehydration-...
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WO/2023/142855A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a recombinant microorganism, a method for constructing same and use thereof. According to the present invention, by means of constr...
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WO/2023/142872A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of corynebacterium genus producing threonine, a method for constructing the same, and use thereof. The act...
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WO/2023/142854A1 |
Provided is a method for constructing a threonine production strain. By means of constructing a corynebacterium having an enhanced transketolase activity, the threonine production capacity of the strain is improved. In combination with e...
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WO/2023/142871A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of the corynebacterium genus, a method for constructing same and use thereof. The activity of oxaloacetate...
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WO/2023/142848A1 |
Provided is a promoter, which has a nucleotide sequence shown in SEQ ID NO.1. The promoter is obtained by means of rationally designing a promoter of a dapA gene, has obviously reduced transcriptional activity and can be used for the wea...
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WO/2023/142178A1 |
Provided is a glutamic acid decarboxylase (GAD) mutant with improved pH tolerance and use thereof in gamma-aminobutyric acid synthesis. The mutant is obtained by mutating an amino acid sequence, such as the GAD set forth in SEQ ID NO. 3....
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WO/2023/142860A1 |
The present invention provides a method for constructing a threonine-producing genetically engineered bacterium. According to the present invention, by means of reducing the activity of 2-formyl-citrate synthase 2 or inactivating the syn...
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WO/2023/142859A1 |
The present invention relates to the technical field of microbial engineering, and in particular to a modified Corynebacterium microorganism, a method for constructing same and use thereof. The present invention provides use of weakening...
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WO/2023/142873A1 |
The present invention relates to the technical field of microbial engineering. Specifically disclosed are a modified microorganism of corynebacterium genus, use thereof in producing threonine, and a method for constructing the same. The ...
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WO/2023/142862A1 |
Provided are a recombinant microorganism for producing threonine and the use thereof in the fermentation production of threonine or a derivative thereof. A 20-30 bp fragment upstream of an initiation codon of a gene encoding phosphoenolp...
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WO/2023/142853A1 |
Provided is a method for constructing a genetically engineered bacterium for highly producing threonine. The ability of the strain to produce threonine is improved by means of reducing the activity of the transcriptional regulation facto...
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WO/2023/143621A1 |
Provided are a D-amino acid oxidase and use thereof in the preparation of L-phosphinothricin or an intermediate thereof. Provided is a D-amino acid oxidase having an amino acid sequence comprising an amino acid residue difference as comp...
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WO/2023/136421A1 |
The present invention relates to a mutant in Escherichia having enhanced L-histidine productivity and a method for producing L-histidine using the mutant in Escherichia. The mutant in Escherichia increases or strengthens the expression o...
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WO/2023/136422A1 |
The present invention relates to a mutant in Escherichia having enhanced L-histidine productivity and a method for producing L-histidine using the mutant in Escherichia. The mutant in Escherichia weakens the activity of genes coding for ...
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WO/2023/133484A1 |
Aspects of the disclosure relate to modified skin commensal bacterial host cells capable of producing anthranilate or derivatives thereof.
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WO/2023/132122A1 |
This invention relates to a microorganism (NITE BP-03572) belonging to Rhodosporidiobolus azoricus or a microorganism (NITE BP-03573) belonging to the Vanrija genus.
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WO/2023/123589A1 |
Disclosed are a transaminase mutant and the use thereof, wherein the transaminase mutant has a sequence formed after an amino acid mutation occurs in the sequence shown in SEQ ID NO: 1, wherein the site at which the amino acid mutation o...
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WO/2023/126017A2 |
Disclosed in the present invention are an L-threonine aldolase, and a preparation method therefor and the use thereof. An L-threonine aldolase. The differences between the L-threonine aldolase and SEQ ID NO: 1 lie in that the L-threonine...
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WO/2023/125769A1 |
Modified glutamate dehydrogenase (GluDH) is provided. Specifically, the modified GluDH has increased activity of catalyzing PPO to react with an amino donor and generate L-glufosinate and/or an improved dyanamical property. Further provi...
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WO/2023/125330A1 |
Provided is a type of Saccharomyces cerevisiae, the preservation number thereof being CCTCC NO: M20211621. Further provided is a preparation method for a low-irritation γ-aminobutyric acid product. The preparation method comprises the f...
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WO/2023/124062A1 |
Provided is a method for preparing γ-PGA coupled with an ATP regeneration enzyme and a poly(glutamic acid) synthetase, specifically a method for preparing a poly(glutamic acid) (γ-PGA) using glutamic acid or sodium glutamate as a subst...
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