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WO/2019/213017A1 |
Methods for increasing carbon-based chemical product yield in an organism by perturbing redox balance in an organism as well as nonnaturally occurring organisms with perturbed redox balance and methods for their use in producing carbon-b...
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WO/2019/207812A1 |
This transformant obtained by introducing, to hydrogenophilus genus bacteria, DNA of (a1), (a2) or (a3), and (b) a gene of alcohol dehydrogenase, can efficiently produce isobutanol using carbon dioxide as the only source of carbon. DNA (...
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WO/2019/200874A1 |
Provided are a recombinant E. coli and the use thereof in the production of danshensu. The recombinant E. coli simultaneously expresses α-hydroxycarboxylic acid dehydrogenase, L-α-amino acid aminotransferase, and any one of glucose deh...
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WO/2019/198872A1 |
The present invention relates to a method for preparing an amino acid by decomposing protein components in a muscle part of a squid into amino acid components by using activation of a biotic enzyme of the squid caused by adding vitamin C.
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WO/2019/196262A1 |
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor....
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WO/2019/198367A1 |
This invention provides a method for efficiently producing an N-acyl-amino group-containing compound using an enzymatic method. Specifically, this invention provides a method for producing an N-acyl-amino group-containing compound, inclu...
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WO/2019/192438A1 |
Provided herein are engineered decarboxylase polypeptides that are useful for catalyzing the decarboxylation of amino aicds such as L-tyrosine to produce tyramine or catalyzing the decarboxylation of L-DOPA to produce dopamine. Also prov...
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WO/2019/193607A1 |
The present invention relates to an improved process for the preparation of 3-isobutyl glutaric acid compound of formula-1 which is used as the key intermediate in the preparation of Pregabalin compound of formula-A. The present inventio...
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WO/2019/184936A1 |
Disclosed in the present invention is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof. The method comprises: by using racemic 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (1) or ra...
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WO/2019/191772A1 |
This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19. Specifically, 7-aminoheptanoic acid is produced using a tran...
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WO/2019/185877A1 |
The invention relates to a method for the preparation of a 4,5-dihydroxyisoleucine derivative comprising the steps of asymmetric Claisen rearrangement of a Z-aminocrotyl-glycin ester and subsequent kinetic resolution of the product diast...
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WO/2019/190192A1 |
The present application relates to a novel promoter, and a method for producing L-amino acid by using same and, more specifically, to: a novel polynucleotide having a promoter activity, a vector and a Corynebacterium sp. microorganism co...
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WO/2019/190193A1 |
The present application pertains to a microorganism having enhanced glycine productivity and a method for producing a fermented composition by using same and, more particularly, to a Corynebacterium sp. microorganism that has a mutation ...
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WO/2019/189277A1 |
A method for producing an amide compound, said method comprising a step for contacting optionally treated microbial cells containing nitrile hydratase with a nitrile compound in an aqueous medium in a first reactor to give a liquid react...
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WO/2019/183358A2 |
The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrom...
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WO/2019/182413A1 |
The present application relates to granules containing L-amino acid and a method for preparing same.
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WO/2019/169849A1 |
Provided are a glutamate dehydrogenase mutant and use thereof in preparing L-glufosinate. The amino acid sequence of said mutant, which is as shown in SEQ ID NOs: 1-9, 11, 13, 15, 17-19, or 22, is obtained by means of a molecular modific...
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WO/2019/169467A1 |
The present invention relates to Escherichia coli strains optimized for use of glucose, glycerol, xylose and arabinose as carbon sources for the production of L-lysine, as well as the upregulation and downregulation/deletion of certain g...
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WO/2019/172825A1 |
The present invention relates to a method of separating amino acids from an aqueous solution comprising amino acids as well as proteins and/or protein decomposition products by combining phosphoric acid with the aqueous solution to preci...
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WO/2019/170705A1 |
This invention relates to a compound according to general formula (IA), which acts as a selective cysteine protease inhibitor; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination p...
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WO/2019/172702A1 |
The present application relates to a novel promoter and an L-amino acid production method using same and, more specifically, to a novel polynucleotide having promoter activity, a vector and a Corynebacterium sp. microorganism comprising ...
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WO/2019/168203A1 |
Provided is a novel method for producing 4-aminocinnamic acid from 4-nitrophenylalanine. This method comprises: (1) converting 4-nitrophenylalanine into 4-nitrocinnamic acid; and (2) converting 4-nitrocinnamic acid into 4-aminocinnamic a...
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WO/2019/165551A1 |
Disclosed are methods for converting a substrate into a product alkaloid, including a benzylisoquinoline compound or benzylisoquinoline precursor compound, in a biosynthetic system involving the growth of host cells. The cells comprise a...
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WO/2019/164348A1 |
The present application relates to a microorganism producing L-tryptophan, which is modified to express a novel protein having tryptophan export activity, and a method for producing L-tryptophan using the microorganism.
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WO/2019/163767A1 |
Provided are a method for producing ergothioneine in high yield at low cost and a bacterium for use in the method. This method is designed to produce ergothioneine, a related substance thereof, or a mixture of these, and is characterized...
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WO/2019/164351A1 |
The present application pertains to a mycosporine-like amino acid-producing microorganism and a method for production of mycosporine-like amino acids by using the microorganism. Having an improved mycosporine-like amino acid-producing po...
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WO/2019/164346A1 |
The present application relates to a Corynebacterium sp. microorganism for producing L-tryptophan by using a gene manipulation technique and a method for producing L-tryptophan by using the microorganism.
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WO/2019/160301A1 |
The present application relates to a modified polypeptide with attenuated activity of citrate synthase and a method for producing aspartate-derived L-amino acids using same.
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WO/2019/157921A1 |
Disclosed is a nitrilase mutant and an application thereof. The mutant is obtained by one or more substitutions of amino acids at position 201 or amino acid sequences at positions 324-381 of the amino acid sequence shown in SEQ ID No. 2....
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WO/2019/160705A1 |
The invention provides a process for the preparation of a modified triethanolamine/fatty acid ester composition ratio by treatment of a conventional tnethanolamine fatty acid ester composition with a hydrolytic enzyme. Also provided are ...
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WO/2019/160059A1 |
Provided is a method for recycling s-adenosylmethionine that is characterized in that after s-adenosylmethionine is demethylated, s-adenosylmethionine is regenerated by converting s-adenosylmethionine from methionine obtained by transfer...
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WO/2019/154670A1 |
The present invention relates to recombinant Corynebacterium spp. host cells comprising, in relation to wild-type cells, at least one mutation selected from the group consisting of mutations that (i) reduce the activity of a protein, sel...
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WO/2019/151769A1 |
The present disclosure relates to a method for preparing L-cysteine hydrochloride hydrate crystals, and L-cysteine hydrochloride hydrate crystals prepared by the method. Through the method for preparing L-cysteine hydrochloride hydrate c...
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WO/2019/151770A1 |
The present disclosure relates to a method for preparing L-cysteine crystals, and L-cysteine crystals prepared by the method. Through the method for preparing L-cysteine crystals of the present disclosure, L-cysteine crystals can be obta...
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WO/2019/147059A1 |
The present application relates to a microorganism of the genus Corynebacterium for producing an L-amino acid and a method for producing an L-amino acid by using the microorganism.
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WO/2019/140687A1 |
Disclosed in the present invention is a method for enzymatic synthesis of chloramphenicol intermediate. In the method, nitrobenzaldehyde and glycine are used as substrates, and are reacted under the catalysis of aldolase to obtain a chlo...
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WO/2019/136585A1 |
Provided in the disclosure relates to microorganisms genetically modified to overexpress biofilm dispersal related polypeptides to enhance the production of lysine and lysine derivatives by the microorganism, method of generating such mi...
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WO/2019/137083A1 |
Disclosed in the present invention are a one-step process for producing a nylon 5X salt and a prepared high-purity nylon 5X salt. The process comprises: subjecting a lysine fermentation liquid to ion exchange and desorption to obtain a p...
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WO/2019/132549A1 |
The present invention relates to a method for preparing choline alfoscerate, usable as a food raw material, from phosphatidylcholine or lecithin, and a choline alfoscerate preparation method according to the present invention uses a spec...
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WO/2019/128894A1 |
Provided are amino acid sequences of engineered transaminase polynucleotide that are useful for asymmetrically synthesizing chiral amine compounds, and its preparation process and reaction process under industrial-relevant conditions. Al...
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WO/2019/130723A1 |
The present invention provides a method for producing glycine or a salt thereof by fermentation of a bacterium which has been modified to overexpress a gene encoding a protein having L-threonine 3-dehydrogenase activity and a gene encodi...
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WO/2019/124932A2 |
The present application pertains to a Corynebacterium sp. microorganism producing L-arginine and a method using the same for producing L-arginine.
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WO/2019/119614A1 |
Disclosed in the present invention is a method for synthesizing L-aspartic acid by means of the whole cell catalysis of maleic acid by coupling two enzymes, which relates to the field of bio-engineering. In the present invention, a recom...
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WO/2019/125686A1 |
Described are methods for improving the production of the amino acids glutamate and lysine in submerged Corynebacterium culture comprising adding to a submerged Corynebacterium culture a non- enzymatic fraction of spent Trichoderma ferme...
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WO/2019/121876A1 |
The present invention relates to the production of organic acids by anaerobic fermentation of molasses and/or pulp, residues of the sugar industry, in which the molasses and/or the pulp are fermented in an aqueous medium containing vinasse.
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WO/2019/123311A1 |
Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention ar...
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WO/2019/118548A1 |
This disclosure provides engineered strains of Corynebacteria for the cost-effective production of lysine, tools and methods used to produce the engineered strains, and methods of using the engineered strains to produce lysine.
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WO/2019/104518A1 |
Provided microorganisms genetically modified to overexpress an imine/enamine deaminase to enhance the production of lysine and lysine derivatives by the microorganism. Also provided a method of generating such microorganism, and methods ...
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WO/2019/104179A1 |
This disclosure relates to deuterated D-serine, pharmaceutically acceptable salts thereof, analogs and prodrugs thereof, pharmaceutical compositions thereof, and methods of use.
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WO/2019/097123A1 |
The present invention relates to a process for producing aqueous acrylamide solution by hydrating acrylonitrile in an aqueous solution in the presence of a biocatalyst. The present invention further relates to aqueous acrylamide solution...
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