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WO/2020/032038A1 |
The present invention provides a compound represented by formula (I), which has high specificity and high selectivity for monoamine oxidase B, and which is capable of imaging monoamine oxidase B with a good sensitivity, or a pharmaceutic...
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WO/2020/019911A1 |
Disclosed are a boron nitrogen ligand based on a chiral 1,2-ethylenediamine backbone, and a preparation method and use thereof. The boron nitrogen ligand has a structural formula as shown in formula (I), wherein R1, R2, and R3 are respec...
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WO/2019/233209A1 |
A catalyst and a method for preparing S-indoxacarb using the catalyst. The catalyst is prepared using 3-tert-butyl-5-chloromethyl salicylaldehyde and cyclohexanediamine as raw materials, where an original quinine catalyst such as cinchon...
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WO/2019/233211A1 |
The present invention relates to the field of asymmetric catalytic synthesis, and in particular to a preparation method for a high optical indoxacarb intermediate. The present invention comprises reacting 5-chloro-2-methoxycarbonyl-1-ind...
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WO/2019/213987A1 |
Disclosed are a monophosphine ligand based on a tetramethyl spirobiindane skeleton and an intermediate thereof, and a preparation method therefor and the use thereof. The monophosphine ligand is a compound having the structure represente...
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WO/2019/208710A1 |
The present invention provides: a method for producing 3-hydroxymethyltetracyclo[4. 4. 0. 12, 5. 17, 10]dodecane, which is characterized by subjecting tetracyclo[4. 4. 0. 12, 5. 17, 10]-3-dodecene to a hydroformylation reaction and subse...
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WO/2019/180084A1 |
The present invention relates to the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds. The present invention provides a process for the synthesis of compound of formula (I). This process...
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WO/2019/176732A1 |
[Problem] To provide a production method capable of easily synthesizing a compound having a structure in which a plurality of tetrahydroisoquinoline rings are linked together, using a reduced number of steps. [Solution] It was found that...
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WO/2019/160037A1 |
The purpose of the present invention is to provide methods for producing a carboxamide compound, a sulfonamide compound, and an ester compound using an acid halide. The methods for producing a carboxamide compound, a sulfonamide compound...
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WO/2019/119516A1 |
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in ...
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WO/2019/115597A1 |
Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I) : their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalyst...
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WO/2019/075084A1 |
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-l...
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WO/2019/060953A1 |
The present invention relates to chiral auxiliaries and the syntheses thereof and uses thereof.
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WO/2019/035775A1 |
A method for the preparation of tapentadol in the form of a base or its hydrogen chloride, which involves the preparation of a salt (III) from a mixture of diastereomers (II) by means of crystallization-induced asymmetric transformation ...
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WO/2019/035453A1 |
Provided is a catalyst represented by general formula (1). In general formula (1), R1-R14 each independently represent a hydrogen atom or a substituent.
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WO/2018/207888A1 |
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1...
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WO/2018/209243A1 |
The present disclosure provides methods for enantioselective synthesis of acyclic α- quaternary carboxylic acid derivatives via iridium-catalyzed allylic alkylation.
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WO/2018/189107A1 |
The present invention is related to a new chiral biphenyl diphosphine ligand of formula (I), wherein R1, R2, and R3 are independently H, alkyl or aryl; R6 and R7 is independently a substituent; and A is independently aryl or heteroaryl, ...
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WO/2018/189060A1 |
The invention comprises novel chiral metal complex compounds of the formula (I) wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter io...
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WO/2018/143165A1 |
The present invention provides a method for producing a compound represented by formula (VII), the method including reacting a compound represented by formula (VI) with a malonic acid derivative in the presence of a base and an asymmetri...
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WO/2018/106746A2 |
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands
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WO/2018/106621A1 |
This invention relates to novel phosphorous ligands useful for organic transformations. Methods of making and using the ligands in organic synthesis are described. The invention also relates to processes for preparing the novel ligands.
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WO/2018/099146A1 |
Disclosed is a method for asymmetrically synthesizing aspidosperma alkaloid. In this method, a key intermediate of formula (4) is obtained by 6 steps of reactions, including [4+2] cycloaddition of the compound of formula (1a) and the com...
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WO/2018/086197A1 |
The present invention relates to the field of organic syntheses, and provides a catalytic asymmetric synthesis method for a chiral SPINOL derivate, comprising: using chiral phosphoric acid as a catalyst and reacting same with a compound ...
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WO/2018/021508A1 |
The present invention is a production method for a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, or a hydrate of said compound or salt.
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WO/2017/197670A1 |
Disclosed in the present application is a method for synthesizing a 1,2-dimethylene cyclobutane chiral compound. The 1,2-dimethylene cyclobutane chiral compound is synthesized from an allenylamine compound in the presence of a rhodium co...
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WO/2017/177715A1 |
The present invention discloses a method for synthesizing a chiral ferrocene-like P, P ligand, and belongs to the technical field of organic synthesis. The method is implemented through the following steps: (1) using vinyl ferrocene as a...
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WO/2017/168313A1 |
The present invention provides an improved process for preparation of L-threo-(2S,3R)-3-(3.4- dihydroxyphenyl)serine (I) (Droxidopa) and its salts; comprising (a) reaction of the aldehyde compound (III) (as described herein) with Metal c...
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WO/2017/170952A1 |
The present invention relates to: a novel compound that is useful as a ligand in a variety of catalytic organic synthetic reactions; a method for easily and efficiently producing said novel compound; a synthetic intermediate of said nove...
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WO/2017/154738A1 |
The present invention addresses the problem of providing a novel method for producing an optically active amine compound that is useful as an intermediate for a medicine, an agrochemical, an electronic material and the like. A method for...
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WO/2017/122822A1 |
The present invention addresses the problem of providing an industrially advantageous method for producing an optically active amidocarboxylic acid derivative, which is an important intermediate of a depsipeptide compound expected to be ...
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WO/2017/114058A1 |
The present invention discloses a method for preparing an optically active carbonyl compound, comprising the following steps: subjecting an α,β-unsaturated aldehyde or an α,β-unsaturated ketone to an asymmetric hydrogenation catalyze...
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WO/2017/107789A1 |
Disclosed are a compound having a chiral spirobiindane skeleton and a preparation method therefor. The compound having a chiral condensed ring spirobiindane skeleton of the present invention is represented by formula I or I'. The prepara...
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WO/2017/111176A1 |
Synthesis of an organic compound with chirality is an important technique in the fields of medicines, pesticides, health foods, etc. However, catalysts to be used for such synthesis are produced from expensive starting materials and, fur...
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WO/2017/098975A1 |
A method for producing methyl (2Z)-3-(1,1'-biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]- prop-2-enoate, comprising the steps of: reacting 4-phenylbenzaldehyde with glycine in the presence of sodium hydroxide or potassium hydroxide to pr...
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WO/2017/057642A1 |
Provided is a novel method for producing optically active 2-(2-fluorobiphenyl-4-yl) propanoic acid. This method is characterized by reacting an organometallic reagent prepared by the action of the compound represented by formula [1] and ...
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WO/2017/051856A1 |
A method for producing a specific enantiomer in a larger amount than the other enantiomer, said method comprising reacting a reaction substrate in the presence of cellulose nanofiber or a derivative thereof and a catalyst so as to improv...
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WO/2017/043626A1 |
Provided is a method for producing an optically active 4-carbamoyl-2,6-dimethylphenylalanine derivative, which is a compound useful as an intermediate for a medicine, in a simple manner and with high efficiency. 4-carbamoyl-2,6-dimethylb...
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WO/2017/037141A1 |
The present invention relates to chiral phosphoramidimidates, their salts and metal complexes as well as derivatives thereof and their use as catalysts, Formula (I).
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WO/2017/036577A1 |
The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound (I) a...
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WO/2017/037662A1 |
The present invention provides an improved process for the preparation of N-protected ((3S,4R)- 4-(4-fluorophenyl)piperidin-3-yl)methanol (compound (A)) and further its transformation to Paroxetine and its pharmaceutically acceptable sal...
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WO/2017/029362A1 |
The present invention relates to processes, process steps and intermediates useful in the asymmetric bisamidation of malonic ester derivatives wherein the new processes, process steps and intermediates are, for example, useful in the pre...
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WO/2017/006929A1 |
The present invention makes it easy to obtain, with good yield and stereoselectivity, an optically active α-tetrasubstituted α-amino nitrile derivative, or an intermediate for the synthesis of said derivative, by reacting a cyanometala...
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WO/2016/208699A1 |
[Problem] To provide a method for the industrial production of an optically active fluoroalkyl ethylene oxide. [Solution] An optically active fluoroalkyl chloromethyl alcohol having a high optical purity can be produced at a high yield b...
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WO/2016/203005A1 |
The present invention relates to a complex of the Formula 2, and a compound of Formula 1, and the use of said compound of Formula 1 for the synthesis of said complex of Formula 2, processes for synthesis of said compound of Formula 1, an...
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WO/2016/198836A1 |
Processes of forming Csp2-Csp3 bonds at the allylic carbon of a cyclic allylic compound starting material are disclosed, in which a racemic mixture of a cyclic allylic compound having a leaving group attached to the allylic carbon is rea...
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WO/2016/195016A1 |
The present invention provides: a novel HYA derivative that has excellent physiological functions inherent to HYA and allows easy intake and handling; and a use for said HYA derivative. The present invention relates to: a triglyceride or...
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WO/2016/160579A1 |
This invention provides efficient and scalable enantioselective methods that yield 2-alkyl-2-allylcycloalkyanone compounds with quaternary stereogenic centers. Methods include the method for the preparation of a compound of formula (I), ...
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WO/2016/146689A1 |
Provided is an organozinc composition comprising (a) an organozinc complex carrying an allylic ligand, (b) a magnesium component and (c) a lithium component. The organozinc composition is useful as a synthetic intermediate with excellent...
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WO/2016/140189A1 |
The purpose of the present invention is to provide a novel method for producing an optically active α-fluoro amino acid compound or a salt thereof. More specifically, the purpose is to produce an α-fluoro amino acid compound or a salt ...
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