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Matches 1 - 50 out of 10,525

Document Document Title
WO/2021/065893A1
The purpose of the present invention is to provide a novel low-molecular-weight compound that exhibits agonistic activity on an orexin receptor and is expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the li...  
WO/2021/062559A1
This disclosure relates to carmabinoid derivatives of Formula (1) wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the carmabinoid derivatives. These compounds are poten...  
WO/2021/062231A2
A prodrug compound of cannabidiol (CBD), pharmaceutical composition thereof and methods of use thereof in patients in need.  
WO/2021/055195A1
A latent base catalyst and compositions and methods involving latent base-catalyzed Michael addition reaction are described herein. The described latent base catalyst is a substituted carbamate salt. The compositions described herein are...  
WO/2021/054632A1
The present invention relates to an ultra-thin form release agent and a method for producing same and, more specifically, to a method for producing a release agent capable of being coated in an ultra-thin form without thermal deformation...  
WO/2021/052353A1
The present invention relates to the technical field of enzyme inhibitors, and relates in particular to a hydroxamic acid derivative, a preparation method therefor and an application thereof. The hydroxamic acid group in the hydroxamic a...  
WO/2021/004973A9
The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.  
WO/2017/117530A9
What is described is a compound of formula I wherein X is an ethene, or an unsubstitiited or substituted arene or heteroarene; Y is a bond, an ethene, or an unsubstituted or substituted arene or heteroarene; Z is S or O; L is a linear or...  
WO/2021/036256A1
The present application is suitable for use in the technical field of drug synthesis, and provides a method for synthesizing an HIV protease inhibitor intermediate compounds. The method comprises subjecting compound 1a to an asymmetric t...  
WO/2021/027237A1
The present invention relates to a method for preparing a supercritical carbon dioxide thickener for the exploitation of tight oil and gas reservoirs. The method can solve the problem of oil and gas deposits being damaged as a result of ...  
WO/2021/029406A1
A urethane allyl compound having a urethane bond and an allyloxy group.  
WO/2021/026494A1
Methods for the steam sterilization of hydrogels crosslinked with a beta-eliminative linker without the drawback of significant degradation are provided.  
WO/2021/021634A1
Compositions for delivering nucleic acids to cells or tissue microenvironments are provided. In one embodiment, the compositions are lipid nanoparticle compositions formulated to have reduced splenic and hepatic clearance. It has been di...  
WO/2021/004973A1
The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.  
WO/2021/005588A1
A method for producing a solution of ammonium carbamate is provided. The method comprises reacting ammonium hydroxide with sodium bicarbonate. The method avoids the complications of using carbon dioxide and can be carried out using stand...  
WO/2021/004516A1
Disclosed is a method for preparing 2-indolinospirone compound and intermediate thereof, specifically disclosed is a method for preparing a compound of formula 5. The method is relatively simple and has high stereoselectivity and yield.  
WO/2021/001457A1
The present invention relates to crystalline salt forms of (R)-2-amino-3-phenylpropylcarbamate and a process for their preparation. The invention also relates to a pharmaceutical composition comprising one or more of the crystalline salt...  
WO/2021/002407A1
Provided is a novel production method by which a fluoroalkyl group-containing compound can be efficiently synthesized. This method is for producing a compound represented by general formula (3) (Rf represents a C1-30 alkyl group substi...  
WO/2021/002408A1
The present invention provides a peptide having a fluoroalkyl group as a side chain. The present invention is a method for manufacturing a fluoroalkyl-group-containing peptide in which a compound represented by general formula (6-2) or (...  
WO/2021/000053A1
The present invention provides cannabinoid derivatives, a pharmaceutical composition comprising said derivative and a method of using said derivatives in treating or preventing a disease associated with cannabinoid receptors. The claimed...  
WO/2020/264474A1
The present invention is directed to a compound of formula I, as shown in claim 1, wherein R1 comprises hydrogen, an alkyl group, or an aryl group; R2 comprises hydrogen or a methyl group; R3 comprises a divalent organic group; R4 compri...  
WO/2020/261156A1
Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X1, R1, R2, R3, R4, R5 and R6 are as defined herein, for the treatment of BRAF-associated diseases and dis...  
WO/2020/262648A1
The present invention provides a compound that has an excellent pest-controlling effect and that is represented by formula (I) [in the formula, L represents an oxygen atom or CH2, E represents a C2-C10 chain hydrocarbon group or the like...  
WO/2020/262258A1
A method for producing a peptide compound including a step that uses a condensed polycyclic aromatic hydrocarbon compound represented by formula (1), a reagent for forming a protecting group that includes the compound, and the compound. ...  
WO/2020/252713A1
The present invention relates to the preparation of a hydrophobic medicinal auxiliary material and a drug-loaded fat emulsion, and in particular to a hydrophobic auxiliary material with the structural formula as shown below, wherein R is...  
WO/2020/257694A1
Solutions formed from ammonium carbonate and/or bicarbonate and ammonium hydroxide are disclosed. An amount of ammonium carbonate or bicarbonate is added to water with mixing. Furthermore, an amount of ammonium hydroxide is added to the ...  
WO/2020/255062A1
Pharmaceutical compositions containing hepatitis B virus (HBV) vaccines and lipids are described. Methods of inducing an immune response against HBV or treating an HBV-induced disease, particularly in individuals having chronic HBV infec...  
WO/2020/237749A1
Provided is a compound having a long-acting therapeutic effect. The compound can be used to prepare an antidepressant drug and drugs for anesthesia, analgesia, improvement of cognitive function, lung protection, amyotrophic lateral scler...  
WO/2020/227264A1
The disclosure provides recording materials include fluorene derivatized monomers and polymers for use in volume Bragg gratings, including, but not limited to, volume Bragg gratings for holography applications. Several fluorene structure...  
WO/2020/219876A1
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepa...  
WO/2020/212510A1
The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymme...  
WO/2020/207129A1
Disclosed is an ammonium salt with a structural formula represented by formula (I). A synthesis method thereof comprises using 8 mol% zinc chloride as a catalyst, 5 mmol of 1-phenyl-1,3-butanedione, 1.2 g of benzylamine, and 40 mL of chl...  
WO/2020/193419A1
The present invention relates to novel compounds, pharmaceutical compositions comprising such compounds and their use for treating, alleviating or preventing diseases or disorders relating to the activity of potassium channels.  
WO/2020/196553A1
The purpose of the present invention is to provide a method that enables efficient and safe production of an N-substituted trihaloacetamide which also serves as a synthetic intermediate for isocyanate compounds, carbamate compounds, urea...  
WO/2020/189540A1
The present invention provides a method for efficiently preparing various optically active aromatic amino acid derivatives by performing a reaction, in the presence of a catalyst, on a specific ester compound by using an aromatic halide ...  
WO/2020/178776A1
A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4- (hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product hav...  
WO/2020/169054A1
The present invention relates to crystalline forms I and II of a (E)-α,β-unsatured amide compound, preparation methods therefor, and uses thereof. The crystalline forms all have excellent properties in physical and chemical stability a...  
WO/2020/167829A1
The present disclosure provides a method of preparing a compound of Formula I, wherein R1 is C1-C4 alkyl; R2 is C1-C4 alkyl; and R3 is selected from the group consisting of C1-C6 alkyl, (aryl)alkyl, and (heteroaryl)alkyl in >95% chemical...  
WO/2020/158931A1
The purpose of the present invention is to provide: a novel compound which is useful as a film forming material for lithography or as a material for forming an optical component; a resin which contains a constituent unit that is derived ...  
WO/2020/150639A1
The present disclosure provides therapeutic methods of treating a cancer in a subject with isopropyl (S)-2-((S)-2-acetamido-3-(1H-indol-3-yl)propanamido)-6-diazo -5-oxohexanoate or isopropyl (S)-2-((S)-6-acetamido-2-((3S,5S,7S)-adamantan...  
WO/2020/148760A1
The invention generally concerns a novel class of CB 1 receptor binding molecules and uses thereof.  
WO/2020/145584A1
The present invention relates to a novel serine derivative compound having improved blood-brain barrier (BBB) permeability, and a use of same, and more specifically, to a novel serine derivative compound having further improved BBB perme...  
WO/2020/143198A1
Ketamine derivatives and pharmaceutical compositons thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used ...  
WO/2020/137545A1
A method for producing an amide, wherein after causing a dehydration condensation of carboxylic acids or a reaction between a carboxylic acid and a halogenated formic acid ester, a first base is reacted therewith and an amine is reacted ...  
WO/2020/123792A1
The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors tha...  
WO/2020/122182A1
The present inventor found that the membrane permeability of a peptide compound can be improved by employing at least one amino acid which has a side chain capable of forming an intermolecular hydrogen bond, as one of the amino acids con...  
WO/2020/119908A1
The present invention relates to (meth)acrylate-functionalized waxes and curable compositions, such as anaerobic adhesive compositions, made therewith.  
WO/2020/114150A1
A synthesis method for a carbamate using dimethyl sulfoxide ylide, amine and carbon dioxide is provided. The carbamate is obtained by adding dimethyl sulfoxide ylide, an amine and a solvent into a pressure reactor, then adding a catalyst...  
WO/2020/118041A1
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepa...  
WO/2020/105536A1
Provided is a carbamate ester compound represented by the general formula Z-OCONH(CH2)nNHCOO-Z [I] wherein Z is [i], [ii], or [iii] and n is an integer from 2 to 10 (wherein R1 and R2 are each independently a C1-5 lower alkyl group, R3 i...  

Matches 1 - 50 out of 10,525