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WO/2004/058694A1 |
The invention relates to a process for the manufacture of optically pure (R) or (S)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide with D-i.e. (2S, 3S) or L-i.e. (2R, 3R)-tartaric acid to form a mixture of diastereomeric salts, separating...
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WO/2004/058693A1 |
The present invention relates to a process for the production of alkanesulfonic acid. More particularly, the present invention relates to a process for the production of alkanesulfonic acid from alkyl mercaptan effluents generated in che...
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WO/2004/058695A1 |
A novel 4−halo−2−oxyimino−3−oxo butyric acid−N, N−dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics, wherein X is chlorine or bromine&semi R is hydrogen, C1−...
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WO/2004/054960A1 |
The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfona...
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WO/2004/050606A1 |
The present invention comprises the simultaneous ring opening and concomitan N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitriles in presence of catalytic amount of metal triflates to afford differe...
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WO/2004/041399A2 |
Reagents and methods with low thermodynamic barriers can convert lower alkanes such as methane into methanol or other derivatives. One system uses a small quantity of a non-salt radical initiator such as Marshall's acid, a di-acid peroxi...
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WO/2004/039768A1 |
The invention relates to a method for producing phenyliso(thio)cyanates of general formula (I) according to which a compound of general formula (II) or the HCl adduct thereof is reacted with a phosgenating agent, wherein W represents oxy...
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WO/2004/035531A1 |
A process for producing an aminoalkylsulfonic acid represented by the general formula [2]: [2] (wherein R1 and R2 each represents hydrogen, aryl, etc.; and R3 and R4 each represents hydrogen or alkyl), characterized by reacting a solutio...
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WO/2004/035530A2 |
The invention relates to a method for producing alkylaryl sulfonates, the alkylaryl sulfonates obtained according to said method, alcohol mixtures and olefin mixtures obtained as intermediate products, alkylaromatic compounds obtained th...
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WO/2004/035532A1 |
A process for easily and efficiently producing an aminoalkylsulfonic acid salt on an industrial scale. The process, which is for producing an aminoalkylsulfonic acid salt represented by the general formula [3]: [3] (wherein R1 and R2 eac...
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WO/2004/031134A1 |
A process for making substituted aryl sulfonamides by sulfamoylation of an activated aromatic compound using an indium compound as a catalyst.
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WO/2004/029006A2 |
The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon...
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WO/2004/026808A1 |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donatin...
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WO/2004/024737A1 |
The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then...
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WO/2004/022532A1 |
New process for industrial preparation of R-(-)-tamsulosine HCl of formula (I). In this process (R,S)-5-[2-(N-benzyl-amino)-propyl]-2-methoxy-benzenesulphon
amide of formula (I), acid addition salts and enantiomers thereof and R-5-[2-[N-...
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WO/2004/022531A1 |
The invention relates to a method for the production of sulphated alcohols, whereby an alcohol which is to be sulphated or a mixture of two or more alcohols which are to be sulphated are reacted with one acidic sulphation product of an a...
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WO/2004/020401A1 |
The novel method of synthesis of sulphonamide derivatives (I), comprising reaction of alkyl-4-halophenylsulfonate with an amine. Formula (I) wherein X is halogen and R1 and R2 are independently selected from group comprising (i) C¿1? to...
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WO/2004/018413A1 |
A method of drying a fluorinated 2-alkoxypropionic acid derivative, comprising sequentially subjecting to drying step (1) and drying step (2) a fluorinated 2-alkoxypropionic acid derivative represented by the general formula: (I) (wherei...
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WO/2004/016578A2 |
The present invention concerns compounds of formula (I) and salts, solvates, and physiologically functional derivatives thereof, wherein: R1 is hydrogen or -XSO2NR6R7; R2 and R3 are independently selected from hydrogen, C1-6 alkyl, C1-6 ...
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WO/2004/016683A1 |
A quaternary onium aromatic sulfonate represented by the formula (I), wherein each R1 independently comprises substituted or unsubstituted, aliphatic or aromatic, hydrocarbyl, carbocyclic or heterocyclic radicals, each X is selected from...
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WO/2004/016582A1 |
The present invention relates to an improved process for the preparation of Tamsulosin hydrochloride. Tamsulosin hydrochloride is a widely used drug for the treatment of benign prostate hyperplasia. Tamsulosin hydrochloride has the formu...
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WO/2004/013094A2 |
One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond b...
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WO/2004/011420A1 |
A process by which an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-ylacetic acid derivative useful as an intermediate for medicines can be easily produced through short steps from an inexpensive, easily available material. The proce...
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WO/2004/007438A1 |
A method of purifying a water-soluble fluorinated vinyl ether represented by the following general formula (I): (I) (wherein Y1 and Y2 are the same or different and each represents halogeno, perfluoroalkyl, or fluorochloroalkyl; n is an ...
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WO/2004/006829A2 |
The invention relates to a method of separating enantiomers R(-)- and S(+)-5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenz
enesulphonamide. The inventive method consists in: (a) reacting a mixture of the aforementioned enantiomer...
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WO/2004/002951A2 |
The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp3 hybrid...
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WO/2004/002941A1 |
The invention concerns cosmetic or dermopharmaceutical compositions comprising tyramine derivatives and their salts. The invention also concerns the method for preparing same and use thereof for reducing pigmentation.
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WO/2004/000798A1 |
The invention relates to compounds of the general formula (I) and, if appropriate, enantiomers thereof. The active compounds have advantageous pesticidal properties. They are suitable, in particular, for the control of parasites in warm-...
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WO/2004/000795A1 |
A process for producing easily and at a low cost vinyl perfluoroalkanesulfonate derivatives of the general formula (IV) useful as intermediates in the synthesis of drugs, natural products, and so on, characterized by reacting a carbonyl ...
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WO/2004/000797A1 |
The invention relates to &agr -sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally...
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WO/2003/106408A1 |
A process for producing a fluorinated fluorosulfonylalkyl vinyl ether represented by the general formula (2): CF2=CFO(CF2CF(CF3)O)nCF2CF2SO2F (2) (wherein n is an integer of 0 to 10), characterized by fluorinating a perfluoro(vinyl ether...
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WO2003004463A9 |
The invention concerns fluorofunctional statistical polymers of formula (V1), wherein: X, Y and Z represent a hydrogen atom and exhibiting in particular low glass transition temperatures obtained in particular from a monomer of formula (...
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WO/2003/106405A1 |
The present invention provides compounds having formula (I): wherein R’, R0, R1, X1, R2, R3, R3’, X2, X3, and R4 are as defined herein, and pharmaceuticals compositions thereof. The present invention also provides methods of inhibiti...
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WO/2003/106407A1 |
A process for the production of fluorine-containing fluorosulfonylalkyl vinyl ethers represented by the general formula: CF2=CFO(CF2CF(CF3)O)nCF2(CF2CF2)mCF2SO2F (wherein m is an integer of 0 to 5 and n is an integer of 0 to 10), charact...
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WO/2003/106409A1 |
A process for producing compounds represented by the general formula (II): CF2=CF-O-(CF2CF(Y1)-O)n-(CFY2)m-Z (II) [wherein Y1 and Y2 are each fluoro, chloro, perfluoroalkyl, or fluorochloroalkyl; Z is a hydrophilic group; n is an integer...
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WO/2003/104333A1 |
The present invention relates to novel yellow anionic dyes, a process for their preparation, certain novel intermediates necessary for their preparation and the use of these dyes for dyeing natural or synthetic materials, in particular, ...
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WO/2003/101942A1 |
The invention relates to novel substituted aryl and heteroaryl derivatives of general formula (I), in which A, Ar, n, X, Y1, Y2, Y3, Y4, R1, and R5 are defined as per claim 1, to their prodrugs, tautomers, stereoisomers, mixtures and sal...
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WO/2003/099777A1 |
The present invention relates to a novel process for the preparation of compounds of the formula (I) (I)by reacting in a first step amino alcohols of the formula (II) (II)with oleum to give sulphuric acid esters of the general formula (I...
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WO/2003/097568A1 |
A process for producing a 4-phenyl-4-oxo-2-butenoic ester derivative, characterized by simultaneously or continuously reacting a sulfuric ester, aromatic hydrocarbon, and maleic anhydride derivative. By the process, a 4-phenyl-4-oxo-2-bu...
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WO/2003/097589A1 |
The invention relates to a method for the production of sulphamic acid halogenides of primary or secondary amines, comprising the following steps: i) reaction of a primary or secondary amine A1 with at least equimolar amounts of SO3 or a...
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WO/2003/097588A2 |
Hexafluoroisobutylene and its higher homologs are easily reacted with SO3 to give fluorosulfates of the formula CH2=C(R)CF2OSO2F, wherein R is a linear, branched or cyclic fluoroalkyl group comprised of 1 to 10 carbon atoms and may conta...
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WO/2003/095422A2 |
The present invention provides a catalytic process for preparing perfluoroethanesulfonyl fluoride and/or perfluorodiethylsulfone by reaction of tetrafluoroethylene with sulphuryl fluoride in a polar aprotic solvent using a two-part catal...
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WO/2003/095402A1 |
The invention relates to a method for producing a C13- alcohol mixture which is particularly suitable as a precursor for the production of compounds having surfactant properties and softeners.
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WO/2003/093227A1 |
The optically active compound, R (-)-5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino] propyl]-2-hydroxybenzenesulfonamide in good chemical and optical purity, a metabolite of the &agr 1-adrenergic blocking agent tamsulosin, and methods for the pre...
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WO/2003/091228A2 |
The invention relates to a method for producing a compound of formula (I) or the salts thereof. In formula (I), Q, X*, Y, Z, R, R1, R2 and R3 are defined as in patent claim 1, and in (Ia), (II): (R* = Hal, R** = Hal), (III): (R* = -Q-R, ...
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WO/2003/091207A2 |
This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfmyl group a residue of an alcohol, thiol or amine, or reacting a sulfmylimine stereoisome...
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WO/2003/089393A1 |
A liquid vegetable unsaturated alcohol of 88 to 100 iodine value and below 7ºC cloud point, obtained by reducing a vegetable unsaturated fatty acid produced from at least one vegetable oil selected from the group consisting of palm oil,...
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WO/2003/087026A1 |
Compounds of the general formula (I) are valuable therapeutics for the treatment of cancer and cancer related diseases.
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WO/2003/084982A2 |
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel ...
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WO/2003/084942A2 |
The present invention describes the synthesis of the following compounds in high stereochemical purity by a novel stereoselective alkylation of 2-methyl-4-protected piperazines using an inorganic base. (I)
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