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WO/2005/075416A1 |
In the present invention, amorphous tamsulosin hydrochloride, the process for preparation thereof by lyophilisation or spray-drying and the properties thereof are disclosed. Amorphous tamsulosin hydrochloride is useful in the preparation...
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WO/2005/075406A1 |
An adamantane derivative (I) having a structure represented by the general formula (I); an adamantane derivative (II) having a structure represented by the general formula (II); and a process for producing these adamantane derivatives. A...
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WO/2005/075073A1 |
The present invention is to provide a recyclable water-soluble transition metal complex catalyst which is a novel metal complex catalyst capable of producing an optically active alcohol from a ketone with good yield and good optical puri...
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WO/2005/075623A1 |
The present invention provides acylalkylisethionate esters useful in consumer products. The acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates unde...
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WO/2005/075651A1 |
A low-cost and efficient industrial process for producing (S)-2-pentanol, (S)-2-hexanol, 1-methylalkylmalonic acid and 3-methylcarboxylic acid with high optical purity. There is provided a process for producing (S)-2-pentanol and (S)-2-h...
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WO/2005/075415A1 |
A method of preparation of (R)-(-)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of formula I and its use for production tamsulosin. A protective group is introduced to N-[(1R)-2(4-methoxyphenyl)-1-methylethyl]-N- [(1 R)-1-phenylethyl)...
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WO/2005/073182A1 |
A method for producing a fluorine-containing unsaturated sulfonyl fluoride represented by the chemical formula: RfSO2F (wherein Rf is as defined below) is characterized in that a fluorine-containing unsaturated sulfonyl chloride represen...
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WO/2005/073388A1 |
A process for producing an optically active 1,4-pentanediol which comprises asymmetrically reducing 5-hydroxy-2-pentanone, which is easily available at low cost. Also provided is a process for producing an optically active 1-substituted ...
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WO/2005/069751A2 |
Radicals with unpaired electrons are used to initiate a chain reaction that converts small hydrocarbons such as methane into oxygenated liquids. An initiator such as Marshall's acid is used to create methyl radicals. These radicals combi...
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WO/2005/068405A1 |
A process for producing phenyl-alkanes by paraffin dehydrogenation followed by olefin isomerization and then by alkylation of a phenyl compound by a lightly branched olefin is disclosed. An effluent of the alkylation section comprises pa...
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WO/2005/065164A2 |
A process for preparing fluorochemical monoisocyanates comprises reacting at least one fluorochemical alcohol represented by the formula CnF2n+1SO2NCH3 (CH2) mOH, wherein n = 2 to 5, and m = 2 to 4, with 4,4' -diphenylmethane diisocyanat...
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WO/2005/063700A1 |
The invention relates to a process for catalyzing the preparation of directly esterified fatty acid isethionate (DEFI) reaction using group 4 metal based catalyst (according to IUPAC). Directly esterified fatty acyl isethionate (DEFI) is...
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WO/2005/063701A1 |
The present invention relates to a new process for the preparation of optically pure (R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.
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WO/2005/063702A1 |
In the present invention, the process for the preparation of tamsulosin hydrochloride and subsequent purification with thermal crystallisation to provide essentially pure tamsulosin hydrochloride is disclosed.
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WO/2005/061447A2 |
The production of alkylaryl compounds comprises the following stages: a) reaction of a C4/C5 olefin mixture on a metathesis catalyst to produce a C4-8 olefin mixture containing 2-pentene and the optional isolation of the C4-8 olefin mixt...
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WO/2005/058806A1 |
A method for producing chlorosulfonyl isocyanate wherein chlorocyanogen is reacted with sulfur trioxide to form chlorosulfonyl isocyanate, characterized in that chlorosulfonyl isocyanate or a fluid containing chlorosulfonyl isocyanate is...
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WO/2005/058810A1 |
A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.
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WO/2005/056521A1 |
Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting ®-2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methylethylamine or its salts with a compound selected form the group con...
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WO/2005/051897A1 |
There is provided a process for the preparation of tamsulosin of formula 5, involving a coupling reaction in the presence of an aluminum reagent between an ester of formula 2A and (R)-5-(2-amino)propyl-2-methoxy-benzenesulfonamide of for...
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WO/2005/049556A2 |
The subject matter of the invention is a process for the production of metal salts of trifluoromethane sulphonic acid by reacting trifluoromethane sulphonic acid with a metal alcoholate and the use thereof as esterification catalyst and/...
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WO/2005/044795A1 |
The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3- &lcub [3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]c
arbonyl&rcub cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro- 2H-pyran-4-yl...
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WO/2005/019164A2 |
The present invention relates to a novel process for the preparation of phenethanolamine derivatives, which process comprises the step of reacting a compound of formula RO(CH2)nBRaRb with a compound of formula (II).
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WO/2005/014539A2 |
HMGCo-A reductase inhibitor compounds of formula (I) useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compo...
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WO/2005/012238A1 |
A process for making a compound of formula (I) in which process the compound HC≡C-(CH2)n-NH2 is reacted with the compound R1-SO2Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of fo...
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WO/2005/012239A1 |
Provided are ionically dissociative functional molecules which are thermally and chemically stable under the conditions required for electrochemical equipment and useful as the material of protonic conductors of fuel cells; processes for...
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WO/2005/010011A2 |
Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in...
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WO/2005/007865A1 |
Optically active &agr -methylcysteine derivative is efficiently produced from an inexpensive raw material. An optically active 2-amino-2-methyl-1,3-propanediol derivative monoester is produced by esterifying one of the hydroxyls of 2-ami...
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WO/2005/007612A1 |
A process for the production of optically active 1-(2-trifluoromethylphenyl)ethylamine or salts thereof which comprises reacting 1-(2-trifluoromethylphenyl)ethyl alcohol with a sulfonylating agent in the presence of a base to obtain a su...
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WO/2005/004803A2 |
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention ...
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WO/2005/003082A1 |
The invention provides a process for the production of fluorinated sulfonyl fluorides useful as the material of ion -exchange resins or the like and novel chemical substances useful as the intermediate in the process. Namely, a process w...
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WO/2005/003062A2 |
The invention aims at providing a process by which fluorinated sulfonyl fluorides having various molecular structures can be obtained efficiently and inexpensively with production problems solved. The invention provides a process which c...
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WO/2005/000797A1 |
The invention relates to a process for the preparation of a compound of formula (1) which comprises reaction of a compound of formula (II) with a compound of the formula (III) in the presence of a chlorinating agent, followed by reaction...
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WO/2004/113258A1 |
A process for the production of compounds represented by the general formula (I), salts of the same, or solvate thereof from compounds represented by the general formulae (II) and (III), salts of the same, or solvates thereof, comprising...
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WO/2004/113391A2 |
The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-l-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-...
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WO/2004/110976A2 |
There is provided a process for the preparation of aromatic amines of Formula (1): where Rx is optionally substituted aryl and Ry is optionally substituted hydrocarbyl, which comprises: (a) reducing a compound of Formula (2): to give a c...
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WO/2004/108636A2 |
A radioisotope labeled reagent includes a compound having the general formula (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number ...
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WO/2004/101860A1 |
Disclosed is a solution for an electrochemical process, the solution containing a sulfonic acid and having a low concentration of sulfur compounds, either low or high valence, that are susceptible to reduction and which is intended for u...
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WO/2004/096759A1 |
A method for producing a perfluoroalkanesulfonyl fluoride represented by the general formula: Rf-CF2-SO2F (wherein Rf represents F, CF3 or C2F5) is characterized in that a monohydroperfluoroalkanesulfonyl fluoride represented by the gene...
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WO/2004/094366A1 |
The invention relates to a process for the preparation of a low-base number calcium sulfonate that is essentially chloride free. The process involves preparing a sulfonic acid solution by adding a solvent to a sulfonic acid, optionally r...
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WO/2004/094365A1 |
A method for producing a fluorine-containing sulfonyl fluoride compound which comprises oxidizing RB-E-RA-S-S-RA-E-RB to form XSO2-RA-E-RB (2), reacting the oxidation product with fluorine in a liquid phase to form FSO2-RAF-EF-RBF, and d...
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WO/2004/092096A2 |
The invention relates to a method for producing alkyl aromatic compounds by reacting C3-30 olefins or alcohols, from which C3-30 olefins are formed under the reaction conditions, with an aromatic hydrocarbon in the presence of an alkylat...
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WO/2004/087623A2 |
A process for the preparation of (R)(-) Tamsulosin hydrochloride [(R)(-)-5-[2-[[2-(o-ethoxy-phenoxy)ethyl]amino]-2-methylethy
l]-2-methoxybenzenesulfonamide hydrochloride] of formula (III), The (R)(-) Tamsulosin hydrochloride of formula ...
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WO/2004/087881A2 |
The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.
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WO/2004/085489A2 |
Disclosed herein is a process for preparing 4-(2-sulfoethylcyclohexane)-1,2 diol, at ambient condition and in the presence of a buffer and an initiator, from vinylcyclohexane-1,2-diol.
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WO/2004/083166A1 |
The invention provides processes by which (R)-3-[4- (trifluoromethyl)phenylamino]pentanamide derivatives useful as intermediates of drugs, particularly, cholesteryl ester transfer protein (CETP) inhibitor can be easily and simply produce...
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WO/2004/080974A1 |
Disclosed is an ionic liquid purification method for preparing high purity ionic liquids which can be used as solvents for organic, inorganic and biochemical reactions or as electrolytic solutions of storage batteries, secondary batterie...
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WO/2004/069789A1 |
A solid acid or a composite solid strong acid comprising the solid acid and a carbon material which is prepared by subjecting a polycyclic aromatic hydrocarbon or a polycyclic aromatic hydrocarbon in combination with the carbon material ...
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WO/2004/067492A1 |
The invention relates to a method for the production of $g(b)-ketocarboxylic acid derivatives of formula (I) or the salts thereof, where X = NR', O or S, R, R', R1-R4 independently = H, alkyl, alkenyl, aryl or heteroaryl, by reaction of ...
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WO/2004/060857A1 |
A method is provided for making a perfluorinated vinyl ether having a sulfonyl fluoride end-group according to the formula FSO?2#191-(CF?2#191)?n#191-O-CF&equals CF?2#191, where n is 2-5, comprising the steps of: a) fluorination of: (PLE...
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WO/2004/060849A1 |
A method is provided for reacting hexafluoropropylene oxide (HFPO) with a perfluoroacyl fluorides according to the formula X-Rf-COF (II) to selectively produce a monoaddition product according to the formula X- Rf- CF2-O-CF(CF3)COF (I), ...
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