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WO/2004/022766A1 |
A process for easily producing an L-&agr -methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethy...
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WO/2004/016583A1 |
The compounds of formula (I) are substituted glycine derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropatho...
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WO/2004/016569A1 |
The present application relates to a new process for the reduction of sulfoxides to sulfides, wherein said process provides the production of a sulfide compound of formula (I), by the reduction of a sulfoxide compound of formula (II): wi...
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WO/2004/013094A2 |
One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond b...
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WO/2004/005245A1 |
A process for the preparation of compound (III) which comprises the reaction between a compound of general formula (V) and dicyano acetylene (IV), said reaction carried out in the presence of water (IV), (V), (III) wherein R is selected ...
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WO/2004/002951A2 |
The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp3 hybrid...
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WO/2004/002939A2 |
The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrog...
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WO/2004/000790A1 |
The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one o...
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WO/2003/106689A1 |
It is intended to provide a process for conveniently producing on an industrial scale an optically active &agr -methylcysteine derivative or its salt in the form of an L- or D-compound, which is useful as an intermediate of a drug, etc.,...
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WO/2003/104168A2 |
A process for reacting a first component with itself or a second component to produce a third component in which a first material comprising a first component or said first component and a second component is fed to divided wall column h...
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WO/2003/101944A1 |
A process for producing a compound of the general formula (IV) or a salt or solvate thereof, characterized in that a compound of the general formula (V) or a salt or solvate thereof is subjected to reaction for conversion to an alkylthio...
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WO/2003/099774A1 |
The present invention provides processes for the preparation of modafinil which includes the step of reacting benzhydrylthiol and chloroacetamide.
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WO/2003/099409A1 |
The invention concerns a method for producing specific crystalline modifications of an organic polymorphous substance. In accordance with said method, the specific crystalline modification is obtained by precipitation from a salt of the ...
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WO/2003/099777A1 |
The present invention relates to a novel process for the preparation of compounds of the formula (I) (I)by reacting in a first step amino alcohols of the formula (II) (II)with oleum to give sulphuric acid esters of the general formula (I...
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WO/2003/097582A2 |
Benzonitrites and benzimidates represent important intermediates and starting materials, which are typically not commercially available. The present invention discloses a facile synthesis for 2,4-dihydroxybenzonitrile, and ethers and die...
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WO/2003/097568A1 |
A process for producing a 4-phenyl-4-oxo-2-butenoic ester derivative, characterized by simultaneously or continuously reacting a sulfuric ester, aromatic hydrocarbon, and maleic anhydride derivative. By the process, a 4-phenyl-4-oxo-2-bu...
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WO/2003/096989A2 |
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided....
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WO/2003/097622A2 |
The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to des...
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WO/2003/093226A1 |
A process for synthesizing pharmaceutically active disulfides, particularly Dimesna and certain derivatives thereof. The process includes reacting an alkylene salt with a sulfurating reagent, then alkalizing the intermediate and flowing ...
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WO/2003/087026A1 |
Compounds of the general formula (I) are valuable therapeutics for the treatment of cancer and cancer related diseases.
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WO/2003/084916A2 |
This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods o...
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WO/2003/084982A2 |
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel ...
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WO/2003/076406A1 |
Compounds of formula (I) in which each of the phenyl rings represented is optionally substituted one or more times; n represents an integer selected from 0, 1, 2, 3, 4 and 5; W represents -CO-or -SO2-; Z represents H; alkyl; aryl; or ary...
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WO/2003/072597A1 |
More efficient and/or economical methods for synthesizing heptap eptide alcohol analogs of oxytocin are provided along with novel intermediates which are useful in synthesizing such oxytocin analogs. Efficient and economical methods for ...
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WO/2003/070696A2 |
The invention relates to novel substituted aryl ketones of formula (I), in which Z, X, R and n have the meanings as cited in the description. The invention also relates to a method for producing these substituted aryl ketones, to their u...
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WO/2003/068913A2 |
The present invention is directed to labeled compounds, [2-13C]dithiane wherein the 13C atom is directly bonded to one or two deuterium atoms. The present invention is also directed to processes of preparing [2-13C]dithiane wherein the 1...
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WO/2003/068737A2 |
The present invention is directed to labeled compounds, [2 111, 13C], [2 H2, 13C] and [2 H3, 13C]methyl aryl sulfides wherein the 13C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms a...
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WO/2003/068721A1 |
The invention relates to a continuous method for the purification of acrolein, wherein: an aqueous acrolein solution is supplied, devoid of gas which is difficult to condense, in a distillation column fitted with at least one boiler at t...
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WO/2003/066582A1 |
A process for the preparation of highly pure 1-(mercaptomethyl)-cyclopropaneacetic acid is described. Treatment of 1-(hydroxymethyl)-cyclopropaneacetonitrile with an acid provides the corresponding imino ester and/or halo-amide, which wh...
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WO/2003/062178A1 |
A process is disclosed for preparing a C¿4? stream for feeding to an alkylation process which reacts isobutane with butene to produce isooctane. The C¿4? stream is treated in a first distillation column reactor to remove dienes and mer...
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WO/2003/051826A1 |
A compound of formula (I); wherein R1 represents chloro, fluoro or hydroxy as well as optical isomers and racemates thereof as well as pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof, to processes for ...
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WO/2003/050071A1 |
The invention relates to a process for the preparation of methionine of high bulk density, in which a mixture which comprises a compound which has a foaming action and a compound which influences the crystallization is added to the hydro...
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WO/2003/045904A1 |
The invention aims at providing a process by which high-quality crystals of methionine in the form of granules or thick plates having high bulk density can be stably produced. The aim can be attained by a process for production of methio...
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WO/2003/042168A1 |
The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...
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WO/2003/042163A1 |
Disclosed is the synthesis of N-methyl-homocystines and the use thereof.
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WO/2003/040088A1 |
A process for preparation of fluorinated sulfides, characterized by reacting a sulfide of the general formula (1) having at least one hydrogen atom with IF5 to thereby replace at least one hydrogen atom of the sulfide by a fluorine atom:...
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WO/2003/037854A1 |
Disclosed is a method of preparing intermediates required for synthesis of natural carotenoid products using sulfone compounds, which is advantageous in terms of high preparation efficiency due to a relatively simple process. Specificall...
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WO/2003/035603A1 |
The invention relates to novel substituted acetic acid derivatives, to methods for their production and to their use in medicaments, in particular as potent compounds for PPAR-delta activation, for the prophylaxis and/or treatment of car...
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WO/2003/031399A1 |
A process for preparing an intermediate compound of formula (II) where n is an integer of from 3 to 14; R?1¿ is haloC¿1-10?alkyl, C¿1-10?alkyl, C¿2-10?alkenyl, C¿2-10?cycloalkyl, carboxyC¿1-10?alkyl, C¿1-10?alkoxycarbonylC¿1-10?a...
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WO/2003/029185A1 |
There are provided novel compounds of formula (I) wherein A, R?1¿, R?3¿, R?4¿, R?5¿, T, U, V, W, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparatio...
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WO/2003/029200A2 |
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿8?, R¿9? and X aredefined herein. The compoundsare useful for treating autoi...
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WO/2003/024591A1 |
The invention relates to a process for the preparation of an active alumina catalyst impregnated with a base, which is chosen from alkali or alkaline earth metals and its synthetic applications. The catalyst has been used for the protect...
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WO/2003/020696A1 |
The invention relates to C2-substituted indane-1-ols and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as per ...
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WO/2003/020697A1 |
The invention relates to C2-disubstituted indane-1-ones and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as p...
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WO/2003/020677A2 |
The invention relates to C2-substituted indane-1-ones and to their physiologically compatible salts and physiologically functional derivatives. The invention also relates to compounds of formula (I), wherein the groups are defined as per...
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WO/2003/018544A1 |
The present invention relates to an efficient and industrially advantageous process for the preparation of pure cilastatin.
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WO/2003/016271A1 |
A process is provided for removing color byproducts and residues from a colored ditertiarydodecyldisulfide (DTDDDS) stream. Particularly, a process is provided for removing the color byproducts and residues from the colored DTDDDS stream...
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WO/2003/011819A1 |
The present invention relates to a compound of the formula I: (Formula I) in which: A, B, R?1¿, Z, n and R?2¿ are as defined in Claim 1. These compounds are useful in the treatment of dyslipidaemia, atherosclerosis and diabetes.
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WO/2003/010148A1 |
The invention relates to novel pyrazoline derivatives of formula (I), in which R?1¿, R?2¿, R?3¿ and R?4¿ have the meanings as cited in the description, to a number of methods for producing these substances, to their use for controlli...
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WO/2003/010122A1 |
High yields of ester-substituted diary carbonates such as bis-methyl salicyl carbonate were obtained by the condensation of methyl salicylate with phosgene in the presence of a phase transfer catalyst (PTC) in an interfacial reaction sys...
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