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WO/1998/030537A1 |
The present invention relates to novel amidino compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use as selective inhibitors of ...
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WO/1998/024748A1 |
The invention concerns a novel process for the racemization of substituted 4-ketocarboxylic acids. The process represents a novel economic way of returning an inactive enantiomer to the synthesis sequence and hence considerably increasin...
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WO/1998/018757A1 |
A process for preparing intermediates and benzoquinolin-3-one pharmaceuticals, such pharmaceuticals are effective in treating conditions consequent on 5$g(a)-reductase.
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WO/1998/014426A1 |
A two step single-pot process for producing dimesna (NaSO�3?-(CH�2?)�2?-S-S-(CH�2?)�2?-SO�3?Na) begins by reacting an $g(v)-alkenesulfonate with a sulfide such as NaSH to yield mesna (HS-(CH�2?)�2?-SO�3?Na). (This can b...
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WO/1998/013331A1 |
The present invention relates to a hydrogenation process for the preparation of aromatic amino compounds containing directly on the aryl ring or in a side chain one or more entities that may also undergo hydrogenation, such as carbon mul...
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WO/1998/013327A1 |
A process for the production of hydroxyalkylated phenolic or hydroxyalkylated thiophenolic compounds is disclosed. The process comprises providing a phenolic or thiophenolic compound, a cyclic organic carbonate compound, and a catalyst s...
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WO/1998/011065A1 |
The instant invention is directed to a process for removing odor from alkylthioethylamine reaction product mixtures having said odor. The process comprises first contacting an alkylthioethanamine reaction product mixture with a neutraliz...
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WO/1998/009935A1 |
A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R�1? and R�2? independently is optionally substituted C�1?-C�6? alkyl; each of W and X is independently hydrogen or C�1?-C�6? a...
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WO/1998/005609A1 |
The invention concerns a method for grafting a substituted difluoromethyle group on a compound containing at least one electrophilic function, comprising the following steps: i) bringing said compound containing at least one electrophili...
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WO/1998/004518A1 |
A process for preparing N-acylglycine derivatives of general formula (III) is characterised in that a carboxylic acid amide of general formula (II) is carbonylated with an aldehyde of formula RCHO in the presence of a solvent and of a mi...
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WO/1998/003451A1 |
The invention is directed to a process for reducing or reductively cleaving an organic compound susceptible to dissolving metal reduction comprising exposing the organic compound to a solution of lithium in a polyamine including at leat ...
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WO/1998/002414A1 |
N-Phenylcarbamate compounds represented by formula (1), wherein R?1� represents a hydrogen atom, an alkoxy group having 1 to 4 carbon atoms, an alkyl group having 1 to 4 carbon atoms, an alkynyl group having 3 to 5 carbon atoms, an alk...
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WO/1997/048678A1 |
A new process for the preparation of salts of an organic base and N,N'-diacetylcystine (DiNAC) is described, whereby N-acetylcysteine is oxidised in an aqueous or alcoholic solution in the presence of the organic base, or a salt containi...
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WO/1997/048679A1 |
New hydrated salts of N,N'-diacetylcystine are described, as well as processes for the preparation thereof.
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WO/1997/045420A1 |
The invention encompasses a process for making compounds of formula (I) or (Ia) useful in the treatment of cyclooxygenase-2 mediated diseases.
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WO/1997/045482A1 |
A process of the preparation of alkylthiopropionic pentaerythritol esters from pentaerythritol tetra-3-mercaptopropionate. In a first embodiment of the invention, pentaerythritol tetra-3-mercaptopropionate and an alpha-olefin are caused ...
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WO/1997/042358A1 |
The process comprises (A) obtaining N-acetylcysteine form L-cystine, through the following steps: (i) acetylation of L-cystine in order to produce N-acetylcystine; (ii) electroreduction and desalination by electrodialysis of N-acetylcyst...
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WO/1997/041093A1 |
Methods for the synthesis of Fmoc-protected amines are provided. These methods involve the treatment of an amine component with a silylating agent and then an activated Fmoc-reagent. The methods can be conducted under anhydrous conditions.
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WO/1997/037971A1 |
A process for the preparation of a thiol comprising reacting hydrogen with a thiocyanate or disulfide wherein the reaction with thiocyanate is conducted in the presence of a catalyst comprising a Group VIII metal or a mixture thereof; an...
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WO/1997/036848A1 |
Processes are disclosed for the conversion of propylene to methylmercaptopropanal by converting propylene to acrolein and converting acrolein to methylmercaptopropanal. The processes utilize oxygen and recycle propane to the acrolein rea...
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WO/1997/033865A1 |
A process for preparing thiol compounds of general formula (2): HS-CH2-CHR1-COOR2 (wherein R1 is H or methyl and R2 is H or a C1-C18 hydrocarbyl) by reacting an unsaturated compound of general formula (1): CH2=CR1-COOR2 (wherein R1 and R...
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WO/1997/032571A1 |
Graphitic nanotubes, which include tubular fullerenes (commonly called 'buckytubes') and fibrils, which are functionalized by chemical substitution or by adsorption of functional moieties. More specifically the invention relates to graph...
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WO/1997/031893A1 |
Thiols are trapped, and converted to disulfide compounds, by a process of reacting them with compounds containing a 1,2,4-thiadiazole ring structure carrying a substituent at position 3 of the thiadiazole ring, and being unsubstituted at...
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WO/1997/030762A1 |
An exercise apparatus including first and second elongated support members (14) pivotally mounted upon a support frame (12). First and second foot holders (20, 22) are movably mounted upon the first and second support members (14), respe...
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WO/1997/030962A1 |
A process for preparing 'alpha'-hydroxy acids by heating ammonium salts of 'alpha'-hydroxy acids of general formula (I), removing the formed ammonia and water, adding water to the residue, and heating the obtained mixture, wherein R is h...
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WO/1997/030037A1 |
The invention relates to a process for preparing a compound of formula (I), wherein R, R1 and Ar are as defined in the description, by the reaction of a compound of formula (II), wherein R, R1 and Ar are as defined in the description, wi...
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WO/1997/030026A1 |
The invention relates to a process for preparing a 2-(thiosubstituted)-4-haloacetophenone such as those of formula (I), which comprises reacting a 2,4-dihaloacetophenone with a thiolating agent under substantially anhydrous conditions. I...
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WO/1997/028105A1 |
Processes for reducing carbonyl compounds into hydroxyl compounds easily under milder conditions, particularly a process for reducing an 'alpha'-aminohaloketone derivative stereoselectively. The above process comprises treating a carbony...
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WO/1997/028122A2 |
The invention relates to a process for preparing compounds of formula (I), wherein R2 is lower alkyl; or phenyl optionally substituted by from one to five groups which may be the same or different selected from lower alkyl, lower haloalk...
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WO/1997/024417A1 |
Sulphur monochloride and a phenol are reacted to produce an oil-soluble intermediate which is then reacted with an unsaturated organic compound having one or more olefinic or acetylenic bonds to reduce the amount of active sulphur in the...
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WO/1997/024416A1 |
This invention concerns a process for preparing a sulfurized olefin containing reduced amounts of thiones using a low molecular weight hydrocarbon to precipitate the thiones from the sulfurized olefin.
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WO/1997/023452A1 |
In known processes: the MHA is isolated from a reaction mixture obtained by addition of hydrocyanic acid (HCN) to methylmercapto-propionaldehyde (MMP) and hydrolysis of the resulting methylmercapto-propionaldehyde cyanhydrine (MMP-CH) wi...
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WO/1997/022598A1 |
The present application discloses a synthesis of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]-isothiazol-2-yl)pe
ntanoic acid and [S-(R*,R*)], L-2-{2-[2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl
]-benzoylamino}-3-methylpentanoic acid.
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WO/1997/021667A1 |
Known acetylation processes for producing N-acetyl-D,L-'alpha'-aminocarboxylic acids from the corresponding D,L-'alpha'-aminocarboxylic acids by acetylation with acetic anhydride in acetic acid and isolation of the resulting N-acetyl-D,L...
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WO/1997/021673A1 |
A method for achieving improved conversion rates and/or a faster reaction rate, particularly in reaction (a), than those achievable with prior art resins.
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WO/1997/021671A1 |
The invention provides the novel compound 4,4,4-trichlorobutyl methanesulfonate, useful as an intermediate in the production of certain agricultural pesticides, and a process for its manufacture.
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WO/1997/021649A1 |
A method for preparing organic disulphides and polysulphides by reacting sulphur with a mercaptan or a low-sulphur polysulphide to convert it into a high-sulphur polysulphide, or by reacting a mercaptan with a high-sulphur organic polysu...
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WO/1997/021650A1 |
With known methods of racemizing N-acetyl-D(L)-'alpha'-aminocarboxylic acids in the non-aqueous state by heating them to temperatures above room temperature, significant quantities of by-products are formed, especially acetyl dipeptides....
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WO/1997/021663A1 |
The disclosure relates to a process for obtaining optically active L-'alpha'-aminocarboxylic acids from the corresponding racemic D,L,'alpha'-aminocarboxylic acids. The following steps are involved: (a) the D,L,'alpha'-aminocarboxylic ac...
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WO/1997/021672A1 |
Mercaptocarboxylic acid of formula (I) is prepared by reacting an unsaturated carboxylic acid of formula (II) with a hydrosulphide of formula ASH, wherein A is an alkali metal cation or a cation NR3R4R5R6+, where each of R3 to R6 is H or...
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WO/1997/019918A1 |
Novel 2,3,5-trimethyl-4-hydroxy anilide derivatives of general formula 1, wherein, in particular, R1 is phenyl, R2 is H, R3 is C12H25 and A is a sulphur atom, are disclosed. A method for preparing said derivatives, pharmaceutical composi...
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WO/1997/019917A1 |
A novel method for preparing (+)compactin and (+)mevinolin analog compounds having a 'beta'-hydroxy-'delta'-lactone grouping is disclosed. The method for preparing said compounds uses novel reaction intermediates. Said reaction intermedi...
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WO/1997/019038A1 |
A perfluoroalkylation method and a reagent therefor are disclosed. The method comprises contacting a material of formula RfH and a base (or a species capable of generating a base) with a substrate bearing at least one electrophilic funct...
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WO/1997/017324A1 |
An aromatic thioether acylation method is disclosed. In a preferred embodiment, the method comprises condensing acetic anhydride or acetyl chloride with thioanisole. According to said aromatic thioether acylation method, said thioether i...
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WO/1997/016421A1 |
A process for producing optically active trans-vinyl sulfide alcohols represented by general formula (III), wherein R1 represents alkyl or aryl; which comprises reducing trans-vinyl sulfide ketones with a borane reducing agent in the pre...
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WO/1997/011937A1 |
A process for producing amide derivatives represented by general formula [XV] or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is a...
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WO/1997/011938A1 |
A process for producing amide derivatives represented by general formula (XV) or enantiomers thereof, novel intermediate compounds useful for producing these compounds, etc., and a process for producing the same, wherein each symbol is a...
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WO/1997/010195A1 |
A simple, high yielding synthesis of 'alpha'-chloro ketones is described, involving acylation of Grignard and organolithium reagents with N-methoxy-M-methylchloroacetamide. The efficiency of the process is further enhanced by recycling N...
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WO/1997/008163A1 |
A process for easily producing alkoxythiochroman-carboxylic acids, which are used in the production of pyrazole derivatives having a thiochroman ring and useful as a herbicide, via the hydrolysis of alkoxythiochroman-carboxylic acid este...
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WO/1997/008139A1 |
Novel sulfur compounds represented by general formula (I) wherein n represents an integer of 0 to 2 and R represents hydrogen, vinyl, methacryloyl, vinylbenzyl, glycidyl, acryloyl or allyl, provided the case where n is 0 to R is hydrogen...
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