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WO/1999/059965A1 |
A process for producing an organic trisulfide compound comprises contacting, in the presence of a catalyst, a mercaptan with an organic polysulfide compound to produce a product mixture and optionally contacting the product mixture with ...
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WO/1999/059941A1 |
The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amoun...
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WO/1999/058509A1 |
The invention relates to a method for producing isoxazolene of the formula (I), where the substituents have the following meanings: R?1¿ is hydrogen, C¿1?-C¿6? alkyl, R?2¿ is C¿1?-C¿6? alkyl, R?3¿, R?4¿, R?5¿ are hydrogen, C¿1?...
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WO/1999/054296A1 |
A process for producing a compound represented by formula (I) which comprises reacting a compound represented by formula (V) with a compound represented by formula (VI) in the presence of a base; a process for producing a compound repres...
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WO/1999/051663A1 |
The invention concerns a sulphur product obtained by additive reaction of at least a polythiol (I), (A) on at least a compound of formula (II): wherein R?1¿ represents an aliphatic radical, linear or branched, comprising a double ethyle...
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WO/1999/051276A1 |
There are provided methods for the treatment or diagnosis of cancer in a mammal, including the step of administering to the mammal an effective amount of a substantially tin-free solution of ?188¿Re(V)-2,3-dimercaptosuccinic acid, ?186Â...
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WO/1999/048865A1 |
Compounds of general formula (I), wherein R represents a straight or branched chain alkyl group containing from 1 to 16 carbon atoms, pharmaceutically acceptable salts thereof and/or optical isomers thereof have an immunostimulating effe...
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WO/1999/048851A2 |
The invention relates to processes for the preparation of compounds of formula (I), wherein R?1¿ and R?2¿ are as defined in the description.
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WO/1999/047508A1 |
Compounds of formula (I), pharmaceutically acceptable salts or $i(in vivo) hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens where said nitrogens are optionally ...
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WO/1999/047474A1 |
This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the $g(m)-halo(triisopropylp...
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WO/1999/044988A2 |
The invention relates to a method for preparing sulfanyl-type endothelin receptor antagonists of general formula (I) wherein R?1¿ represents hydroxy, alkoxy, sulfonamidyl, amino; R?2¿ represents alkyl, aryl or heteroaryl, optionally su...
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WO1998022435A9 |
The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at lea...
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WO/1999/041234A2 |
An aqueous solution of basic mercaptide salt and water-soluble peroxide are mixed together in a reaction zone and maintained under reaction conditions effective to produce a vapor phase comprising organic disulfide, and concurrently vapo...
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WO/1999/040066A1 |
A process for the preparation of S-alkylcysteines of formula (I) wherein R is a lower or branched C¿1?-C¿4? alkyl group; by S-alkylation of cysteines with dialkylcarbonates
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WO/1999/037610A1 |
Novel trifluoromethylated intermediates are provided which are useful in synthesizing trifluoromethylated organic compounds. Specifically, compounds of the formula CF¿3?CR are provided, wherein R is (C1)=CHCH¿2?SO¿2?Ph, (C1)=CHCH¿2?C...
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WO/1999/036399A1 |
A process whereby optically active cysteine derivatives having a high optical purity and excellent qualities can be economically advantageously produced at a high efficiently even on an industrial scale. This process comprises reacting a...
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WO1999016736A9 |
A method wherein a sour natural gas stream can be treated to produce formaldehyde from methane and methyl mercaptans, (primarily methanethiol (CH3SH) and a small amount of dimethyl sulfide (CH3SCH3)) from hydrogen sulfide, and the methyl...
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WO/1999/035126A1 |
The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid co...
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WO/1999/033830A1 |
A process for the preparation of the compound represented by chemical formulae (1, 2, 3, 4, 5, 6, 7, 8a, 8b, 9, 10) which is useful as a raw material for the preparation of antibiotics; and intermediates used for the preparation of the c...
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WO/1999/033778A1 |
A method wherein a gas stream containing hydrogen, a carbon oxide and hydrogen sulfide is first passed in contact with a catalyst comprising a porous alumina supported sulfided metal selected from the group consisting of molybdenum (Mo),...
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WO/1999/033785A1 |
An industrially advantageous process for producing $g(b)-halogeno-$g(a)-aminocarboxylic acids; and a process for producing optically active N-protected-S-phenylcysteine having a high optical purity and its intermediates with the use of t...
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WO/1999/032440A1 |
The invention concerns a method for preparing an aromatic thiol bearing an amino group from a hydroxylated compound bearing an amino group. The invention also concerns the starting reagents, the intermediate products such as an aromatic ...
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WO/1999/029699A1 |
A process for producing toluene derivatives represented by general formula (2) (wherein R represents fluoro, chloro, alkoxy or alkylthio; and X represents halogeno), which comprises reacting a 2-chloro-6-substituted-toluene derivative re...
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WO/1999/025687A1 |
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-...
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WO/1999/020604A1 |
The invention relates to novel S-(4-biphenyl)-thiosulphuric acids and their salts, to a method for producing them from S-(4-biphenyl)-sulphinic acids and their salts, and to a method for producing 4-mercaptobiphenyls from the S-(4-biphen...
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WO/1999/020603A1 |
A process which allows the re-use of compounds of formula (III-(2R, 3R)) in diltiazem synthesis through a process of conversion to a mixture of enantiomers III-(2R,3R) and III-(2S,3S) is described.
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WO/1999/020602A1 |
The invention relates to a particularly advantageous method for producing aryl thiols through the catalytic hydrogenation of diaryldisulphides. According to the invention, the hydrogenation is carried out in a basic alcoholic medium.
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WO/1999/018947A1 |
A process to make the S(+)mandelic acid salt of $i(N)-methyl-3$i(R)-hydroxy-3-phenylpropylamine comprising reacting $i(N)-methyl-3($i(R,S))-hydroxy-3-phenylpropylamine with S(+)mandelic acid is described and claimed. Also described and c...
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WO/1999/018069A1 |
Maleic acid derivatives of general formula (1) (wherein one of R?1¿ and R?2¿ is alkyl or halogen-substituted alkyl, and the other is a polyethylene glycol residue, a polyethylene glycol monomethyl ether residue or a halogen-substituted...
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WO/1999/014172A2 |
The present invention relates to catalysts for the synthesis of methylmercaptan which is used in the production of methionine, agricultural chemicals and other chemical compounds. The purpose of this invention is to increase the catalyst...
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WO/1999/011610A1 |
A process for producing a mercaptan is disclosed. The process comprises contacting a feed stream comprising an olefin or alcohol and hydrogen sulfide with an acidic catalyst.
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WO/1999/007330A2 |
The invention relates to a method and agents for permanently styling hair, characterised in that they contain a keratin reduction agent in the form of N,N- disubstituted mercaptoacetamide of general formula (I) or salts thereof, R¿1? an...
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WO/1999/006013A2 |
The object of the invention is an agent for permanent shaping of hair, characterised in that it contains an N-alkylmercaptoacetamide of formula (I) wherein R represents a straight-chain alkyl radical with 3-6 carbon atoms or a straight-c...
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WO/1999/006364A1 |
A process for the purification or isolation of (2S, 3R)-1-halo-2-hydroxy-3-(protected amino)-4-phenylthiobutanes of general formula (1) or optical antipodes thereof, which comprises ridding a compound of general formula (1) contaminated ...
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WO/1999/003827A1 |
A process for producing diaryl sulfide derivatives useful as intermediates for medicinal compounds and a process for producing dibenzo[b,f]thiepine derivatives by using the intermediates. A halogen-substituted phenyl derivative represent...
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WO/1999/002489A1 |
A process for the preparation of a compound of formula (I): wherein R represents hydrogen, or C¿1-6?alkyl; R¿1? represents C¿1-6?alkyl; R¿2? represents C¿1-6?haloalkyl, C¿1-6?alkyl, C¿1-6?haloalkoxy, C¿1-6? alkoxy, SO¿n?R¿5? or...
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WO/1999/002476A1 |
This invention relates to a process for the preparation of compounds of formula (I) wherein: R¿2? is C¿1-6? straight- or branched-chain alkylthio, C¿1-6?alkyl, C¿1-6?haloalkyl, CH¿2?SR¿5?, C¿1-6?alkoxy, C¿1-6?haloalkoxy, or halog...
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WO/1999/002490A1 |
This invention relates to a process for preparing compounds of formula (I) wherein R¿1? represents C¿1-6?alkyl; R¿2? represents C¿1-6?haloalkyl, C¿1-6?alkyl, C¿1-6?haloalkoxy, C¿1-6?alkoxy, SO¿n?R¿5? or halogen; R¿4? represents...
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WO/1998/058908A1 |
Odor formation during storage of (hydrocarbylthio)aromatic amines due to formation and release of odoriferous sulfur-containing species such as dihydrocarbyldisulfides, is suppressed. To accomplish this, a small amount of N,N-dihydrocarb...
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WO/1998/056762A2 |
A process for preparing an optically active phenyloxirane compound represented by formula (II), wherein ring A is a substitued or unsubstituted benzene ring; R is a group represented by -CO�2?R?q�, or a group convertible to the group...
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WO/1998/055446A1 |
The preparation of aromatic ketones substituted with a thioether group at the ortho position is accomplished by the initial reaction of an aromatic nucleus substituted with a halide and an ortho nitro group with a nitroalkane in the pres...
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WO/1998/055438A1 |
The condensation reaction of a ketone with either an ester or a carbonate to form, respectively, a 1,3-diketone or a $g(b)-ketoester often affords poor results under the standard condensation reaction conditions. High yields and high pur...
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WO/1998/054118A1 |
A method wherein a gas stream containing carbon oxide and hydrogen sulfide is first passed in contact with a catalyst comprising a supported metal oxide of a metal selected from the group consisting of vanadium (V), niobium (Nb), molybde...
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WO/1998/050350A1 |
A mixture formed from one or more alkyl disulfides, benzene, and at least about 1.5 equivalents of Lewis acid catalyst is heated to form alkanethiobenzene. Reaction in a mixture formed from excess benzene, dimethyldisulfide (DMDS) and A1...
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WO/1998/049124A1 |
The invention relates to a novel method for producing enantiomer-free biarylketocarboxylic acids, whereby S-phenylethylamine is used as an auxiliary base in racemate resolution. Biarylketocarboxylic acids, specially substituted biaryl-4-...
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WO/1998/045271A1 |
A process for the manufacture of a phenylthiobutyl-isoquinoline of formula (II) and novel intermediates therefor.
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WO/1998/043967A1 |
A new process for producing 2-(benzo[b]thiophen-5-yl)-2-hydroxyacetic acid derivatives used as intermediates for compounds of general formula [1] or optically active compounds thereof, useful as a cerebral function ameliorant.
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WO/1998/035934A1 |
A highly economical and efficient process for producing optically active homophenylalanine derivatives represented by general formula (IV); and intermediates therefor and a process for producing the same. The process comprises reacting a...
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WO/1998/032735A1 |
A process for the free-radical addition of a mercaptan to a nonconjugated olefinic substrate having a terminal carbon-carbon double bond is disclosed. 2-Hydroxy-4-(methylthio)butanoic acid (HMBA) or methionine can be prepared using this ...
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WO/1998/030538A1 |
A process for producing cysteine derivatives having especially high optical purities economically advantageously at a high production efficiency even on an industrial scale. The process for producing cysteine derivatives represented by g...
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