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WO/2002/081080A1 |
The invention concerns a method for semi-continous photochemical synthesis which consists in using a reactor comprising two zones (1, 3), the radiating part (2a) of the lamp(s) being totally immersed in a first zone (1) which is complete...
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WO/2002/081464A1 |
The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R�1? and R�2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hyd...
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WO/2002/079122A2 |
This invention relates to the method of placing a sulfone or sulfonamide group ortho to a phenol in a drug substance in order to increase the metabolic stability and the half-life of the compound, while maintaining the acidity of the phe...
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WO/2002/079126A1 |
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligan...
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WO/2002/076962A1 |
A process for producing a 3-oxo-2-(2-thiazolyl)propanenitrile useful as an intermediate for agricultural chemicals, medicines, etc., especially as an intermediate for an acrylonitrile derivative which is an active ingredient for insectic...
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WO/2002/072540A2 |
The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-m...
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WO/2002/070131A1 |
A microencapsulated Group VIII metal catalyst which is stable even in air, easy to recover, and reutilizable. It comprises a polymer having side chains each comprising an aromatic substituent and, encapsulated in the polymer, a metal cat...
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WO/2002/069909A2 |
This invention encompasses a process for making a compound of Formula A AThese compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammatory agents.
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WO/2002/064553A1 |
A process for preparation of halogenoalcohol derivatives represented by the general formula (1) and novel useful intermediates are provided. Halogenoalcohols of the general formula (1), i.e., (2S,3R)-N-Cbz-3-amino-1-halogeno-4-phenylsulf...
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WO/2002/050021A1 |
A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with prosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic sel...
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WO/2002/044140A1 |
The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compou...
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WO/2002/042258A1 |
N-protected-L-homocysteine disulfide of the formula (I) or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula (II). The disulfide intermediate ...
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WO/2002/042261A2 |
The present invention relates to a biphasic process for preparing a compound of formula (I) from a compound a compound of formula (II) and (III).
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WO/2002/042262A2 |
A composition comprising 2-alkylthio- or 2-aryl(heteroyl)thio-substituted p-phenylenediamine of formula (I), where X and Y are the same or different and selected from the group NH¿2? or NHR (whwere R is alkyl, cycloakyl or aryl); and R'...
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WO/2002/038539A2 |
A method of making calcium-2-hydroxy-4-(mercaptomethyl)butanoate includes combining and mixing 2-hydroxy-4-(mercaptomethyl)butanoic acid and a calcium salt selected from calcium oxide and calcium hydroxide and water in a first reaction z...
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WO/2002/036544A1 |
A method of resolving optical isomers which comprises mixing in an aqueous solution an amino acid derivative in the form of a mixture of D- and L-isomers (for example, N-(tert-butoxycarbonyl)-DL-alanine) with a hydrophilic compound isome...
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WO/2002/030883A1 |
A process for the preparation of thiophenols of formula (I) wherein n is an integer from 1 to 5 and R is hydrogen, alkyl, hydroxyalkyl, alkylamino, dialkylamino, alkenyl, alkynyl, alkoxy, alkylthio, phenyl, naphthyl, phenoxy, phenylthio,...
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WO/2002/030947A2 |
Compositions and methods of preparing amino acid chelates and complexes without added water are disclosed. In certain embodiments, the compositions prepared are free of interfering ions, and optionally, electrically neutral. More particu...
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WO/2002/030918A2 |
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)$g(...
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WO/2002/024638A1 |
The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I (I), The formula I compounds exhib...
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WO/2002/022569A1 |
The invention relates to a method for producing chiral compounds according to the condition of a 1.4 Michael reaction in addition to a compound of general formula (31) and the use thereof as an antalgic.
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WO/2002/022554A1 |
Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.
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WO/2002/018333A1 |
A compound of general formula (I) wherein R?1¿ and R?2¿ are H, C¿1?-C¿6?alkyl or (CH¿2?)¿d?(C¿3?-C¿6?cycloalkyl) wherein d = 0, 1, 2 or 3; or R?1¿ and R?2¿ together with the nitrogen to which they are attached from an azetidine...
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WO/2002/010151A2 |
The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents...
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WO/2002/008181A1 |
A process for producing 2-hydroxy-4-methylthiobutanoic acid which comprises hydrating 2-hydroxy-4-methylthiobutanenitrile in the presence of sulfuric acid, hydrolyzing the 2-hydroxy-4-methylthiobutanamide contained in the reaction mixtur...
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WO/2002/006216A1 |
The invention concerns a novel method for industrial preparation of disodium 2,2'-dithiobis(alkylsulphonates), and in particular disodium 2,2'-dithiobis(ethanesulphate) (dimesna). Said novel method is summarised by the reaction diagram (...
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WO/2002/006211A1 |
A process for preparing 4-thioalkylbromobenzene derivatives of the formula I, (I), where: R?1¿ is C¿1?-C¿6?-alkyl, C¿1?-C¿6?-haloalkyl, C¿1?-C¿6?-alkoxy, C¿1?-C¿6?-haloalkoxy, C¿3?-C¿8?-cycloalkyl, halogen; R?2¿ is C¿1?-C¿6...
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WO/2002/002464A2 |
A process for extracting from aqueous solution the alkali metal or ammonium salt of a phenol, naphthol, anthrol or phenanthrol or the corresponding thiol, which comprises contacting an aqueous alkaline or neutral solution of the alkali m...
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WO/2002/000574A2 |
Phosphine oxide and sulfoxide compounds were used with transition metals, preferably palladium and nickel, to produce biaryls, arylthiols, arylphosphine oxides and arylamines via cross-coupling reactions with aryl halides and arylboronic...
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WO/2001/096285A1 |
The present invention relates to compound of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof...
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WO/2001/096348A1 |
3-Substituted benzotrifluorides are selectively deprotonated and functionalized in the 2-position. The selectively is achieved by equilibrating the mixture of lithiobenzotrifluorides initially formed in the presence of a primary or secon...
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WO/2001/096292A1 |
A calixarene dimer of the general formula (I-G), comprising a first calixarene moiety I and a second calixarene moiety G, wherein: L is [ - CH¿2? -] or [ -O-CH¿2?-O- ] and is the same or different between each aryl group; R?5¿ is H, N...
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WO/2001/096290A1 |
A method for the production of methyl mercaptan is provided. The method comprises providing raw feed gases consisting of methane and hydrogen sulfide, introducing the raw feed gases into a non-thermal pulsed plasma corona reactor, and re...
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WO/2001/096263A1 |
A process for the production of fluorinated organic compounds, characterized by fluorinating an organic compound bearing a hydrogen atom with IF¿5?; and a novel fluorination process of fluorinating an organic compound bearing a hydrogen...
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WO/2001/092369A1 |
A polymer comprising structural units of the formula (I) is prepared according to a novel method, in which the starting compound R¿1?'S-(CHR'¿2?)-Ar-(CHR¿2?)-SR¿1? is polymerized with a base, preferably in an aprotic solvent. The pol...
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WO/2001/083421A1 |
A process for the preparation of 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of the general formula (II) with a halogenating agent in the presence of a Pd catalyst. [In the formulae, A is -OH,...
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WO/2001/083435A1 |
The present invention is directed to a composition that contains polysulfides and that has a reduced odor level and to a method for reducing the odor of polysulfides. The composition contains a polysulfide and an inhibitor that reduces t...
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WO/2001/081333A2 |
A novel process for preparing 3,4-di(carbocyclyl or heterocyclyl)thiophenes comprising reacting a compound of Formula IV with a ring cyclizing reagent to form the compound of Formula V to yield a compound of Formula V wherein R?1¿, R?2Â...
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WO/2001/081299A1 |
A process for producing a bishalophenyl disulfide, characterized by reacting a halothiophenol with an alkali metal hydroxide to obtain an alkali metal halothiophenolate and subsequently converting the halothiophenolate into a disulfide w...
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WO/2001/081274A1 |
A phosphazenium compound represented by the formula (1) (1) (wherein Q?-¿ is an anion formed by removing a proton from an inorganic acid or from an active-hydrogen compound having an active hydrogen atom on an oxygen, nitrogen, or sulfu...
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WO/2001/081365A2 |
A metal chelating composition having the formula: wherein Q is a carrier; S?1¿ is a spacer; L is -A-T-CH(X)- or -C(&equals O)-; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl o...
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WO/2001/081332A2 |
Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more 2-fluorobenzenesulfonyl compounds corresponding to Formula (I) wherein A, R?1¿, R?2¿, and R...
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WO/2001/074318A2 |
The invention relates to an agent for the durable forming of hair. The inventive agent is characterised in that said agent contains a compound of general formula (I) as the keratin-reducing active agent. R¿1? and R¿2?, independently fr...
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WO/2001/072687A1 |
A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein R?3� is independ ently CF�3?, OCF�3?, C�1?-C�4?alkylthio or C�1?-C�4?alkoxy; n is 1, 2 or 3; and the other var...
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WO/2001/072668A1 |
A process for preparing alkyl substituted aromatic compounds by alkylating an aromatic compound with an alkylating agent in the presence of a porous crystalline zeolite in which the zeolite has been selectively dealuminated to remove non...
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WO/2001/070679A1 |
Invention relates to H¿2?S scavengers polysulfide compounds and methods for scavinging H¿2?S from polysulfide compounds. Furthermore, the invention uses a scavenger for selectively reducing the levels of hydrogen sulfide present in a p...
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WO/2001/070680A1 |
A process whereby 4-bromothioanisole, which is useful in drugs, pesticides, functional materials, etc., can be industrially advantageously produced at a high purity by a convenient procedure. This process is characterized by reacting thi...
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WO/2001/068599A2 |
A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the ...
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WO/2001/068637A2 |
Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzot...
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WO/2001/066517A1 |
This invention relates to a process for the production of an aryl thiol, which comprises hydrogenating an aryl sulfonyl chloride in a solvent in the presence of a palladium catalyst and a base whose conjugate acid has a pK¿a? of about 2...
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