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Matches 751 - 800 out of 5,505

Document Document Title
WO/2002/100339A2
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide inter...  
WO/2002/100824A1
The present invention is to provide a novel colchicine derivative represented by the formula (I) with halogen or nitric ester group, or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same as effecti...  
WO/2002/100818A2
The present invention relates to compounds of formula useful in treating Alzheimer's disease and other similar disease. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheimer's diseas...  
WO/2002/100850A1
A process for preparation of heterocyclic compounds represented by the general formula (I), characterized by cyclizing an acetal (II) or an aldehyde (III) in the presence of a phosphoric acid compound in a molar amount below that of the ...  
WO/2002/094764A1
The present invention ralates to compounds of formula (I): wherein R is hydrogen (H) or c¿1-6? alkyl; and X is defined such that - NH - (X) - COOH is the residue of an amino acid, which amino acid may itself optionally be substituted at...  
WO/2002/094742A1
The present invention relates to a cost effective and industrially advantageous process for the preparation of amorphous cilastatin sodium.  
WO/2002/094771A1
A process for the production of an organic sulphur-containing product which comprises reacting a sulphur-containing compound with an unsaturated hydrocarbon in the presence of a boron compound at a temperature of less than or equal to 50...  
WO/2002/092225A1
A catalyst composition is disclosed comprising a zeolite having a non-framework aluminum content of about less than 25 percent of the total aluminum content, a bulk silica:alumina ratio of about 6.5 to about 10.0 and a unit cell size ran...  
WO/2002/090314A1
Certain known and novel pyruvate derivatives are particularly active in restoring or preserving metabolic integrity in oxidatively competent cells that have been subjected to oxygen deprivation. These pyruvate-derived compounds include, ...  
WO/2002/085838A1
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...  
WO/2002/081436A2
Disclosed is a method for producing organic disulphide by oxidation of the corresponding thiol with sulphur disolved in organic disulphide using an amine as a catalyst in a reaction column (K). The thiol used is a crude thiol flow from c...  
WO/2002/081080A1
The invention concerns a method for semi-continous photochemical synthesis which consists in using a reactor comprising two zones (1, 3), the radiating part (2a) of the lamp(s) being totally immersed in a first zone (1) which is complete...  
WO/2002/081464A1
The invention concerns 3-arylthio-propyl-amino-3,4-dihydro-2H-1,5-aryloxathiepin derivatives of general formula (I), wherein: R�1? and R�2?, identical or different, represent a hydrogen atom, a fluorine atom or a chlorine atom, a hyd...  
WO/2002/079122A2
This invention relates to the method of placing a sulfone or sulfonamide group ortho to a phenol in a drug substance in order to increase the metabolic stability and the half-life of the compound, while maintaining the acidity of the phe...  
WO/2002/079126A1
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligan...  
WO/2002/076962A1
A process for producing a 3-oxo-2-(2-thiazolyl)propanenitrile useful as an intermediate for agricultural chemicals, medicines, etc., especially as an intermediate for an acrylonitrile derivative which is an active ingredient for insectic...  
WO/2002/072540A2
The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-m...  
WO/2002/070131A1
A microencapsulated Group VIII metal catalyst which is stable even in air, easy to recover, and reutilizable. It comprises a polymer having side chains each comprising an aromatic substituent and, encapsulated in the polymer, a metal cat...  
WO/2002/069909A2
This invention encompasses a process for making a compound of Formula A AThese compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammatory agents.  
WO/2002/064553A1
A process for preparation of halogenoalcohol derivatives represented by the general formula (1) and novel useful intermediates are provided. Halogenoalcohols of the general formula (1), i.e., (2S,3R)-N-Cbz-3-amino-1-halogeno-4-phenylsulf...  
WO/2002/050021A1
A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with prosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relatively non-hygroscopic sel...  
WO/2002/044140A1
The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compou...  
WO/2002/042258A1
N-protected-L-homocysteine disulfide of the formula (I) or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula (II). The disulfide intermediate ...  
WO/2002/042261A2
The present invention relates to a biphasic process for preparing a compound of formula (I) from a compound a compound of formula (II) and (III).  
WO/2002/042262A2
A composition comprising 2-alkylthio- or 2-aryl(heteroyl)thio-substituted p-phenylenediamine of formula (I), where X and Y are the same or different and selected from the group NH¿2? or NHR (whwere R is alkyl, cycloakyl or aryl); and R'...  
WO/2002/038539A2
A method of making calcium-2-hydroxy-4-(mercaptomethyl)butanoate includes combining and mixing 2-hydroxy-4-(mercaptomethyl)butanoic acid and a calcium salt selected from calcium oxide and calcium hydroxide and water in a first reaction z...  
WO/2002/036544A1
A method of resolving optical isomers which comprises mixing in an aqueous solution an amino acid derivative in the form of a mixture of D- and L-isomers (for example, N-(tert-butoxycarbonyl)-DL-alanine) with a hydrophilic compound isome...  
WO/2002/030883A1
A process for the preparation of thiophenols of formula (I) wherein n is an integer from 1 to 5 and R is hydrogen, alkyl, hydroxyalkyl, alkylamino, dialkylamino, alkenyl, alkynyl, alkoxy, alkylthio, phenyl, naphthyl, phenoxy, phenylthio,...  
WO/2002/030947A2
Compositions and methods of preparing amino acid chelates and complexes without added water are disclosed. In certain embodiments, the compositions prepared are free of interfering ions, and optionally, electrically neutral. More particu...  
WO/2002/030918A2
Process for the synthesis of R(+)$g(a)-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)$g(a)-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)$g(...  
WO/2002/024638A1
The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I (I), The formula I compounds exhib...  
WO/2002/022569A1
The invention relates to a method for producing chiral compounds according to the condition of a 1.4 Michael reaction in addition to a compound of general formula (31) and the use thereof as an antalgic.  
WO/2002/022554A1
Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.  
WO/2002/018333A1
A compound of general formula (I) wherein R?1¿ and R?2¿ are H, C¿1?-C¿6?alkyl or (CH¿2?)¿d?(C¿3?-C¿6?cycloalkyl) wherein d = 0, 1, 2 or 3; or R?1¿ and R?2¿ together with the nitrogen to which they are attached from an azetidine...  
WO/2002/010151A2
The invention relates to a method for producing R-lipoic acid and S-lipoic acid comprising a step selected from the following: (a) distillation of dihydrolipoic acid, (b) reaction of (2) or the stereoisomer thereof, wherein Ms represents...  
WO/2002/008181A1
A process for producing 2-hydroxy-4-methylthiobutanoic acid which comprises hydrating 2-hydroxy-4-methylthiobutanenitrile in the presence of sulfuric acid, hydrolyzing the 2-hydroxy-4-methylthiobutanamide contained in the reaction mixtur...  
WO/2002/006216A1
The invention concerns a novel method for industrial preparation of disodium 2,2'-dithiobis(alkylsulphonates), and in particular disodium 2,2'-dithiobis(ethanesulphate) (dimesna). Said novel method is summarised by the reaction diagram (...  
WO/2002/006211A1
A process for preparing 4-thioalkylbromobenzene derivatives of the formula I, (I), where: R?1¿ is C¿1?-C¿6?-alkyl, C¿1?-C¿6?-haloalkyl, C¿1?-C¿6?-alkoxy, C¿1?-C¿6?-haloalkoxy, C¿3?-C¿8?-cycloalkyl, halogen; R?2¿ is C¿1?-C¿6...  
WO/2002/002464A2
A process for extracting from aqueous solution the alkali metal or ammonium salt of a phenol, naphthol, anthrol or phenanthrol or the corresponding thiol, which comprises contacting an aqueous alkaline or neutral solution of the alkali m...  
WO/2002/000574A2
Phosphine oxide and sulfoxide compounds were used with transition metals, preferably palladium and nickel, to produce biaryls, arylthiols, arylphosphine oxides and arylamines via cross-coupling reactions with aryl halides and arylboronic...  
WO/2001/096285A1
The present invention relates to compound of formula (I) wherein R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof...  
WO/2001/096348A1
3-Substituted benzotrifluorides are selectively deprotonated and functionalized in the 2-position. The selectively is achieved by equilibrating the mixture of lithiobenzotrifluorides initially formed in the presence of a primary or secon...  
WO/2001/096292A1
A calixarene dimer of the general formula (I-G), comprising a first calixarene moiety I and a second calixarene moiety G, wherein: L is [ - CH¿2? -] or [ -O-CH¿2?-O- ] and is the same or different between each aryl group; R?5¿ is H, N...  
WO/2001/096290A1
A method for the production of methyl mercaptan is provided. The method comprises providing raw feed gases consisting of methane and hydrogen sulfide, introducing the raw feed gases into a non-thermal pulsed plasma corona reactor, and re...  
WO/2001/096263A1
A process for the production of fluorinated organic compounds, characterized by fluorinating an organic compound bearing a hydrogen atom with IF¿5?; and a novel fluorination process of fluorinating an organic compound bearing a hydrogen...  
WO/2001/092369A1
A polymer comprising structural units of the formula (I) is prepared according to a novel method, in which the starting compound R¿1?'S-(CHR'¿2?)-Ar-(CHR¿2?)-SR¿1? is polymerized with a base, preferably in an aprotic solvent. The pol...  
WO/2001/083421A1
A process for the preparation of 2-halobenzoic acids of the general formula (I), characterized by reacting a benzoic acid of the general formula (II) with a halogenating agent in the presence of a Pd catalyst. [In the formulae, A is -OH,...  
WO/2001/083435A1
The present invention is directed to a composition that contains polysulfides and that has a reduced odor level and to a method for reducing the odor of polysulfides. The composition contains a polysulfide and an inhibitor that reduces t...  
WO/2001/081333A2
A novel process for preparing 3,4-di(carbocyclyl or heterocyclyl)thiophenes comprising reacting a compound of Formula IV with a ring cyclizing reagent to form the compound of Formula V to yield a compound of Formula V wherein R?1¿, R?2...  
WO/2001/081299A1
A process for producing a bishalophenyl disulfide, characterized by reacting a halothiophenol with an alkali metal hydroxide to obtain an alkali metal halothiophenolate and subsequently converting the halothiophenolate into a disulfide w...  

Matches 751 - 800 out of 5,505