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WO/1995/003033A1 |
An osmotic device that, following the imbibement of water vapor, provides for the controlled release of a beneficial agent to an aqueous environment. The device comprises a hydrophilic formulation including a beneficial agent, and if nee...
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WO/1995/002591A1 |
This invention relates to a novel group of imidazole compounds, processes for the preparation thereof, the use thereof in treating cytokine mediated diseases, and pharmaceutical compositions for use in such therapy.
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WO/1995/001333A1 |
The present invention relates to compounds of formula (I) wherein R1 is selected from H and 3-chloro; R2 is selected from a phenyl group and a pyridyl group; R3 and R4 are selected independently of each other from H and methyl; R5 and R6...
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WO/1995/001330A1 |
A process for producing an alpha-alkoxyiminophenylacetonitrile represented by general formula [III], (wherein R1, R2, R3 and Y are each as defined in the specification) by reacting an alkali metal salt of an alpha-hydroxyiminophenylaceto...
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WO/1995/000476A1 |
Novel beta-aminovinyl ketones of general formula (VI), wherein R1 is, in particular, an alkenyl, alkynyl, cycloalkyl or cycloalkenyl group; R2 is, in particular, an electron attracting substituent such as nitro, acyl, ester, alkylthio, c...
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WO/1995/000477A1 |
The invention concerns nitrates containing a disulphide group and having for instance formula (I) in which R, R', R1, R1', R2, R2', R3, R3', R4, R4', R5, R5', m, m', n, n', o, o', p, p', q and q' are as defined in claim 1, plus methods o...
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WO/1994/029253A1 |
A method for preparing difunctional compounds, e.g. diols, having high enantiomeric purity (compound If) from alpha-hydroxycarboxylic acid esters (compound Id) in an anhydrous medium by a) reducing compound (Id) into compound (If) in an ...
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WO/1994/029254A1 |
A process for the continuous preparation of 3-(methylthio)propanal. A liquid reaction medium is contacted with a gaseous acrolein feed stream in a gas/liquid contact zone. The reaction medium contains 3-(methylthio)propanal, methyl merca...
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WO/1994/028717A1 |
A process for the preparation of sulfuric acid by burning the oxidizable components of a feed solution obtained as a by-product of the preparation of 2-hydroxy-4-(methylthio)butyric acid ("HMBA") by hydrolysis of 2-hydroxy-4-(methylthio)...
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WO/1994/027961A1 |
The present invention relates to certain polyamine thiols which are useful as radioprotective agents.
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WO/1994/026704A1 |
Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula (II) in which R5 is H or alkyl; Y is an alkylene chain optionally substituted by one o...
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WO/1994/025435A1 |
Compounds of formula (1), wherein R represents a -CONHOR6 [where R6 is a hydrogen atom or an acyl group], carboxyl (-CO2H), esterified carboxyl, -SR6 or -P(O)(X1R7)-X2R8 group, where X1 and X2, which may be the same or different, is each...
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WO/1994/024099A1 |
A process for producing a compound represented by general formula [I] according to the above steps, and an intermediate represented by general formula [VIII], wherein R1 represents C1-C6 alkyl which may be substituted by C1-C6 alkoxy or ...
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WO/1994/020446A1 |
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R7)-, where R7 is a hydrogen atom or an alkyl group; R2 is an optionally s...
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WO/1994/019315A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, aryloxy, ...
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WO/1994/019316A1 |
The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of general formula (I) wherein R1 and R2 are the same or different and selected from H, alkyl, aryl and arylalkyl; X and Y are the same or different...
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WO/1994/015927A1 |
Catalytic oxidation of thiols or thiol salts or dithiocarbamic acids or their salts using oxygen, optionally in the presence of a primary or secondary amine, is accomplished with a carbon catalyst which contains no metal complex of porph...
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WO/1994/012450A1 |
The invention relates to a method of preparing sulfur-containing compounds, comprising reacting a sulfur compound with a compound containing unsaturated carbon-carbon bonds, wherein in a solvent one or more compounds containing non-activ...
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WO/1994/008957A1 |
The direct saponification of methionine nitrile obtained from methylmercaptopropionaldehyde, prussic acid and ammonia gives low yields, catalyst and educt losses and unwanted side-products. The aim of the invention is therefore to provid...
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WO/1994/007850A1 |
Compounds of formula (I) can be produced in a multi-day process from the compounds of formulae (II): R1-SH and (III), in which the constituents R1, R2 and R3 have the meaning given.
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WO/1994/007841A1 |
Carboxylic acids and their derivatives, especially amino acids and their derivatives, are reduced to the corresponding amines or amino alcohols or diamines by expensive and complicated reducing agents and processes. The novel process is ...
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WO/1994/000427A1 |
The process oxidizes thiols to disulfides using elemental selenium as a catalyst. Elemental selenium complexes with the thiol to form the species RSSe- which is rapidly oxidized by molecular oxygen to the disulfide RSSR.
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WO/1993/024263A1 |
Novel zerovalent metal species and organometallic reagents are disclosed. The zerovalent metal species are directly produced by reaction of a reducing agent on a metal cyanide salt. Preferably, the zerovalent metal species are directly p...
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WO/1993/023372A1 |
A process for producing 2-hydroxy-4-methylthiobutanoic acid together with methanol, which comprises hydrating 2-hydroxy-4-methylthiobutyronitrile into 2-hydroxy-4-methylthiobutanamide, reacting the amide with methyl formate to yield meth...
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WO/1993/023370A1 |
This present invention is directed towards a novel process to prepare optionally substituted fluoromethyl phenyl sulfides (I) for use as intermediates in the preparation of ribonucleotide reductase inhibitors. In formula (I) X is a hydro...
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WO/1993/023369A1 |
Disclosed is a process for preparation of an aromatic thiol corresponding to the structure A-(SH)n wherein A is a substituted or unsubstituted aromatic radical and n is 1, 2, 3, 4, 5 or 6 comprising contacting at a temperature of at leas...
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WO/1993/021914A1 |
The invention provides a class of water-soluble probucol derivatives having one or more ester groups replacing the phenyl hydroxyl groups of the probucol molecule. Some derivatives have polar or charged functionalities such as carboxylic...
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WO/1993/020047A1 |
Hydroxamic acid derivatives of formula (I) wherein R?1¿ represents hydrogen or a (C¿1?-C¿6?)alkyl, (C¿1?-C¿6?)alkoxycarbonyl(C¿1?-C¿6?)alkyl, phenyl, substituted phenyl, phenyl(C¿1?-C¿6?)alkyl, heterocyclyl, (C¿1?-C¿6?)alkylca...
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WO/1993/019749A1 |
Novel compounds of formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the presen...
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WO/1993/019024A2 |
New pharmacologically active derivatives of N-(2-mercapto-acetyl) homocysteine, both in its cyclised gamma-thiolactonic form or in the open chain form are described, such derivatives having formula (I) wherein R represents a hydrogen ato...
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WO/1993/018207A1 |
An electrolyte containing a tetravalent salt of titanium in a methanesulfonic acid solution. A reducing agent consisting of trivalent titanium in the same solution. A cell wherein the catholyte is the above electrolyte. The reduction of ...
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WO/1993/016036A1 |
Compounds of formula (I), which are defined in more detail in the description, can be prepared by conventional methods and are used for therapeutic purposes in the usual galenical preparations.
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WO/1993/016039A1 |
Thiobisphenols of formula (I) wherein X is 1, 2, 3 or 4 and R1 and R2 are straight or branch-chained alkyl group of 1 to 10 carbon atoms, which are useful as antioxidants and synergists for antioxidants, are prepared by reaction of a 2,6...
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WO/1993/013060A1 |
A compound represented by general formula (I) which is a novel intermediate for synthesizing a 2-(substituted benzoyl)-1,3-cyclohexanedione compound useful as a herbicide; a process for the production thereof; and a process for the produ...
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WO/1993/013055A1 |
Amidino derivatives of formula (I) and salts, and pharmaceutically acceptable esters and amides thereof, in which: R1 is a C1-6 straight or branched chain alkyl group, a C2-6alkenyl group, a C2-6alkynyl group, a C3-6cycloalkyl group or a...
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WO/1993/013058A1 |
Compounds represented by general formulae (II), (III) and (IV), and a process for producing the same, wherein R1 represents hydrogen or lower alkyl, and R2 to R4 may be the same or different from one another and each represents lower alkyl.
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WO/1993/013059A1 |
This invention relates to a stabilizing composition for S-substituted aldehydes with general formula (I) having 4-15 carbon atoms, where: R1 = C1-C5 alkyl, C6-C9 aryl, furfuryl, benzyl; R2 = H, R1; R3 = H, R1, characterized by the fact t...
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WO/1993/012054A1 |
This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.
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WO/1993/011760A1 |
Compounds of the formulae (I, II or III) wherein: R1, R2, R3 and R4 which may be the same or different, are selected from the group consisting of hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3 to 6 carbons, alkenyl of 2-6 carbons, or to...
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WO/1993/011103A1 |
Fluorinated hydrocarbon compounds have formula (I): RF-(CH2)n-X-[C3H5(OH)]-(Y)x-RH, in which C3H5(OH) represents structures (Ia) or (Ib): RF is a perfluorinated C4-C20 alkyl radical or a mixture of perfluorinated C4-C20 radicals; RH is a...
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WO/1993/011104A1 |
New crystalline organic salts of N, N'-diacetyl cystine with immunomodulating effect, processes for their preparation, pharmaceutical compositons containing them and methods of their pharmacological use.
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WO/1993/010097A1 |
A few nitro compound of formula (I), wherein R?1¿ and R?2¿ are each lower alkyl or lower alkoxy(lower)-alkyl, or (a) is cyclized to form (b), X is -O-, -S- or -NH-, m is an integer 0 or 1, and R?3¿ is carbamoyl, lower alkylcarbamoyl, ...
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WO/1993/008162A1 |
The present invention is directed to a compound of formula (I), wherein R represents a hydrogen atom or an acyl, aroyl or cycloalkylcarbonyl radical or a residue of formula (Ia); R1 represents an alkyl radical; R2 represents an aryl or h...
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WO/1993/002034A1 |
Enantiomer-free compounds having the formula (I) are disclosed, in which the substituents R?1¿, R?2¿ and R?3¿ have the meaning described in the claims, as well as a process for preparing the same and their use for producing enantiomer...
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WO/1992/019623A1 |
A novel zerovalent copper species and an organocopper reagent are disclosed. The zerovalent copper species is directly produced by reaction of a reducing agent with a combination of copper cyanide or halide and an alkali metal halide sal...
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WO/1992/019591A1 |
A process for producing alpha-alkoxy acetic acids and salts thereof which comprises reacting an alcohol of formula (II), wherein R1, R2 and R3 can be hydrogen, alkyl, alkoxy, halo, phenyl, substituted phenyl, or hydroxy; A can be S, O or...
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WO/1992/017443A1 |
2-alkylthio-benzole sulphonic acid chlorides (I) (which may be used as intermediates products in the synthesis of herbicidal active agents) may be produced in very good quantities and with a high degree of purity if 2-alkylthio-aniline (...
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WO/1992/016496A1 |
N-[[4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]ca
rbonyl] amino acids having anti-inflammatory action, of general formula (I) wherein: X is selected from H and OH; R is a residue which, linked to the group alpha, forms an amin...
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WO/1992/015560A1 |
A continuous process for the hydrocarbylthiation of aromatic amines is disclosed. The process involves forming an admixture of aromatic amine, hydrocarbyl disulfide and an effective amount of a Lewis acid catalyst and subsequently allowi...
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WO/1992/012127A1 |
Bis(5-acetamido-2-chloro-4-fluorophenyl) disulfide, a novel disulfide represented by formula (1), which can be readily converted into 5-amino-2-chloro-4-fluorothiophenol at a high yield.
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