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WO/1992/011236A1 |
A polymorph of a monohydrate of an amine salt of a benzoic acid with formula (I) and aerosol formulations thereof are disclosed herein.
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WO/1992/010472A2 |
These new sulphurous compounds are thioalcanol ester mercaptals. The use of these sulphurous esters in preparing polymers with a refraction index of over 1.50 is also described. The manufacture of optical discs and waveguides is one of t...
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WO/1992/010464A1 |
4,5-Dihydroxy- and 4,5,8-trihydroxy- 9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid dicarbonates and urethans having therapeutical activities, a process for the preparation thereof and pharmaceutical compositions containing them.
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WO/1992/007824A1 |
A process for preparing a compound of formula (IV) comprising: a) contacting an oxazoline compound of formula (I) wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and a...
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WO/1992/005151A1 |
This invention relates to salts of formula (I) where, A is 1 and X is 1 or 2; R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 alkylthio, C10 to C12 1-alkynyl, 10-undecynyloxy, 11-dodecynyl, phenyl-C4 to C10 alkyl, phenyl-C3 to C9 alko...
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WO/1992/004020A1 |
The present invention relates to a method of inhibiting superoxide generation which comprises administering to a mammal in need of such treatment an amount of a compound of formula (I), wherein R1 and R2 are the same or different and ind...
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WO/1992/003412A2 |
A benzamide derivative of formula (I) wherein R1 represents alkyl optionally containing one or more carbon-carbon double or triple bonds, and optionally interrupted by one or more hetero atoms, or sulphinyl or sulphonyl groups, optionall...
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WO/1992/002519A1 |
This invention relates to intermediate compounds of formula (VI), wherein: R1 is (L)a-(CH2)b-(T)c-B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH=CH, C=C, or CH2; B is H, C1-4alkyl, ethynyl, triflu...
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WO/1991/019695A2 |
Compounds of formula (I) where R is C1-15 alkyl, X is hydrogen, fluorine or chlorine, m and n are independently selected 1 or 0, W is C1-15 alkyl or alkoxy, CN or halogen, rings A and B are independently selected from phenyl, laterally f...
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WO/1991/013867A1 |
The invention relates to N-acyl-aminoalkyl-2-hydroxyethylsulphides of formula R-CONH-(CH�2?)�n?-S-CH�2?-CH�2?-OH, where R is a hydrogen atom or a (C�1?-C�4?) alkyl group and n is an integer between 3 and 6, and to a method fo...
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WO/1991/007370A1 |
The present invention relates to a method for the synthesis of alpha, beta-unsaturated ketones which comprises, in the method for the synthesis of alpha, beta-unsaturated ketones represented by general formula (I) (where R1 is an aliphat...
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WO/1991/007454A1 |
Polymers comprising fluorine-containing poly(ether sulfones) and monomers comprising aromatic fluorine-containing sulfones used in the preparation of these polymers.
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WO/1991/007368A1 |
The present invention relates to a method for the preparation of alpha,beta-unsaturated ketones represented by general formula (II) (where R is as defined above) which comprises that aldehydes represented by general formula (III): RCHO (...
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WO/1991/007385A1 |
Compounds of formula (I), in which Ar is aryl and R?1¿ and R?2¿ are alkyl, are obtained by a process in which a compound of formula (II), where Z is a disubstituted amino group, is reacted (a) with an alcohol, R?2??OH, preferably under...
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WO/1991/007386A1 |
Carboxyalkylcarbonyl aminoacid inhibitors of endopeptidases of formula (I), or pharmaceutically acceptable salt thereof, wherein R1 is H, alkyl, arylalkyl, aryl or aryloxyalkyl; R2 is alkyl, alkenyl, alkynyl, alkoxy or alkylthio, wherein...
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WO/1991/007369A1 |
The present invention relates to a method for the preparation of beta-hydroxyketones represented by general formula (I), (where R is an alkyl group which may have a methyl group at the alpha position, an alkyl group substituted by alkylt...
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WO/1991/002718A1 |
Compounds having the properties of morphinic substances, particularly analgesia, with beneficial effects on behaviour and with peripheral effects without their major drawbacks (tolerence, addiction), the blood-brain barrier and having th...
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WO/1991/001300A1 |
Compounds of formula (I) or of formula (II), wherein Ar is a substituted or unsubstituted aryl group, and T is selected from the class consisting of carboxy, carboxy ester groups, or a substituted or unsubstituted aryl group, Z is a coup...
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WO/1991/000270A1 |
The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphen
yl)propionic acid [hereinafter: (+)-threo acid] and ...
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WO/1990/015795A1 |
The invention relates to a process for the preparation of guanidine-derivatives of general formula (I), wherein R means a C1-4 alkyl group, M means a hydrogenatom, sodium-, potassium-, or calcium ion, A means an -S-, -SO-, or -SO2-group;...
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WO/1990/014434A1 |
A process for separating enantiomer esters in a racemic mixture of formulae (I) and (II) by hydrolyzing one of the enantiomer esters in the racemic mixture with an enzyme to its corresponding carboxylic acid. The enzyme is a protease der...
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WO/1990/014335A1 |
An improved and simplified process for the selective N-monacylation of cysteine according to which L-cysteine is acylated with an acid halide in water containing more than one chemical equivalent of alkali carbonate, based on L-cysteine,...
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WO/1990/012003A1 |
Novel mercapto-acylamino acids of the formula (I), wherein Q is hydrogen or R7CO-; R1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R2 is hydrogen; lower alkyl; cyclolower alkyl; lower alkyl substituted with hydroxy, lower alkoxy...
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WO/1990/011994A1 |
A clathrate compound composed of a host crystal comprising a specified crystal of a salt of a ring-substituted salicylic acid with a polyvalent metal or its hydrate and a guest molecule comprising an organic compound having 1 to 12 carbo...
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WO/1990/012019A1 |
A bis(1,2-diaryl-1,2-ethylenedithiolato) nickel complex is produced by reacting a benzil or benzoin compound with phosphorus pentasulfide in 1,2-dimethyl-2-imidazolidinone and reacting the reaction product with nickel chloride.
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WO/1990/012002A1 |
A potassium salt useful in the production of certain N-substituted alkyl or arylalkyl thionitroethenamines is produced by the reaction of the dipotassium salt of a 2-nitrodithio aliphatic acid such as 2-nitrodithio acetic acid with branc...
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WO/1990/009975A1 |
Process for the oxidation of aromatic aldehydes in which an aldehyde obeying general formula (1) in which n represents an integer from 1 to 3, and the or each X represents hydrogen or an electron-withdrawing substituent or a mildly elect...
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WO/1990/005718A1 |
Strong acids, e.g., aluminosilicates and sulfonic acids are employed as catalysts for the (alkyl or aryl)thiolation of phenols using dialkyl or diarlyl disulfides and/or (alkyl- or arylthio) phenols as thiolating agents, and for the isom...
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WO/1990/004580A1 |
The invention concerns a novel process for the manufacture of various aryloxyaliphatic aldehydes and related arylthio analogues, certain of which are novel, which are useful as chemical intermediates and which have been hitherto obtained...
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WO/1990/000543A1 |
The present invention relates to an aminoacetonitrile derivative or salts thereof, having formula (I), wherein R represents an alkyl group which may be substituted by phenyl groups (which may be substituted by halogen atoms or C1-3 alkyl...
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WO/1989/010759A1 |
The invention relates to a method of preparing a diaminedithiol chelating agent by reacting a cyclic diamine disulfide with a thiol compound as a reducing agent, said thiol compound being selected from the group consisting of dithiothrei...
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WO/1989/005796A1 |
Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating hypertension are disclosed.
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WO/1989/005806A1 |
Novel compounds of formula (I), wherein A is a group (a), (b), (c), (d), (e), (f) or (g), useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparati...
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WO/1989/005795A1 |
Novel compounds of formula (I), wherein A is a group (a), (b), (c), (d), (e), (f), (g), useful for the treatment of cardiac arrythmia, pharmaceutical compositions containing such compounds as active ingredients, processes for preparation...
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WO/1989/005794A1 |
A compound of formula (I) and when appropriate in the form of a racemic mixture or in the form of a stereoisomeric component and the pharmaceutically acceptable salts thereof, in which formula: n is an integer 0, 1 or 2, Y is [CH2]m, CHO...
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WO/1989/003374A1 |
2-Acetonaphthones are prepared by heating a ketal or enol ethers of acetyl-substituted benzalacetone at a temperature effective to cyclize the compound and form said 2-acetonaphthones.
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WO/1989/001931A1 |
The present invention relates to the chemical modification of generally inert compounds containing at least one perfluorocarbon moiety of the general formula R1R2R3C-F wherein each of R1, R2 and R3 may represent F or a substituted carbon...
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WO/1989/001463A1 |
A method for preparing aryl sulfides by heating an iodoaromatic compound with elemental sulfur at a temperature above 150�C.
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WO/1989/001467A1 |
The hydroformylation of olefins with rhodium complex catalysts is described. The catalysts employed comprise a rhodium complex with at least one phosphine having a specified structure, e.g., tris(benzyl)phosphine. Preferred phosphines ha...
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WO/1988/008416A1 |
Compounds of formula (I), in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is 2-methyl[1,1'-biphenyl]-3-yl, 3-phenoxy-phenyl, 4-fluoro-3-phenoxyphenyl, or 6-phenoxy-2-py...
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WO/1988/007511A1 |
The invention relates to a process for isomerizing iodoaromatic compounds over a non-acidic zeolite catalyst in the liquid or gas phase in the presence of a source of iodine.
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WO/1988/007512A1 |
The invention relates to a process for isomerizing and transiodinating iodoaromatic compounds over a non-acid catalyst.
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WO/1988/007510A1 |
The invention relates to a process for isomerizing liquid iodoaromatic compounds over an acid catalyst.
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WO/1988/007509A1 |
A process for iodinating an aromatic compound in which a source of iodine is reacted with the aromatic compound in the presence of oxygen over a non-acid catalyst wherein the aromatic compound in the presence of oxygen over a non-acid ca...
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WO/1988/007031A2 |
A process for producing a sulfurized olefin product substantially free of ash containing waste is disclosed. The process involves dehydrohalogenation of an olefin/sulfur halide complex by contacting the complex with a protic solvent in t...
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WO/1988/005436A1 |
For the preparation of compounds such as ranitidine, niperotidine and cimetidine a urea of the formula (I) R1-NH-C-NH-(CH2)n-S-S-(CH2)n-NH-C-NH-R1, which is synthesized by reaction with a compound of formula (VIII), with a bis-dithio-alk...
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WO/1988/001264A1 |
2,3-Diaminoacrylonitrile derivative or salts thereof, having formula (I), (wherein R represents an alkyl group which may be substituted by (unsubstituted or substituted phenyl groups, halogen atoms, C1-6 alkoxycarbonyl groups, carboxy gr...
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WO/1987/000165A1 |
The system comprises two immiscible liquid phases and one or more enantioselectively binding chiral components, each of which is substantially in one of said phases. Also disclosed is a method for chiral resolution of racemic mixtures, o...
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WO/1986/006371A1 |
Sulfur-containing compositions which are prepared by sulfurizing (A) at least one fatty acid ester of a polyhydric alcohol, or (B) at least one fatty acid, fatty acid ester of a monohydric alcohol, or a mixture thereof, or (C) at least o...
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WO/1986/002638A1 |
A sulfurized composition prepared by sulfurizing a mixture of at least one terpene and at least one other olefinic compound. More particularly, sulfurized compositions prepared by sulfurizing a mixture of pine oil and at least one other ...
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