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JP2894636B2 |
PCT No. PCT/FR93/00111 Sec. 371 Date Aug. 3, 1994 Sec. 102(e) Date Aug. 3, 1994 PCT Filed Feb. 4, 1993 PCT Pub. No. WO93/16058 PCT Pub. Date Aug. 19, 1993This invention relates to novel anhydrides of general formula (I), (I) wherein Ar i...
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JP2889975B2 |
A decarboxylation process which comprises contacting a carboxylated compound with a metal oxide catalyst under conditions effective to decarboxylate the carboxylated compound.
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JPH11116562A |
To obtain a amide group-containing propionic acid compound useful as an intermediate for producing a taxol derivative by hydrolyzing an oxazoline compound, reacting the hydrolyzate with a carboxylic acid and subsequently selectively clea...
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JPH1192468A |
To obtain a new compound having improved water solubility and high antitumor activity. This taxane derivative is shown by formula I [A is a group of formula II (R is H, etc.), etc.; X is an alkyl, etc.; Y is H, etc.; Ac is acetyl; B is b...
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JPH11504004A |
PCT No. PCT/FR96/00487 Sec. 371 Date Oct. 2, 1997 Sec. 102(e) Date Oct. 2, 1997 PCT Filed Apr. 1, 1996 PCT Pub. No. WO96/31493 PCT Pub. Date Oct. 10, 1996Novel taxoids of general formula (I), wherein R is a substituted alkyl radical or a...
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JP2880292B2 |
A composition of taxol and polyethoxylated castor oil is pH balanced to have a pH less than 8.1 to improve stability. This composition can include an acid, preferably citric acid, to adjust the pH value. The invention includes a method o...
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JP2875651B2 |
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JPH11502516A |
The invention relates to a process for converting Taxol A, B and C to Taxol primary amine which can then be easily and efficiently converted to Taxol A or docetaxel, thereby significantly increasing the yield of these products from bioma...
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JPH1160566A |
To simply produce the subject derivative useful as a synthetic intermediate for taxol derivatives excellent in water solubility by reacting a hydrolyzate of an oxazoline compound with an acid or the like and then deprotecting the resulta...
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JPH1160565A |
To efficiently purify the subject taxol-containing ingredient from a taxol-containing mixture by adsorbing and eluting the taxol-containing ingredient with a porous material having a specific pore diameter as an adsorbent. A taxol-contai...
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JPH11501931A |
An antitumor compound of formula (5) in which R is Ac or H, and R1, R2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 is H; R1 and R2 and R3 are H; R1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2, R3 is H; R...
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JPH1129562A |
To provide a method producing 3-chloromethyl-3-alkyloxetane in a short reaction time and in excellent yield. In the process producing 3-chloromethyl-3-alkyloxetane by carrying out the dehydrochlorination or decoxychlorination reaction of...
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JPH1112261A |
To obtain the subject compound in a high yield, by reacting a triol compound with dimethyl carbonate in the presence of a catalyst while removing methanol as a by-product to form a cyclic carbonate and then decarboxylating the carbonate....
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JPH11500753A |
A novel process for extraction, isolation and separation of taxanes, particularly paclitaxel, from natural sources such as bark, needles and twigs from Taxus species, tissue cultures, and fungi is described, wherein the taxanes are separ...
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JPH11500712A |
This invention provides a taxane derivative of formula (I), wherein a hydrophobic organic moiety is attached to a taxane. R and R<1> is each independently H or a hydrophobic organic moiety, as long as at least one of R and R<1> is not H....
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JP2843920B2 |
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JPH10330301A |
To obtain a new compound suitable for a ligand of metal complex by including a donor center which has different structure from a cyclopentadiene structure. The compound is expressed by formula I [E is an eliminable group X, -N(R), -P(R) ...
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JPH10316670A |
To obtain the new subject compound extremely useful as a polymerizable composition providing low skin irritation in various fields of a coating material, an ink, a paint, etc. This compound is an oxetane vinyl ether of formula I [(m) is ...
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JPH10316562A |
To obtain the subject agent having excellent acyl-CoA: cholesterol acyl transferase(ACAT) inhibiting action and useful for the treatment and prevention of arteriosclerosis by including an amide and a urea derivative as active components....
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JPH10291930A |
To obtain the subject composition useful for treatment for psoriasis, solid tumor and particularly ovarian tumor by formulating a specific new taxoid thereto. The objective composition which shows significant inhibitory activity on abnor...
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JP2805930B2 |
The polymer portion in the production of diketene by the dimerization of ketene obtained from acetic acid by pyrolysis is reduced by the addition of sulfur dioxide to the ketene gas or to the reaction medium.
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JPH10259171A |
To accomplish safe and efficient solvent extraction of a taxane compound in a short time by bringing a taxane compound-contg. mixture into contact with a solvent capable of dissolving at least part of the taxane compound to effect extrac...
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JPH10251241A |
To provide the subject new compound extremely useful as an optically active intermediate for pharmaceuticals, agrochemicals, etc., and applicable to various uses. This compound is expressed by the formula (R is H or a halogen and the num...
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JP2797539B2 |
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JPH10245380A |
To obtain a new compound useful as an antitumor agent. This 1-deoxypaclitaxel is a compound of formula I {R is H, a 1-6 alkyl, a 2-6C alkyl, a 2-6C alkynyl, a 3-7-membered ring containing a heterocyclic ring, etc.; RA, RB are each H, HNC...
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JPH10237056A |
To obtain a new compound useful as an intermediate, etc., for pharmaceuticals and agrochemicals by reacting 2,2,3,3-tetrafluorooxetane (hereinafter abbreviated to TFO) with F gas. This compound is represented by the formula, i.e., new 2,...
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JPH10508836A |
This invention provides inclusion complexes of Taxol ((2aR-(aalpha,4beta,4alphabeta,6beta,9alpha(alphaR*,betaS*),
11alpha,12alpha,12aalpha,12balpha))-beta-(benzoylamino)-alph
a-hydroxy-benzene-propanoic acid 6,12-b-bis(acetyloxy)-12-(ben...
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JP2785248B2 |
New taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I), Ar represents an aryl radical, R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical, R1 re...
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JPH10212282A |
To provide a method for industrially and advantageously producing a 3-chloromethyl-3-alkyloxetane useful as a monomer polymerizable by a ring- opening polymerization. This method for producing a 3-chloromethyl-3-alkyloxetane by carrying ...
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JPH10508015A |
PCT No. PCT/FR95/01393 Sec. 371 Date Apr. 24, 1997 Sec. 102(e) Date Apr. 24, 1997 PCT Filed Oct. 23, 1995 PCT Pub. No. WO96/13494 PCT Pub. Date May 9, 1996This invention relates to compounds of the formula (I), preparation thereof, and p...
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JPH10508022A |
This invention relates to a taxoid of the formula (I) wherein R1 is 1-propenyl radical; R2 is a C3-C5 branched alkyl radical; R3 and R4 are independently selected from hydrogen and hydroxyl protecting groups including functional groups w...
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JP2780932B2 |
Pharmaceutical composition containing as active ingredient a glucosidase and/or amylase inhibitor and a lipase inhibitor and conventional pharmaceutical vehicles.
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JPH10506888A |
The invention includes compositions of 1,2,2,3,3,4,4,4-octafluorobutane and bis(fluoromethyl) ether, 2,2,4,4-tetrafluorooxetane, 2,2,3,3-tetrafluorooxetane, 1-difluoromethoxy-1,1,2,2-tetrafluoroethane, 1-difluoromethoxy-1,2,2,2-tetrafluo...
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JP2771243B2 |
Substituierte Cycloalkyl- bzw. Heterocyclyl-carbonsäureanilide der allgemeinen Formel (I) …… in welcher… X, Y<1>, Y<2>, Y<3> und Hal die in der Beschreibung angegebenen Bedeutungen haben und ihre Verwendung zur Bekämpfung von Sch...
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JPH10158255A |
To produce an oxetane alcohol useful as an intermediate for organic agents and oxetane compounds on an industrial scale at a low cost. This manufacturing method consists of an intramolecular cyclodehydration reaction of a 1,1,1-trimethyl...
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JPH10139714A |
To provide a new analog of taxol known as an anticancer agent and producible in a high yield without using a reagent having safety problem such as heavy metal. This compound is expressed by the formula I [X is H or a (substituted)methyl;...
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JP2753403B2 |
Novel oxetanones inhibiting pancreatic lipase, of the formula in which Q, R<1> and R<2> have the meaning given in the description, are disclosed, which are prepared starting from the corresponding beta -hydroxycarboxylic acids.
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JPH10101560A |
To obtain the subject medicine containing a specific oxygen-containing heterocyclic derivative as an active ingredient, capable of inhibiting the action of carpaine in the brain and effective for preventing and treating neurodegenerative...
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JPH10101558A |
To obtain the subject medicine containing an oxygen-containing heterocyclic derivative as an active ingredient and enabling to treat ischemic diseases. This medicine for treating ischemic diseases contains an oxygen- containing heterocyc...
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JPH10101557A |
To obtain the subject medicine containing an oxygen-containing heterocyclic derivative as an active ingredient and enabling the therapy of cataract. This medicine for treating cataract contains an oxygen- containing heterocyclic derivati...
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JP2740345B2 |
Process for the preparation of enantioselective preparation of phenylisoserine derivatives of general formula (I) in which R denotes a phenyl or tert-butoxy radical and R1 denotes a hydrogen atom or an alkyl radical containing 1 to 4 car...
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JPH1087547A |
To make it possible to obtain the subject compound useful for synthesizing natural products with good yield, by reacting (R)-β-trichloromethyl-β- propiolactone with a Grignard reagent or a lithium reagent. (A) (R)-β-Trichloromethyl-β...
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JP2721826B2 |
Novel substituted dioxanones obtained from (R)-3-hydroxybutyric acid, for example 2,2-dimethoxy-6-methyl-1,3-dioxan-4-one, a method for their preparation and processes using the dioxanones as starting material. The dioxanones can be used...
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JPH1052296A |
To provide a method for producing taxane compounds having antitumor activities by which the productivity of the taxane compounds is extremely improved. The objective taxane compounds are produced by culturing the cell capable of producin...
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JPH10502066A |
The present invention a process for the preparation of a compound of the formula (X) useful as precursor for the A-ring in taxanes (X) wherein R' is an in which R'' is a linear, branched or cyclic alkyl group of 1 to 10 carbon atoms. The...
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JPH1052294A |
To provide a method for producing taxane compounds having antitumor activities by which the productivity of the taxane compounds is extremely improved. The objective taxane compounds are produced by culturing a cell capable of producing ...
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JPH1052295A |
To provide a method for producing taxane compounds having antitumor activities by which the productivity of the taxane compounds is extremelyimproved. The objective taxane compounds are produced by culturing a cell capable of producing t...
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JPH10502077A |
This invention provides 7-ether-taxol analogs of formula (I). The compounds of formula (I) are useful for the treatment of the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and maligna...
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JPH1045584A |
To obtain a new platelet aggregation inhibitor useful for prevention and treatment of cerebral embolism, chronic arterial obstruction, etc., by using a specific heterocyclic derivative containing oxygen, its salt or its solvated or hydra...
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JPH1045583A |
To obtain a medicine composition having a low toxicity and useful for treatment of wide range tumors such as mammary cancer, a ovarian cancer, lung cancer by using a new baccatin derivative having excellent anti-tumor activities and impr...
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