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JP2708346B2 |
PURPOSE: To prepare a new baccatine III deriv. having antimitotic activity and antitumor activity by subjecting aboveground parts of Taxus-Wallicbiana to solvent extraction and carrying out treatment with a water-immiscible solvent, puri...
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JPH10500979A |
New taxoids having general formula (I), (II) preparation thereof and pharmaceutical compositions containing them. In general formula (I): Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy, and Rb is hydrogen or Ra and Rb form toget...
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JPH10500981A |
New taxoids having general formula (I), (II), preparation thereof and pharmaceutical compositions containing them. In general formula (I), Ra is hydrogen, hydroxy, alkoxy, acyloxy, alkoxyacetoxy and Rb is hydrogen or Ra and Rb form toget...
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JP2686975B2 |
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JP2680152B2 |
Antineoplastic, water soluble, taxol derivatives and methods for preparing the same are described.
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JPH09511212A |
of formula (I) and their salts are new: R1 = Me, phenyl (opt. substd. by 1-3 substits. from 1-4C alkyl, 1-3C alkoxy or alkylthio, halo, CF3, 2-6C dialkylamino, OH, or nitro), 2-furyl, 2-thienyl, 1- or 2- naphthyl, or 3,4-methylene-dioxyp...
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JPH09511245A |
PCT No. PCT/FR95/00420 Sec. 371 Date Oct. 3, 1996 Sec. 102(e) Date Oct. 3, 1996 PCT Filed Apr. 3, 1995 PCT Pub. No. WO95/26961 PCT Pub. Date Oct. 12, 1995This invention relates to a process for the preparation of 7-hydroxy taxanes of gen...
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JPH09511235A |
Compounds having the formula (I) wherein -OR1 comprises alkanoyl or the C-13 side-chain of taxol; R2, R3, and R6 can be oxygenated or hydrogen in various combinations; and R4 and R5 are acyl groups, as well as a process for the preparati...
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JPH09510486A |
PCT No. PCT/EP95/00904 Sec. 371 Date Sep. 24, 1996 Sec. 102(e) Date Sep. 24, 1996 PCT Filed Mar. 11, 1995 PCT Pub. No. WO95/25755 PCT Pub. Date Sep. 28, 1995Copolymers comprise a) from 1 to 65 mol % of at least one diketene of the genera...
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JPH09509942A |
This invention concerns a process for the preparation of polyfluorooxetanes by the reaction of fluoroketones or fluoroepoxides with haloethylenes in the presence of a Lewis acid catalyst. Polyfluorooxetanes are useful as solvents and pla...
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JPH09509431A |
PCT No. PCT/EP95/04302 Sec. 371 Date Jun. 25, 1996 Sec. 102(e) Date Jun. 25, 1996 PCT Filed Nov. 2, 1995 PCT Pub. No. WO96/14308 PCT Pub. Date May 17, 1996Taxane derivatives modified at 13-position of the taxane derivative skeleton (taxo...
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JPH09235225A |
To obtain a new taxol derivative having excellent antitumor activity and improved water solubility, and useful as a treating agent for mammary cancer, ovarian cancer or malignant melanoma. A compound of formula I [R is H or an alkanoyl; ...
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JPH09227441A |
To selectively obtain the subject compound important as a starting raw material for a physiologically active compound, by using a readily obtainable specific lactone as a chiral pool and subjecting the lactone to ring opening reaction wi...
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JPH09508385A |
PCT No. PCT/US95/00551 Sec. 371 Date Jul. 23, 1996 Sec. 102(e) Date Jul. 23, 1996 PCT Filed Jan. 26, 1995 PCT Pub. No. WO95/20582 PCT Pub. Date Aug. 3, 1995This invention provides 7-deoxy- DELTA 12,13-iso-taxol of formula (I) which are u...
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JPH09507864A |
Taxane derivatives modified at 7-position of the taxane derivative skeleton (taxol numbering) of formula (I) wherein R1 is N3, CN, 1H-tetrazol-5-yl, or -NR7R8 and R2, R3, R4, R7 and R8 are organic residues, are endowed with antitumor act...
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JPH09208572A |
To obtain a new taxol derivative having excellent antineoplastic action, higher in efficacy against digestive organ cancers such as colon cancer among others, thus useful as an antineoplastic agent. This new taxol derivative (salt) is ex...
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JPH09202796A |
To produce the subject new water-soluble ands relatively nontoxic prodrug, comprising paclitaxel bonded to a cleavable N-(aliphatic or an aromatic)-O-glycosyl carbamate spacer group and useful for treatment, etc., of cancer. This new pac...
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JP2634215B2 |
Antiviral activity is exhibited by compounds having the formula and pharmaceutically acceptable salts thereof wherein R2 and R3 are independently hydrogen, -PO3H2 or - @-X7 and R1 is either a purine, pyrimidine or an analog thereof. <
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JPH09169752A |
To obtain the subject new compound having strong cysteinprotease- inhibiting action, excellent in oral absorbing property, tissue transplantation and cell membrane permeability and useful as a treating agent for muscular dystrophy, apopl...
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JPH09169753A |
To suppress the formation of by-products and stably obtain a 2- oxetanones compound useful as a raw material for chemicals, polymers, especially a biodegradable polypropiolactone, etc., in high selectivity by passing an oxirane compound ...
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JP2620562B2 |
PURPOSE: To produce diketene with a liq. ejector having no driving unit without using a vacuum pump. CONSTITUTION: Gaseous ketene under reduced pressure is pressurized, absorbed in an absorbing liq. and allowed to react to produce the ob...
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JPH09136884A |
To obtain an unsaturated cyclic ether by bringing a diol into contact with a cobalt-contg. supported catalyst. This compound, an unsaturated cyclic ether of formula II is obtained by reaction of a diol of formula I [Z is (CHR4)q or (CHR4...
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JP2610578B2 |
PURPOSE: To provide a method for preparing a ketene dimer in high yield and purity with high productivity in the substantial absence of organic solvents. CONSTITUTION: The method for preparing a ketene dimer comprises reacting an fatty a...
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JPH09504801A |
Novel taxoids of general formula (I), their preparation and pharmaceutical compositions containing them. In general formula (I), Ar is an aryl, alkyl, alkenyl, cycloalkyl or cycloalkenyl radical; R is a hydrogen atom or an alkanoyl, alky...
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JP2608563B2 |
Novel substituted dioxanones obtained from (R)-3-hydroxybutyric acid, for example 2,2-dimethoxy-6-methyl-1,3-dioxan-4-one, a method for their preparation and processes using the dioxanones as starting material. The dioxanones can be used...
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JPH09504230A |
PCT No. PCT/DE94/01270 Sec. 371 Date Apr. 17, 1996 Sec. 102(e) Date Apr. 17, 1996 PCT Filed Oct. 27, 1994 PCT Pub. No. WO95/12445 PCT Pub. Date May 11, 1995The invention pertains to a method and device for separating a mixture having at ...
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JPH09504033A |
PCT No. PCT/US94/12133 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Oct. 19, 1994 PCT Pub. No. WO95/11020 PCT Pub. Date Apr. 27, 19952'- and/or 7'- substituted taxoid derivatives having improved water-solubility a...
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JPH0940657A |
To obtain taxol, which is an anticancer agent effective for leukemia, etc., but little in the contents in plants, in a good yield from Taxus cuspidata var. nana. Hort. ex Rehder as a raw material. The leaves, duramen or bark of Taxus cus...
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JPH0923894A |
To obtain the subject compound with a good efficiency, useful for an anticancer agent e.g. for ovarian cancer, breast cancer, lung cancer by tissue culturing a yew tree in a medium used for tissue culture added with specific concentratio...
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JPH09500370A |
A method of preparing a taxoid of formula III by esterifying protected baccatin III or deacetylbaccatin III using an oxazolidinecarboxylic acid, or an acid halide, or an acid anhydride thereof.
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JPH09500138A |
A compound or prodrug thereof having the formula ain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R'', -CH=NR', -CH=NOR', -CH=NNR=R'', -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of the ...
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JPH08337589A |
To obtain the subject new derivative compound of Taxol (paclitaxel), having an excellent antitumor activity and useful as antitumor drugs, etc., obtainable by extraction from of the Pacific Taxaceae trees, Taxus brevifolia. This new pacl...
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JPH08301860A |
To simply and economically obtain the subject compound by reacting a carboxylic acid chloride with a tertiary amine in a nonpolar solvent and then carrying out distillation of the resultant compound in two stages under specific condition...
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JPH08298993A |
PURPOSE: To stably and efficiently obtain a taxane compound useful for medicines (raw materials) such as an anticancer medicine excellent for the therapy of ovarian cancer, breast cancer, and lung cancer, etc., by subjecting the tissue o...
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JPH08301859A |
PURPOSE: To obtain an oxetane compound capable of forming a side-chain type liquid crystal polymer having independently controllable liquid crystal transition temperature and glass transition temperature. CONSTITUTION: This oxetane compo...
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JPH08291062A |
PURPOSE: To stably and economically produce a new antitumoral compound capable of manifesting cancer cell proliferation inhibiting actions on human tumoral cells in a trace amount by culturing a cell having an origin in the genus Taxus. ...
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JPH08291119A |
To obtain a new oxazolidine compound useful as an intermediate for synthesizing 13C acyloxy side chain-bound taxanes having pharmacological activity, and to provide a method for producing taxanes by using the above intermediate. A compou...
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JPH08277280A |
PURPOSE: To obtain an extract containing a taxane compound useful as a raw material for medicines by decomposing a taxaceous plant and the wall of the cultured cells therefrom followed by conducting an extraction. CONSTITUTION: First, a ...
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JPH08509494A |
PCT No. PCT/SE94/00371 Sec. 371 Date Feb. 26, 1996 Sec. 102(e) Date Feb. 26, 1996 PCT Filed Apr. 26, 1994 PCT Pub. No. WO94/25020 PCT Pub. Date Nov. 10, 1994The present invention is directed to the use of taxol or a pharmaceutically and ...
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JPH08253465A |
PURPOSE: To obtain a new compound useful as an antitumor agent. CONSTITUTION: This taxol derivative is shown by formula I (R1 is an alkyl, an alkenyl or an alkynyl; R2 is H, an alkyl, etc.; R3 is H, OH or OCOR9; R4 and R5 are each H, a h...
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JPH08239373A |
To obtain a new compound useful as an antitumor agent. A compound of formula I [R1 is H, a 1-8C alkyloxy, a 2-8C alkenyloxy or the like; R2 is hydroxy, OC(O)Rx (Rx is a 1-8C alkyl, a 3-8C cycloalkyl or the like which are substituted by o...
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JPH08508469A |
Pharmaceutical compositions are disclosed which contain, in addition to one or more pharmacologically acceptable, inert or physiologically active diluents or adjuvants, a taxane derivative having a C13 side chain which includes a furyl o...
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JPH08508471A |
Taxane derivatives having a pyridyl substituted C13 side-chain.
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JPH08225558A |
To obtain a new amino acid derivative of paclitaxel useful as an antitumor agent, having water solubility. This compound is shown by formula I [R1 and R2 are each H or (CH2O)nCOCH2Y ((n) is 1-6; Y is NRrRr or the like); R6 is H, a 1-8C a...
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JPH08508255A |
Pharmaceutical compositions are disclosed which contain, in addition to one or more pharmacologically acceptable, inert or physiologically active diluents or adjuvants, a taxane derivative having a C13 side chain which includes a furyl o...
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JPH08217772A |
PURPOSE: To obtain the subject compounds useful as a medicine or an agrochemical or its intermediate, especially an important intermediate, etc., for difluoroprostaglandins in high yield by reacting difluorolactones with specific phospho...
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JPH08208636A |
To obtain a new pseudopolymorph of paclitaxel useful as antitumor agents. This crystalline paclitaxel hydrate contains 7.3% water at room temperature and 33% RH and 8.5% water at 75% RH and is a tetrahydrate (called form B). When dried a...
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JPH08198797A |
PURPOSE: To obtain a new aldehyde compound useful as an intermediate for avoiding the complicatedness of synthesis and more simply and efficiently synthesizing taxol having excellent antitumor activities than a synthetic method according...
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JPH08198812A |
PURPOSE: To simply and efficiently obtain the subject ester useful as an active ingredient, etc., of a medicine by reacting a bulky alcoholic compound with a cyclic acid anhydride under a high pressure. CONSTITUTION: (A) An alcoholic com...
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JPH08198863A |
PURPOSE: To easily obtain in large quantities the subject compound including taxol useful as a medicine for ovary cancer, breast cancer, etc., by treating a taxane-type diterpene-productive plant, before or after its harvest, with a taxa...
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