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JP2516836B2 |
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JPH08506324A |
Pharmaceutical compositions containing taxane derivatives which have alternative C7 substituents selected from hydroxy and acyloxy and which are valuable antileukemia and antitumour agents.
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JP2510905B2 |
PURPOSE: To provide a new acrylate containing alcohol, aldehyde and/or ether functional group utilized in producing the new polymers and copolymers. CONSTITUTION: The compounds of formulae I to III, e.g. methyl-3-(4- carboxyaldehydopheny...
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JP2507830B2 |
Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: wherein R1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR7 wherein R7 is alkyl, alkenyl, alkynyl, aryl or hete...
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JP2506633B2 |
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JPH08143457A |
PURPOSE: To obtain an antienzyme against esterase and lipase, containing ebelactone B and/or ebelactone A as an active ingredient and to provide an inhibitor for hyperlipemia having high inhibitory activity against hyperlipemia. CONSTITU...
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JP2500198B2 |
PURPOSE: To provide a novel β-lactam which is a specific N-acylazetidin-2-one compd. and is useful as a material for producing taxol which is a chemotherapy preparation of cancer having a wide spectrum of antileukemic and tumor- inhibit...
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JPH08127574A |
PURPOSE: To efficiently isolate and purify a large amount of taxol, capable of manifesting remarkable effects on cancers such as ovarian or mammary cancer and extremely useful as medicines from a plant. CONSTITUTION: An extract separated...
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JPH08503486A |
PCT No. PCT/FR93/01145 Sec. 371 Date May 23, 1995 Sec. 102(e) Date May 23, 1995 PCT Filed Nov. 22, 1993 PCT Pub. No. WO94/12484 PCT Pub. Date Jun. 9, 1994This invention relates to a method for the preparation of taxane derivatives having...
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JPH08503261A |
Process for the electrochemical preparation of taxane derivatives of general formula (I), based on a taxane derivative of general formula (III). The invention also concerns pharmaceutical compositions with outstanding antitumour and anti...
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JPH08503218A |
Taxane derivatives having a 3' butenyl substituted C13 side chain.
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JPH08502971A |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compou...
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JPH0830050B2 |
A beta -lactam of the formula: wherein R1 is aryl, substituted aryl, alkyl, alkenyl, or alkynyl; R2 is hydrogen, alkyl, acyl, acetal, ethoxyethyl, or other hydroxyl protecting group; and R3 is aryl, substituted aryl, alkyl, alkenyl, or a...
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JPH08502280A |
Novel taxane derivatives of general formula (I), their preparation by electrochemical reduction of a taxane derivative of general formula (III) and pharmaceutical compositions containing a product of general formula (I) in which R3 is a ...
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JPH0862212A |
PURPOSE: To provide a method of assaying or isolating taxol, 10- deacetylbaccatine III(DAB) or these homologues which may be either of botanical source and biological source. CONSTITUTION: By use of multichlone IgY antibody produced from...
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JPH08502051A |
PCT No. PCT/FR93/00966 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07847 PCT Pub. Date Apr. 14, 1994This invention relates to a method of stereoselective preparation of a derivative o...
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JPH08500973A |
Successful culture methods have been developed which result in stable, long-term tissue cultures derived from Taxus explants and hydroponically grown roots. These cultures offer a rapidly reproducible, continuously-available source for t...
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JPH08500337A |
Besides the usual excipients and additives, a medicament contains a compound having formula (I), in which A and B, which are the same or different, each stand for a phenyl residue substituted if desired by halogen, hydroxy, C1?-C6? alkyl...
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JPH0812661A |
PURPOSE: To provide a method for purifying 2-oxetanone by which the purified 2-oxetanone capable of affording a high molecular weight polyester, having film- or fiber-forming properties and excellent in physical properties is stably obta...
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JPH07330656A |
PURPOSE: To produce the intermediate useful as a synthetic intermediate for readily producing taxol hopeful as an antitumor active substance. CONSTITUTION: A cyclooctenone derivative of formula I (R1 to R4 are each a hydroxyl protecting ...
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JPH07316145A |
PURPOSE: To obtain a new compound which is useful as an antitumor agent because it manifests high selectivity of cytotoxicity with a lowered concentration. CONSTITUTION: A compound of the formula (R1, R2 and Y each is a lower alkyl, a lo...
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JPH07309856A |
PURPOSE: To obtain the subject macromonomer having narrow molecular-weight distribution, preferable for uses of coating, adhesive, etc., and useful as a raw material, etc., for graft copolymers in high introducing ratio of oxetane- conta...
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JPH07304761A |
PURPOSE: To provide an unsaturated taxane compound having an antitumor activity and capable of treating overain cancers such as platinum-resistant ovarian cancer, metastatic breast cancer, non-small cell lung cancer, head and neck part c...
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JPH07509447A |
Disclosed is a method for identifying a compound which inhibits the esterase activity of beta -protein. More specifically, in the method disclosed, beta -protein is combined with an appropriate substrate and a compound to be tested for i...
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JPH07509259A |
The present invention relates to a new taxane having the structure (1), which is isolatable from root bark of plants of the Taxus genus. The compound (1) is endowed with antitumor activity higher than the one of taxol, the former being a...
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JPH07247279A |
PURPOSE: To efficiently obtain a lactone derivative under milder conditions by reaction between a hydroxycarboxylic acid, a carboxylic anhydride and a halogenoalkylsilane in the presence of a catalyst. CONSTITUTION: This lactone derivati...
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JPH07224052A |
PURPOSE: To provide a method for surely and highly purifying 2-oxetanone containing various kinds of impurities by using simple operations. CONSTITUTION: The characteristic of this method for purification of 2-oxetanone is that it involv...
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JPH07506586A |
Novel taxane derivatives of formula (I), their preparation and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical, R1? is a hydrogen atom or an acetyl radical or a radical according to formula (II)...
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JPH07505887A |
Compounds having the formula wherein -OR1 comprises the C-13 side-chain of taxol and R3 comprises hydrogen, as well as a method for the preparation thereof.
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JPH07505778A |
Taxol is produced from taxol-producing micro-organisms. Methods of obtaining the taxol-producing microorganisms are described. Radioactive labelled taxol products and methods for use of the radioactive labelled taxol and for the treatmen...
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JPH07138244A |
PURPOSE: To provide a 2-oxetanone composition which is a monomer of poly(2- oxetanone) useful as a plastic material degradable by the action of microorganisms in the environment and having excellent storage stability. CONSTITUTION: This ...
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JPH07504461A |
Process for electrochemical preparation of taxane derivatives of general formula (I) based on a product of general formula (II). In general formula (I), Ar denotes an aryl radical, R1? is a benzoyl radical or R2?-O-CO- radical in which R...
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JPH07504173A |
The invention relates to compounds of formula (I) in which E is -CH= or -N=, and with the proviso that a) at least one of the radicals R3, R4, R5, R6 and R7 is C1-C4 alkyl, b) E is -CH= when X is halogen and c) E is -CH= when X or Y are ...
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JPH07109339A |
PURPOSE: To obtain the composition useful for an antifouling coating compound for ship bottom, etc., having excellent biodegradability, solubility in general purpose organic solvents, maintenance of marine environment, etc., comprising a...
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JPH07503477A |
Novel taxane derivatives of general formula (I), their preparation, and pharmaceutical compositions containing same. In general formula (I), Ar is an aryl radical; R1? is hydrogen or acetyl; R is optionally substituted alkyl, alkenyl, al...
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JPH0730061B2 |
Certain novel hydroxamic acid and hydroxyurea derivatives having structure (I), wherein R<1> is hydrogen, alkyl, alkenyl, amino or substituted amino, R<4> is hydrogen, a pharmaceutically acceptable cation, aroyl or alkoyl, A is alkylene ...
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JPH0730105B2 |
Compounds of the general formulae I and II Formula I Formula II in which R1 and R2 independently of one another represent H-(CH2)a-(O-(CH2)b)c-O, where a=0 to 4, b=1 to 4 and c=1 to 7, an alkoxy or arylalkoxy group with 1 to 20 carbon at...
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JPH0790062A |
PURPOSE: To obtain a 2-oxetanone composition having excellent storage stability of 2-oxetanone, effective for separating 2-oxetanone in high purity, suitable for vapor-phase polymerization and useful as a raw material for a biodegradable...
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JPH07500836A |
A method for activating potassium channels and for treating hypertension, addiction, asthma, incontinence, and other conditions treatable by potassium channel activators, such as spasms and convulsions, comprising administering a compoun...
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JPH0710858A |
PURPOSE: To provide novel taxol derivatives, which comprise specific taxol derivatives and are obtained from bark of Taxus baccata, useful as anti-tumor agents for injections exhibiting excellent therapeutical effects and have aiti- tumo...
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JPH072822A |
PURPOSE: To obtain the compound useful as a size agent of paper or the like by the dehydrohalogenation reaction of an aliphatic fatty acid halide and a tertiary amine using a specified solvent with a smaller problem on health and environ...
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JPH06102641B2 |
A method of inhibiting the growth or replication of viruses of the HIV group is disclosed. Also disclosed are compounds useful in the method and pharmaceutical formulations incorporating such compounds. The method involves the use of com...
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JPH0699410B2 |
Sulfonated 2 min -acryloyltaxol and sulfonated 2 min -O-acyl acid taxol derivatives are synthesized which have improved water solubility and stability while maintaining bio-activity. In particular, 2 min -[(3-sulfo-1-oxopropyl)oxy] taxol...
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JPH06329662A |
PURPOSE: To obtain a method for producing lactones in which disadvantages in a conventional method for producing the lactones are solved and the lactones are obtained in high yield while suppressing the formation of cyclic lactones and o...
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JPH06329650A |
PURPOSE: To provide a compound exhibiting antitumor activity and useful in the treatment of cancer. CONSTITUTION: A compound of formula I (wherein R1 represents substituted alkyl; R2 represents H, OH, oxy-protecting group or acyl; R3 rep...
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JPH06321896A |
PURPOSE: To produce novel β-lactams useful for an intermediate or the like in the preparation of a side chain-bearing taxanes valuable for a carcinostatic agent by hydrolyzing a 3-acetyloxy-azetidinone derivative and then, reacting an a...
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JPH06510033A |
Process for the preparation of new ss-phenylisoserine derivatives of general formula (I) and their use for preparing biologically active taxane derivatives.
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JPH0686440B2 |
Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R2 and R3 protecting the hydroxy groups. (II) (I)
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JPH0686441B2 |
Process for preparing derivatives of baccatine III and of 10-deacetylbaccatine III, of general formula (I), in which R is hydrogen or acetyl, by condensation of an acid of general formula (II) with a derivative of baccatine III or of 10-...
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JPH0684364B2 |
In a preferred embodiment, taxol is treated with mesyl chloride to prepare a taxol derivative with a contracted A-ring, which has comparable activity to taxol in a tubulin depolymerization assay, and which shows cytotoxicity against KB c...
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