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Patent Searching and Data


Matches 101 - 150 out of 2,204

Document Document Title
WO/2002/055486A2
The invention relates to novel triazene compounds, the use thereof and novel alkylation methods. Said triazene compounds have the general formula, X-Y-Z-N=N-NH-R, where X = an insoluble support material, Y = an atom, or group of atoms, f...  
WO/2002/017916A1
Disclosed are guanidine and biguanidine derivatives which have anti-viral and anti-bacterial activity. Also disclosed are pharmaceutical compositions containing such compounds as an active ingredient, and anti-viral and anti-bacterial me...  
WO/2002/016371A1
Crystals of 2-methyl-2-triazolylmethylpenam-3-carboxylic acid 1,1-dioxide diphenylmethyl ester. Even when allowed to stand for 1 year at 5 to 35°C, the crystals are stable and undergo substantially no decomposition or alteration. The cr...  
WO/2002/014325A1
Stable crystals of diphenylmethyl 2-methyl-2-triazolyl-methylpenam-3-carboxylate, which cause substantially no decomposition or deterioration even after allowing to stand at room temperature for one year. The crystals are produced by con...  
WO/2001/098518A2
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicam...  
WO/2001/092268A1
Process for drying amoxicillin (compositions), characterised in that a gas, which is inert towards amoxicillin (compositions) and having a relative humidity content which is greater than zero is used for drying.  
WO/2001/087299A1
The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is admin...  
WO/2001/085664A2
The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.  
WO/2001/079210A2
Highly crystalline, highly filterable sodium Cefoperazone in the form of needle crystal aggregates, obtainable by a process comprising the controlled addition of acetone to a solution of water/acetone/alcohols/sodium Cefoperazone at 20 $...  
WO/2001/054691A1
Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.  
WO1999063937A9
Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptogramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more prot...  
WO/2001/030783A1
Process for the preparation of a $g(b)-lactam antibiotic by acylation of a $g(b)-lactam nucleus with the aid of an acylating agent, use being made of a complexing agent, and the acylating agent containing L-isomer and an aldehyde being a...  
WO/2001/026691A1
Attempts are made to develop a widely applicable technique for developing granules for oral use which can be quickly disintegrated or dissolved in the oral cavity at the administration or in the dissolution or suspension step in using an...  
WO/2001/012584A2
Compounds or their salts of general formula (I): A$m(Y)B$m(Y)N(O)¿s? wherein: s is an integer equal to 1 or 2; A = R$m(Y)T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1c?, R¿1c? is H or a...  
WO/2001/009135A1
An industrially excellent novel process for the preparation of addition salts of basic antibiotics with inorganic acids (such as hydrochloric acid), by subjecting a basic antibiotic-oxalic acid addition salt (II) to salt-exchange with an...  
WO1999064049A9
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...  
WO/2000/061537A2
Compounds or their salts having general formulas (I) and (II): wherein s is and integer equal to 1 or 2, preferably s = 2; A is the radical of a drug and is such as to meet the pharmacological tests reported in the description, C and C¿...  
WO/2000/061115A2
Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.  
WO/2000/061549A2
Compounds or their salts of general formula (I): A-(B) wherein A = R-T¿1?-, wherein R is the drug radical and T¿1? = (CO)¿t? or (X)¿t'?, wherein X = O, S, NR¿1C?, R¿1C? is H or an alkyl having from 1 to 5 carbon atoms, or a free va...  
WO/2000/061541A2
Compounds or their salts having general formulas (I) and (II) wherein: s = is an integer equal to 1 or 2, preferably s = 2; b0 = 0 or 1; A is the radical of a drug and is such as to meet the pharmacological tests reported in the descript...  
WO/2000/053207A1
The invention relates to novel biologically active compounds of fungi of the species $i(Ganoderma pfeifferi) DMS 13239, to methods of preparing same and to their use. From the fruit-body and mycelium of $i(Ganoderma pfeifferi) DMS 13239 ...  
WO1999064033A9
This invention relates to novel multibinding compounds that bind to the enzyme phosphodiesterase V (PDE V) and modulate its activity. The compounds of this invention comprise 2-10 PDE V modulator (particularly inhibitor) ligands covalent...  
WO/2000/043399A1
Compounds are provided having formulae (I) and (II) wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide gro...  
WO1999064048A9
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 l...  
WO/2000/041478A2
The present invention describes novel agglomerates in crystalline form of $g(b)-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one $g(b)-lactam compound in ...  
WO/2000/037484A1
Process for the preparation of amido compounds in which an amino acid R¿1?R¿2?-C(NHR)-(CH¿2?)¿n?-COOH, where R¿1? and R¿2? represent an amino acid residue, n is 0 or 1 and R is H, alkyl or aryl, is in a solvent brought into contact...  
WO/2000/034289A1
A new synthesis of penicillanic sulfoxide acid ester is claimed. The synthesis starts with 6-amino penicillanic acid and proceeds through conversion to a bromide via diazotization, esterification, reduction of the bromide, and oxidation ...  
WO1999063988A9
Disclosed are multibinding compounds which inhibit nitric oxide synthases (NOSs), enzymes which form nitric oxide and L-citrulline from L-arginine. The multibinding compounds of this invention contain from 2 to 10 ligands covalently atta...  
WO1999064047A9
Novel compounds are disclosed, useful as antiviral agents.  
WO1999063929A9
Disclosed are multibinding compounds which inhibit microsomal triglyceride transferase protein (MTP), a protein which mediates the transfer of lipids during the assembly of lipoproteins and related biomolecules. The multibinding compound...  
WO1999064054A9
Disclosed are multibinding compounds which inhibit topoisomerases which are essential enzymes in higher encaryotes for DNA replication and repair. The multibinding compounds of this invention containing from 2 to 10 ligands covalently at...  
WO/1999/064051A1
Novel multibinding compounds are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of inhibiting bacterial Type II DNA topoisomerase, thereby modulating the biol...  
WO/1999/063940A2
Disclosed are multibinding compounds which inhibit H?+¿/K?+¿-ATPase, an enzyme which is involved in the control of acid secretion in the stomach. The multibinding compounds of this invention containing from 2 to 10 ligands covalently a...  
WO/1999/064037A1
Novel multi-binding compounds are disclosed that modulate enzymatic processes. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an enzyme, enzyme substrate o...  
WO/1999/062910A1
A novel process for preparing a crystalline alkali metal salt of amoxycillin is dislcosed.  
WO/1999/061448A1
The present invention relates to penem antibacterial agents in which the penem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. ...  
WO/1999/055709A1
A process to prepare a crystalline $g(b)-lactam compound by the addition of a base to an acidic solution of a $g(b)-lactam compound obtained by the addition of an acid to a solution or suspension of a $g(b)-lactam compound obtained by (a...  
WO/1999/055710A1
The invention relates to a method for crystallizing a $g(b)-lactam, wherein the $g(b)-lactam is crystallized from a nitric acid solution.  
WO/1999/052912A1
A process for producing a halogenated $g(b)-lactam compound represented by general formula (4), characterized by reacting a $g(b)-lactam-derived amino compound represented by general formula (1) with nitrous acid or a nitrite in the pres...  
WO/1999/052530A1
Antibacterial agents exerting excellent effects in preventing or treating respiratory mixed infection with two or more bacteria belonging to different genera selected from among $i(Streptococcus, Moraxella, Haemophilus, Klebsiella), etc....  
WO/1999/048895A1
The invention relates to a process for recovering 6-aminopenicillanic acid from a mother liquor, wherein 6-aminopenicillanic acid is extracted from the mother liquor with a recovery solution, which recovery solution is collected and re-u...  
WO/1999/042466A2
Compounds of formula (1a) or (1b) or (2a) or (2b) and the salts, esters and amides thereof wherein Z is S, SO, SO¿2? or O; each of R?1¿, R?2¿ and R?3¿ is independently substituted or unsubstituted alkyl (1-10C), substituted or unsubs...  
WO/1999/036098A1
An antibacterial composition for topical administration having a potent antibacterial effect over a broad range and a high safety and containing in a stable state penem antibiotics which are chemically unstable to hydrolysis, oxidation, ...  
WO/1999/033837A1
A method for preparing a $g(a)-oxolactam comprising, reacting a corresponding $g(a)-diazolactam with an oxygen donor, in the presence of a transition metal catalyst, to yield the corresponding $g(a)-oxolactam.  
WO/1999/033838A1
Compounds of formula (I), wherein R?1¿ and R?2¿ are each independently hydrogen, (C¿1?-C¿10?)alkyl, (C¿3?-C¿8?)cycloalkyl, (C¿2?-C¿10?)alkenyl, (C¿2?-C¿10?)alkynyl, -COOR¿a?, -CONR¿b?R¿c?, cyano, -C(=O)R¿d?, -OR¿e?, aryl, ...  
WO/1999/032493A1
A process for purifying a solution of an ampicillin pro-drug, e.g. bacampicillin, or an acid addition salt thereof, which comprises a step wherein a crude solution thereof is subjected to an evaporation which is controlled by the evapora...  
WO/1999/028308A1
A group of reagents, as diisocyanates, dianhydrides, diacidchlorides, diepoxides, carbodiimides and the like are utilized to link a wide variety of antibiotic moieties, reacted two at a time with said reagents, the said antibiotic moieti...  
WO/1999/024441A1
A process for the crystallization of $g(b)-lactam compounds involving simultaneous addition of a solution of said $g(b)-lactam compound and a titrant to a crystallization vessel. In case of zwitterionic $g(b)-lactam compounds, the pH-val...  
WO/1999/015532A1
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 °C and ...  
WO/1999/015531A1
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains...  

Matches 101 - 150 out of 2,204