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Matches 351 - 400 out of 3,261

Document Document Title
WO/2003/087034A1
The invention relates to 3-aminophenol derivatives of formula (I) or to their physiologically compatible, water-soluble salts, wherein R1 is identical to a radical of formula (II) or to a radical of formula (III), and to dyes that contai...  
WO2002081483A3
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention comp...  
WO/2003/087035A1
2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said method are also described. Fomula (I).  
WO/2003/086605A2
One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acid group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronst...  
WO2002076939A3
Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present ...  
WO/2003/078387A1
A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R'R' of at least 2 carbon atoms and R' and R' are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxy...  
WO/2003/068731A1
The invention relates to beta-amino ketones of general formula (I), in which R1-R4 are defined as per the description. The invention also relates to a method for the production, in particular stereoselective production of said beta-amino...  
WO/2003/059339A1
Novel tricyclic−bis−enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and&sol or treatment of cancer, Alzheimer's disease, Parkinson's disease, mul...  
WO/2003/048106A2
The invention concerns 1,3-diarylprop-2-en-1-ones and derivatives, compositions containing same and the use thereof. The invention concerns in particular novel substituted 1,3-diarylprop-2-en-1-ones having a therapeutic activity for use ...  
WO/2003/048096A1
The invention concerns products of formula (I), wherein: A represents a saturated or partly saturated cyclic hydrocarbon, optionally substituted; X is selected from the group consisting of O, N-O(R2); Ar1 represents a substituted phenyl ...  
WO2002044144A3
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.  
WO/2003/040174A2
The present invention relates to compounds of the general formula (I): B-(CH--R?1¿)¿n?--C(=X?2¿)-D and pharmaceutically acceptable salts thereof including steroisomers, to the use of the compounds for the treatment of impaired glucose...  
WO/2003/037846A1
An improved method of producing keto acids having the formula (I), wherein R¿1? and R¿2? independently represent (a) hydrogen, wherein at least one of R¿1? and R¿2? do not stand for hydrogen, (b) branched or unbranched alkyl of 1-18 ...  
WO2002102782A3
Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the ...  
WO/2003/033447A1
Compounds represented by the following general formula (I): R−Y−(−X−Phe−COCH2COCnF2n&plus 1)m (I) wherein R represents hydrogen, alkyl, phenyl or a group capable of binding to a protein, a peptide, an amino acid, a nucleic acid...  
WO/2003/029186A1
Compositions comprising (±)-2-((dimethylamino)methyl)cyclohexanone, a transition-metal salt, and an organic solvent and methods ofpreparing (±)-cis-2-((dimethylamino)methyl)-l-(aryl)cyclohexanols, in particular (±)-cis-2-((dimethylami...  
WO2002034708A3
The invention involves a methods and compositions for use in photodynamic therapy. Novel perylenequinone derivatives, conjugates comprising perylenequinone derivatives and a binding agent, and methods of treatment using these composition...  
WO/2003/018535A2
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compo...  
WO/2003/017955A1
The invention concerns dyeing agents for keratinous fibers based on a developer-coupler combination, characterized in that they contain at least a 3-aminophenol derivative of formula (I) or a salt thereof, water-soluble and physiological...  
WO/2003/018536A1
The invention provides 1,2-substituted cyclic compounds useful for treatment of diseases or disorders arising from abnormal or inappropriate cell proliferation, such as tumour growth, tumour metastasis and associated angiogenesis, as wel...  
WO/2003/015761A1
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for t...  
WO2002076995A3
Compounds of formula (I), wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive...  
WO/2003/006420A1
The present invention is directed to a method of converting an aryl compound to an aniline compound, comprising the steps of (1)providing an aryl compound containing a halide group or a sulfur-containing group; (2) reacting the aryl comp...  
WO2001062705A3
A compound of the formula (I) wherein X1 is bond or -O(CH2)m- (in which m is an integral number of 1, 2 or 3); X2 is bond, -(CH2)n-, etc. (in which n is an integral number of 1, 2 or 3); R1 is hydrogen or amino protective group; R2 is hy...  
WO/2003/002511A1
(−)−3−[3−[(1R,2R,4S)−bicyclo[2.2.1]hept−2−ylox y]−4−methoxyanilino]−2−methyl−2−cyclopenten−1 one or a hydrate or solvate thereof&semi or a medicinal composition containing any of these.  
WO/2002/102782A2
Use of compound of formula (I), wherein (a) is (b) or (c) and wherein the symbols are as defined, or a pharmaceutically-acceptable and-cleavable ester, or acid addition salt thereof, for the preparation of a medicament for promoting the ...  
WO2002042248A3
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)2, S(O)2NH, P(O)OCH3, P(O)OH, NH, N(CH3), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH2NH, C(=NH); R<1> is aryl or heteroaryl; R...  
WO/2002/098400A1
Arylaminopropane analogues are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more ...  
WO2002078693A3
The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor.  
WO/2002/096850A1
The present invention refers to compounds of formula (I) as precursors for a ketone of formula (II), an aldehyde or ketone of formula (III), and an aldehyde or ketone of formula (IV). These compounds are useful in perfumery, especially i...  
WO2001042243A3
Disclosed are compounds which inhibit or modulate the activity of protein kinases and pharmaceutical compositions containing such compounds. The disclosed compound contain two or more ligand moieties covalently linked together by one or ...  
WO2001047866A9
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.  
WO2001070675A3
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell pr...  
WO2001098265B1
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO/2002/083624A1
There are disclosed compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.  
WO2002002516A3
The present invention is a series of novel and effective inhibitors of integrase, an essential in the life cycle of retroviruses. These compounds were designed to have a restricted conformation for the determination of the integrase bind...  
WO/2002/081483A2
The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention comp...  
WO/2002/078693A2
The present invention provides compounds of formula (I), which are antagonists of the 5-HT¿6? receptor.  
WO/2002/076939A2
Compounds having quinone and quinone analogs useful for pharmaceutical preparations have now been found which inhibit cysteine proteases, in particular, caspases and 3C-cysteine proteases. The cysteine protease inhibitors of the present ...  
WO/2002/076926A1
There are disclosed compounds of formula (I) wherein the variables A and B are an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of sa...  
WO/2002/076995A2
Compounds of formula (I), wherein m, R, R¿1? and R¿3? to R¿6? are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosu...  
WO/2002/076447A1
Compounds of formula I and pharmaceutically-acceptable and -cleavable esters thereof and acid addition salts thereof wherein the symbols are as defined are MAP kinase inhibitors, useful pharmaceutically for treating TNF$g(a) and IL-1 med...  
WO/2002/072620A1
A compound is of general formula (I) wherein (A) is a moiety comprising one of more of a heterocylcic ring, a carbocyclic ring and a fused ring system, the ring or ring system being essential for a biological activity of the compound by ...  
WO2002058630A3
Primary intermediate for hair coloring compositions for oxidative dyeing of hair is 4-amino-2-(1-hydroxy-ethyl)-phenol.  
WO/2002/066416A1
To more efficiently provide CPT, which is a starting compound for irinotecan hydrochloride and various camptothecin derivatives, by a practically usable total synthesis, a means whereby 2'-amino-5'-hydroxypropiophenone corresponding to t...  
WO/2002/064136A2
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...  
WO/2002/064130A1
PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipo-protein-cholesterol and to lower certain plasma lipid levels, ...  
WO/2002/062307A1
The invention relates to colouring agents for keratin fibres containing [1.1'-biphenyl]-2.4-diamine derivatives of general formula (I) or physiologically acceptable, water soluble salts thereof in addition to novel [1.1'-biphenyl]-2.4-di...  
WO2001098265A3
The present invention describes a new process for obtainment of the cetamine enantiomers, form the racemic cetamine resolution with the aid of an agent of chiral resolution, which provides the selective crystallization of its enantiomers...  
WO2002053537A8
The present invention relates to a process for preparing (+/-)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperid ine of formula (I). The present invention also relates to novel intermediates of the formula (IX) and (IX') methods for...  

Matches 351 - 400 out of 3,261