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Matches 101 - 150 out of 444

Document Document Title
WO/2005/030796A1
The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. T...  
WO/2005/017124A2
Novel PDF inhibitors and novel methods for their use are provided.  
WO/2004/099162A1
Compounds of Formula 8 are provided: A and B are each independently selected from the group consisting of -NO-, -SO-, and - NR9-. C is a single bond or a double bond. D is selected from the group consisting of single bond, E is selected ...  
WO/2004/089300A2
The present invention relates to compounds of Formula (I): their pharmaceutical composition and their utility in treating neoplasm.  
WO/2004/084809A2
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterised by ne...  
WO2004007445A3
One aspect of the present invention relates to amide-bearing substituted benzolactams, and individual stereoisomers thereof. A second aspect of the present invention relates to combinatorial libraries of the aforementioned amide-bearing ...  
WO/2004/007445A2
One aspect of the present invention relates to amide-bearing substituted benzolactams, and individual stereoisomers thereof. A second aspect of the present invention relates to combinatorial libraries of the aforementioned amide-bearing ...  
WO/2003/106480A1
The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.  
WO/2003/074476A1
An arylamidine derivative represented by the general formula (1) (wherein X means optionally substituted lower alkylene or alkenylene; G1 means oxygen, sulfur, or imino; G2 means carbon or nitrogen; Ra means at least one member selected ...  
WO2002028863A8
There is provided 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3. 3.1]non-3-yl]propyl}amino)benzonitrile, benzenesulfonic acid salt, which compound is useful in the prophylaxis and in the treatment of arrhythmias, in particu...  
WO/2003/008390A1
Compounds of general formula (I):in which: R¿1? is hydrogen, C¿1?-C¿2O? alkyl, C¿3?-C¿10? cycloalkyl, C¿4?-C¿2O? cycloalkylalkyl, aryl, arylalkyl, or two R1, taken together, form a straight or cyclic C¿2?-C¿10? alkylene group or...  
WO/2003/002545A1
The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.  
WO/2002/088115A1
The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and inte...  
WO/2002/085838A1
The present invention relaters to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the ...  
WO/2002/028864A1
There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R?1¿, R?2¿, R?3¿, R?4¿ and R?41¿ to R?46¿ have meanings given in the description...  
WO/2002/028863A1
There is provided 4-({3-[7-(3,3-dimethyl-2-oxobutyl)-9-oxa-3,7-diazabicyclo[3. 3.1]non-3-yl]propyl}amino)benzonitrile, benzenesulfonic acid salt, which compound is useful in the prophylaxis and in the treatment of arrhythmias, in particu...  
WO2001010848A3
Compounds of formula (I) in which M is the following central building block (a) are novel effective trypase-inhibitors.  
WO2001040198A3
The invention concerns macrocyclic hydroxamic acid derivatives of general formula (I) wherein: Y is -CH2-, -CH2-CH2- or -CH=CH- and Z and Z' represent -CH2- or Y-Z or Y-Z' represent -CH=CH- and Z and Z' are defined as above; X is -CH2, O...  
WO/2001/040198A2
The invention concerns macrocyclic hydroxamic acid derivatives of general formula (I) wherein: Y is -CH¿2?-, -CH¿2?-CH¿2?- or -CH=CH- and Z and Z' represent -CH¿2?- or Y-Z or Y-Z' represent -CH=CH- and Z and Z' are defined as above; ...  
WO/2001/016110A1
Formulation components such as bleach boosting compounds selected from the group consisting of bleach boosters comprising quaternary imine cations, zwitterions, polyions having a net charge of from about +3 to about -3 and mixtures there...  
WO/2001/010848A2
Compounds of formula (I) in which M is the following central building block (a) are novel effective trypase-inhibitors.  
WO/2000/069830A1
The synthesis of individual di- and tri-substituted-1,4-diazacyclic compounds having 6- to 8-atoms in the cyclic ring, their corresponding 1,6-diketo-2,5-diazacyclic compounds and similar 1,4-diazacyclic ring compounds having one ring ca...  
WO/2000/058294A1
Compounds of formula (I) are antibacterial agents wherein: R¿3? and R¿4?, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 1...  
WO/2000/048990A1
The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalami...  
WO/2000/027627A1
In its first aspect, the invention is directed to a solid support mediated method for the synthesis of diverse polycyclic heterocycles according to general formula (V). A second aspect of the invention is directed to a solid support boun...  
WO/1999/043662A1
The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting th...  
WO/1999/040047A1
The invention relates to methods for preparing macrocyclic products with 9 or more ring atoms by ring-closing diine metathesis of suitable diine substrates. The diine substrates can be converted into cycloakynes or into cycloalkadiines b...  
WO/1999/020599A1
The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the inv...  
WO1998051665A3
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...  
WO/1998/051665A2
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions ...  
WO1998023565A3  
WO/1998/030551A1
Macrocyclic compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting comp...  
WO/1998/023565A2
Aminoguanidine and alkoxyguanidine compounds, including compounds of formula $i((I)) wherein X is O or NR?9� and R?1�-R?4�, R?6�-R?9�, R?11�, R?12�, R?a�, R?b�, R?c�, Y, Z, n and m are set forth in the specification, ...  
WO/1997/043268A1
Compounds of formula (I) wherein R1 is H, (C1-C5)alkyl, ORa, SRa, N(Ra)(Rb), halo, NO2, NHC(O)[(C1-C4)alkyl] or NHOH; R2 is a (C5-C22) hydrocarbyl group, optionally comprising 1-3 double bonds, 1-2 triple bonds or a mixture thereof, or (...  
WO/1997/032860A1
Compounds of formula (I), wherein one of U and V is -CHR2-, and the other of U and V is selected from -N(COR4)-, -CH(COR4)-,-N(SO2R4)- and -CH(SO2R4)-, in which R2 is H, -COOR5, -CONR6R7 or -COR7 and R4 is H, C1 to C6 hydrocarbyl (in whi...  
WO/1997/030992A1
This invention relates to compounds that inhibit farnesyl-protein transferase and ras protein farnesylation, thereby making them useful as anti-cancer agents. The compounds are also useful in the treatment of diseases, other than cancer,...  
WO1997018207A3  
WO/1997/025324A1
The present invention concerns aza- and diazacycloheptane and cyclooctane compounds from the following formula (I) Ar1-A-B-Ar2 wherein Ar1, A, B, and Ar2 have the meanings given in the description. The compounds according to the inventio...  
WO/1997/018207A2
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
WO/1996/040614A1
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpene and benzolactan phorboids.  
WO/1996/031474A1
A compound of formula (I), in which Z is selected from (a), (b), (c), (d), (e), (f), (g), (h), (i), (j) and (k). The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substitu...  
WO/1996/030348A1
The present invention provides an efficient process of reacting a bis-indolyl acid of Formula (II), wherein R1 is a hydrogen or C1-C4 alkyl and R, X, and Y are optional substitutions; to produce a bis-indolyloxallic acid of Formula (III)...  
WO/1996/004288A1
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotropic lateral sclerosis, Huntingto...  
WO/1995/009160A1
A benzolactam derivative represented by general formula (I) and an antiretroviral drug containing the same as the active ingredient, wherein n represents an integer of 1 to 3; R1 represents linear or branched alkyl, or aralkyl; R2 repres...  
WO/1995/007093A1
A topographic model useful to design and synthesize memory-enhancing substances is disclosed. Administration of substances designed by this method to enhance memory in mammals, including humans, is disclosed. Such substances include pept...  
WO/1995/007269A1
The invention relates to retroviral protease inhibitors of the general formula (I): W-(A)n-B-(A*)m-V where W, A, B, A*, V, n and m are as defined herein, including related prodrugs of general formula (I) comprising a solubilising group w...  
WO/1995/001967A1
The present invention relates to novel heterocyclic compounds having general formula (1) wherein: X is O, S, Se, or NR2; and A is (a) or (b) wherein W is O, S, NH or N-lower alkyl; with the proviso that when X is N-H or N-(aryl-methyl), ...  
WO/1994/022840A1
This invention relates to novel substituted caprolactams, including 4-azacaprolactams such as those of formula (Ic) in which R4, R7, R22, and R27 are as defined in the description, and derivatives thereof which inhibit HIV protease and a...  
WO/1994/022440A1
This invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibit...  
WO/1994/019329A1
This invention relates to substituted cyclic carbonyls and derivatives thereof useful as Human Immnunodeficiency Virus (HIV) protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these com...  

Matches 101 - 150 out of 444