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WO/2024/036254A3 |
The present invention relates to a process for producing compounds of formula I and/or formula I'. The present invention also relates to a process of selectively cleaving the main ring of a compound of formula IV to provide the starting ...
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WO/2024/042226A3 |
A method for producing a purified morphinan-glycoside conjugate. The method includes the steps of contacting a morphinan compound with an activated saccharide or activated oligosaccharide and a glycosyltransferase in a reaction mixture u...
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WO/2024/068889A2 |
Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biologic...
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WO/2024/055106A1 |
This disclosure relates to heterocyclic compounds of Formula (I) as well as the preparation and use thereof. As contemplated herein, heterocyclic compounds of Formula (I) can be any one of a carbohydrate conjugate and an amino acid conju...
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WO/2024/058023A1 |
Provided is a method for producing a protected glycoside in which a phenol compound is bonded to the anomeric position of a saccharide and other hydroxyl groups in the saccharide are protected, the method comprising reacting a saccharide...
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WO/2024/058024A1 |
Provided is a method for producing a glycoside having such a structure that a phenolic compound is bound to the anomeric position in a sugar, the method comprising a step (1) for reacting a peracetylated sugar with a phenolic compound in...
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WO/2024/052939A1 |
A nanocomposite for treating bacterial urinary tract infections is disclosed. Said nanocomposite broadly comprises: an about 10 mg/mL of zinc oxide nanoparticles; an about 2 mg/mL of type-A procyanidin; and methanol. Said zinc oxide nano...
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WO/2024/053648A1 |
The present invention provides candidate molecules for constituent components of various lipid nanoparticles. The present invention pertains to a C-glycoside glycolipid compound represented by formula (I) or formula (II), a lipid nanop...
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WO/2024/042226A2 |
A method for producing a purified morphinan-glycoside conjugate. The method includes the steps of contacting a morphinan compound with an activated saccharide or activated oligosaccharide and a glycosyltransferase in a reaction mixture u...
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WO/2024/036254A2 |
The present invention relates to a process for producing compounds of formula I and/or formula I'. The present invention also relates to a process of selectively cleaving the main ring of a compound of formula IV to provide the starting ...
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WO/2024/030662A1 |
The disclosure provides host cells engineered to express non-naturally occurring polyketide synthases that produce b-keto-d-lactones (BKDLs); methods of generating such host cells, and methods of producing BKDLs employing the host cells.
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WO/2024/007104A1 |
Provided is use of a glucopyranoside compound for enhancing the sweetness of a sweetness regulator and reducing the amount of the sweetness regulator used in consumables.
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WO/2024/005460A1 |
The present invention provides a compound comprising a self-immolative group and a ligand-drug conjugate comprising same. According to the present invention, an active material may be stably delivered up to a target site, and the active ...
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WO/2024/005461A1 |
The present invention provides a novel linker compound and a ligand-drug conjugate therefor. This can stably deliver an active ingredient to a target site and rapidly release the active ingredient at the target site, and thus can increas...
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WO/2023/250513A1 |
Provided are 13-membered macrolides that can be used to treat proliferative diseases such as cancer as well as genetic diseases that are associated with a premature termination codon mutation or other nonsense mutations. The compounds ca...
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WO/2023/245037A1 |
The disclosure provides processes for preparing the compound of formula (VIa-1) and pharmaceutically acceptable salts thereof. Intermediates useful in preparing the compound of formula (VIa-1) are also provided.
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WO/2023/236534A1 |
Provided is a catalyst for selectively reducing spinosad J, relating to the technical field of spinosad preparation. The weight of active components of the catalyst accounts for 1%-10% of the weight of the catalyst, and the active compon...
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WO/2023/236453A1 |
The present invention belongs to the field of compounds, and discloses a method for preparing albiflorin-6'-O-benzenesulfonate. The method comprises the following steps: taking a medicinal material that is rich in albiflorin as a startin...
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WO/2023/240221A2 |
High yield separation and purification of one or more cannabinoid glycoside species from a complex mixture of cannabinoids. In one preferred aspect, the novel systems and methods of the invention can separate one or more cannabinoids and...
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WO/2023/233301A1 |
Disclosed herein are macrolide compounds having senolytic activity. These compounds selectively target senescent cells, and may be used to reduce or eradicate senescent cells in a subject, and/or delay the onset of aging. These compounds...
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WO/2023/209440A1 |
The present disclosure relates to tellurophene analogues of small molecules, and methods of detecting small molecules using their tellurophene analogues. The present disclosure further relates to compositions and kits comprising tellurop...
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WO/2023/205615A1 |
Disclosed herein are ionic liquid composition(s) of amphotericin B comprising amphotericin B; a complexing agent component; a solvent component comprising acidified solvent(s); and a solubilizing component. Disclosed composition(s) compr...
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WO/2023/193601A1 |
A method for simultaneously separating and purifying myricetin-3-O-(2"-O-galloyl)-α-L-rhamnoside and myricetin-3-O-(4"-O-galloyl)-α-L-rhamnoside from myrica rubra leaves and the use of the above-mentioned compounds in the preparation o...
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WO/2023/125818A1 |
The present invention relates to the technical field of pharmaceutical chemistry, in particular to a 8-debenzoylpichlorin-6'-O-benzenesulfonate, a preparation method therefor, and the use thereof in treating Sjögren's syndrome and rheum...
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WO/2023/118961A1 |
The present disclosure is directed toward drugs and toxins functionalized by at least one saccharide, sulfate or sulfonate; drug conjugates comprising said drugs or toxins and a cleavable linker; and targeted conjugates comprising said d...
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WO/2023/118061A1 |
The present invention relates to a process of purification of a crude compound of formula (I) wherein it comprises an isolation step of said crude compound of formula (I) including: (i) a solubilization step of said crude compound of for...
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WO/2023/090764A1 |
The present invention relates to a wallpaper composition and wallpaper from which a flavor ingredient is released by heat and, more particularly, to a wallpaper composition and wallpaper, comprising a compound which includes a moiety der...
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WO/2023/082574A1 |
The present invention provides a method for synthesizing selamectin, specifically comprising: oxidizing doramectin by means of manganese dioxide, oximating and desugaring same by using a hydroxylamine hydrochloride aqueous solution in a ...
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WO/2023/072069A1 |
Disclosed is the new use of Isorhoifolin and a derivative thereof. Isorhoifolin and the derivative thereof can be used for promoting the regeneration of damaged brain neurons and retinal nerves.
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WO/2023/040733A1 |
Disclosed in the present invention are a class of baicalein derivatives, and a preparation method therefor and the uses thereof. The structure of the baicalein derivative of the present invention is as represented by the following genera...
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WO/2023/035479A1 |
Disclosed is a traditional Chinese medicine composite which has the effect of promoting directional differentiation of stem cells into cardiomyocytes, comprising: syngnathus, pilose antler, hippocampus, ginseng, astragalus membranaceus, ...
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WO/2023/038852A1 |
Defined herein are immunomodulating Formula (1) compounds, wherein R, R0, R1, R2 and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention...
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WO/2023/018326A1 |
Provided are compounds of formula (I) and (II), which are useful as surfactants. Also provided are methods of preparing compounds of formula (I) and (II).
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WO/2023/014082A1 |
The present invention relates to a novel thalidomide-based compound derivative having significantly improved water solubility due to the introduction of a sugar or sugar derivative into lenalidomide or pomalidomide, which are thalidomide...
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WO/2023/000516A1 |
The present invention provides a purification method for paeoniflorin-6-O'-benzene sulfonate. According to the purification method, the purification process for paeoniflorin-6-O'-benzene sulfonate can be reduced, and impurities, such as ...
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WO/2023/000517A1 |
Provided in the present invention is a method for preparing paeoniflorin-6-O'-benzene sulfonate. The method uses crude paeoniflorin instead of paeoniflorin as a raw material, which more complies with actual requirements of an industrial ...
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WO/2023/002349A1 |
A chlorinated 4'-alkylumbelliferyl α-D-glucopyranoside represented by the structural formula (I) One of R1 and R2 is Cl and the other is H. R3 represents an alkyl group having 1 to 12 carbon atoms. A method of assessing efficacy of a st...
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WO/2023/000518A1 |
Provided in the present invention is a method for synthesizing a paeoniflorin derivative of formula III. The synthesis method can obviously reduce the use amount of a reaction solvent, shortens the reaction time, has the characteristics ...
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WO/2023/285323A2 |
The invention relates to a process for the production of amcipatricin diascorbate and the use of the same for an improved treatment of invasive fungal infections having proof/prevalence of resistance to traditional antifungal agents.
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WO/2023/280857A1 |
Disclosed is a process preparing diosmin and flavonoid fraction by direct oxidation of hesperidin.
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WO/2023/274313A1 |
The present invention provides an amphotericin B semi-synthetic derivative, and a preparation method therefor and a use thereof. Specifically, disclosed are a compound having a structure as shown in formula (V), as well as a water-solubl...
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WO/2023/275715A1 |
The present invention provides compounds of Formula X-1, X-2, X-3, or X-4, or metabolites of Compound 1 or metabolites of a compound of Formula 3-A or 3-B, including compositions and salts thereof, which are useful in the prevention and/...
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WO/2022/258692A1 |
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
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WO/2022/256920A1 |
Provided herein are β-1,3-linked biopolymers (acholetin polysaccharides). Furthermore, provided herein are enzymatic methods and systems for producing β-1,3-linked oligosaccharides and polysaccharides using β-1,3-N-acetylglucosaminide...
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WO/2022/255416A1 |
The purpose of the present invention is to provide: a method for producing a catechin conjugate with high efficiency by a semi-synthesis process; and an intermediate for the production of the catechin conjugate. Provided is a method fo...
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WO/2022/254868A1 |
Provided are a novel active ingredient derived from carob and usage thereof. The present invention is a compound represented by formula (I) or a salt thereof, or a solvate of the compound or the salt.
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WO/2022/250322A1 |
The present invention relates to a novel compound isolated from spinach, and a composition comprising same for preventing or treating inflammatory diseases, and, more particularly, to a novel medicagenic acid glycoside compound isolated ...
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WO/2022/251730A1 |
Provided are 13-membered ribosome targeting compounds that can be used to treat genetic diseases, including genetic diseases that are associated with a premature termination codon mutation or other nonsense mutation. The compounds can in...
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WO/2022/240098A1 |
The present invention identifies moisturizing and physiological activities of agarobiose, and provides a novel substance alkyl-agarbioside for maintaining moisturization activity of agarbiose and securing both pH and temperature stabilit...
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WO/2022/223779A1 |
The present invention generally relates to the field of pesticides. More specifically, the present invention relates to novel spinosyn compounds having advantageous properties, processes for their preparation, and their use as pesticides.
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