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WO/2016/056610A1 |
The present invention provides a method for manufacturing 7-dehydrocholesterol (7-DHC), the method being characterized by culturing, in a culture medium, a labyrinthulean micro-organism that produces 7-DHC and that has decreased sterol 2...
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WO/2016/042267A1 |
The invention concerns a method for producing a compound of interest of the sterol biosynthesis pathway in a eukaryotic organism or a derivative of a compound of the sterol biosynthesis pathway in said eukaryotic organism, in particular ...
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WO/2016/039359A1 |
The present invention relates to: a terpenoid derivative which is capable of activating a Keap1/Nrf2/ARE signaling pathway and has an excellent anti-inflammatory activity and an excellent cell-protecting activity; and a sustained-release...
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WO/2016/023933A1 |
The invention relates to novel 3α-hydroxysteroid dehydrogenase mutants, to sequences which code for these enzyme mutants, to methods for producing the enzyme mutants, and to the use thereof in enzymatic reactions of cholic acid compound...
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WO/2016/016213A1 |
The invention relates to novel 7β-hydroxysteroid dehydrogenase mutants, to sequences encoding said enzyme mutants, to methods for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid compounds, an...
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WO/2015/197698A2 |
The invention relates to novel biocatalytic processes, comprising the whole cell reduction of dehydrocholic acid (DHCS) compounds, novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences encoding said enzyme mutants, to methods ...
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WO/2015/188742A2 |
The present invention relates to a group of glycosyltransferases and a use thereof. Specifically, the use of glycosyltransferase gGT29-7 and a polypeptide derived therefrom in catalytic glycosylation of a terpenoid and in synthesizing ne...
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WO/2015/167282A1 |
The present invention relates to a uridine diphosphate (UDP)-glycosyltransferase protein which has glycosylation activity for a hydroxyl group at the C-20 position of a protopanaxadiol (PPD)- or protopanaxatriol (PPT)-type ginsenoside, a...
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WO/2015/162305A1 |
The present invention relates to a recombinant microorganism which is capable of expressing a cytochrome P450 reductase (CPR) and, optionally, a cytochrome P450 enzyme (CYP) and which is capable of overexpressing a Ice2p comprising the a...
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WO/2015/131798A1 |
Provided is a nicotinamide adenine dinucleotide (NADPH)-cytochrome P450 reductase and a use thereof. Also provided is a polynucleotide encoding the NADPH-cytochrome P450 reductase, an expression vector and a host cell which express the N...
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WO/2015/128534A1 |
The invention relates to bacterial strains of the species M. smegmatis with the activity 3-ketosteroid-9α-hydroxylase inactivated or with the activities 3-ketosteroid-9α-hydroxylase and 3-ketosteroid-∆1-dehydrogenase, and to the use ...
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WO/2015/115775A1 |
The present invention relates to a method for bioconverting ginsenoside Rb1 into ginsenoside F2 by using Ralstonia pickettii LSA71 strain. Particularly, the Ralstonia pickettii LSA71 strain isolated from Codonopsis lanceolata rhizosphere...
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WO/2015/111155A1 |
An 11β-hydroxysteroid such as hydrocortisone is produced using protein (a1), (b1), or (c1). (a1) A protein containing an amino acid sequence of SEQ ID NO: 43. (b1) A protein containing an amino acid sequence in which one or several amin...
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WO/2015/108058A1 |
The present invention provides a method for manufacturing 7-dehydrocholesterol, the method being characterized by deleting, replacing or adding at least one base in a gene that is present on the chromosomal DNA in a parent strain and tha...
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WO/2014/086842A9 |
The invention relates to methods for producing mogrosides with the aid of enzymes. In particular the invention proposes various biosynthetic pathways useful for mogroside production and enzymes useful for mogroside production are provide...
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WO/2015/018206A1 |
The present invention provides a method for preparing functional grease rich in phytosterol ester and diglyceride. The method comprises the following steps of: (1) adding phytosterol, triglyceride, molecular sieves into a reaction kettle...
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WO/2014/202627A2 |
The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also...
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WO/2014/197979A1 |
The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the endogenous luteinizing hormone. The present disclosure also provides associated t...
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WO/2014/183550A1 |
Provided in the present invention are a phosphatidyl sterol and/or phosphatidyl stanol rich in polyunsaturated fatty acyls and the preparation method thereof, which are mainly for solving the following technical problems: poor solubility...
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WO/2014/169666A1 |
The invention relates to a protopanoxadiol biosynthesizing method and provides a bacterial strain for producing the protopanoxadiol. In the present invention, a pichia pastoris engineering bacterial strain constructed through a genetic e...
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WO/2014/148455A1 |
Provided is a novel terpenoid derivative which exhibits anti-inflammatory action and cytoprotective action by activating Keap1/Nrf2/ARE signal transduction pathways. Terpenoid derivative A is represented by formula (1).
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WO/2014/139989A1 |
The present invention relates to a process for the production of squalene and/or sterol in high amounts using an alkaline solution and an organic lysis solvent at high temperature and high pressure for effectively lysing yeast cells and ...
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WO/2014/114342A1 |
There is provided yeast cell walls comprising vitamin D2. The vitamin D may be added vitamin D2 or obtained by treatment of a yeast cells walls fraction with UV light or by treatment of a yeast with UV light followed by autolysis and/or ...
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WO/2014/046347A1 |
The present invention relates to a method for producing ginsenoside Rg2 by using an enzyme used to improve the yield rate of producing and filtering extracts of fruits and vegetables. According to the present invention, the method for pr...
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WO/2013/179210A2 |
New process for the stereo- and regioselective enzymatic reduction of bile acids, their salts or derivatives, such as 7-keto-lithocholic acid, 7- ketodesoxycholic acid methyl ester, or 7,12 diketolithocholic acid methyl ester, in a buffe...
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WO/2013/167751A1 |
The invention relates to a method for enhancing the biosynthesis and/or secretion of sapogenins in the culture medium of plant and microbial cellcultures. Further, the present invention also relates to the identification of novel genes i...
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WO/2013/160365A1 |
The present invention relates to novel cytochrome P450 monooxygenase with modified (higher) substrate selectivity and/or (re)activity towards aromatic hydroxylation of benzenes. In particular, the invention provides nucleic acid sequence...
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WO/2013/149570A1 |
Provided are several types of ginsenoside polymorphic substances and a method for preparing same. In particular, new crystal form A, crystal form B, crystal form C, crystal form E, crystal form F, crystal form I, crystal form K, crystal ...
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WO/2013/117585A1 |
Disclosed is a method for obtaining furan derivatives from D-glucose. In said method, A) D-glucose is transformed into D-fructose in an enzymatic process in which redox cofactors are used and regenerated, one of the two redox cofactors b...
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WO/2013/117251A1 |
Disclosed is a method for enzymatically regenerating the redox confactors NAD+/NADH und NADP+/NADPH in a one-pot reaction. In said method, one of the two redox cofactors is obtained in the reduced form thereof while the other redox cofac...
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WO/2013/117584A1 |
Disclosed is a method for enzymatically regenerating the redox confactors NAD+/NADH and NADP+/NADPH in a one-pot reaction. In said method, one of the two redox cofactors is obtained in the reduced form thereof while the other redox cofac...
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WO/2013/114650A1 |
[Problem] To provide a method for producing a Korean ginseng medicinal ingredient whereby Rb1, which is an ingredient contained in Korean ginseng extract, is decomposed into a medicinal ingredient by a decomposition route for decompositi...
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WO/2013/110191A1 |
Provided herein are ATP-binding cassette transporters (ABC transporters). More specifically, the present disclosure relates to ABC terpenoid transporters, nucleic acid sequences, amino acids, proteins, vectors, cells, transgenic organism...
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WO/2013/102619A2 |
The invention relates to a method for the selective reduction of a secosteroid derivative to stereoisomerically pure, singly reduced compounds (seconols) by means of an enzyme from the class of alcohol dehydrogenases (ADHs), which method...
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WO/2013/076577A1 |
Methods and materials for enzymatic synthesis of mogroside compounds described.
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WO/2013/050760A2 |
The present invention relates to cofactor regeneration systems, components and uses thereof and methods for generating and regenerating cofactors. The cofactor regeneration system comprises a first electron transfer component selected fr...
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WO/2013/021138A2 |
The invention relates to yeast flakes enriched with vitamin D2, to compositions including said flakes, and to the uses thereof, as well as to a method for preparing yeast flakes enriched with vitamin D2 and to the device for implementing...
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WO/2013/001126A1 |
The invention relates to a method for the acylation of free phytosterols or saturated derivatives thereof with an acylation agent selected from the group consisting of a free fatty acid and a fatty acid ester, catalysed by a sterol ester...
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WO/2012/175453A1 |
The subject of the present invention is a process for preparing a genetically modified yeast by multicopy integration of at least four expression cassettes, allowing the production of a molecule of interest at high titre. The subject of ...
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WO/2012/157677A1 |
Provided are: a gene coding for an enzyme that reduces position 24 of a steroid skeleton; and a method for producing a steroid and a vitamin D3. The present invention involves: an enzymatic transformation method that, using a cell-free s...
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WO/2012/131591A1 |
New process for the regioselective enzymatic oxidation of bile acids, salts or derivatives thereof, such as cholic acid, chenodeoxycholic acid or cholic acid methyl ester, by NAD (P) +-dependent hydroxysteroid dehydrogenase (HSDH) in the...
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WO/2012/080504A1 |
The invention relates to novel 7ß-hydroxysteroid dehydrogenase mutants, to the sequences which encode these enzyme mutants, to processes for the preparation of the enzyme mutants and to their use in enzymatic reactions of cholic acid co...
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WO/2012/070724A1 |
The present invention relates to an alpha-N-arabinofuranosidase derived from Rhodanobacter ginsenosidimutans and uses thereof, wherein the protein has an activity of converting PPD(protopanaxadiol)- or PPT(protopanaxatriol)-type ginsenos...
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WO/2010/114255A9 |
The present invention relates to an androgen-containing fermentation product obtained by fermenting a sterol-containing natural substance using microorganisms, and to a method for preparing same. More particularly, the present invention ...
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WO/2012/029914A1 |
A method for enzymatically converting a methyl group at the 28-position of a pentacyclic triterpene compound of, for example, the oleanane- ursane- or lupane-type into a hydroxymethyl group or a carboxyl group, either in a cell-free syst...
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WO/2012/004248A1 |
The invention relates to the subject matter characterised in the claims, that is, an improved microbiological method for producing (6β,7β;15β,16β-dimethylene-11α-hydroxy-3-oxo-17-pregn-4
-ene-21,17β-carbolactone (formula I).
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WO/2011/147957A1 |
The invention relates to novel microbial 7α-hydroxysteroid dehydrogenase (7α-HSDH) knockout mutants and to the use thereof for producing other HSDHs having various functionalities, such as 3α-, 7ß- or 12α-HSDH, and to the use of thu...
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WO/2011/093686A2 |
The present invention relates to a method for preparing coumestrol, comprising a step in which beans are germinated and a step in which the beans are fermented, and to coumestrol prepared by the method.
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WO/2011/067144A1 |
This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also related to various enzymes catalyzing the reduction of the do...
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WO/2011/064404A1 |
The invention relates to novel 7β-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for produc...
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