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WO/2022/115645A1 |
The present disclosure provides for improved compositions of ionizable lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids are engineered with improved stability to oxidative degradation ...
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WO/2022/099374A1 |
The present invention relates to a compound of formula (I): or a salt or solvate thereof, combinations comprising same, uses and methods thereof, and kits comprising same.
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WO/2022/079637A1 |
Analogues of oleuropein and oleacein and pharmaceutically acceptable salts thereof and processes for the preparation of these compounds are disclosed. The invention further relates to use of oleuropein and oleacein analogues for the trea...
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WO/2022/061365A1 |
The disclosure relates generally novel sulfur containing glycerol mono- ester derivatives and methods useful for treating gram positive, gram negative, fungal and envelope viral infections in a patient.
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WO/2022/038224A1 |
A method for the preparation of an alpha-substituted carbonyl compound or an alpha- substituted nitrile compound carrying an aryl or heteroaryl group as an alpha-substituent, said method comprising reacting a sulfoxide compound S1 compri...
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WO/2021/153720A1 |
The present invention provides: a 3-alkoxy benzoic acid amide derivative having an excellent pest control effect, or a salt thereof; and a pest control agent and a production intermediate which contain the same as an active ingredient.ã€...
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WO/2021/019071A1 |
The present invention relates to novel aminoesters compounds or its pharmaceutically acceptable salts or optical isomers, racemates, diastereoisomers, enantiomers or tautomers. The present invention also relates to their process of prepa...
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WO/2021/014368A1 |
According to one embodiment, there is provided a method of producing a gene modification T cell (CAR-T cells) which expresses a chimeric antigen receptor (CAR). This method includes stimulating a cell population containing a T cell with ...
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WO/2020/262603A1 |
The purpose of the present invention is to provide a drug for the prevention and/or treatment of a disease associated with the activation of an EP2 receptor, the drug containing, as an active ingredient, a compound having an antagonistic...
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WO/2020/254484A1 |
The present invention provides a novel isolated succinate prodrug as the free com- pound or a salt, hydrate, solvate or complex thereof being cell permeable and aimed for increasing the ATP-production in mitochondria. The compound is use...
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WO/2020/227085A1 |
The present invention provides, in part, di-thioester cationic lipid compounds or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a...
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WO/2020/219427A1 |
The present invention provides, in part, thioester cationic lipid compounds of formula A, and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of...
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WO/2020/215726A1 |
A recycling process of waste generated in synthesis of thioacetic acid, comprising: in a thioacetic acid synthesis process, pretreating a thioacetic acid synthesis reaction solution, transferring the reaction solution to a filter device,...
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WO/2020/217710A1 |
Provided is a compound having at least one characteristic proprety selected from high chemical stability, high ability to horizontally align liquid crystal molecules, high alignability over a broad range of addition concentrations, prope...
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WO/2020/212543A1 |
The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive unit, said polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalm...
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WO/2020/165601A1 |
Methods are provided for the synthesis of a compound of formula (X). R2 is selected from -H, -C1-C4-alkyl,-C2-C4-alkenyl and C1-C4-aryl; R3 is selected from -C(O)H and -C(O)C1-C4-alkyl; and A is a pharmaceutically acceptable anion (e.g.a...
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WO/2020/147704A1 |
Disclosed is a method for synthesizing a S-(-)-benzoylmercapto-2-methylpropanoic acid compound, comprising hydrolyzing the S-(-)-3-acetylmercapto-2-methylpropanoic acid represented by formula (II) as a raw material in a reaction solvent ...
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WO/2020/142865A1 |
Disclosed in the present invention are a Benzamide compound, intermediates, a preparation method, and an application. The present invention provides a Benzamide compound as represented by formula I, and pharmaceutically acceptable salts,...
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WO/2020/129899A1 |
In order to provide a method for the economical and efficient industrial production of C-aryl hydroxy glycoxide derivatives, the present invention provides a method for producing a C-aryl hydroxy glycoxide derivative represented by formu...
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WO/2020/117608A1 |
Oxidized disulfide oil (ODSO) solvent compositions are derived from by-product disulfide oil (DSO) compounds produced as by-products from the generalized mercaptan oxidation (MEROX) processing of a refinery feedstock. The oxidized disulf...
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WO/2020/102348A1 |
Provided herein are compositions and methods for preparing albumin-targeting moieties that feature a thioamide linkage. Methods to use the albumin targeting molecules to generate drugs with improved in vivo pharmacodynamics and biodistri...
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WO/2020/059790A1 |
The the present invention addresses the problem of providing a DP receptor antagonist. Compounds represented by general formula (I): (in the formula, all of the symbols are as defined in the specification) and pharmacologically acceptabl...
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WO/2019/234651A1 |
A process is described for the preparation of thiadiazole derivatives and more specifically a new synthetic process of compounds having general formula (I) and intermediate compounds having general formula (XVI).
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WO/2019/222805A1 |
The disclosure relates to the synthesis of amide containing compounds in flow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation in flow. The disclosure also relates to selective desulfur...
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WO/2019/226925A1 |
Disclosed are cationic lipids which are compounds of Formula (I), (II), (III), (IV), (V), or (VI). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal d...
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WO/2019/219758A1 |
A process comprising the following steps: a-i) treating a polyunsaturated ester with a base in a solvent of lower alcohol and water to form the corresponding polyunsaturated acid; a-ii) treating the product from step a-i), especially the...
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WO/2019/189787A1 |
In this method for producing an organic mercapto compound or an intermediate thereof, a method for producing a thioester compound comprises a reaction step for reacting an alcohol compound containing a sulfur atom with a thioamide compou...
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WO/2019/176079A1 |
[Problem] To provide a biodegradable compound that has a structure degraded in cells, a lipid particle comprising the biodegradable compound and a medicinal composition containing the lipid particle. [Solution] According to one embodimen...
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WO/2019/162806A1 |
Controlled radical initiators, reaction mixtures containing the controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing th...
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WO/2019/107533A1 |
The present invention provides a compound for suppressing cell transformation, the compound being represented by the following general formula (wherein n is 1 or 2; R1 is H, methoxy(-OCH3), or Cl; R2 is H, -OCH3, or Cl; R3 is H, -OCH3, C...
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WO/2019/097503A1 |
The present invention relates to the treatment of cancer using combination therapy comprising a dual modulator of Insulin Receptor Substrate (IRS) and signal transducer and activator of transcription 3 (Stat3), in combination with an ant...
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WO/2019/087580A1 |
[Problem] To provide: a novel alkanethioic acid derivative which is capable of imparting characteristic scent or flavor to cosmetics or to food and beverages; and a perfume composition that comprises the pertinent compound as an active i...
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WO/2019/046931A1 |
Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions invol...
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WO/2019/044478A1 |
The invention is an electroconductive substance comprising a complex containing a rubeanic acid ligand and a copper ion. The copper ion included in the complex comprises a copper (I) ion. In addition, this electroconductive substance is ...
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WO/2019/034468A1 |
Process for the preparation of a compound with at least one monothiocarbonate group by reacting: - a compound with at least one mercaptoalcohol group and - a dialkylcarbonate, in the presence of a catalyst wherein the catalyst is a salt ...
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WO/2018/234139A1 |
2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)a
cetamides for combating phytopathogenic fungi The present invention relates the compounds of the formula I and their N-oxides and agriculturally acceptable salts thereof, and t...
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WO/2018/183261A1 |
The present invention relates to a compound of Formula (I): where â„— R, R1, R2, R3, and Z are as described herein and to a process for preparing a compound of Formula (I). This invention also relates to a process for the synthesis of a ...
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WO/2018/128386A1 |
Disclosed is a method for synthesizing a gamma-nitro dithioester derivative compound (a γ-nitro dithioester compound). The gamma-nitro dithioester derivative compound may be synthesized by subjecting a nitroalkene compound having two ca...
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WO/2018/128383A1 |
Disclosed is a method for preparing a chiral alpha-hydroxy thioester compound. In order to prepare a chiral alpha-hydroxy thioester compound, an alpha-oxo-aldehyde compound and a thiol compound may be stereoselectively reacted with each ...
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WO/2018/075848A1 |
Provided herein are sulfated compounds that are useful as high refractive index monomers for optical and other applications and methods for producing the same. The sulfated compounds are liquid at room temperature and exhibit good miscib...
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WO/2018/052936A1 |
Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone c...
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WO/2018/009830A1 |
The present invention relates to a compound having the structure of formula (I), wherein R1, R2, R3, R4, R5, R6, and R7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula...
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WO/2017/140754A1 |
A process for preparing aminothiol ester compounds and salts thereof. The present invention relates to a process for preparing compounds of formula (I), (I) comprising the following steps: a) reacting a compound of formula (II) with an i...
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WO/2017/129483A1 |
The invention relates to a novel hetero-diels-alder cross-linker, to methods for the production thereof and use thereof for reversibly crosslinked polymer systems.
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WO/2017/130679A1 |
Provided is a method with which it is possible to produce a high-purity thiocarbonyl compound via an industrially practicable production method by removing a sulfurizing agent-derived byproduct via a simple post-reaction purification met...
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WO/2017/104248A1 |
The purpose of the present invention is to provide a nitrone compound having excellent productivity of a modified polymer, a method for producing said compound, a modifier composition, a modified polymer and a method for producing said p...
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WO/2017/099531A1 |
The present invention relates to a novel phenolic acid derivative compound having whitening and antioxidative activities and a use thereof and, more specifically, to a compound represented by chemical formula (1) below, an isomer thereof...
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WO/2017/090581A1 |
According to the present invention, a method for producing a carboxylic acid thioester is provided, which comprises reacting a compound represented by formula (I) with a carboxylic acid and a thiol in the presence of a catalyst comprisin...
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WO/2017/060422A1 |
The present invention provides novel cell-permeable carboxylic acid-based metabolites and cell permeable precursors thereof aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic ...
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WO/2017/060420A1 |
The present invention provides novel cell-permeable fumarate acyl mercaptoethylamines (FAMs) which have cellular effects including induction of Nrf2 and inhibition of the NFkB pathway. These compounds have utility in medicine including t...
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