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JP2788427B2 |
PURPOSE: To provide a method for recovering quinic acid in high efficiency and purity from a stock liquid containing sodium sulfate and quinic acid, dispensing with the marine disposal of a waste liquid discharged in the production of ga...
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JP2774381B2 |
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JPH10182546A |
To obtain a new azulene derivative having excellent antiinflammatory, antipyretic, analgesic, and antarthritic actions and little in side effects such as gastrointestinal disorders. An azulene derivative of formula I [R1 is a (substitute...
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JPH10506383A |
Compounds, methods and compositions are provided for inducing natriuresis in a mammal. Methods for isolating and synthesizing the natriuretic compounds are also provided. Therapeutic methods using the natriuretic compounds are also provi...
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JPH10505597A |
The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are...
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JPH10505610A |
An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-
yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operatio...
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JP2758902B2 |
This invention encompasses compounds of Formula 1 and the pharmaceutically acceptable salts thereof. wherein R<1> represents alkyl having 2-6 carbon atoms; R<2> represents methyl or ethyl; R<3> represents alkyl having 1 to 5 carbon atoms...
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JP2756971B2 |
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JP2740919B2 |
Novel platinum complexes of the formula: wherein R<1> and R<2> are identical or different lower alkyl groups, or R<1> and R<2> taken together form a -(CH2)m- bridge, and m is an integer from 2 to 5, and antitumor agents comprising the co...
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JP2740829B2 |
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JPH1087548A |
To make it possible to obtain the subject compound useful for producing medicines and agrochemicals with excellent yield and purity without requiring severe reactional conditions by using a catalytic transfer hydrogenation. (A) A 1,3-dih...
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JP2717787B2 |
Compounds of formula (I): in which X1 and X2 = Hal, R1 = alkyl, aryl, perfluoroalkyl, C IDENTICAL N, and R=H, alkyl or the residue of an alcohol employed in the synthesis of the pyrethrinoid esters.
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JP2710097B2 |
PURPOSE: To produce a compound useful for exterminating parasites, nematodes and mites by reacting cyclopropanecarboxylic acids with a reducing agent. CONSTITUTION: A compound represented by formula I (X1 and X2 are each a halogen; R1 is...
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JP2708118B2 |
Di- and tri-substituted perfluorocycloalkane compounds which have a cyclohexane or decahydronaphthalene nucleus are provided. These perfluorocycloalkane compounds are carbonyl fluorides and derivatives thereof.
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JP2705792B2 |
Bicyclic aromatic compound having the formula (R) wherein R1, R2, R3 and R4 represent hydrogen or alkyl, at least two of R1-R4 radicals being other than hydrogen, A represents methylene or dimethylene; when A represents dimethylene, R1 a...
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JP2693843B2 |
The present invention includes compounds represented by the formula: wherein n is 0 or 1; R1, R2, R3, and R4 are independently selected from hydrogen, hydroxy, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thi...
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JP2681648B2 |
NEW MATERIAL:A compound shown by formula I (A is CH or N, R<1> is aryl; R<2> is hydroxyl or amino) and a salt thereof. EXAMPLE:1-[Carbamoyl)cyclopropane-1-yl]-1-(4-chlorophenyl)-2
-(l,2,4-tr iazol-1-yl) ethanol. USE:An antifungal agent h...
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JPH09278708A |
To obtain a sesquiterpene-based compound useful as a raw material for a medicine, especially an antibacterial agent or an antifungal agent. This sesquiterpene-based compound is shown by formula I (R is H, ammonium, an alkali metal or a l...
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JP2668796B2 |
2- and 3-substituted (1 min ,5 min -diaryl-3 min -pyrazolyl)-N-hydroxypropanamides, a method for their preparation, compositions containing the same and methods of their use are disclosed. The N-hydroxypropanamides are useful in alleviat...
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JP2667294B2 |
Indane and indene derivs. of formula (I) and their salts are new. In (I), R1 = X(CH2)nAr, X(CH2)nR8 or a gp. (a); R2 = H, Ar or (a); P1 = X(CH2)nR8; P2 = X(CH2)nR8 or XR9Y; R3, R5 = R11, H, OH, 1-8 alkoxy, S(O)qR11, N(R6)2, Br, F, I, Cl,...
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JP2644818B2 |
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JP2637113B2 |
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JPH09183724A |
To obtain a uzedicine useful as an antitumor agent and expected as an antitumor medicine having high safety and little side effect by compounding a specific naphthalene carboxylic acid derivative obtained from propolis or its salt as an ...
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JPH09506864A |
Compounds of Formula 1 Formula 1 wherein m is 1-4; R1-R4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; ...
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JP2622135B2 |
Indene derivatives of the general formula wherein R<1> is a) a phenyl group optionally substituted with one or more groups selected from halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfonyl, dilower alkylamino, acylam...
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JP2621309B2 |
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JPH09124489A |
To obtain the subject agent containing a specific saponin as an active ingredient, capable of suppressing the production of interleukin-6 caused by a stimulation with various physiological materials, and anticipated as a therapeutic agen...
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JPH09104693A |
To obtain new glycosides having action capable of controlling immune system of warm-blooded animals and usable as an active substance in medicines for treating tumor and viral diseases by separating from an aqueous extract of a plant pol...
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JP2599413B2 |
NEW MATERIAL:A cyclocondensation quinone derivative shown by formula I (R<1>, R<2> and R<3> are H, methyl or methoxy; R<4> is hydroxymethyl or carboxyl which may be amidated or esterified; X is H, halogen, lower alkyl or methoxy; Y is CH...
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JP2587902B2 |
PURPOSE: To obtain a new 1-phenylbicyclo[2,2,2]octane compound useful for the treatment of arthritis and inflammatory phenomenon due to denaturation of acute phase protein. CONSTITUTION: The compound of formula I [R1 is a halogen, OH, 1-...
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JP2583241B2 |
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JPH0940606A |
To obtain the subject compound effectively, without producing by- products and causing the problem of the corrosion of an apparatus, and useful as an intermediate, etc., for a liquid crystal through the hydrogenation of the aromatic ring...
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JP2572173B2 |
The invention relates to the use of carnosic acid for the production of a composition intended for preventing or treating cancer and for treating herpes.
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JP2559723B2 |
Vinylphenol derivatives of the formula I where A and R1 to R7 have the meanings stated in claim 1 and in the description, and their physiologically tolerated salts, drugs prepared from these, and their use for the treatment of various di...
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JPH08283116A |
PURPOSE: To obtain a skin lightener and a skin cosmetic which have excellent skin-lightening effect and can prevent and treat skin spots and ephelis caused by sun burn by using a specific 1,3-diarylindan-2-carboxylic acid. CONSTITUTION: ...
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JP2546992B2 |
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JPH08509220A |
Novel cyclopentane derivatives are described which are endothelin receptor antagonists.
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JP2533565B2 |
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JP2523140B2 |
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JP2521191B2 |
New phenylethanolaminomethyltetralins of formula (I) (I) wherein E represents hydrogen, (C1-C4)alkyl, (C1-C4)alkoxy, phenyl, nitro, halogen, or trifluoromethyl, L represents hydrogen, (C1-C4)alkyl, (C1-C4)alkyoxy, phenyl, nitro, or halog...
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JPH08143508A |
PURPOSE: To provide a method for easily producing a carboxylic acid derivative or its alkali metal salt useful as an intermediate for agricultural chemicals, medicines, etc. CONSTITUTION: An alcohol compound of formula I (R3 is lower alk...
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JPH0892157A |
PURPOSE: To provide the subject novel compound that originates from a specific microorganism, has strong and selective inhibitory action against catecholamine- O-methyl transferase and is useful for the treatment of Parkinsonism. CONSTIT...
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JPH0838193A |
PURPOSE: To effectively obtain optically active tetralin derivatives in an enzymatic process by hydrolyzing the specific racemic esters of tetralin derivatives with lipase to the specific yields, and subsequently inactivating the enzyme ...
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JPH082835B2 |
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JPH07330661A |
PURPOSE: To produce the new dehydroabietic acid derivative capable of improving water and oil repellency, stain proofing properties, heat resistance, etc., therefore, useful as an additive for paper, rubber, ink, etc., having a biologica...
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JPH07116095B2 |
A process for preparing cyclohexanonecarboxylic acid compounds by catalytically hydrogenating the corresponding hydroxybenzoic acid compounds in a secondary alcohol or tertiary alcohol solvent.
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JPH07110830B2 |
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JPH07291857A |
PURPOSE: To obtain a preventing and therapeutic agent for bone resorption osteopathy such as malignant hypercalcemia, bone Paget disease or osteoporosis containing a glycyrrhetinic acid compound as an active ingredient. CONSTITUTION: Thi...
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JPH07291858A |
PURPOSE: To obtain a preventing and therapeutic agent for bone resorption osteopathy such as malignant hypercalcemia, bone Paget disease or osteoporosis containing a gypsogenin compound (salt) as an active ingredient. CONSTITUTION: This ...
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JPH07285909A |
PURPOSE: To provide a new phenanthrene derivative having IL-1 inhibiting activity and useful for the treatment of chronic inflammatory diseases. CONSTITUTION: This phenanthrene derivative is a compound selected from the compounds of form...
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