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JP2001508782A |
A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, from another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate c...
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JP3160291B2 |
Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The inventi...
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JP2001505179A |
The present invention provides tertiary and secondary amine compounds of the formula (* CHEMICAL STRUCTURE *) and the pharmaceutically acceptable salts thereof which are antagonists for alpha-2 adrenoreceptors and which inhibit serotonin...
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JP3157607B2 |
PURPOSE: To produce the subject novel compd. useful as a protein indicator which strongly develops a blue color when the indicator is dipped in a protein- containing biological sample and in which its coloring strength reflects a concn. ...
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JP2001504808A |
N-(4-(Etherified or esterified hydroxy)-phenyl)-amide compounds of formula (I) are new. Y1-Y4 = H, halo, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio or haloalkylthio; R1 =alkyl, alkenyl, aryl, cycloalkyl, cycloalkenyl or heterocyclyl...
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JP3150155B2 |
Compounds having both calcium antagonist and antioxidant activity are disclosed. The compounds are useful in preventing or alleviating damage to tissues at the cellular level. Methods of treatment which employ these properties of the com...
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JP2001501183A |
HIV protease inhibitors inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds can be prepared by the novel methods of the present invention using the n...
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JP2001019690A |
To obtain an analog of BCH-189 from an inexpensive precursor.This method comprises such processes that an allyl ester 1 or ester is ozonized to produce an aldehyde 2, the aldehyde 2 produces a lactone 3 by reacting with thioglycolic acid...
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JP2000516917A |
Carbanilide derivatives of formula (I) are new: R = halo, nitro, cyano, 1-8C alkyl, 1-6C haloalkyl, 1-8C alkoxy, 1-6C haloalkoxy, 1-8C alkylthio, 1-6C haloalkylthio, 2-8C alkenyloxy, 2-8C alkynyloxy, 3-8C cycloalkyl, carbalkoxy (with 1-8...
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JP3117217B2 |
A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a beta -dioxolanyl purine nucleoside of the formula: wherein R is OH, Cl, NH2, or H, or a pharmaceutica...
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JP2000319172A |
To obtain the subject composition in which a bicyclic aromatic compound is solubilized in a physiologically permissible solubilizing agent by including a specific bicyclic aromatic compound and an alkylalkanol. This composition comprises...
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JP3105154B2 |
To obtain the subject new compound capable of readily synthesizing a low toxic effective anti-HIV compound. This 1,3-oxathiolane is represented by formula I [R1 is H; Z is S, S=O or SO2; R2 is represented by the formula (R3 is H or a 1-6...
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JP3092272B2 |
A novel process for the preparation of cyclopropanenitrile derivatives is described, starting from a diol of the general formula in which this diol is converted with thionyl chloride to a compound of the general formula this is then oxid...
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JP2000512269A |
This invention includes novel sultine compounds and the reaction of these compounds to form colored compounds. The invention also includes the use of these color-forming compounds in the manufacture and imaging of thermal imaging papers ...
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JP3085675B2 |
There is provided novel 2-substituted-4-substituted-1,3-dioxolanes which are particularly useful as antiviral agents.
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JP2000511197A |
Aliphatic Nitrate esters having a sulfur or phosphorus atom beta or gamma to a nitrate group having efficacy as vasodilators are described. Preferred nitrate esters may be synthesized by nitration of a 3-bromo-1,2-propanediol, and subseq...
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JP2000509718A |
(57) [Summary] Compounds represented by formula (I), as well as their N-oxides and agriculturally suitable salts, are disclosed which are useful in controlling unwanted vegetation. In equation (I) above, Q is (Q-1), (Q-2) or (Q-3); and A...
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JP3066488B2 |
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JP2000191615A |
To produce a new compound which is a nonpeptidic compound having regulating actions on somatostatin receptor functions and useful as a preventing or a therapeutic agent for diabetes, obesity, diabetic complications, etc. This compound is...
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JP3053222B2 |
PCT No. PCT/IB95/00279 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 20, 1995 PCT Pub. No. WO96/33172 PCT Pub. Date Oct. 24, 1996A compound of the formula I wherein R1, R2 R3, R4 R5, R6, R7, R8, R9 and Ar are as...
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JP2000159734A |
To obtain the subject new compound useful for production of a medicine, especially usable for production of halohydrin useful as a synthetic intermediate of HIV proteinase inhibitor or the like.A new compound of formula I [R1 is a (subst...
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JP3047045B2 |
PCT No. PCT/KR95/00135 Sec. 371 Date Jun. 11, 1997 Sec. 102(e) Date Jun. 11, 1997 PCT Filed Oct. 21, 1995 PCT Pub. No. WO96/12716 PCT Pub. Date May 2, 1996Nucleoside derivatives represented by formula (I); wherein, R1 represents hydrogen...
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JP2000143662A |
To provide a new substituted 1,3-oxathiolane compound capable of being easily synthesized, having low toxicity, and useful as an effective anti- human immunodeficiency virus(anti-HIV) compound. A single enantiomer or the enantiomer mixtu...
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JP2000505449A |
PCT No. PCT/EP97/00802 Sec. 371 Date Aug. 17, 1998 Sec. 102(e) Date Aug. 17, 1998 PCT Filed Feb. 20, 1997 PCT Pub. No. WO97/30986 PCT Pub. Date Aug. 28, 1997Hetaroyl derivatives of the formula I where the substituents have the following ...
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JP3036853B2 |
Provided is a method of treating inflammatory bowel disease in mammals utilizing certain benzyl-substituted rhodanine derivatives. Also provided are novel benzyl-substituted rhodanine derivatives, a process for producing same and pharmac...
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JP2000109477A |
To obtain a sulfur-containing heterocyclic carbamate derivative not giving chemical damages to paddy rice in paddy fields and further to useful crops in upland fields even under any condition, having an excellent herbicidal activity, and...
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JP3027196B2 |
PCT No. PCT/EP96/03800 Sec. 371 Date Feb. 26, 1998 Sec. 102(e) Date Feb. 26, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09324 PCT Pub. Date Mar. 13, 1997Benzoyl derivatives of the formula I where the substituents L, M, X, Y and n hav...
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JP3022968B2 |
Dioxolanes, thio analogs thereof, and derivatives of these and methods of preparation are described. These materials are useful as additives in lubricants and fuels. Methods for reducing fuel consumption in internal combustion engines em...
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JP2000080092A |
To obtain a fuel composition reduced in fuel consumption and useful for internal combustion engines, etc., by including a major amount of liquid fuel and a small amount of specific compound. This fuel composition comprises (A) a major am...
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JP2000502663A |
PCT No. PCT/EP96/05645 Sec. 371 Date Mar. 30, 1999 Sec. 102(e) Date Mar. 30, 1999 PCT Filed Dec. 16, 1996 PCT Pub. No. WO97/23476 PCT Pub. Date Jul. 3, 1997Cyclic sulphones of formula (I) are disclosed, in which: R1 and R2 each independe...
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JP2000053676A |
To obtain a new compound of a sulfur atom-containing aromatic hydrocarbon compound, and useful as a constituent material of an organic electroluminescence element having high thermal stability, high luminescent characteristics and a low ...
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JP2000053601A |
To obtain the subject new compound useful as a chemically amplifying type resist. This resist is a compound of formula I or formula II (R1 and R2 are each an aromatic organic group, an alkyl, a cycloalkyl or the like; R8-R10 are each an ...
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JP2000026458A |
To obtain a new benzoyl derivative capable of exterminating weeds without damaging raised plants. This new compound is shown by formula I [L and M are each H, a 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl or the like; Y is C=O, C=N-R3 (R3 is ...
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JPH11349585A |
To provide an industrially useful production route for 2-oxo-1,3-dioxa-2- thiolane derivative. In the production of 2-oxo-1,3-dioxa-2-thiolane that is represented by formula I (R is a hydrocarbon group which may be substituted), 1,2,3,4-...
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JPH11514357A |
PCT No. PCT/EP96/04263 Sec. 371 Date Apr. 20, 1998 Sec. 102(e) Date Apr. 20, 1998 PCT Filed Sep. 30, 1996 PCT Pub. No. WO97/14693 PCT Pub. Date Apr. 24, 1997A compound of the general formula I where the indices and the substituents have ...
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JP2972377B2 |
New catechol derivatives and pharmaceutically acceptable salts and esters thereof useful as pharmaceutical antioxidants are disclosed. Cellular damage by oxygen derived radicals is a significant factor in heart disease, rheumatoid arthri...
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JP2948783B2 |
To obtain the subject liquid crystal compound bearing an antipodic haloalkyl residue, and useful for displays having a memorizing capability for displaying letters, signs or figures and quick in startup. This ferroelectric liquid crystal...
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JP2921676B2 |
Fast-switching displays with memory properties are provided, which can display digits, symbols, and images, and which contain as chemically and thermally stable ferroelectric liquid crystalline substances, according to the invention, liq...
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JP2918598B2 |
A (perfluoroalkyl)dibenzonium salt represented by the following general formula wherein Rf represents a perfluoroalkyl group having 1 to 10 carbon atoms, A represents a sulfur or selenium atom, R<1> and R<2>, independently from each othe...
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JPH11180976A |
To obtain the subject new compound stable irrespective of the basic value, etc., of a perbasic alkaline earth metal phenate sulfide concentrate used as an additive for lubricants, capable of improving the high temperature washability of ...
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JP2901160B2 |
Enantiomerically enriched cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolane-5-yl
)-(1H)-pyrimidin-2-one, derivatives and pharmaceutical compositions thereof.
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JP2890039B2 |
To obtain an antimocroalgal agent excellent in new kinds of bioactivity such as antimicrobial activity for fish diseases, antimicroalgal activity and antiallergic activity by using a specific seven-membered heterocyclic compound bearing ...
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JPH11116561A |
To obtain an epoxy compound at a low cost without using chlorine gas by reacting a specific carbonate with an alkylene oxide. A compound of formula I or II (Ra is a group of formula III or the like) (e.g. a bis-cyclic carbonate ester obt...
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JPH11503414A |
Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors...
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JPH1180140A |
To obtain the 2-position conjugated double bond introduced substance of a benzoxazolium quaternary ammonium salt without depending upon the structure of the substance, by using a specific production method. A benzoxazolium derivative of ...
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JP2868429B2 |
PURPOSE: To provide the subject compound having strong antagonist activity with respect to 5-HT1A and 5-HT1C receptors, useful for treatment or prevention of stress, anxiety, depression, mental diseases (schizophrenia), pain or the like....
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JPH1129567A |
To provide the subject new compound exhibiting remarkable controlling action on various plant blights such as rice blast, apple scab and late blight of tomato and usable as an active component of a new fungicide for agricultural and hort...
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JPH1125505A |
To improve light resistance and preservation durability by using a dyestuff compd. introduced with a cation part having an onium ion of a bis type as a pair ion into a dyestuff component having the anion part of an oxonol dyestuff compd....
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JPH10279583A |
To obtain a new heterotricyclic herbicide comprising a specific heterotricyclic compound, its N-oxide or an agrichemically suitable salt thereof and useful as an inexpensive, low-toxic and environmentally safe herbicide for controlling u...
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JPH10510248A |
Disclosed are compounds of formula I: I wherein X is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl; Z is nitrogen or CH; Ar1 and Ar2 independently represent aryl groups; and Y is hydrogen; o...
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