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JP3421335B2 |
The present invention provides enantiomerically pure ²-D-(-)-dioxolane-nucleosides. The enantiomerically pure dioxolane nucleosides are active HIV agents, that are significantly more effective than the prior prepared racemic mixtures of...
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JP2003519693A |
The present invention provides a compound of the formula (I) and pharmaceutically acceptable salts having useful antiviral activity against viruses of the herpes family. In said formula, X=O, (CH2)m, S, SO, SO2, NH, NR8, or a chemical bo...
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JP2003171370A |
To obtain a new fungicide for agricultural and horticultural use.This invention provides a heterocyclic imino aromatic compound expressed by formula (1) [A1 is a (substituted) heterocyclic group; A2 is a group selected from the group of ...
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JP2003519176A |
Use of certain nitrate ester compounds or pharmaceutically acceptable salts thereof in the manufacture of a medicament for treating pain or providing analgesia.
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JP2003515601A |
Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or imroved recognition domains are disclosed, including methods of preparing and utilizing the same.
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JP3397352B2 |
PURPOSE: To provide a new acrylonitrile derivative having a wide germicidal spectrum and especially having an extremely excellent germicidal activity against rice Rhizoctonia solani, apple Venturia inaequalis, Botrytis cinerea, etc. CONS...
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JP2003081951A |
To provide a germicidal insecticide for agriculture and horticulture.This germicidal insecticide for agriculture and horticulture comprises one or more kinds of compounds selected from an aminocarbonyl heterocyclic imino compound represe...
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JP2003081966A |
To provide a method for the stereoselective synthesis of a nonnatural halogenated sugar expressed by general formula (1).The method for the selective production of the α-isomer or the β-isomer of a nonnatural halogenated sugar comprise...
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JP2003073367A |
To provide a new agrochemical, especially a germicical agent and an insecticidal agent.The tricyclic heterocyclic imino compound represented by formula (1) [wherein, G is -CH2COOMe or the like; A is a ring formed by 5-7 atoms arbitrarily...
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JP2003034744A |
To obtain a composition which, when cured, gives a cured product excellent in electrical insulation, adhesion, heat resistance, chemical resistance, weatherability, moisture resistance, adhesion to metals and mechanical strength. This co...
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JP2003504373A |
This invention provides novel oxathiepino[6,5-b]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharm...
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JP3355367B2 |
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JP2002540197A |
Compounds of formula (I) are antibacterial agents wherein: R3 and R4, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 16 atom...
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JP2002540066A |
A process for preparing alkanesulfonic acids from dialkyl sulfites comprises the following steps:rearrangement of dialkyl sulfite in the presence of a suitable catalyst to form the corresponding alkyl alkanesulfonate andhydrolysis of the...
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JP2002539152A |
Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effect...
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JP2002539084A |
Dimethyl sulfite is prepared by transesterification of a cyclic alkylene sulfite of at least 2 carbon atoms with methanol, in the presence or absence of a catalyst, by a process which is carried out continuously in a column.
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JP2002322172A |
To provide a method for producing o-sulfobenzoic acid anhydride industrially advantageously.A benzaldehyde-o-sufonic acid salt is oxidized to give an o- carboxybenzenesulfonic acid salt and then the o-carboxybenzenesufonic acid salt is s...
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JP3330972B2 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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JP2002532489A |
(57) [Summary] The present invention is in formula (I) (where A may be optionally substituted saturated or unsaturated alkyl chain; R.1Is cyano, rodano, nitro, OR4, SR5, SOR6, SO2R6, ONR6NR7, ON = CR6R8, NR9R10, P (O) R11R12, P (S) R11R1...
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JP2002527504A |
This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in t...
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JP2002527501A |
The present invention relates to compounds of the general formula (I)The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (...
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JP2002226463A |
To provide a new method for producing a heterocyclic imino compound useful as an agricultural and horticultural bactericidal and insecticidal agent.This method for producing the heterocyclic imino compound (1) is provided by reacting a h...
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JP2002524550A |
A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (...
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JP2002523455A |
The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treat...
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JP3298954B2 |
PURPOSE: To obtain the subject new compound useful as an insecticide in aspects of a paddy field, a farmland, an orchard, a forest and environmental sanitation and a controlling agent for parasites parasitic to man or animals. CONSTITUTI...
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JP3299542B2 |
PCT No. PCT/AU93/00667 Sec. 371 Date Jul. 20, 1995 Sec. 102(e) Date Jul. 20, 1995 PCT Filed Dec. 21, 1993 PCT Pub. No. WO94/14792 PCT Pub. Date Jul. 7, 1994Compound of the Formula 1 Formula 1 wherein: R1 and R2 are independently selected...
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JP3292830B2 |
To obtain the novel subject compound that comprises racemic βD,L-2- hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane or its resolved enantiomers and has antiviral activity. This compound is (±)-β-D,L-2-hydroxymethyl-5-(5-fluoroc...
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JP2002515860A |
The present invention is directed to (D)-amino acid containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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JP3286056B2 |
PURPOSE: To obtain a tricyclic condensed heterocyclic derivative, having excellent inhibiting activities against choline esterases and inhibiting actions on uptake of monoamines and useful as a therapeutic and preventing agent for senile...
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JP2002514192A |
The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
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JP3282047B2 |
PURPOSE: To inexpensively purify a crown compound simply and efficiently. CONSTITUTION: A crown compound is made into a complex, dissolved in an organic solvent, purified, mixed with water and recovered to purify the crown compound. The ...
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JP2002510290A |
The invention relates to compounds of formula (I):wherein:R1, R2 and R3 are as defined in the description,X is as defined in the description,Y represents an oxygen atom, a sulphur atom, a C(H)q group, SO or SO2,n is equal to from 0 to 5,...
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JP3262333B2 |
This invention concerns compounds of formula (I) in optionally substituted by lower alkyl; Z is a bicyclic oxygen-containing aryl radical (e.g. 2,3-dihydro-1,4-benzodioxin-5-yl); R is hydrogen or lower alkyl; R1 is aryl or aryl(lower)alk...
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JP3256171B2 |
To obtain the subject new compound being a polymer electrolyte containing a sulfonio group as a functional group, having low viscosity, excellent heat resistance and chemical stability, useful as a monomer for an ionic conductor, an ion ...
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JP2002502832A |
The present invention relates to methods for preparing macrocyclic products having 9 or more ring atoms by ring-closing diyne metathesis of suitable diyne substrates. The diyne substrates can be converted into cycloalkynes or into cycloa...
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JP2002501475A |
PCT No. PCT/US97/23486 Sec. 371 Date Mar. 11, 1999 Sec. 102(e) Date Mar. 11, 1999 PCT Filed Aug. 19, 1997 PCT Pub. No. WO98/12190 PCT Pub. Date Mar. 26, 1998The present invention provide phenoxathiin compounds useful in the prophylaxis a...
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JP2002501042A |
The invention relates to novel naphthyl substituted and heterocyclic substituted sulfonamides of general formula (I) in which A, D, E, R<1> and R<2> have the meanings given in the description. The invention also relates to a method for t...
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JP2001527556A |
A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I),wherein X is oxygen, NR4 or CHR5; R1 is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R2 is hydrogen, alkyl, aryl, heteroaromatic,...
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JP2001523662A |
A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-...
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JP2001523662A5 |
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JP2001316386A |
To provide a perfume composition extremely useful as an excellent and unique agent for imparting persistent fragrance, or a modulator in wide field such as a favorite food, a drink and food, a health and pharmaceutical preparation, a per...
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JP3229013B2 |
PURPOSE: To obtain optically active cis-nucleoside and a compd. analogous to the nucleoside by glycosylating purine or pyrimidine bases with a specified intermediate in the presence of a specified Lewis acid. CONSTITUTION: Desired purine...
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JP2001302660A |
To provide a more sensitive indicator and a test piece for the determination of protein. This indicator is 3', 3'',5',5''-tetraiodophenol-3,4,5,6- tetrabromosulfophthalein expressed by formula (1), and an indicator for the test piece for...
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JP2001302605A |
To obtain a compound having an excellent plant pest control effect. This biphenyl compound is expressed by general formula [wherein R1 expresses a 1-10C alkyl, a-10C haloalkyl; n expresses 0-3 integer; R2 expresses fluorine; m expresses ...
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JP3224419B2 |
PURPOSE: To obtain an analyzing test piece for detecting protein in biospecimen by incorporating absorptive carrier impregnated with phenolsulfonphthalane protein error indicator and merocyanine protein error indicator. CONSTITUTION: An ...
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JP3220711B2 |
To obtain a new compound capable of bonding to the surface of gold in a lot of points and easily forming a stable self-organized film on the surface of gold by introducing a disulfide group in phthalocyanine. This new compound of phthalo...
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JP3221141B2 |
PURPOSE: To obtain a new compound exhibiting high refractive index and high Abbe's number and useful as an optical resin and an optical product having excellent transparency and heat resistance. CONSTITUTION: The compound of formula I (R...
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JP3202079B2 |
PURPOSE: To obtain new acid anilide derivatives useful for combating fungi, particularly Botrytis, having improved fungicidal action compared with nicotinic acid anilides such as 2-chloronicotinic-2'-ethyl anilide. CONSTITUTION: 2-Alkyla...
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JP2001512455A |
A process allows the preparation of a fluorinated beta-sultone by reacting a fluorinated olefin with oleum.
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JP2001226373A |
To provide a new substituted 1,3-oxathiolane cyclic compound having pharmacological activity.This new compound is a cis-2-hydroxymethyl-5-(thymine-N-1'- yl)-1,3-oxathiolane compound in the form of a single enantiomer or an enantiomeric m...
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