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Matches 401 - 450 out of 1,390

Document Document Title
JP2018065866A
To provide novel high penetration compositions (HPCs) or high penetration prodrugs (HPPs) for treatment of Parkinson's disease.The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the bio...  
JP2018510845A
The field of this indication is in the active material of an organic image sensor. This indication is related with those use in squaraine, Thiophene system active material and a photoelectric conversion layer (plurality is good), and/or ...  
JPWO2016199789A1
In order to manufacture various functional trifluoromethyl compounds, let it be subjects a short process and to compound efficiently for a trifluoromethyl substitution semi Squares rate. The method of compounding a trifluoromethyl substi...  
JP2018043951A
To provide a method for producing berberine alkaloid that makes it possible to produce berberine alkaloid efficiently.A production method includes the step in which, by using trifluoromethanesulfonic acid anhydride and 2,6-di-tert-butyl-...  
JP2018505198A
The present invention is inside of a general formula (I) [type, and R.1R2R3R4R5And Ar provides the method of using the new molecular entity which has] which is as a statement on these specifications, the constituent in which the compound...  
JP2018504437A
The compound which has the structure of formula (I) (R1 is as this specification being defined) containing the stereoisomeric form, the salt permitted pharmacologically, and solvent Japanese food . Such a compound is inhibitor of small g...  
JP2018502159A
The present invention exhibited a series of BTK inhibitor. Specifically, the compound shown in formula (I), formula (II), formula (III), or formula (IV), its salt of its permitted pharmacologically, its tautomerism object, or its prodrug...  
JP2018501293A
The present invention provides Mangiferin *6*O* berberine salt and a manufacturing method for the same. The use which treats diabetes etc. by using the above-mentioned Mangiferin *6*O* berberine salt as an AMPK active agent is provided.  
JP2016196487A5  
JP2017105793A5  
JP6186438B2
The present invention relates to benzoimidazole-carboxylic acid amide compounds of the formula I, in which R′, R″, R′″, R1, R2, R3, R4, R5, R6 and Z are defined as indicated below. The compounds of the formula I are APJ receptor ...  
JP2017518987A
This indication provides the method for using the process for preparing an oxidized type bell bottle derivative and them, and the oxidized type bell bottle derivative. The bell bottle class of a heterocyclic compound relates to vegetable...  
JP6162133B2
Disclosed are derivatives of protoberberine biological alkaloids or physiologically acceptable salts thereof produced by means of a derivative reaction of a source material of biological alkaline quaternary ammonium salts of protoberberi...  
JP2017518627A
The present invention relates to a cyclic amine surface modification agent. The present invention relates to an organic electronic devide containing this cyclic amine surface modification agent again.  
JP2017105793A
To provide compounds for treating or preventing HIV infection.The present invention relates to substituted quinolizine derivatives represented by Formula (I), and pharmaceutically acceptable salts or prodrug thereof, and also relates to ...  
JP6126102B2
Pure S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-m ethyl-1-oxo-1H,-5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate and a process for its preparation is disclosed.  
JP2017504633A
The present invention is R.1R2R3R4R5And R6General formula (I) which is as being indicated in a There are books specificationThe method of using a compound in the medical treatment of the constituent and hepatitis B virus containing the n...  
JP2017501141A
The present invention relates to the new manufacturing method of benzoquinoline inhibitor of small granule vesicle monoamine transporter 2 (VMAT2), and these intermediates.  
JP2016538304A
The present invention provides prevention of the disease characterized on the unusual HIF activity or level like for example, inhibitor of a hypoxic induction factor (HIF), and tumor advance or prevention, and those use in the medical tr...  
JP2016196487A
To provide a novel benzoquinolone compound having a vesicle monoamine transporter 2 (VMAT2) inhibitory action, and capable of avoiding side effects accompanying oxidative metabolism observed in dihydrotetrabenazine which is an existing m...  
JP2016533396A
Bischler*Napieralski whose substitution bell bottle, preferably reduction of the present invention follow -- an intermediate used by composition of a process for composition of a substitution bell bottle compound by cyclization and a sub...  
JP2016531863A
The salt in which the present invention is permitted as Quinolizine derivative: by which formula (I) was replaced, and medicine of that, or a prodrug (X, Y, R)1R2R3R4R5R9And R10It is as a definition on The book specifications. It is rela...  
JP5970037B2
The compound or a salt thereof, wherein each position represented as D has deuterium enrichment of no less than 10%.  
JP5969004B2
A compound having the following general formula (I): wherein: X is a nitrogen atom and Y is a carbon atom; or X is a carbon atom and Y is a nitrogen atom; the Ar group is an aryl or heteroaryl group; and the RN and RN' groups, together w...  
JP2016516683A
It is a method for making the phosphine oxide reduction speed in a Wittig reaction increase preferably, and a method including use of an acid additive agent is provided. It is indicated that the reduction speed of room temperature cataly...  
JP2016516018A
One mode of the present invention provides the new high penetration constituent (HPC) or high penetration prodrug (HPP) for the medical treatment of Parkinson's disease. Since HPC/HPP may be changed into parent active medicine or a drug ...  
JP2016020338A
To provide conventionally unknown, novel compounds, discovered from natural products, the compounds having pharmacological activity such as diabetes modulator (e.g. α-glucosidase) inhibitory action, radical removal action and LDL oxidat...  
JP2016502545A
or [that this indication is useful as inhibitor of proteinkinase C (PKC), therefore the activity of PKC acts as intermediary] -- or it is related with a useful compound to treating the various diseases and obstacles which are maintained....  
JP2015532916A
The present invention is formula I. [Formula 1]a formula -- inside -- R -- ' -- R -- '', R''', and R1R2R3R4R5R6And Z is related with the benzimidazole * carboxylic amide of the compound defined as follows. A compound of formula I is an A...  
JP5799011B2
The present invention provides a mangiferin-berberine salt and manufacturing method thereof. Otherwise, the present invention also provides the use of mangiferin- berberine salt as AMPK activator.  
JP5778145B2
13-substituted 5,6-dihydrodibenzo[a,g]quinolizinium salt compounds of the general formula (I): processes for the preparation of said compounds, pharmaceutical compositions containing said compounds and the use of said compounds for the m...  
JP5770102B2
In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present inven...  
JP2015110563A
To provide a novel metomidate derivative compound having increased selectivity for CYP11B2 over CYP11B1.This invention provides a compound represented by a predetermined general formula or salt thereof.  
JP2015007124A
To provide new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.This invention provides a compound of a structural formula I or salt thereof, where R-...  
JP5652918B2
The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl subs...  
JP2014530883A
A protoberberine biological alkaloid derivative or its physiologically permissible salt is indicated. They are manufactured by the derivative-ized reaction of biological alkalinity quarternary ammonium salt of protoberberine alkaloid as ...  
JP5615261B2  
JP5616345B2
The compound or a salt thereof, wherein each position represented as D has deuterium enrichment of no less than 10%.  
JP5597835B2  
JP5551711B2
The present technology relates to compounds of Formulas (V) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis,...  
JP2014129347A
To provide a composition, a film containing the composition, and an electronic device containing the composition.The composition comprises a tetraphenylene ethylene having a structure of either of the examples 1 to 25, a tetraphenylene e...  
JP2014122246A
To provide a method of manufacturing a Magnoliidae compound.A Magnoliidae compound is produced by obtaining a part of Magnoliidae plant. The part of Magnoliidae plant is mixed with alcohol and water. The mixture of the part of Magnoliida...  
JP2014502963A
The present invention relates to photochromic fused naphthopyrans having a benzene ring which is adjacent to the pyran oxygen and is linked to the para substituent via both meta positions, and to the use thereof in plastics of all types,...  
JP5392622B2
This invention relates to a method of imaging vesicular monoamine transporters and to labeled compounds and pharmaceutical compositions thereof, and methods of making labeled compounds useful in imaging vesicular monoamine transporters. ...  
JP2011505363A5  
JP2011517312A5  
JP5359100B2
To provide a new oxime ester compound that can function as a highly sensitive radical polymerization initiator, and a curable composition using the same. The compound is represented by general formula (1) (wherein R1-R5are each a hydroge...  
JP5255183B2
The invention relates to crystalline S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-met hyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid L-arginine salt tetrahydrate, a process for its preparation and pharmaceutical form...  
JP2013520425A
The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof These compounds are useful in the treatment of RAGE-mediated diseases. The present invention further relates to met...  
JPWO2011078030A1
発色時の色調が中間色を示し、初期着色が小 さく、発色濃度が高く、退色速度が速く、良 好な耐久性を有する新規なフォトクロミック 化合物を提供する。フォトクロミック化...  

Matches 401 - 450 out of 1,390