Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 351 - 400 out of 406

Document Document Title
JP2006502238A
A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydrothieno[3,2-c]pyridine-5(4H) -acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compoun...  
JP2005336088A
To provide a new bioactive substance having activities for inhibiting MRSA and VRE.The thiazole-based compound is represented by formula A (wherein, R is a group represented by formula B or an amino group). The compound has the anti-MRSA...  
JP2005523275A
The present invention provides compounds of formula: wherein R a and R b together with the carbon to which they are attached form a group of formula: where each X 1 is independently selected from hydrogen or substituted or unsubstituted ...  
JP2005517227A
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or va...  
JP2005514387A
Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Als...  
JP2005509650A
Improved dosing schedules for ecteinascidin 743 are given for treatment of cancer.  
JP2005508898A
The invention relates to novel substituted, annelated indole and heteroindole derivatives of general formula (I), to tautomers, stereoisomers, mixtures and pharmaceutically acceptable salts thereof and to the production and use thereof a...  
JP2004526676A
This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.  
JP2003508535A
The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing t...  
JP2003012953A
To provide a method capable of efficiently preparing an azomethine colorant without the necessity for heat.This method for preparing an azomethine colorant comprises exposing an azomethine colorant precursor represented by general formul...  
JP2002544231A
ET743 is used in the preparation of a medicament for the treatment of the human body for cancer,  
JP2002544231A5  
JP2002520365A
Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.  
JP2002519376A
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions contai...  
JP2002519427A
The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions contai...  
JP2002517502A
The current invention relates to compounds of Formula Ipharmaceutical compositions and methods of use as nitric oxide synthase inhibitors, wherein the substituents are defined in the application.  
JP2002517502A5  
JP3226920B2
PCT No. PCT/FR92/00392 Sec. 371 Date Dec. 27, 1993 Sec. 102(e) Date Dec. 27, 1993 PCT Filed Apr. 30, 1992 PCT Pub. No. WO92/19613 PCT Pub. Date Nov. 12, 1992.The present invention relates to therapeutic compositions based on compounds ch...  
JP3098029B2
Ecteinascidins 722 and 736 (Et's 722 and 736) have been isolated from the Caribbean tunicate Ecteinascidia turbinata and their structures have been assigned as tetrahydro- beta -carboline-substituted bis(tetrahydro- isoquinolines) relate...  
JP2000007565A
To obtain an antibiotic exhibiting an excellent antitumor action against solid tumor and multiple medicine-resistant tumor and capable of being used for cancer chemotherapy by compounding a specific compound (salt) as an active ingredien...  
JP2950795B2
The invention is concerned with a new process for the preparation of compounds of formula wherein R<1> is trityl, acetyl, tetrahydropyranyl or cyclopentyl; R<2> is hydrogen, hydroxy, lower alkyl, cycloalkyl, lower alkoxy, lower alkenyl, ...  
JPH10508036A
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more brid...  
JPH09512549A
The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): (I) (II) wherein (1) R1, R2, R3, R9 and R10 form any of a variety of quinolone and related hete...  
JP2569455B2
PURPOSE: To efficiently obtain the subject derivative useful as a synthetic intermediate, etc., for antimicrobial agents according to simple operation by treating a specific azathiazabicycloalkane compound (salt) with a base in the prese...  
JP2562162B2
Novel compounds ecteinascidins 729, 743, 745, 759A, 759B, and 770 having antibacterial and antitumor properties.  
JPH08269058A
To obtain a piperidine derivative useful in the treatment and prevention of disorders involving 5-HT3, and 5-HT4 receptors, central nervous system disorders, dysgnosia, headache (including sick headache), digestive tract dysfunction, car...  
JP2531183B2
The compounds, having a 4,10-dioxo-3-oxa-7-thia-1-azatricyclo[6,2,0,0<2.6>]decane-2- carboxylic acid skeleton as the base structure, their esters and their salts, are useful antibacterial agents.  
JPH0780889B2  
JPH0629248B2
(A) Bicyclic cpds. of formula (I) and their salts are new; where n = 0 or 1; m = 0-3; X = CH2, O, S, SO, SO2, NH or 1-4C alkylimino; X1 = CH2, O, S, SO or SO2; Y+Y1 = O, or Y = H and Y1 = OH or in-vivo hydrolysable acyloxy; Z = CH2, CHMe...  
JPH0576480B2
NEW MATERIAL:A compound expressed by formula I (Y is =CH- or N; R is lower alkyl). EXAMPLE:7beta-[2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoace tami-do]-3 -(1-morpho lino[4,3-b]pyrazolio)methyl-3-cephem-4-car-boxy-late expressed by formu...  
JPH0565515B2
A herbicidal composition which comprises a carrier and, as active ingredient, a compound of the general formula I or where possible, an acid addition salt thereof: in which Y represents a sulphur, selenium or tellurium atom; R<1> and R<2...  
JPH0516428B2  
JPH0368582A
NEW MATERIAL: A compd. of formula I, (where R1 = a lower alkyl, an alkoxy, a halogen; n=0, 1 or 2; R2=H, a lower alkyl or an acyl; R3=H, a lower alkyl, an alkoxycarbonyl or optionally a substd. phenyl; A = a saturated heterocycle compose...  
JPH0321543B2  
JPH02218686A
NEW MATERIAL:A compound expressed by the formula (X is Cl or Br). USE: Anti-fungus agent or anti-tumor agent. PREPARATION: Microorganism [e.g. Trichoderma longibrachiatum) KAC-13125 (FERM BP-1824)] belonging to genus Trichodermae and hav...  
JPH02111772A
NEW MATERIAL: A compd. represented by formula I [wherein R, R1, and R2 are each H provided R and R1 may combine with each other to form a 5- to 6-membered satd. heterocycle and so may do R1 and R5; R3 is H or OH; R4 is C(R11)-XR12 (where...  
JPH0138119B2  
JPS6466120A
PURPOSE: To obtain an active oxygen production increase, containing a pentalene compound as an active ingredient, effective in breaking cancerous cells, etc., and having high safety. CONSTITUTION: An active oxygen production increase con...  
JPS62283960A
The invention relates to new di- and tetrahydroisoquinoline derivatives having interesting cytostatic properties, to the preparation of the said new compounds, and to compositions comprising such a compound as a cytostatically active sub...  
JPS6252754B2
A process for preparing 5-methyl- 1,2,4-triazolo[3,4-b]benzothiazole, effective in controlling rice blast, involves the reaction of 2-hydrazino- 4-methylbenzothiazole and excess formic acid and utilizes an aromatic hydrocarbon during wor...  
JPS6236388A
The invention provides a method of combating a microorganism which comprises allowing a heterocyclic pentalene derivative of general formula I wherein X represents an oxygen atom, a sulphur atom or an -SO- moiety; Y represents a sulphur,...  
JPS61277690A
NEW MATERIAL:A compound expressed by formula I (R1WR3 are H or acetyl). EXAMPLE: (S)-(-)-14-Hydroxy-15-aminomethyl-2, 8-dithia[9](2, 5)pyridinophaneS, S, S', S'-tetraoxide. USE: A synthetic reagent for optically active amino acids. PREPA...  
JPS6157317B2
The new antibiotic of the formula: wherein R represents the group-CONH2, designated 35665 RP, possesses growth-promoting properties when added to animal feed.  
JPS6111954B2
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...  
JPS60166627A
Process for the formation of carbon-containing free radicals R., which optionally include functional groups, wherein thermal and/or photochemical energy is supplied to a thiocarbonyl-containing ester corresponding to the general formula ...  
JPS6029716B2
1,4-Oxathiino[2,3-c]pyrrole derivatives of the formula: wherein A represents a phenyl, 2-pyridyl, 3-pyridazinyl, 2-quinolyl or naphthyridinyl radical, or a said radical substituted by one or two atoms or radicals selected from halogen, a...  
JPS5933595B2
PURPOSE:Spiropyrane compounds of formula I -(Z is S, NR<1>;R<1> is alkyl, aralkyl, aryl, acyl; Y is O, NR<2>;R<2> is alkyl, aralkyl, aryl, in the proviso that when Y is O, X is not acyl); for example, 1',3',4',-triphenylspiro [2H-benzopy...  
JPS5850669B2  
JPS588085A
Optically active trans-6-substituted-5(R)-2-penem-3-carboxylic acid derivatives of formula wherein R and R1 are each organic groups and R2 is hydrogen, a cation or a carboxy protecting group, are prepared by a multi-stage process of whic...  
JPS5653689A  

Matches 351 - 400 out of 406