Heterocyclic Compounds

Matches 901 - 950 out of 5,407	< 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 >

Document	Document Title
WO/1997/019953A2	NEW LH-RH ANTAGONISTS WITH IMPROVED EFFECTIVENESS New LH-RH antagonists are disclosed, in particular peptidomimetics and peptides modified in a side chain, their salts with pharmaceutically acceptable acids and a process for preparing these LH-RH antagonists and their salts. The disclos...
WO/1997/019943A1	SUBSTITUTED PIPERAZINE DERIVATIVES A compound of formula (I), or a salt or prodrug thereof, wherein L is selected from (A) wherein G represents oxygen or sulphur; M represents halogen or C1-6 alkyl; R1 represents aryl or heteroaryl, either of which groups may be optionall...
WO/1997/019926A1	QUINOLINE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS NEUROKININ 3 (NK-3)- AND NEUROKININ 2 (NK-2) RECEPTOR ANTAGONISTS. A compound of formula (I), or a salt thereof, or a solvate thereof, wherein, Ar is an optionally substituted aryl or a C5-7 cycloalkdienyl group, or an optionally substituted single or fused ring aromatic heterocyclic group; R is C1-6 al...
WO/1997/019073A1	PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES A class of substituted piperidine and tetrahydropyridine derivatives, linked through the 4-position thereof via an alkylene chain to a fused bicyclic heteroaromatic moiety such as indolyl, and further substituted at the 1-position by an ...
WO/1997/019074A1	SUBSTITUTED 4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES The present invention relates to novel substituted piperidine derivatives of formula (1), stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor ant...
WO/1997/018711A1	METHOD OF CONTROLLING UNDESIRED PLANT GROWTH IN RICE The invention concerns a method of controlling weeds in rice crops, the method being characterized in that one or more compounds of the formula (I), in which R1 is an acyl group selected from the series CO-R2, CS-R2, CO-OR3, CS-OR3, CO-S...
WO/1997/017850A1	HEMOREGULATORY COMPOUNDS Novel compounds of general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
WO/1997/018187A1	AZINOOXIMETHERS, PROCESSES AND INTERMEDIATE PRODUCTS FOR MANUFACTURING SAME, AND THE USES THEREOF IN COMBATING HARMFUL FUNGI AND PESTS Disclosed are azinooximethers of formula (I) in which X stands for NOCH3, CHOCH3, CHCH3, Y stands for O, NZ, Z being H or alkyl, R1 stands for H, alkyl, R2 stands for cyano, nitro, trifluoromethyl, halogen, alkyl, alkoxy, m is 0, 1 or 2,...
WO/1997/018203A1	PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES A class of N-substituted piperazine, piperidine and tetrahydropyridine derivatives, linked by a fluoro-substituted alkylene chain to a fused bicyclic heteroaromatic moiety such as indolyl, and further substituted at the 4-position by an ...
WO/1997/018207A2	NOVEL MACROCYCLIC COMPOUNDS AS METALLOPROTEASE INHIBITORS This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
WO/1997/017964A1	HEMOREGULATORY COMPOUNDS The present invention relates to novel compounds which have hemoregulatory activities and can be used to stimulate hematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
WO/1997/017966A1	HEMOREGULATORY COMPOUNDS Novel compounds of general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
WO/1997/018201A1	AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES A class of substituted azetidine, pyrrolidine and piperidine derivatives, linked by a fluoro-substituted alkylene chain to a fused bicyclic heteroaromatic moiety such as indolyl, are selective agonists of 5-HT1-like receptors, being pote...
WO/1997/017851A1	HEMOREGULATORY COMPOUNDS Novel compounds of general formula (I) which have hemoregulatory activities and can be used to stimulate haematopoiesis and for the treatment of viral, fungal and bacterial infectious diseases.
WO/1997/018202A1	SUBSTITUTED PIPERIDINE DERIVATIVES AS SELECTIVE AGONISTS OF 5-HT RECEPTORS A compound of formula (I), or a salt or prodrug thereof, wherein G is attached at position 3 or 4 of the piperidine ring and represents halogen or C1-6 alkoxy; R1 represents C3-6 alkenyl, C3-6 alkynyl, aryl(C1-6)alkyl or heteroaryl(C1-6)...
WO/1997/017338A1	SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYLPIPERAZINE DERIVATIVES A class of 1-[3-(1H-indol-3-yl)propyl]-4-benzylpiperazine derivatives, substituted at the 5-position of the indole nucleus by a 1,2,4-triazol-4-yl moiety, and on the methylene linkage of the benzyl moiety by a range of substituted alkyl ...
WO/1997/017337A1	SUBSTITUTED 1-INDOLYLPROPYL-4-BENZYL-TETRAHYDROPYRIDINE DERIVATIVES A class of 1-[3-(1H-indol-3-yl)propyl]-4-benzyl-1,2,5,6-tetrahydropyrid ine derivatives, substituted at the 5-position of the indole nucleus by a 1,2,4-triazol-4-yl moiety, and on the methylene linkage of the benzyl moiety by an alkyl, a...
WO/1997/017070A1	INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES Compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R1 is selected from: (a) hydrogen, (b) loweralkyl, (c) alkenyl, (d) alkoxy, (e) thioalkoxy, (f) halogen, (g) haloalkyl, (h) aryl-L2 - and (i) heterocyclic...
WO/1997/016419A1	METHODS OF PRODUCING AMINOPHENYLSULPHONYL CARBAMIDES AND INTERMEDIATE PRODUCTS FOR USE IN THE PROCESS The invention relates to the production of compounds of formula (I), in which A is H or acyl and R1, R2, R3, R, n, X, Y, Z have the definitions indicated in claim 1, by halogenation or rearrangement of compound (II) (optionally salt) to ...
WO/1997/016446A1	BICYCLIC HETEROARYL-ALKYLENE-(HOMO)PIPERAZINONES AND THIONE ANALOGUES THEREOF, THEIR PREPARATION AND THEIR USE AS SELECTIVE AGONISTS OF 5-HT1-LIKE RECEPTORS A class of piperazinones, homopiperazinones and their thione analogues of formula (I), or salt or prodrug thereof: wherein Z represents hydrogen, halogen, cyano, nitro, trifluoromethyl, -OR5, -OCOR5, -OCONR5R6, -OCH2CN, -OCH2CONR5R6, -SR...
WO/1997/016443A1	FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES The present invention is concerned with compounds of formula (I), the stereoisomeric forms thereof and the pharmaceutically acceptable acid or base addition salts thereof, wherein the dotted line represents an optional bond; X is oxygen ...
WO/1997/016413A1	ARYL ACRYLICS FOR USE AS FUNGICIDE Novel compounds of Formula (I) and methods of making and using the compounds which are useful as fungicides, particularly in the agricultural field, wherein C1 anc C2 are carbon atoms which are part of an aromatic ring; W is alkoxyimino,...
WO/1997/016445A1	AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES A class of azetidine, pyrrolidine and piperidine derivatives, substituted by inter alia a phenylmorpholinyl, phenylpiperidinyl or benzimidazolone moiety, are selective agonists of 5-HT1-like receptors, being potent agonists of the human ...
WO/1997/016412A1	PHENYLACETIC ACID DERIVATIVES, PROCESS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION, AND THEIR USE AS FUNGICIDES AND PESTICIDES The invention concerns phenylacetic acid derivatives of formula (I), in which the variables have the following meanings: X = NOCH3, CHOCH3 or CHCH3; Y = O or NZ, Z standing for hydrogen or alkyl; R1 = H or alkyl; R2 = cyano, nitro, trifl...
WO/1997/015555A2	IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS The invention relates to the compounds of the formula (I), and to the preparation and use thereof in drugs.
WO/1997/014671A1	CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS The present invention is directed to certain novel compounds represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R3, R6, R7, R8, R11, R12, R13, A, Q, W, X, Y, Z and n are defined herein. The inven...
WO/1997/014417A1	FIBRINOGEN RECEPTOR ANTAGONISTS Fibrinogen receptor antagonists having structure, for example, of (I) or for example (II).
WO/1997/014681A1	HETEROCYCLIC COMPOUNDS AS H+-ATPASES This invention relates to a compound of formula (I), wherein R1 is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), A is -CONH- or -NHCO-, n is an integer of 0 or 1, and (II) is a group of form...
WO/1997/013747A1	OXYAMINO OXIME ETHERS, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, AND AGENTS CONTAINING THEM AND USED FOR CONTROLLING HARMFUL FUNGI AND PESTS The disclosure concerns oxyamino oxime ethers of formula (I), wherein: X is NOCH3, CHOCH3, CHCH3; Y is O or NZ, Z being H or alkyl; R1 is H or alkyl; R2 is cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy, m = 0, 1 or 2 and the gr...
WO/1997/013749A2	NOVEL CINNAMAMIDES AND THEIR USE AS STABILIZERS The invention relates to novel cinnamamides, a process for their manufacture and their use as UV absorbers. The cinnamamides of the invention may be used as UV absorbers in a variety of engineered resins such as polyamides (especially ny...
WO/1997/012873A1	PROCESS TO PREPARE 1-ARYL-2-(1-IMIDAZOLYL)ALKYL ETHERS AND THIOETHERS A novel process is disclosed for the preparation of imidazole derivatives, in particular, 1-aryl-2-(1-imidazolyl)alkyl ethers and thioethers, and more particular for the preparation of tioconazole. The preferred process involves alpha br...
WO/1997/011695A1	SUBSTITUTED INDOLYLPROPYL-PIPERAZINE DERIVATIVES AS 5-HT1DALPHA AGONISTS A class of 1-[3-(1H-indol-3-yl)propyl]-4-(2-phenylethyl)piperazine derivatives, substituted at the 5-position of the indole nucleus by a five-membered heteroaromatic moiety, on one or other of the ethylene carbon atoms of the phenethyl m...
WO/1997/011065A1	PHENYLACETIC ACIDS, PROCESSES FOR THEIR PREPARATION AND AGENTS CONTAINING THEM The invention concerns phenylacetic acids of formula (I) in which the substituents and the index have the following meanings: X is NOCH3, CHOCH3, CHCH3 and CHCH2CH3; Y = O and NR (R = hydrogen and alkyl); Z is an optionally substituted n...
WO/1997/011069A1	HETEROCYCLIC COMPOUNDS AS BRADYKININ ANTAGONISTS This invention relates to a compound of formula (I) wherein A1 is lower alkylene, R1 is substituted quinolyl, etc., R2 is hydrogen, halogen or lower alkyl, R3 is halogen or lower alkyl, and R4 is a group of the formula: -Q-A2-R5, etc., i...
WO/1997/011079A1	NOVEL IMIDAZOLE LIPOXYGENASE INHIBITORS The present invention provides a compound of formula (I) and a pharmaceutically acceptable salt thereof, wherein Ar is phenylene optionally substituted with halo, hydroxy, cyano, amino, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 h...
WO/1997/010219A1	BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES The present invention relates to a new heterocyclic compound of formula (I), wherein R1 is acyl, lower alkenyl or lower alkyl optionally substituted with aryl, a heterocyclic group, etc., R2 is hydrogen, lower alkyl, hydroxy(lower)alkyl,...
WO/1997/010224A1	BENZOXAZEPINE COMPOUNDS, THEIR PRODUCTION AND USE AS LIPID LOWERING AGENTS This invention provides new benzoxazepine compounds represented by formula (I), wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionall...
WO/1997/009311A1	NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY New piperidine derivatives have the general formula (I), in which R1, R2, R3, R4, Q, X, W, Z, m and n have the meanings given in the description, are renin inhibitors and may be used for example to treat high blood pressure, heart and ki...
WO/1997/007114A1	1-(PYRIDYL)-PYRAZOLS AND THEIR USE AS HERBICIDES The invention concerns substituted 1-(pyridyl)-pyrazols of general formula (I) in which the substituents have the following meanings: R1: hydrogen, C1-C3 alkyl, halogen, C1-C3 alkyl halide; R2: C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkinyl, ...
WO/1997/007116A1	PROLYLENDOPEPTIDASE INHIBITORS The present invention relates to new prolylendopeptidase inhibitors of general formula (I).
WO/1997/006159A1	SUBSTITUTED 1-INDOLYLPROPYL-4-PHENETHYLPIPERAZINE DERIVATIVES A class of 1-[3-(1H-indol-3-yl)propyl]-4-(2-phenylethyl)piperazine derivatives, substituted at the 5-position of the indole nucleus by a five-membered heteroaromatic moiety, and on the phenyl ring of the phenethyl moiety by fluoro, chlor...
WO/1997/005131A1	NEW CARBOXAMIDES WITH ANTIFUNGAL ACTIVITY Compounds of general formula (I) and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these compounds and processes for their prepa...
WO/1997/005130A1	NEW PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY Compounds of general formula (I) and their salts and solvates are antifungal agents and as such are useful in the treatment of various fungal infections. Pharmaceutical compositions including these compounds and processes for their prepa...
WO/1997/005121A1	METHOD OF PREPARARING SULPHONYL UREAS WITH HERBICIDAL PROPERTIES AND N-PYRIMIDINYL OR N-TRIAZINYL CARBAMATES AS INTERMEDIATES IN THE REACTION The invention concerns a method of preparing a carbamate of formula (IV) Ar-O-CO-NR-B by reacting a salt of formula (II-S) with a diaryl carbonate of formula (III) (ArO)2CO, Ar, B and R being as defined in claim (1). The carbamate can be...
WO/1997/005182A1	ANTI-MICROBIAL COATING COMPOSITIONS A water-erodible organic polymer bearing anionic salt groups, at least a proportion of which has as counter ions a biologically active heterocyclic cation having a delocalised positive charge. The heterocyclic cation is preferably a bis-...
WO/1997/003964A1	INDOLE DERIVATIVES Indole derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R1 and R2 are the same or different and each represents hydrogen, lower alkyl, -(CH2)n-OR6 or (a); R3 represents hydrogen, lower...
WO/1997/003971A1	PROCESS FOR THE MANUFACTURE OF BIS-TRIAZOLE COMPOUNDS AND INTERMEDIATES USEFUL IN THE MANUFACTURE THEREOF HAVING ANTIFUNGAL ACTIVITY A process to prepare a compound of formula (I) wherein Y and Z can be identical or different and represent a halogene. The bis-triazole compounds of formula (I) and intermediates have antifungal activity.
WO/1997/002821A2	ANTIFUNGAL AGENT, COMPOUND THEREFOR, PROCESS FOR PRODUCING THE SAME R-(+)-(E)-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1-imi dazolylacetonitrile, R-(-)-(E)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1 -imidazolylacetonitrile, and pharmaceutically acceptable salts thereof which can be used as a ...
WO/1997/003070A1	NOVEL BENZIMIDAZOLE DERIVATIVES HAVING CGMP-PHOSPHODISTERASE INHIBITING ACTIVITY The present invention provides novel benzimidazole derivatives or salts thereof represented by general formula (1), wherein R1 is a hydrogen atom or a halogen atom; R2 is a phenyl-lower alkyl group; R3 is a heterocyclic group selected fr...
WO/1997/003068A1	A TRIAZOLYLMETHYL-INDOLE ETHYLAMINE BISULFATE SALT The bisulfate salt of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]e thylamine is a selective agonist of 5-HT1-like receptors and is useful in the treatment of migraine and associated disorders.

Matches 901 - 950 out of 5,407	< 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 >