Heterocyclic Compounds

Matches 1,051 - 1,100 out of 5,407	< 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 >

Document	Document Title
WO/1996/005176A1	FUSED PYRIDAZINE COMPOUND A fused pyridazine compound represented by general formula (I) and having the inhibitory effect against cyclic GMP-phosphodiesterase (cGMP-PDE), and a pharmacologically acceptable salt thereof. These compounds are useful as preventives a...
WO/1996/004256A1	PROCESS FOR PREPARING AN ANTIFUNGAL AZOLE WITH HYDRAZINO AND AMIDRAZONE INTERMEDIATES A process for preparing an antifungal azole compound of formula (I) by reacting an epoxide with hydrazine to form a hydrazino compound which is subsequently reacted with an iminoether. The amidrazone product is subsequently reacted with ...
WO/1996/004278A1	OXAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE An oxazole derivative represented by general formula (I) and a salt thereof, excellent in herbicidal activity, and useful as a herbicide, wherein A represents a nitrogen atom or an R3-substituted carbon atom; B represents a nitrogen atom...
WO/1996/004274A1	AZETIDINE, PYRROLIDINE AND PIPERIDINE DERIVATIVES A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D'alpha' receptor subtype whilst possessing at least a 10-fold selective aff...
WO/1996/004242A1	ARYLTHIO COMPOUNDS AS ANTIBACTERIAL AND ANTIVIRAL AGENTS Arylthiol and dithiobisarylamide antibacterial and antiviral agents have general formula (I) where A is monocyclic or bicyclic aryl which can contain up to 3 heteroatoms selected from O, S, and N, R1 and R2 are substituent groups, X is (...
WO/1996/004287A1	TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS Compounds of general formula (I) for drugs having therapeutic use in the treatment of anxiety, psychosis, epilepsy, convulsion, motor control disorders, amnesia, cerebrovascular diseases and senile dementia.
WO/1996/004269A1	INDOLINE AND AZAINDOLINE DERIVATIVES AS 5-HT1D ALPHA RECEPTOR AGONISTS Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyraz...
WO/1996/004257A1	CRYSTALLINE FORM OF AN ANTIFUNGAL AZOLE A crystalline form of the antifungal agent (+)-2-(2,4-difluorophenyl)-1-[3-[(E)-4-(2,2,3,3-tetrafluorop ropoxy)-styryl]-1H-1,2,4-triazol-1-yl]-3- (1H-1,2,4-triazol-1-yl)propan-2-ol (code D0870) is described. Furthermore processes for the...
WO/1996/004231A1	NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC A novel amine derivative represented by general formula (I) and a salt thereof, each being useful as an antiarrhythmic, wherein, for example, A represents -(CH2)-O-, -(CH2)2-O- or -(CH2)2-NH-; B represents -(CH2)2-; R1 represents hydroge...
WO/1996/003389A1	AZOLYLMETHYL-SUBSTITUTED CYCLOALKANOLS AS MICROBICIDES The invention concerns novel azolylmethylcycloalkanol derivatives, their preparation and their use for protecting technical materials and plants against microbial infection.
WO/1996/003390A1	AZOLYLMETHYLCYCLOPENTANOL DERIVATIVES AS MICROBICIDES The invention concerns novel azolylmethylcyclopentanol derivatives, their preparation and use for protecting technical materials and plants against microbial infection.
WO/1996/002532A1	7-SUBSTITUTED 1-[4-(1H-1,2,4-TRIAZOL-1-YL-METHYL)PHENYL] SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS AS ANTIVIRAL AGENTS The present invention concerns 7-substituted 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituted quinolone carboxylic acids of general formula (I), in which the substituents have the meanings given in the description. The invention fu...
WO/1996/002539A1	SUBSTITUTED TRIAZOLYL METHYL PHENYL NAPHTHYRIDONES Novel substituted triazolyl methyl phenyl naphthyridones of general formula (I) in which A is hydrogen or methyl, R1 is phenyl, naphthyl, pyridyl, pyrimidyl or pyrazinyl, which may be substituted triply identically or differently by nitr...
WO/1996/002505A1	THIOPYRIDYL COMPOUNDS FOR CONTROLLING HELICOBACTER BACTERIA Compounds having the formula (I), in which the substituents and symbols have the meanings given in the description, are useful for controlling helicobacter bacteria.
WO/1996/002533A1	NOVEL 6- AND 6,8-SUBSTITUTED 1-[4-(1H-1,2,4-TRIAZOL-1-YL METHYL) PHENYL] QUINOLONE CARBOXYLIC ACIDS The invention pertains to 6- and 6,8-substituted 1-[4-(1H-1,2,4-triazol-1-yl methyl) phenyl] quinolone carboxylic acids of general formula (I), in which A is hydrogen or methyl, R1 is phenyl, naphthyl, pyridyl, pyrimidyl or pyrazinyl, op...
WO/1996/002664A1	PROCESS FOR PRODUCING OPTICALLY ACTIVE TRIAZOLE COMPOUND AND METHOD OF RACEMIZING OPTICALLY ACTIVE TRIAZOLE COMPOUND A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis.
WO/1996/002498A1	PRODUCTION OF CARBAMIC ACID VINYL ESTERS Carbamic acid vinyl ester compounds are produced by the reaction of corresponding secondary amines with carbon dioxides and acetylenically unsaturated compounds in the presence of a compound of a metal of the platinum group, especially a...
WO/1996/002508A1	CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS The present invention provides novel cyclic amide derivatives having activity for protecting against the ultraviolet rays, activity for scavenging active oxygen species and activity for inhibiting the formation of lipid peroxides, which ...
WO/1996/002564A1	PROCESS FOR THE PREPARATION OF COMPOUNDS HAVING ACE INHIBITORY ACTION AS WELL AS NOVEL COMPOUNDS USEFUL AS STARTING MATERIALS OR INTERMEDIATES IN SAID PROCESS There is disclosed a process for the preparation of compounds having ACE inhibitory action of formula (1) wherein R has the meanings as in claim 1, wherein the stereospecific amino acid N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine i...
WO/1996/002511A1	NOVEL N1 DIVERSE 6-FLUORINE-8-DIFLUOROMETHOXY SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS N1 diverse 6-fluorine-8-difluoromethoxy substituted quinolone carboxylic acids of the general formula (I) in which A is hydrogen or methyl, R1 is phenyl, pyridyl, pyrimidyl or pyrazinyl, which may be substituted up to triply, equally or ...
WO/1996/002499A1	DIFLUOROSTATONE ANTIVIRAL AGENTS The present invention provides novel difluorostatone derivatives of general formula (I), which are useful as antiviral agents. More specifically, these novel compounds are useful as inhibitors of retroviral proteases required for replica...
WO/1996/002003A1	N-TERMINAL PROTEIN SEQUENCING REAGENTS AND METHODS WHICH FORM AMINO ACID DERIVATIVES Novel alkoxythiocarbonylimidazoles provide new reagents for the N-terminal sequencing of small polypeptides samples. These reagents form an alkoxy thiourea derivative which is cleaved with acid to remove the N-terminal amino acid as a st...
WO/1996/001817A1	BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE There are provided compounds of formula (I), wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alky...
WO/1996/001823A1	PROCESS FOR THE PREPARATION OF CHIRAL INTERMEDIATES USEFUL FOR THE SYNTHESIS OF ANTIFUNGAL AGENTS Described is a process for preparing chiral compounds of formula (II), wherein X1 and X2 are independently F or Cl, and Y is Cl, Br or I, comprising reacting a triol of formula (VIII), wherein X1 and X2 are as defined above, with acetone...
WO/1996/001814A1	HERBICIDAL 1,2,4,6-THIATRIAZINES Compounds of formula (I), in which R1 is a substituent bonded via a carbon atom, R4 is a substituent, R2 and R3 are hydrogen or substituents and X is O, S, SO or SO2, are suitable as herbicides.
WO/1996/000738A1	ENDOTHELIN ANTAGONISTS II Novel antagonists of endothelin containing an N-terminal fragment (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute an...
WO/1996/000214A1	ARYLSULFONAMIDO-SUBSTITUTED HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS Compounds of formula (I) wherein R, R1, R2 and Ar are as defined in the specification, have valuable pharmaceutical properties and are effective especially as matrix metalloproteinase inhibitors, for example for the treatment of arthriti...
WO/1996/000219A1	PYRIMIDINYL- AND TRIAZINYL-OXY AND THIO-3-HALOALKYL-PROPIONIC ACID DERIVATIVES AS HERBICIDES Compounds of formula (I), wherein R1 is C1-C7 haloalkyl; X is oxygen or sulfur; and salts of compounds of formula (I) that contain a carboxy or sulfonamide group, and stereoisomers of the compounds of formula (I), are suitable as active ...
WO/1996/000378A1	PHOTOLABILE COMPOUNDS AND METHODS FOR THEIR USE Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporatinf these linking groups and methods for their use are also described.
WO/1996/000223A1	PROCESSES FOR PRODUCTION OF QUINOLINE OR QUINAZOLINE DERIVATIVES AND INTERMEDIATES THEREFOR A process for producing a compound of formula (2) of value as anti-inflammatory agents, which comprises reacting a compound of formula (3) or a salt thereof with 4-amino-1,2,4-triazole to give a compound of formula (1) or a salt thereof ...
WO/1995/035308A1	INHIBITORS OF INTERLEUKIN-1'beta' CONVERTING ENZYME The present invention relates to novel classes of compounds which are inhibitors of interleukin-1'beta' converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This i...
WO/1995/035275A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (II) wherein X is a hydroxamic or carboxylic acid group, Y is carbonyl or sulphonyl and R1 and R2 are as defined in the claims, are matrix metalloproteinase inhibitors.
WO/1995/035276A1	METALLOPROTEINASE INHIBITORS Compounds of general formula (II), wherein X is a hydroxamic or carboxylic acid group, Y is sulphonyl and R1 and R2 as defined in the claims are matrix metalloproteinase inhibitors.
WO/1995/035281A1	TRI-SUBSTITUTED PHENYL DERIVATES USEFUL AS PDE IV INHIBITORS Compounds of general formula (1) are described, wherein = W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XRa group where X is -O-, -S(O)m- [where m is zero or an integer of value 1 or 2], or -N(Rb)- [where Rb is a hydrogen a...
WO/1995/035286A1	NEW HIV PROTEASE INHIBITORS Oligopeptide analogs containing sulfonamide, urea or carbamate linkages in the backbone are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AID...
WO/1995/035283A1	TRI-SUBSTITUTED PHENYL DERIVATIVES USEFUL AS PDE IV INHIBITORS Compounds of general formula (1) are described, formula wherein =W- is (1) =C(Y)- where Y is a halogen atom, or an alkyl or -XRa group where X is -O-, -S(O)m- [where m is zero or an integer of value 1 or 2], or -N(Rb)- [where Rb is a hyd...
WO/1995/034526A1	METHOD OF PREPARING 'alpha'-METHOXYIMINOCARBOXYLIC ACID METHYLAMIDES, AND INTERMEDIATES USED IN THE METHOD The invention concerns a method of preparing 'alpha'-methoxyiminocarboxylic acid methylamides of formula (I) (X = nitro, trifluoromethyl, halogen, alkyl or alkoxy; n = 0, 1, 2, 3 or 4; Y = an organic carbon group) by the Pinner reaction ...
WO/1995/034542A1	TRIAZOLE COMPOUND AND ANTIFUNGAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT A triazole compound represented by general formula (I) or a physiologically acceptable salt or hydrate thereof, and an antifungal agent containing the same as the active ingredient, wherein R1 represents hydrogen or methyl; R2 represents...
WO/1995/034540A1	BENZOHETEROCYCLIC DERIVATIVES USEFUL AS VASOPRESSIN OR OXYTOCIN MODULATORS A benzoheterocyclic derivative of formula (1) and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopress...
WO/1995/034311A1	PIPERAZINE COMPOUNDS PROMOTE RELEASE OF GROWTH HORMONE Novel piperazine compounds promote the release of growth hormone in humans and animals. This property may be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, t...
WO/1995/034547A1	C-4 AMIDE SUBSTITUTED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS The invention provides certain 5 and/or 8 substituted benzopyran, pyranopyridine or tetrahydroquinaline compounds having a C-4 amide substituent and processes for making them. The compounds described are useful in treating and/or prevent...
WO/1995/033710A1	CARBAMOYL CARBOXYLIC ACID HYDRAZIDES AND THEIR USE AGAINST FUNGI Disclosed are carbamoyl carboxylic acid hydrazides (I) and their salts, wherein: R1 is optionally substitued alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, aryl or heteroaryl or an optionally substituted non-aromatic carbo- or hetero...
WO/1995/032710A1	COMPOUNDS FOR INHIBITING OSTEOCLAST-MEDIATED BONE RESORPTION Compounds of the following general structure: X-Y-Z-Aryl-A-B, for example (I), which inhibit osteoclast-mediated bone resorption.
WO/1995/032950A1	FORMYLAMINOPHENYLSULPHONYL UREAS, METHODS OF PREPARING THEM AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS The invention concerns compounds of formula (I) in which R1 is H, a substituted or unsubstituted hydrocarbon group or a substituted or unsubstituted heterocyclic group; R2 is H, C1-C6 alkyl or C1-C6 alkoxy; R3 is halogen, C1-C6 alkyl, C1...
WO/1995/032951A1	PHENYLSULFONYL UREAS WITH NITROGEN SUBSTITUENTS, METHOD FOR THEIR PREPARATION AND USE AS HERBICIDES AND PLANT GROWTH REGULATORS Salts of formula (I), wherein n is 0, 1, 2 or 3; R is a halogen, alkyl or alkoxy, independently of one another when n is greater than 1; R1 is a substituted or unsubstituted hydrocarbon radical or a substituted or unsubstituted heterocyc...
WO/1995/032944A1	SUCCINYL HYDROXAMIC ACID, N-FORMYL-N-HYDROXY AMINO CARBOXYLIC ACID AND SUCCINIC ACID AMIDE DERIVATIVES AS METALLOPROTEASE INHIBITORS Compounds of general formula (I) wherein X is a -CO2H, -N(OH)CHO or -CONHOH group; R1 is hydrogen; (C1-C6)alkyl; (C2-C6)alkenyl; phenyl; substituted phenyl; phenyl(C1-C6)alkyl; substituted phenyl(C1-C6)alkyl; heterocyclyl; substituted he...
WO/1995/032197A1	PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE A new process is described for the synthesis of the triazolyl tryptamine ('alpha') and related compounds. The process involves a palladium-catalyzed ring closure between a substituted ortho-iodoaniline and a protected 1-alkynol. The proc...
WO/1995/032452A1	NOVEL DIHYDRAZIDES AS DOT-PROMOTING AGENTS IN PHOTOGRAPHIC IMAGE SYSTEMS The subject invention relates to novel dihydrazide compounds of the general formula: B-(A+)-C (G-) where B and C are the same or different and have general structure (I). A+ is an activity regulating group, and G- is a negatively charged...
WO/1995/032185A1	N-(3-AMINO-2-HYDROXYBUTYL)SULPHONAMIDE DERIVATIVES AS HIV PROTEASE INHIBITORS HIV protease inhibitors of formula (1), in which Q1 to Q8, E, and Y are as defined in Claim 1, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV viru...
WO/1995/032196A1	PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES OF INDOL-3-YLALKYL AS 5-HT1D-ALPHA AGONISTS Compounds of formula (I), or a salt or prodrug thereof, wherein Z represents an optionally substituted five-membered heteroaromatic ring selected from furan, thiophene, pyrrole, oxazole, thiazole, isoxazole, isothiazole, imidazole, pyraz...

Matches 1,051 - 1,100 out of 5,407	< 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 >