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WO/1997/001552A1 |
An antifungal agent of formula (I) or a pharmaceutically acceptable salt thereof, where Ar is a phenyl group substituted by 1 to 3 substituents each independently selected from halo and CF3; and X is a group of formula (a), (b), (c), or ...
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WO/1997/000849A1 |
Vinyl sulfides bearing protected arlyoxy substituents and a process for their preparation are provided. In the process a vinyl sulfide is formed by coupling a ketone compound and a thioester compound with a low valent titanium reagent to...
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WO/1997/000853A1 |
Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic m...
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WO/1997/000252A1 |
Compounds of formula (I) wherein X is N or C-R9, Y is N-R10, CH2, O, S, SO, SO2, C=O or CH-OH, R is H or alkyl, R1 is heteroaryl, n is 1-5, and R2-R10 are H or various substituents, are useful as inhibitors of protein farnesyltransferase...
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WO/1997/000247A1 |
Compounds have the formula (I), in which R1 stands for S(O)nR4, SO2NR5R6 or CONR5R6; A stands for a residue having the formula A1 or, should R1 stand for S(O)nR4 or SO2NR5R6, may also stand for a residue having the formula A2 R7R8C=N-NR9...
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WO/1997/000255A1 |
A compound represented by a formula selected from the group consisting of (Ia) and (Ib), wherein X is independently selected from the group consisting of F and Cl; A is CH or N; R1 is a straight or branched chain (C3 to C8) alkyl group s...
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WO/1997/000248A1 |
A compound represented by formula (I), wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydrox...
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WO/1996/040626A1 |
a water-containing composition containing a linear aminoplast-ether copolymer of formula (I), where the divalent R01 contains a divalent alkyleneoxy containing moiety; Amp is the skeletal residue of an aminoplast, R is hydrogen, alkyl co...
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WO/1996/040625A1 |
A coating composition containing a linear aminoplast-ether copolymer of formula (I), where the divalent R01 contains a divalent alkyleneoxy containing moiety, Amp is the skeletal residue of an aminoplast, R is hydrogen, alkyl containing ...
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WO/1996/040101A1 |
The invention relates to the use of compounds of formula (I) wherein Ar, R, R1 and R2 are as defined in the specification, (for the manufacture of a medicament) for the treatment of a tumor selected from human breast carcinoma, lung carc...
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WO/1996/039382A1 |
A compound of formula (I) wherein R1 is cyano, thiocarbamoyl, a group of formula (a) in which R4 is hydrogen, lower alkyl which may have optionally substituted aryl, acyl, optionally substituted aryl, lower alkylthio or 1-lower alkylindo...
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WO/1996/039394A1 |
Disclosed are novel mercapto-bis-triazoles of formula (I) in which R1 stands for alkyl with 1-6 carbon atoms, alkyl halide with 1-6 carbon atoms and 1-5 halogen atoms, cycloalkyl with 3-6 carbon atoms and optionally substituted with halo...
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WO/1996/038443A1 |
A compound represented by formula (I), wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C4 to C5) alkyl group substituted by one or two amino ...
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WO/1996/037467A1 |
The invention encompasses the novel compound of Formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated dise...
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WO/1996/037480A1 |
Compounds of general formula (I) in which R is cyano, halogen, alkyl or alkoxy; n is 0, 1 or 2, in which the components R may be different if n is 2; Het is a 5-membered heteroaromatic substance containing three nitrogen atoms or two nit...
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WO/1996/037204A1 |
The present invention comprises peptidomimetic compounds which comprises a suitably substituted aminoalkylbenzene and analine analogs, further substituted with a second phenyl ring attached via a bond, a heteroatom linker or an aliphatic...
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WO/1996/037479A1 |
Compounds of formula (I), wherein X is -O- or -CH2-; R1 is lower-alkyl or lower-alkoxy which may be substituted with 1 to 4 fluorine atom(s); R2 is a hydrogen atom or lower-alkyl; R3 is methyl or -(CH2)2R4 in which R4 is hydroxy, amino, ...
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WO/1996/036634A1 |
Disclosed are novel oxiranyl-hydroxyethyl triazoles of formula (I) in which: X stands for hydrogen, halogen, alkyl with 1-4 carbon atoms or alkoxy with 1-4 carbon atoms; Z stands for halogen, alkyl with 1-4 carbon atoms, halogen alkyl wi...
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WO/1996/036228A1 |
Compounds of structure (I), the corresponding N-oxides and agriculturally acceptable salts, are disclosed as effective insecticides. In said formula, U is -(CH2)n-; Q is hydroxy; R is formula (II), in which V, W, Y, and Z are each hydrog...
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WO/1996/036634A2 |
Disclosed are novel oxiranyl-hydroxyethyl triazoles of formula (I) in which: X stands for hydrogen, halogen, alkyl with 1-4 carbon atoms or alkoxy with 1-4 carbon atoms; Z stands for halogen, alkyl with 1-4 carbon atoms, halogen alkyl wi...
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WO/1996/036619A1 |
An aminothiazole derivative represented by general formula (I), wherein R1, R2 and R3 represent each hydrogen, hydroxy, lower alkyl, lower alkoxy, etc.; R4 represents hydrogen or lower alkyl; R5 represents hydrogen, halogeno or lower alk...
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WO/1996/036635A1 |
Disclosed are novel oxiranyl-triazoles of formula (I) in which: X stands for hydrogen, halogen, alkyl with 1-4 carbon atoms or alkoxy with 1-4 carbon atoms; Z stands for halogen, alkyl with 1-4 carbon atoms, alkyl halide with 1-4 carbon ...
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WO/1996/036617A1 |
A class of substituted oxazoles is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (I), wherein R is selected from hydrido, halo, mercapto, hydroxyl, ...
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WO/1996/033194A1 |
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof, wherein R3 is (II), wherein A, B and D each is CH, or one or two of A, B and D is N and the others a...
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WO/1996/033184A1 |
The present invention relates to a class of THF-containing sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compo...
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WO/1996/033192A1 |
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is formula (II), wherein A, B and D each is CH, or one or two of A, B and D is N and the o...
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WO/1996/033178A1 |
A process for preparing triazolone compounds of formula (i) comprises heating a mixture of a compound of formula (ii) and a hydrazine derivative of the formula R5-NH-NH-CHO, R5-NH-NH-C(O)OC(CH3)3 or R5-NH-NH-C(O)OCH2C6H5, optionally in t...
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WO/1996/033191A1 |
The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is (II) wherein A, B, and D each is CH, or one or two of A, B and D is N and the others ar...
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WO/1996/033193A1 |
The present invention concerns novel compounds of formula (I), wherein R1 is C1-10alkyl, C3-7cycloalkyl or C1-6alkyl substituted with C3-7cycloalkyl; R2 is hydrogen or C1-6alkyl; Alk represents C1-3alkanediyl; -A- represents a bivalent r...
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WO/1996/033175A1 |
The current invention discloses amidino derivatives of formula (I) useful as nitric oxide synthase inhibitors wherein R1 is selected from the group consisting of cycloalkyl, heterocyclyl and aryl, which may optionally be substituted; L i...
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WO/1996/032384A1 |
Novel 4,6-diarylpyrimidine derivatives represented by general formula (1), salts thereof, a process for producing the same, and a drug comprising the same as the active ingredient, wherein R represents a heterocycle or amino optionally s...
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WO/1996/031491A1 |
A compound having general formula (I) wherein Ar1 represents optionally substituted phenyl; Ar2 represents optionally substituted phenyl or optionally substituted heterocycle; R0 represents hydrogen or lower alkyl; R1 represents lower al...
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WO/1996/031490A1 |
Compounds of formula (II), wherein R1 is chlorine, fluorine or trifluoromethyl; R2 is hydrogen, chlorine, fluorine or trifluoromethyl; Z is CH or N; R3, R4 and R5, the same or different are hydrogen or C1-C4 alkyl, provided that R4 is di...
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WO/1996/030347A1 |
The invention relates to certain 4-(substitutedphenylamino)quinazoline derivatives of formula (I), their produgs and pharmaceutically acceptable salts wherein R1, R2, R3, R4, m and n are described in said formula. The compounds of formul...
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WO/1996/029871A2 |
A method for using a compound represented by general formula (I) (wherein R1 and R2 are the substituents, respectively, defined in the specification) for agricultural and horticultural disease control, and a composition used in said method.
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WO/1996/030341A1 |
The invention provides novel sulphonylurea, sulphonylthiourea and sulphonylguanidine compounds which have the ability to block potassium ion channels regulated by intracellular concentrations of ATP. Methods of synthesis, pharmaceutical ...
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WO/1996/030377A1 |
Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring sytem. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridg...
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WO/1996/030363A1 |
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the...
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WO/1996/030350A1 |
A compound of formula (I), wherein R1 is heterocyclic group, X is (CH2)a in which a is 0 or 1, O or S, Y is CH2, O, S or N-R2 in which R2 is hydrogen or lower alkyl, Z is O or H2, and m and n are each 0 or 1, and pharmaceutically accepta...
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WO/1996/030346A1 |
Uracil derivatives represented by general formula (1) or salts thereof, wherein R1 represents chloro, bromo, iodo, cyano or lower alkyl; and R2 represents a 4- to 8-membered heterocycle optionally substituted by lower alkyl, imino, hydro...
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WO/1996/030014A1 |
The present invention comprises peptidomimetic compounds which comprise a suitably aniline and aminoalkylbenzene moieties. The instant compounds inhibit the farnesyl-protein transferase enzyme and the farnesylation of certain proteins. T...
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WO/1996/030015A1 |
The present invention comprises peptidomimetic compounds which comprise a suitably substituted aminoalkylbenzamide moiety. The instant compounds inhibit the farnesyl protein transferase enzyme and the farnesylation of certain proteins. F...
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WO/1996/029305A1 |
Compounds of formula (I) wherein either a) Z is N, Y is O or NH and W is O, S, SO or SO2, or b) Z is CH, Y is O and W is S, SO or SO2; and R is alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, phenyl or heterocyclyl, each of which is o...
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WO/1996/029325A1 |
The present invention relates to novel homochiral compounds which are intermediates for the preparation of a number of azole antifungal drugs of formula (V), in an enantiomerically pure form, wherein Ar is a phenyl or substituted phenyl ...
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WO/1996/028427A1 |
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to tr...
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WO/1996/027593A1 |
L-arginine derivatives of general formula (I), a method for preparing same, and pharmaceutical compositions containing said derivatives, are disclosed. Such compounds are biologically active as nitric oxide synthase inhibitors. In the ge...
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WO/1996/027589A1 |
A process is disclosed for preparing N-substituted pyrazoles having the general formula (I), in which R1 stands for C1 to C12 alkyl or C7 to C20 phenylalkyl, and R2, R3, R4 represent independently from each other hydrogen, C1 to C12 alky...
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WO/1996/026183A1 |
1-Aryl-2-acylamino-ethane compounds of formula (I), wherein R1 is aryl or heteroaryl; R2 is hydrogen, lower alkyl or aryl-lower alkyl; R3 is hydrogen, lower alkyl, aryl or heteroaryl; R4 is aryl or heteroaryl; X is C1-C7alkylene, C2-C7 a...
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WO/1996/025159A1 |
The present invention relates to a method of treating hyperproliferative epithelial lesions by topical administration. The method prevents growth and actively cross-links these aberrant cells, thereby killing the cells. The present inven...
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WO/1996/025410A1 |
The present invention provides an azole compound represented by formula (I), wherein Ar is an optionally substituted phenyl group; R1 and R2, the same or different, are a hydrogen atom or a lower alkyl group, or R1 and R2 may combine tog...
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