Heterocyclic Compounds

Matches 1,001 - 1,050 out of 5,407	< 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 >

Document	Document Title
WO/1996/024591A1	CYCLOALKYLSULPHONYL-AMINOSULPHONYL UREAS New cycloalkylsulphonyl-aminosulphonyl ureas have the formula (I), in which R1 stands for optionally substituted cycloalkyl; R2 stands for hydrogen or optionally substituted alkyl, alkenyl, alkinyl, alkoxy or cycloalkyl; R3 stands for hy...
WO/1996/024074A1	CROSSLINKED POLYMERS The invention relates to a novel process for the production of mouldings, in particular contact lenses, in which a soluble prepolymer comprising units containing a crosslinkable group and at least one unit containing a modifier is crossl...
WO/1996/022284A1	METHOD OF PREPARING SULFONYL UREAS Herbicidal sulfonyl ureas of formula (I), wherein R is in each case optionally substituted aryl, aralkyl or heteroaryl; X is hydrogen, halogen or in each case optionally halogen- or alkoxy-substituted alkyl, cycloalkyl, alkoxy, phenoxy, ...
WO/1996/021644A1	INDOLE DERIVATIVES USEFUL IN THE TREATMENT OF OSTEOPOROSIS A compound of formula (I) or a salt thereof, or a solvate thereof, wherein either: (i) Ra represents a group R5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a); wherein X represents a hyd...
WO/1996/020939A1	POLYMORPHS B AND C OF 1-[2,4-DICHLORO-'beta'-[(7-CHLOROBENZO[b]THIEN-3-YL)METHOXY]PHENETYL]IMIDAZOLE MONONITRATE Two new polymorphs of 1-[2,4-dichloro-'beta'-[(7-chlorobenzo[b]thien-3-yl)methoxy] phenetyl]imidazole mononitrate have been identified. A process for preparing both polymorphs and their subsequent utilisation are disclosed.
WO/1996/020146A1	USE OF PYRAZOLE DERIVATIVES WITH HYDROPHOBIC GROUPS AS NITRIFICATION INHIBITORS Disclosed is the use as nitrification inhibitors of pyrazole derivatives of formula (I), or salts thereof, in which the groups R1-R4 have the following meanings: R1, R2 and R3 represent C1-C20 alkyl, C3-C8 cycloalkyl, C5-C20 aryl or alky...
WO/1996/020181A1	COMMERCIAL PROCESS FOR THE MANUFACTURE OF FLUCONAZOLE AND INTERMEDIATES USEFUL IN THE MANUFACTURE THEREOF A process for making Fluconazole is provided comprising carrying out scheme of reaction 'alpha'.
WO/1996/020200A1	6-[TRIAZOLYL[3-(TRIFLUOROMETHYL)PHENYL]METHYL]-2-QUINOLINONES AND -QUINOLINETHIONES This invention is concerned with the compounds of formula (I), the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 is hydrogen, amino or C1-4alkyl; R2 is hydrogen, halo or C1-4a...
WO/1996/019450A1	4-[(HETEROCYCLOALKYL OR HETEROAROMATIC)-SUBSTITUTED PHENYL]-2-AZETIDINONES USEFUL AS HYPOLIPIDEMIC AGENTS 4-[(Heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinone hypocholesterolemic agents of formula (I) or a pharmaceutically acceptable salt thereof, wherein: A is optionally substituted heterocycloalkyl, optionally substitu...
WO/1996/019442A1	BENZAMIDOXIME DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND AGROHORTICULTURAL BACTERICIDE A benzamidoxime derivative having an excellent bactericidal activity, being useful as an agrohorticultural bactericide, and represented by general formula (I) wherein R1 represents C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, each of whi...
WO/1996/019440A1	ACETAMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS FOR THE NITRIC OXIDE SYNTHASE A class of acetamidine derivatives of general formula (I), methods for the manufacture thereof in therapy, particularly as inhibitors of nitric oxide synthase, is disclosed or a salt thereof, wherein R1 is hydrogen, a C1-6 hydrocarbyl gr...
WO/1996/016960A1	QUINAZOLINE DERIVATIVES The invention concerns quinazoline derivatives of formula (I) wherein m is 1 or 2; each R1 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy; n is 1, 2 or 3; each R2 includes hydrogen, hydroxy, halogeno and (1-4C)alkyl; and Ar is...
WO/1996/016951A1	SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF Substituted 2-arylcarbonyloxymethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives, pharmaceutical compositions containing them and methods for the treatment of degenerative diseases utilizing them.
WO/1996/016944A1	ALKYLIDENEHYDRAZINOPHENYLSULPHONYL UREAS, METHODS OF PREPARING THEM AND THEIR USE AS HERBICIDES AND PLANT-GROWTH REGULATORS Described are compounds of formula (I), and their salts, in which R1 to R6, W, X, Y and Z are as defined in clause 1 and which have herbicidal or plant-growth-regulating properties. The compounds may be prepared by procedures analogous t...
WO/1996/016945A1	N-SUBSTITUTED HYDRAZINOPHENYLSULPHONYL UREAS USED AS HERBICIDES AND PLANT-GROWTH REGULATORS Described are compounds of formula (I), and their salts, in which R1 to R6, W, Q, X, Y and Z are as defined in Formula (I) of claim 1 and which are suitable for use as herbicides and plant-growth regulators. The compounds (I) may be prep...
WO/1996/016034A1	PROCESS FOR PRODUCING AROMATIC OR HETEROAROMATIC SULFUR COMPOUNDS A process for producing an aromatic or heteroaromatic thiol represented by the following general formula (2): Ar-(-SH)n by hydrolyzing an aromatic or heteroaromatic halomethyl sulfide represented by the following general formula (1): Ar-...
WO/1996/016030A1	IMINOOXYMETHYLENE ANILIDES, PROCESS AND INTERMEDIATE PRODUCTS FOR PREPARING THE SAME AND PESTICIDES CONTAINING THE SAME Iminooxymethylene anilides have the formula (I), in which the substituents and indices have the following meanings: R stands for hydrogen, optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl, cycloalkinyl, alkylcarbo...
WO/1996/016026A1	O-BENZYL OXIME ETHER DERIVATIVES AND THEIR USE AS PESTICIDES Compounds of formula (I), wherein Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR13; A is ...
WO/1996/015101A1	NOVEL AMINO ACID DERIVATIVES WITH IMPROVED MULTI-DRUG RESISTANCE ACTIVITY The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The com...
WO/1996/014846A1	DIHYDROPYRIMIDINES AND USES THEREOF This invention is directed to dihydropyrimidine compounds which are selective antagonists for human 'alpha'1C receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol ...
WO/1996/015119A1	ACYLAMINOPHENYLSULPHONYL UREA SALTS AS HERBICIDES AND PLANT-GROWTH REGULATORS Described are compounds, suitable for use as herbicides and plant-growth regulators, of the formula (I) (salt form) in which R1 to R5, X, Y, Z, M and n are as defined in claim 1 and, in particular, R2 is a (substituted) hydrocarbon group...
WO/1996/014303A1	SULPHUR-SUBSTITUTED PHENYL SULPHONYL UREAS, PROCESS FOR THEIR PRODUCTION AND USE AS HERBICIDES AND PLANT GROWTH REGULATORS Compounds of formula (I) and their salts in which R, R1, R2, R3, X, Y, Z, W, n and m are as defined in claim 1 and especially R is a formyl equivalent of the formula CHO, -CH=NR or CH(X1R')(X2R'') are suitable as herbicides and plant g...
WO/1996/014315A1	SUBSTITUTED AZOLYL SULPHONYL URACILS The invention relates to novel substituted azolyl sulphonyl uracils of the general formula (I) in which Az is possibly substituted azolyl, R1 is hydrogen, cyano or halogen, R2 is cyano, nitro, halogen or a possibly substituted radical of...
WO/1996/014067A1	CYSTEINE PROTEASE AND SERINE PROTEASE INHIBITORS The present invention is directed to irreversible inhibitors of serine and cysteine proteases which most preferably contain a 1-oxytriazole or 1-oxyimidazole functionality. Methods for the use of the protease inhibitors are also described.
WO/1996/014304A1	N-ACYL-N-ALKYLAMINO PHENYL SULPHONYL UREAS WITH SULPHUR SUBSTITUENTS, PROCESS FOR THEIR PRODUCTION AND USE AS HERBICIDES AND PLANT GROWTH REGULATORS N-acyl-N-alkylamino phenyl sulphonyl ureas with sulphur substituents, process for their production and use as herbicides and plant growth regulators. Compounds of formula (I) and thier salts, in which R1, R2, R3, R4, R5, X, Y, Z, W, n an...
WO/1996/013509A1	FLUOROALKENYL COMPOUNDS AND THEIR USE AS PEST CONTROL AGENTS Fluorinated alkene compounds having structure (I) wherein Q is -(C=S)-R1, -(C=W)-R2, or -(P=W)R3R4; wherein W is O or S; and R1 to R4 are as defined in claim 1; are useful for controlling nematodes, insects, and acarids that prey on agri...
WO/1996/013479A1	NITRO-BENZAMIDES USEFUL AS ANTI-ARRHYTHMIC AGENTS A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon ...
WO/1996/013491A1	BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Compounds having the formula (I): R1R2C(OR3)-Ar1-X-Ar2-C(Ar3)=CHCO2H are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also use...
WO/1996/013500A1	BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS Compounds having the formula (I): R1R2C(OR3)-Ar1-X-Ar2-Ar3 are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in tre...
WO/1996/012708A1	HERBICIDAL SULFONYL UREA DERIVATIVES The present invention relates to novel sulfonyl urea derivatives of formula (I) having erythro-type stereoisomer as herbicides for treatment of pre-emergence and/or post-emergence, their use and composition as agriculturally suitable her...
WO/1996/011909A1	DIHALOPROPENE COMPOUNDS, INSECTICIDAL/ACARICIDAL AGENTS CONTAINING SAME, AND INTERMEDIATES FOR THEIR PRODUCTION The dihalopropene compounds of general formula (I) have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.
WO/1996/011902A1	PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS The present invention relates to compounds of formula (I), wherein: A, B and D are various ring systems as defined in the description, R1 is one of a variety of groups as defined in the description, R3 is hydrogen or C1-4 alkyl and Z is ...
WO/1996/011911A1	5-LIPOXYGENASE INHIBITORS Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyrrolyl, pyrazolyl, 1,...
WO/1996/011188A1	SULFONYLAMINOCARBONYLTRIAZOLINONES WITH SUBSTITUENTS BOUND BY OXYGEN AND SULPHUR New sulfonylaminocarbonyltriazolinones with substituents bound by oxygen and sulphur have the formula (I), in which n equals 0, 1 or 2; R1 stands for hydrogen or an optionally substituted rest from the group alkyl, alkenyl, alkinyl, cycl...
WO/1996/010568A1	SUBSTITUTED ARYL PIPERAZINES AS NEUROKININ ANTAGONISTS Disclosed are substituted aryl piperazines of Formula (I) which are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis. In particular compounds of Formula (I) are shown t...
WO/1996/010566A1	SUBSTITUTED PHENYLAMINOSULPHONYL UREAS AS HERBICIDES The invention relates to novel substituted phenylaminosulphonyl ureas of the formula (I) in which A may be N or CH, Q may be O or S, R1 and R2 are mutually independently e.g. C1-C4 alkyl or C1-C4 alkoxy, R3 may be H, halogen, C1-C4 alkyl...
WO/1996/010559A1	UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS Urea derivatives of formula (I), wherein R1 is a group of formula (1) (in which R4 is aryl which may have suitable substituent(s), or heterocyclic group which may have suitable substituent(s), and Y is bond, lower alkylene, -S-, -O-, (a)...
WO/1996/010569A1	QUINOLINE DERIVATIVE A novel quinoline derivative useful in treating diseases relative to TXA2 or LTD4 and usable as a remedy for cerebral infarction, bronchial asthma or allergic diseases. This novel quinoline derivative has a characteristic chemical struct...
WO/1996/010023A1	1,2,3,4-TETRAHYDROQUINOXALINDIONE DERIVATIVE A 1,2,3,4-tetrahydroquinoxalindione derivative represented by general formula (I) or a salt thereof, an NMDA-glycine receptor and/or AMPA receptor antagonist and a kainate neurocytotoxicity inhibitor each containing the same, and a medic...
WO/1996/009807A1	2-HYDROXY-1-ETHANONE DERIVATIVES FOR USE IN DYEING KERATIN-CONTAINING FIBRES The invention concerns the use of 2-hydroxy-1-ethanone derivatives for dyeing keratin-containing fibres, in particular human hair.
WO/1996/010011A1	INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE The present invention comprises analogs of the CAAX motif of the protein Ras that is modified by farnesylation in vivo. These CAAX analogs inhibit the farnesylation of Ras. Furthermore, these CAAX analogues differ from those previously d...
WO/1996/009287A1	NOVEL HETEROCYCLIC DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF A heterocyclic derivative represented by general formula (I) or medicinally acceptable salts thereof, a process for producing the same, and a medicinal composition containing the heterocyclic derivative or medicinally acceptable salt the...
WO/1996/007405A1	EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are...
WO/1996/007633A1	PHENYLACETIC ACID ALKYL ESTERS The invention pertains to phenylacetic acid alkyl esters of formula I, wherein the index and substituents are as follows: R' is formyl, alkyl carbonyl or alkyl; R'' is alkyl; U is -O-, -S-, -NH- or -NHO-; V is -O-, -S-, or -NH-; X is cya...
WO/1996/007636A1	IMIDIC ACID DERIVATIVES AND THEIR USE AS PESTICIDES The invention pertains to new imidic acid derivatives of formula (I), methods for preparing them and their use as pesticides.
WO/1996/007647A1	SUBSTITUTED PYRIMIDINE(THI)ONES The invention concerns novel substituted pyrimidine(thi)ones of general formula (I), in which Q, R1, R2, R3, R4 and R5 have the meanings given in the description, a process for producing these compounds and the use thereof as herbicides.
WO/1996/006822A1	ORTHO-SUBSTITUTED AROMATIC ETHER COMPOUNDS AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS FOR PAIN RELIEF The present invention relates to compounds of formula (I) wherein: A is an optionally substituted ring system as defined herein; B is an optionally substituted 5- or 6-membered heteroaryl ring system or optionally substituted phenyl; D i...
WO/1996/006072A1	OXIME ETHERS AND THEIR USE AS PESTICIDES Compounds of formula (I) are suitable for controlling and preventing infestation by micro-organisms, insects and acarina on plants and their possible isomers and mixtures of isomers, wherein (a) X is CH2F or CHF2, Y is CH and Z is OCH3, ...
WO/1996/006074A1	METALLOPROTEINASE INHIBITORS Compounds of formula (I) principally characterised in that R4 is an optionally substituted C3-C8 cycloalkyl group or optionally substituted C4-C8 cycloalkenyl group are inhibitors of matrix metalloproteinases.
WO/1996/005193A1	(AZETIDIN-1-YLALKYL)LACTAMS AS TACHYKININ ANTAGONISTS The present invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein R is C3-C7 cycloalkyl, aryl or C1-C6 alkyl, said C1-C6 alkyl being optionally substituted by fluoro, -COOH, -COO(C1-C4 alk...

Matches 1,001 - 1,050 out of 5,407	< 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 >