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WO/1997/041107A1 |
Triazolyl mercaptides of the formula (I) in which M is an alkaline metal cation, an equivalent of an alkaline earth cation, an equivalent of a copper, zinc, iron or nickel cation or an ammonium cation and R1 is various radicals, a proces...
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WO/1997/040048A1 |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is further substituted with various subs...
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WO/1997/040052A1 |
Compounds of formula (I) wherein R2 is -CH2CCH or -CH2CC-Het where Het is a 2-aminopyridyl, 2-aminopyrimidyl, 6-aminopyridazinyl, imidazol-4-yl group, R3 and R4 each represent hydrogen, (C1-C4)alkyl, (C1-C4)alkoxycarbonyl, ArCH2CO2- or A...
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WO/1997/040025A1 |
A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation...
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WO/1997/038997A1 |
A fungicidal compound having general formula (I), wherein R1 is a N-or C-linked 5-membered heterocyclic ring containing from 2 to 4 heteroatoms selected from N, O and S, at least one of which is N, and which is optionally N- or C-substit...
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WO/1997/038983A1 |
The present invention provides compounds that are irreversible inhibitors of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis and a pharmaceutical composition that ...
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WO/1997/037980A1 |
The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for...
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WO/1997/037968A1 |
Compounds of general formula (I) are excellent bacteriocides exhibiting wide bacteriocidal spectra, wherein R1 is a heterocyclic group, CHO or CH2OR6; R2 is alkyl; R3 is hydrogen, alkyl, alkoxy, halogeno, nitro, cyano or haloalkyl; R4 is...
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WO/1997/036583A1 |
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compou...
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WO/1997/036864A1 |
A novel butadiene derivative of formula (1-a) wherein Ring A is heterocycle, or benzene being optionally substituted by lower alkyl, alkoxy, nitro, hydroxy, substituted or unsubstituted amino or halogen, Ring B is heterocycle, or benzene...
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WO/1997/036859A1 |
The present invention relates to a class of compounds represented by Formula (I) or a phramaceutically acceptable salt thereof, pharmaceutical composition comprising compounds of Formula (I), and methods of selectively inhibiting or anta...
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WO/1997/035863A1 |
Compounds of the formula (I) and their salts, in which R1 to R6, W, X, Y and Z are defined as in claim 1 and the group R2R3C is a C atom substituted by at least one electron-attracting radical of R2 or R3, are suitable as herbicides and ...
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WO/1997/034896A1 |
The invention concerns imidazoloquinoxalinones of formula (I) in which R1 to R4 have the meanings given in the description and R5 is a five-member optionally substituted heterocycle with between 1 and 4 nitrogen atoms or with 1 or 2 nitr...
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WO/1997/033873A1 |
This invention provides methods for the treatment or prevention of interstitial cystitis or urethral syndrome in a mammal which comprise administering to a mammal in need thereof an effective amount of a substituted benzimidazole, or a p...
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WO/1997/033875A1 |
A novel process makes it possible to produce substituted aromatic thiocarboxylic acid amides of general formula (I) in which R1, R2, R3 and Z have the meanings given in the description, by reacting substituted aromatic nitriles of formul...
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WO/1997/033872A1 |
Compounds of formula (I), wherein the group (A) represents a 5-membered heterocyclic ring; X represents N or C; R10 represents H, C1-6 alkyl optionally substituted by one or more halo or NR1R2. R1 and R2 each independently represent H or...
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WO/1997/033576A1 |
Carbamyl guanidine, thioguanidine and amidine compounds are provided which have the structure (I) wherein Z is a substructure which when linked to (II) forms a prodrug of compounds with pharmaceutically active properties. In preferred em...
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WO/1997/033876A1 |
A novel process makes it possible to produce substituted aromatic thiocarboxylic acid amides of general formula (I) in which R1, R2, R3 and Z have the meanings given in the description, by reacting substituted aromatic nitriles of formul...
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WO/1997/032873A1 |
The invention provides compounds of formula (I) and the pharmaceutically acceptable salts thereof, wherein R is a 5-membered ring heteroaryl group containing 3 or 4 nitrogen heteroatoms which is linked to the quinoxalinedione ring by a r...
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WO/1997/032858A1 |
The present invention relates to a novel condensed heterocyclic compound of formula (I) wherein R1 is alkyl, etc.; R2 is hydrogen, etc.; R3 and R4 are each independently hydrogen, etc.; a group of formula (a) is the group of formula (b),...
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WO/1997/032875A1 |
The invention relates to novel substituted thienyl sulphonyl(thio) ureas of the general formula (I) in which: A is nitrogen or a CH group; Q is oxygen or sulphur, R1 is hydrogen, halogen or possibly substituted alkyl, alkoxy, alkyl thio,...
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WO/1997/032861A1 |
The invention relates to novel substitued aryl sulphonyl(thio)ureas of formula (I) and salts thereof, in which: A is nitrogen or a CH group; Q is oxygen or sulphur; R1 is hydrogen, halogen or possibly substituted alkyl, alkoxy, alkylthio...
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WO/1997/031913A1 |
The present invention relates to novel herbicidal sulfonamide derivatives of formula (I) having erythro stereochemistry as herbicides for treatment of pre-emergence and/or post-emergence, their use and composition as agriculturally suita...
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WO/1997/031903A1 |
Compounds of formula (II-A) wherein R1 is chloro, fluoro, bromo or trifluoromethyl; R2 is hydrogen, chloro, fluoro, bromo or trifluoromethyl; Z is CH or N; R3, R4 and R5, which are the same or different, are hydrogen or C1-C4 alkyl, with...
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WO/1997/031917A1 |
The invention concerns a compound of formula (I) wherein, for example: R1 is hydroxy, chloro, fluoro, amino, azido, of the for mula -NHC(=O)Ra wherein Ra is hydrogen or (1-4C)alkyl, of the formula -N(Me)C(=O)Rb wherein Rb is hydrogen, me...
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WO/1997/030978A1 |
Sulfonylureidopyrazole derivatives represented by general formula (1) or (2). Because of having inhibitory effects on endothelin converter enzyme, these compounds are useful in the prevention and treatment of various circulatory diseases...
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WO/1997/030971A1 |
The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
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WO/1997/030987A1 |
Optically active 1,4-dihydropyridine derivatives of general formula (I), salts thereof with anions, and a process for the preparation thereof (wherein R1 is C1-C6 alkyl; R2 is a quaternary ammonium group derived from an optionally substi...
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WO/1997/030054A1 |
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indol...
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WO/1997/029748A1 |
Compounds of formula (I) inhibit the activity of endothelin. The symbols are defined as follows: R1, R2, R3 and R4 are each directly bonded to a ring carbon and are each independently (a) hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cy...
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WO/1997/030034A1 |
The invention concerns quinazoline derivatives of formula (I), wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); wherein Q1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q1 optionally bears up to 3 ...
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WO/1997/028202A1 |
The disclosure relates to a method of producing press-moulding materials, in particular wood chip boards, by hot pressing of materials containing lignocellulose and mixed and/or impregnated with polyisocyanates as binders, using latent, ...
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WO/1997/028162A1 |
A class of 3-substituted 2,7-diazabicyclo[3.3.0]octane derivatives, further substituted at the 7-position by an optionally substituted alkenyl, alkynyl, cycloalkyl-alkyl, aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5...
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WO/1997/027187A1 |
The invention relates to a 4-benzoylisoxazole derivative of formula (Ia), a 5-phenylisoxazole derivative of formula (Ib) or a 2-cyano-1,3-dione derivative of formula (Ic) wherein R1, R2, R3, X and n are as defined in the description, and...
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WO/1997/027175A1 |
The invention relates to substituted ethyl 'alpha','alpha' - diarylmethyl ether derivatives and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, and methods of treating cocaine addiction and ove...
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WO/1997/025318A1 |
Compounds of formula (I), in which R1, R2 and R3 are as defined in claim 1, are particularly suitable as herbicides.
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WO/1997/025033A1 |
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermedia...
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WO/1997/024333A1 |
Preventives/remedies for complications of diabetes containing as the active ingredient 4-['alpha'-hydroxy-2-methyl-5-(1-imidazolyl)benyzl]-3,5-dime
thylbenzoic acid, optical isomers thereof or pharmaceutically acceptable salts thereof; a...
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WO/1997/024118A1 |
The compounds according to the invention are substituted N-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides of formula (I) herein which exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical co...
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WO/1997/024343A1 |
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolylphenyl derivatives of for...
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WO/1997/022638A1 |
Compositions and processes for using the compositions for applications in a subterranean formation are provided. The compositions include a composition which comprises a nitrogen-containing olefinic compound; a composition comprises a wa...
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WO/1997/022591A1 |
Novel benzazepine derivative of formula (1) wherein R1 is H or halogen, A is lower alkylene, R2 and R3 are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R2 and R3 may c...
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WO/1997/022549A1 |
The present invention relates to stabilised hydroxylamine solutions containing as stabilizer at least one compound of general formula (I) R1R2N -A-NR3R4 or salts thereof. In said formula (I): A stands for alkylene, alkenylene, alkinylene...
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WO/1997/021701A1 |
This invention comprises the novel compounds of formula (I), wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2C1-6alkyl, quinolinylC1-6alkyl, pyridylC1-6alkyl, hydroxyC1-6alk...
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WO/1997/020840A1 |
The invention relates to 1,2,3-thiadiazole carboxylic acid (thio)esters of the formula (I), in which A is a single bond or alkane diyl substituted optionally by aryl or aryl halide, wherein the alkane diyl chain can be broken by oxygen o...
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WO/1997/020816A1 |
The invention relates to phenylacetic acid derivatives of the formula (I), in which the substituents and the index have the following meaning: X is NOCH3, CHOCH3, CHCH3 and CHCH2CH3; Y is NRa and O; Ra, R1 are hydrogen and alkyl; R2 is c...
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WO/1997/020821A1 |
The invention relates to a method of treatment of disorders and diseases associated with NPY receptor subtype Y5 comprising administering to a warm-blooded animal, including man, in need of such treatment a therapeutically effective amou...
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WO/1997/020809A1 |
Compounds of formula (I) in which n, q, A, X, G, Y, Z, R, R2, R3, R4, R5, R7 and R9 are as defined in claim 1, and, where appropriate, E/Z isomers, E/Z isomer mixtures and/or tautomers thereof, in each case in the free form or in an agro...
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WO/1997/020561A1 |
The present invention provides a composition and method for treating pain using a composition comprising Selected Muscarinic Compounds and one or more compounds selected from the group consisting of Nonsteroidal Antiinflammatory drugs, a...
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WO/1997/020466A1 |
Disclosed are compounds of formula (I) in which R1-R5, X, W, n and Z have the definitions indicated in claim 1. These compounds are particularly suitable for use as selective herbicides in crop cultures.
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