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Matches 901 - 950 out of 6,641

Document Document Title
WO/2004/069852A1
What is described are a compound of the formula (I) Wherein A-B is -CH=CH- or -CH2-CH2-; n is 0 or 1; R1, is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 for instance are either, (i) independently from each other for instance...  
WO/2004/069854A1
The application relates to novel macrolides having antibacterial activity. The macrolides are represented by the formula (I) wherein the substituents have the meaning disclosed herein.  
WO/2004/069853A1
What is described are a compound of the formula (I) wherein the bond of atoms C22 and C23 is a single or double bond; m is 0 or l; n is 0, 1 or 2; p is 0 or l; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example H, ...  
WO/2004/067542A1
A compound having a structure represented by the following general formula (I): (I) (A is a cyclic group, etc.; R1 and R2 each is alkyl, hydroxymethyl, etc.; and n is 1 or 2); or a pharmacologically acceptable salt or ester of the compou...  
WO/2004/067534A1
A compound of the general formula (I) pesticidal compositions whose active compound is selected from these compounds and their tautomers; intermediates for the preparation of the said compounds of the formula (I), methods for the prepara...  
WO/2004/066725A2
Disclosed are compounds of the formulain which nis0orl; X-Y is -CH=CH- or -CH2-CH2-; Z is -C(=O)-, -C(=S)- or -S02-; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; and R2 is R3-Z-, R3-O-Z-, R4 or -Z-N(R6)(R7); Q is O or -N-R5; R3 a...  
WO/2004/067543A1
What is described are a compound of the formula (I) Wherein U is -N(R2)OR3 or -N+(O-)=C(RE)RZ); n is 0 or 1; X-Y is -CH=CH- or -CH2-CH2-; R1 is C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl; R2 and R3 are, for example; independently from...  
WO2004012746A3
The present invention provides methods of treating cancer using inhibitors of inosine monophosphate dehydrogenase (IMPDH). The IMPDH inhibitors are combined with compounds that inhibit cellular processes regulated by GTP or ATP. Also pro...  
WO/2004/064715A2
Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or...  
WO/2004/065402A1
The invention relates to derivatives of 9-ketospinosyn derivatives, which are substituted in the C-9 position by a radical =N-(O, NH or NRx)-Ry, to a method for the production thereof, and to their use for controlling animal pests.  
WO/2004/062629A2
The invention provides novel apoptosis-inducing compounds that include isolated, purified isoapoptolidin, and selectively functionalized isoapoptolidin derivatives and stereoisomers thereof; selectively functionalized apoptolidin derivat...  
WO2004019879A8
Motilide compounds having the formula (I), wherein R<1>, R<2>, R<3>, and R<4> are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.  
WO2004024744A3
Methods and materials are provided for E. coli host cells containing an expression system for producing NDP 6-deoxy-sugar, which may also comprise an expression system for expressing 6-deoxyglycosyl transferase and/or an expression syste...  
WO/2004/057983A1
It is intended to provide a composition containing isoflavone which has a high purity in a natural state and yet is highly soluble in water without adding any solubilizers or subjecting to chemically modification. It is found out that a ...  
WO/2004/058790A1
It is intended to provide a nitrogen-containing heterocyclic derivative which has an excellent effect of inhibiting human SGLT2 activity and is useful as a preventive or a remedy for diseases caused by hyperglycemia such as diabetes, dia...  
WO/2004/056843A2
The application provides antibiotic 10-substituted 10-desmethyl macrolides. In a preferred embodiment the macrolides have an erythromycin basic structure according the formula, wherein the variable substituents have the meaning indicated...  
WO/2004/056844A1
What is described are a compound of the formula (I): wherein n is 0 or 1; A-B is -CH=CH- or -CH2-CH2-; R1 is C1-C12-alkyl, C3-C8-cycloalkyl or C2-C12-alkenyl; R2 is for example C1-C12-alkyl, C2-C12-alkenyl or C2-C12-alkinyl; which are op...  
WO2004039822A3
The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a hu...  
WO/2004/052904A2
The invention relates to N'-substituted 9a-N-(N'-carbamoyl-&gammad -aminopropyl), 9a--N-(N'-thiocarbamoyl-&gammad -aminopropyl), 9a-N-[N'-((β-cyanoethyl)-N'-carbamoyl-&gammad -aminopropyl] and 9a-N-[N'-((β-cyanoethyl)-N'-thiocarbamoyl-...  
WO/2004/052903A1
The invention relates to substituted fluoroglycoside heterocyclic derivatives of a formula (I), wherein radicals have predefined bonds, to the psychologically tolerated salts thereof and to methods for the preparation thereof. Said compo...  
WO2004016632A3
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are us...  
WO/2004/052902A1
The invention relates to substituted aromatic fluoroglycoside derivatives of a formula (1), wherein radicals have predefined bonds, to the psychologically tolerated salts thereof, and methods for the preparation thereof. Said compounds c...  
WO2004019879A3
Motilide compounds having the formula (I), wherein R<1>, R<2>, R<3>, and R<4> are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.  
WO/2004/043984A1
The invention relates to substituted 9a-N-[N’-(benzenesulfonyl)carbamoyl-&gammad -aminopropyl] and 9a-N-[N’-(β-cyanoethyl)-N’-(benzenesulfonyl)carbamoyl-& gammad -aminopropyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithro...  
WO/2004/043985A1
The invention relates to substituted 9a-N-&lcub N'-[4-(sulfonyl)phenyl]carbamoyl&rcub derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5-0-desosaminyl­-9-deoxo-9-di-hydro-9a-aza-9a-homoerithrono lide A, novel semisynthe...  
WO/2004/043945A1
A method for purifying isoflavones glycosides of genistin and daidzin from impurities present in a soy isoflavones concentrate. The method includes digesting a soy isoflavones concentrate with an acidic solution and separating insoluble ...  
WO/2004/043983A1
The invention concerns the compound of formula (I), as well as its solvates and hydrates. The invention also concerns a method for preparing said compound, as well as pharmaceutical compositions containing same.  
WO2002024146A9
Methods of providing pain relief by administering a water-soluble derivative of spicamycin. Methods of using pain mediation agents are also provided.  
WO/2004/039821A1
Macrolides with anti-inflammatory activity are described, and more particularly, 9a-azalides without cladinose in position 3 with anti-inflammatory activity, their pharmaceutically acceptable salts and pharmaceutical compositions that co...  
WO2004029066A8
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional hetercyclic com...  
WO2003077830A3
Substantially pure isostructural pseudopolymorphs of 9-deoxo-9a-aza-9a-methyl-9a- homo erythromycin A having the Formula I: wherein S is an organic solvent which is at least partially miscible with water, x is 1, 1.25, 1.5 or 2, y is 0, ...  
WO/2004/039823A1
Substances potentiating the activity of azole antifungal agents which act on fungal infection at a low concentration within a short period of time and make it possible to lower the appearance frequency of tolerant strains. Examples of th...  
WO2003088907A3
The invention provides new isoflavonoid and triterpenoid compounds isolated from a soybean phytochemical concentrate. The new compounds have exhibited cytotoxic activity against selected tumor cells lines. Pharmaceutical compositions com...  
WO/2004/039822A2
The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a hu...  
WO/2004/037273A1
A therapeutic and/or preventive agent for dyschezia which is suitable for persistent administration and contains as an active ingredient either a compound represented by the formula (1): (1) (wherein R1 represents C1-6 alkyl and R2 repre...  
WO2002097082A8
The complete DNA sequence of the gene cluster encoding the polypeptides responsible for the biosynthesis of the polyene antibiotic amphotericin of S. nodosus is provided. Engineered alteration of the amphC) gene so as to eliminate produc...  
WO/2004/035598A2
The invention relates to novel chalcomycin derivatives, medicaments containing said derivatives or the salts thereof, and the use of chalcomycin derivatives for treating diseases, especially infections. The inventive chalcomycin derivati...  
WO2004005310A3
The present invention relates (a) to new compounds represented by Formula (I): wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, S represents...  
WO2003035897A3
This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a beta-D-ribofuranosyl group and the chromogenic ...  
WO2003035896A3
This invention provides novel chromogenic enzyme substrates which are indoxyl beta-D-ribofuranosides. A process for their production is provided. Methods for detecting beta-D-ribofuranosidase activity are given. The advantages of these n...  
WO2003022844A9
The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provide...  
WO2004005309A3
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a...  
WO2003040094A9
The invention features a new solid supports having at least one amino functionality and a linker bound to the solid support through at least a portion of the amino functional groups. The invention also features solid support bound substr...  
WO/2004/031203A1
A pyrazole derivative which exerts an excellent effect of inhibiting human 1,5-anhydroglucitol/fructose/mannose transporters and, therefore, is useful as a preventive, a progress inhibitor or a remedy for a disease caused by the over int...  
WO2004013153A3
Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmace...  
WO/2004/029067A1
The present invention relates to the new 3-decladinosyl derivatives of 9-deoxo-9a-aza­9a-homoerythromycin A 9a,11-cyclic carbamate of the general formula (I), their pharmaceutically acceptable addition salts with inorganic or organic ac...  
WO/2004/029066A2
The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional hetercyclic com...  
WO/2004/028481A2
Disclosed are compounds, compositions and methods for treating hepatitis C virus infections.  
WO2004009061A3
The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity (ies) with their intended use as drug bioavailability enha...  
WO2003031430A3
The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such c...  

Matches 901 - 950 out of 6,641