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Matches 1 - 50 out of 9,005

Document Document Title
WO/2021/089840A1
Described herein is a cost-effective method for fermentation of chalconoids in complex antimicrobial matrices originating from (spent) hops. A product is obtained which is highly enriched in certain phytoestrogens, in particular 8-prenyl...  
WO/2021/081868A1
Disclosed is a mutant of nitrile hydratase derived from Caldalkalibacillus thermarum, which falls within the technical field of enzyme engineering. The half-life period of the nitrile hydratase mutant Cal.t Nhase-A20V provided in the pre...  
WO/2021/081648A1
A genetically engineered microorganism for the production of a cannabinoid biosynthetic pathway product is described. The genetically engineered microorganism comprises at least one nucleic acid molecule encoding at least one cannabinoid...  
WO/2021/081647A1
A genetically engineered microorganism for the production of a cannabinoid is described. The genetically engineered microorganism comprises at least one nucleic acid molecule encoding at least one cannabinoid biosynthetic pathway enzyme....  
WO/2020/165882A3
The present invention relates to a method of producing high-purity 2-pyrone-4,6-dicarboxylic acid (PDC), and a method of producing an intermediate for same, the methods comprising the steps of: 1) producing terephthalic acid (TPA) from P...  
WO/2021/076629A1
The present invention is directed to a process for the synthesis of (1R, 4R, 5S)-4-(2- chloroethyl)-1-((S)-((S)-cyclohex-2-en-1-yl)(hydroxy)methyl) -5-methyl-6-oxa-2- azabicyclo[3.2.0]heptane-3,7-dione; compound 1 (salinosporamide A, mar...  
WO/2021/076638A1
The present invention relates to methods and transformed host cells for the production of eriodictyol from naringenin via bioconversion.  
WO/2021/069714A1
The invention relate to genetically modified hosts cell comprising a pathway having enhanced production of one or more benzylisoquinoline alkaloids wherein the cell expresses heterologous insect genes encoding insect demethylases convert...  
WO/2020/264400A3
The disclosure relates to the biosynthesis of terpenoids, such as, for example, geraniol and derivatives thereof, using genetic engineering. In particular, the disclosure relates to the biosynthesis of nepetalactol, nepetalactone, dihydr...  
WO/2021/063396A1
Provided is various enzymes for cannabinoids synthesis and methods of making and using thereof. Also provided is the recombinant polypeptides having prenyl transferase activity and/or geranylpyrophosphate: olivatolate geranylttransfersae...  
WO/2021/057913A1
Provided are a glycosyltransferase UGT76G1 mutant, an isolated polynucleotide, a carrier, a production method, and a composition and a kit for the glycosylation of substrates. Further provided are a method for increasing the catalytic ac...  
WO/2021/058115A1
The present invention relates to a biocatalytical method for manufacturing of homoeriodictyol dihydrochalcone and/or hesperetin dihydrochalcone by providing at least one first biocatalyst system for the hydroxylation of phloretin and/or ...  
WO/2021/058783A2
The present invention relates to a biocatalytical method for manufacturing of homoeriodictyol dihydrochalcone and/or hesperetin dihydrochalcone by providing at least one first biocatalyst system for the hydroxylation of phloretin and/or ...  
WO/2020/208411A4
Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic ac...  
WO/2021/053513A1
Genetically-modified cell comprising at least one heterologous polynucleotide encoding an enzyme involved in the flavonoid pathway. Method of making a flavonoid or flavonoid derivative in such a genetically-modified cell. Use of a flavon...  
WO/2021/055597A1
The present disclosure provides engineered variants of a tetrahydrocannabinolic acid synthase (THCAS) polypeptide comprising an amino acid sequence of SEQ ID NO:44 with one or more amino acid substitutions, nucleic acids comprising nucle...  
WO/2021/047566A1
Disclosed are a preparation method for a compound as shown in formula (I) and levo-praziquantel. A racemate of ester of the compound of formula (I) is used as a substrate, and reaction is performed under the catalysis of immobilized lipa...  
WO/2021/050371A1
A recombinant microorganism includes a transgene encoding a polypeptide of a Type II biotin synthase, wherein a holo-protein of the Type II biotin synthase comprises per polypeptide chain a first [4Fe-4S] cluster (radical SAM (RS) cluste...  
WO/2021/038095A1
The present invention relates to methods for the preparation of α-hydroxyacyl compounds, and peptides for the catalyzed formation of α-hydroxyacyl compounds as well as their use in the preparation of α-hydroxyacyl compounds.  
WO/2021/035421A1
Provided is a folate producing strain and the preparation and application thereof, in particular, the expression level of the endogenous folCgene in the engineered strain of the present invention is decreased, and the exogenous folC gene...  
WO/2021/036348A1
Provided is a folate producing strain and the preparation and application thereof, in particular, the expression level of the endogenous folC gene in the engineered strain of the present invention is decreased, and the exogenous folC gen...  
WO/2021/037343A1
The invention relates to a cannabinoid concentrate and isolate with a high content of the acidic forms of the cannabinoids, method of obtaining the same and use thereof comprising providing a lipid extract using i.a. paraffin and subject...  
WO/2021/034847A1
The present disclosure relates to the production of cannabinoids in either recombinant microorganism or in cell-free systems using a combination of enzymes, including but not limited to a PKS enzyme, a npgA enzyme, a cs-OLAS-1, a pp-DVAS...  
WO/2021/034848A1
The disclosure relates to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro comprising the use of disclosed prenyltransferase variants.  
WO/2021/018170A1
Provided are the preparation of a transformed microorganism for producing pyridine carboxamide with low by-product and the use thereof, wherein the preparation comprises the steps of construction of a plasmid with gene knockout, transfor...  
WO/2021/015267A1
The present disclosure addresses the problem of providing an enzyme capable of dehydroxylating a hydroxyl group located at a specific position in a urolithin compound that has a hydroxyl group at at least the specific position. The probl...  
WO/2021/004912A1
The invention relates to a Streptomyces clavuligerus strain comprising two point mutations in a ccaR promoter region and a substitution mutation in the ccaR gene, wherein the mutations in the ccaR promoter region are a C to T point mutat...  
WO/2020/247821A3
A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also ...  
WO/2020/262107A1
The present invention relates to a production method of (R)-reticulin comprising: a step for obtaining a recombinant host cell by inserting, to a host cell, a gene 1 which is composed of a nucleotide sequence having at least 70% homology...  
WO/2020/208411A3
Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic ac...  
WO/2020/254745A1
The present invention relates to a selective process for the preparation of sulfones from sulfides by enzymatic catalysis, as well as to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of...  
WO/2020/254744A1
The present invention relates to a selective process for preparing sulfoxides from sulfides by enzymatic catalysis, as well as to a composition comprising a symmetrical sulfide, wherein an oxidoreductase enzyme catalyzes the oxidation of...  
WO/2020/159298A3
The present invention relates to novel microalgae having high loliolide productivity. Scenedesmus sp. HS4 of the present invention has high biomass productivity and high loliolide content, thereby being usable as a biological resource ca...  
WO/2020/247976A1
Provided herein are methods and compositions related to forming cross-links between surfactant molecules at an interface between dispersed phase partitions and a continuous phase in an emulsion, and uses of such cross-linked emulsions.  
WO/2020/237552A1
Provided are a transaminase mutant and a method for producing chiral amines using the transaminase mutant. The amino acid sequence of the transaminase mutant is an amino acid sequence obtained after mutation occurs to the amino acid sequ...  
WO/2020/233506A1
A method for improving the production of streptomyces polyketide compounds is provided. The method greatly improves the capability of the streptomyces polyketide compounds by strengthening a triacylglycerol decomposition pathway in strep...  
WO/2020/232553A1
The present disclosure relates generally to methods and cell lines for the production of phytocannabinoids, phytocannabinoid precursors or intermediates, or phytocannabinoid analogue. Methods for transformation of host cells, such as yea...  
WO/2020/234215A1
The present invention relates to a biological cell that can grow in the absence of biotin under aerobic conditions, comprising a BIO1 gene (i.e. CfBIO1), and preferably a BIO6, BIO2, BIO3, and BIO4 gene. The present disclosure additional...  
WO/2020/229516A1
Herein are provided microbial factories, in particular yeast factories, for production of strictosidine aglycone and optionally other plant-derived compounds. Also provided are methods for producing strictosidine aglycone in a microorgan...  
WO/2020/230833A1
The purpose of the present invention is to provide a novel compound which has the action of effectively enhancing the antifungal activity of an antifungal drug and which has a skeleton structure different from that of known pharmaceutica...  
WO/2020/221795A1
The present invention relates to microbial factories, in particular yeast factories, for production of ergothioneine. Also provided are methods for producing ergothioneine in a yeast cell, as well as useful nucleic acids, polypeptides, v...  
WO/2020/219859A1
Disclosed are trans-enoyl CoA reductase (TER) enzymes and nucleic acids encoding them. In some cases, the TER enzymes are non- natural, engineered trans-enoyl CoA reductase. TER enzymes were shown to catalyse the conversion of 5-carboxy-...  
WO/2020/219863A1
Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam. The engineered microorganisms include selected aldehyde dehydrogenase activity.  
WO/2020/212453A1
The invention relates to the use of an aldolase when carrying out a process comprising multiple successive crossed aldol reactions.  
WO/2020/211013A1
Disclosed are a monooxygenase mutant and use thereof. The amino acid sequence of the monooxygenase mutant is an amino acid sequence obtained by mutating the amino acid sequence as shown in SEQ ID NO: 1. The mutation comprises at least on...  
WO/2020/206051A1
Described herein is a method for producing indole-3-propionic acid and other indole derivatives via bacterial fermentation and compositions of the same. The method comprises adding bacteria Clostridium sporogenes ATCC15579 having a nucle...  
WO/2020/192560A1
The present invention discloses a chiral isoquinoline carboxylic acid (Ⅰ) and a preparation method thereof, the preparation method includes: reacting the racemate of isoquinoline carboxylate in an aqueous buffer solution under the cata...  
WO/2020/185626A1
Provided herein, among other things, is an engineered non-plant cell that produces a tropane alkaloid product, a precursor of a tropane alkaloid product, or a derivative of a tropane alkaloid product. A method for producing a tropane alk...  
WO/2020/177568A1
The present invention relates to an LL-D49194α1 analog, a preparation method therefor and an application thereof. Specifically, provided by the present invention is a deglycosylated and demethylated LL-D49194α1 analog. The obtained LL-...  
WO/2020/180736A2
The present invention provides methods and compositions for producing cannabinoids in photosynthetic microorganisms, e.g., cyanobacteria.  

Matches 1 - 50 out of 9,005