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JPS6122959B2 |
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JPS6119237B2 |
A novel O-transcarbamoylase enzyme and its use in preparing a variety of 3-carbamoyloxymethyl cephalosporins from 3-hydroxymethyl cephalosporins and carbamoyl compounds are described.
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JPS6167489A |
The immobilised Bacillus subtilis cells are used to prepare 7- beta -acylamido-3-hydroxymethyl-3-cephem-4-carboxylic acids from reversibly protected 7- beta -acylamidocephalosporanic acids.
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JPS6111600B2 |
3-Hydroxymethylceph-3-em-4-carboxylic acids are prepared by esterase-catalysed hydrolysis from the corresponding 3-acyloxymethylceph-3-em-4-carboxylic acids. The esterase used for this purpose is obtained by cultivation of a microorganis...
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JPS6147491A |
NEW MATERIAL:The compound of formula I (R1 is H or formylamino; R2 is 1W 2 amino acid or peptide residue selected from serine and alanine, or H; R3 is group of formula II or -CH2-NH2) and its salt, having the following physical and chemi...
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JPS614520B2 |
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JPS60260585A |
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.
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JPS6057837B2 |
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JPS60227675A |
A novel O-transcarbamoylase enzyme and its use in preparing a variety of 3-carbamoyloxymethyl cephalosporins from 3-hydroxymethyl cephalosporins and carbamoyl compounds are described.
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JPS6041587B2 |
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JPS6035115B2 |
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JPS60142993A |
A process for producing unnatural penicillins and cephalosporin derivatives thereof in which peptide analogs of ACV in which the L- alpha -aminodipyl moiety is replaced by L-S-carboxymethyl cysteine or other substituents, are reacted wit...
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JPS60110292A |
NEW MATERIAL:The DNA fragment carrying the gene information concerning the production of the acylase for a cephalosporin compound and obtained by incising the whole DNA of a bacterium belonging to Comamonas genus with a restriction enzym...
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JPS6078989A |
NEW MATERIAL:Chitinovorin-C shown by the formula and its salt. Showing the following physical and chemical properties (all are measured by Na salt except molecular weight). Molecular weight: 416. Solubility: soluble in water or dimethyl ...
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JPS6066987A |
NEW MATERIAL:Cephem based antibiotic substances TAN-547A, B, C or salts thereof having the following properties; Ultraviolet absorption spectra λmaxH2O=260+2nm. Circular dichroic spectrum showing the Cotton effect of (-) at 228±2nm and...
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JPS6066981A |
Self-supported insoluble penicillinamidase prepared by cross-linking the exocellular amidase produced by B. megaterium with a dialdehyde followed by treatment with a salt containing a multivalent anion provides a superior hydrolytic cata...
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JPS6010038B2 |
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JPS606957B2 |
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JPS60995B2 |
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JPS6040B2 |
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JPS5950317B2 |
Pressure-driven enzyme-coupled membranes are prepared starting with a membrane filter having pores of appropriate, molecular dimensions and composed of a polymeric matrix, the activation of that matrix (where necessary) under pressure-dr...
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JPS5937079B2 |
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JPS5931517B2 |
7 alpha -Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7 alpha -methoxycephalosporin derivatives.
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JPS59108790A |
7-(S)-Acylamino-3-hydroxymethyl-3-cephem sulfones are disclosed. These compounds are intermediates in the synthesis of 1-oxa beta -lactam antibiotics.
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JPS5991895A |
The enzymes, cyclase, epimerase and a ring expansion enzyme, are isolated separately from a cell-free extract of a prokaryotic beta-lactam producing organism. The isolated enzymes are used to produce unnatural cephalosporins from polypep...
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JPS5920360B2 |
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JPS5915635B2 |
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JPS5944392A |
PURPOSE: To prepare the titled compound useful as a synthetic intermediate for cephalosporin antibiotic substances under mild conditions in a short time, by directly deacylating the side chain at the 7-position of cephalosporin C biologi...
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JPS5910200B2 |
Increased yields of the known and useful antibiotic cephamycin C [7-(D-5-amino-5-carboxyvaleramido)-3-(carbamoyloxymethyl)-7-
methoxy-3- cephem-4-carboxylic acid] are obtained by the addition of D- or DL-arginine, D- or DL-ornithine and/...
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JPS594120B2 |
A process for producing an antibiotic Cephamycin C which comprises cultivating a strain of Streptomyces sp. OFR 1022 in a culture medium to accumulate therein Cephamycin C and recovering said Cephamycin C.
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JPS5858080B2 |
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JPS58212794A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS5837315B1 |
The invention concerns the decarbonylation of the formyl group in 7-amino-3-formyl-ceph-2-em-4-carboxylic acid compounds and 7-amino-3-formyl-ceph-3-em-4-carboxylic acid compounds by treatment with a platinum metal complex capable of tak...
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JPS5833879B2 |
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JPS5830040B2 |
Cephamycin C is concentrated and purified by subjecting a fermentation broth which contains Cephamycin C to the following sequence of steps: filtration at acidic pH, adsorption of filtrate on activated carbon, removing the adsorbed antib...
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JPS5829079B2 |
A process for the isolation and purification of cephalosporin from a solution containing impurities which includes treating the solution with macroporous non-ionic adsorption resin to adsorb the cephalosporin thereto and then eluting the...
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JPS5879996A |
Plasmid pAC 1, which is obtained from Acremonium chrysogenum ATCC 14553 and has a contour length of about 6.7 mu m and a molecular size of about 20.9 kilobases (=kb), a process for obtaining it and its use for preparing a hybrid vector w...
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JPS5876099A |
PURPOSE: To purify cephamycin C from a cephamycin C-containing culture filtrate efficiently, by treating the culture solution with an ion exchange resin, desalting it by electrodialysis. CONSTITUTION: A mold, etc. is removed from a cultu...
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JPS5874690A |
Cpds. of formula (I): (where R' is H or an amino protecting gp and R" is H or acyl or R' and R" together form a divalent amino-protecting gp; R2 is H or forms a protected COOH gp. the dotted lines represent a double boond in the 2, 3 or ...
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JPS5820265B2 |
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JPS5817594B2 |
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JPS589680B2 |
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JPS588838B2 |
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JPS586476B2 |
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JPS581919B1 |
1321412 New antibiotics MERCK & CO Inc 19 April 1971 [13 March 1970 30 June 1970 9 Dec 1970 16 Feb 1971] 23407/71 Heading C2A Novel cephalosporin-like antibiotics have the Formula I wherein R is hydrogen, halo, hydroxy, lower alkanoyloxy...
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JPS581918B2 |
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JPS5761400B2 |
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JPS5759760B2 |
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JPS5754518B2 |
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JPS5752840B2 |
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