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WO/2024/030345A1 |
Disclosed are compositions, methods, systems, and kits for the detection of African swine fever virus (ASFV) in a test sample, and in particular for distinguishing between wild/reference type ASFV and mutant/variant strains of ASFV. A va...
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WO/2024/029511A1 |
This evaluation method evaluates whether a protein of interest bonds with a target protein and comprises: a step (a) in which a protein of interest, a target protein, a first specific binding substance for the protein of interest, labele...
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WO/2024/028589A1 |
The invention relates to means and methods for producing libraries of analytes, such as polynucleotides, from a plurality of samples, such as single cells. The invention uses micro- particles that include both barcoded analyte capture po...
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WO/2024/026566A1 |
A microfluidic device is provided for culturing cell spheroids or organoids and therapeutics screening, the microfluidic device comprising a shell and an at least one sector, the shell comprising a multiplicity of segments, each segment ...
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WO/2024/031065A2 |
Modified subtilisin proteins and polypeptides are provided herein. Many of the modified subtilisin proteins and polypeptides exhibit an altered poly(L) lactic acid (PLLA) depolymerizing activity. Methods of depolymerizing PLLA methods of...
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WO/2024/022529A1 |
Measuring quantities (e.g., relative frequencies) of particular sequence motifs of cell-free DNA fragments in a biological sample can be used to analyze the biological sample. The particular sequence motifs or sequence sizes in certain g...
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WO/2024/024455A1 |
For each combination of a plurality of wavelengths and a plurality of intensities, an eye cell sample having a wound is intermittently irradiated with light having the wavelength and the intensity of the combination. The status of the co...
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WO/2024/024795A1 |
The purpose of the present invention is to provide a beauty level estimation system and a beauty level estimation method for calculating the beauty level of a pet raised by a user, on the basis of a correlation between diversity data rel...
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WO/2024/024989A1 |
This micro-organism growth detection method involves: preparing droplets containing pigment in which the fluorescence intensity changes due to the interaction between micro-organisms and a film component containing the micro-organisms in...
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WO/2024/023436A1 |
The field of the invention relates to a method for assessing the photoprotective potential of a device, said method comprising measuring DNA photoproducts in body fluids.
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WO/2024/023324A1 |
The disclosure relates to a combination of biomarkers comprising at least: (i-a) one biomarker selected in each of the following group of biomarkers: Patient's age, Plasma steroids, and Urinary steroids, and at least one biomarker select...
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WO/2024/024955A1 |
Provided is a method for producing a vagus-nerve-like parasympathetic nerve cell, the method comprising (a) a step for inducing the differentiation of a pluripotent stem cell into a parasympathetic nerve cell, and (b1) a step for introdu...
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WO/2024/025750A1 |
A non-healthcare setting kit for diagnosing a biological sample from a user is disclosed. The kit includes a mobile application that may run on a mobile device, a collection container for the biological sample, a cartridge that docks wit...
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WO/2024/024583A1 |
Provided is a method for efficiently synthesizing, by a simple procedure, a double-stranded DNA library having different tagment sequences on the 5' terminal and 3' terminal sides. The method includes the following steps (i) to (iii): ...
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WO/2024/026103A1 |
The present disclosure relates to a method of determining whether a subject is at risk of prostate cancer recurrence based on the detection of fusion genes.
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WO/2024/025361A1 |
The present invention relates to: a composition for verifying next-generation sequencing (NGS) panels, comprising homozygous DNA and control genomic DNA; a kit for verifying NGS panels, comprising the composition; a method for verifying ...
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WO/2024/021464A1 |
A method for surface chemical treatment and packaging bonding of a sequencing chip. The method comprises: punching a wafer substrate; etching a flow channel structure on a wafer cover plate; bonding the punched wafer substrate and the et...
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WO/2024/026326A2 |
Methods for treating and/or prognosing breast cancer are provided. The method includes determining an Immunescore (IS) for gene sets selected from an immunological signature gene set, wherein the IS is based on an immunological model, de...
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WO/2024/023368A1 |
The invention relates to a method for the prediction of an increase of dipeptidyl peptidase 3 (DPP3) in a critically ill patient. In particular, the method comprises providing a sample from said patient, determining a level of Dipeptidyl...
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WO/2024/021748A1 |
A droplet preparation device and a method. A chip (3) and a temperature control module (6) are both arranged in a chamber (5); the temperature control module (6) is used for regulating the temperature value of the interior of the chip (3...
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WO/2024/026440A1 |
Provided herein are methods, compositions, kits and systems for the detection, identification and quantification of bacteria and fungi. In particular, provided herein are methods, compositions, kits and systems comprising oligonucleotide...
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WO/2024/026007A1 |
Provided herein are compositions and methodologies for identifying microbes in biofilms and adhered to biotic and abiotic surfaces, utilizing enzymes that degrade biofilms and disperse aggregated clusters of microorganisms. Utilizing enz...
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WO/2024/024427A1 |
The present disclosure provides a method for determining outer membrane detachment in a cyanobacterium that makes it possible to conveniently determine whether or not the outer membrane of the cyanobacterium has been detached from the ce...
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WO/2024/024895A1 |
The present invention provides a treatment agent for NK2 Homeobox 1 (NKX2-1)-negative lung adenocarcinomas that includes a Porcupine inhibitor as an active ingredient, an NKX2-1-negative lung adenocarcinoma organoid, and a screening meth...
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WO/2024/025923A1 |
The present disclosure provides methods for assessing responsiveness or non-responsiveness to a therapeutic agent (e.g., ICB therapy and/or anti-angiogenic) in subjects having a cancer or tumor based on angio-immune panel signatures. The...
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WO/2024/021686A1 |
An ultra-sensitive nanopore structure, a chip, an analysis device, an amino acid detection method, a protein detection method, and a use. The ultra-sensitive nanopore structure relates to a nanopore (8); the pore diameter of the nanopore...
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WO/2024/023523A1 |
The present invention relates to methods for extracting nucleic acids from a sample comprising one or more cells. The methods comprise steps of lysing and mechanically disrupting cells in order to provide optimum parallel extraction of b...
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WO/2024/025831A1 |
Methods and systems for detecting contaminated fragments in a biological sample for cancer classification are disclosed. The system identifies CpG-SNP contamination markers. The CpG-SNP contamination markers include at least one SNP that...
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WO/2024/026336A2 |
Methods and oligonucleotide reagents for genotyping Epstein-Barr virus are disclosed. In particular, genetic profiling is used to detect BALF2 variants in the genome of Epstein-Barr virus in an infected individual to predict the risk of ...
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WO/2024/023219A1 |
In an example of a method, a deoxyribonucleic acid sample is exposed to tagmentation in the presence of a tagmentation buffer including a divalent cation cofactor and a transposase enzyme to generate a tagmented DNA fragment complex. A c...
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WO/2024/026418A1 |
Provided are compositions and methods for prophylaxis or treatment of a disorder associated with type I interferon induced inflammation. The compositions involve use of an agent that inhibits the function and/or reduces the level of long...
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WO/2024/026275A1 |
Methods and systems for determining a loss of heterozygosity (LOH) status of the one or more HLA-T genes are described. The methods may comprise, for example: identifying, using one or more processors, a plurality of genomic segments in ...
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WO/2024/020909A1 |
Disclosed herein is directed to a lactate oxidase variant that exhibits reduced affinity to lactate as compared to a wild-type lactate oxidase. The lactate oxidase variant has one or more amino acid substitutions occurring at positions 9...
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WO/2024/026362A2 |
Provided herein are pseudoviruses expressing a SARS-CoV-2 S glycoprotein. Also provided herein are assays that employ the pseudoviruses to evaluate the immunogenicity of a biological sample against a SARS-CoV-2 virus or variant thereof. ...
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WO/2024/022738A1 |
The present invention is based, in part, on the definition of a plurality of panels of genes and/or fragments thereof (target sequences within the genes) as defined in the claims, which allow the accurate classifying of an endometrium be...
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WO/2024/026427A1 |
Methods and systems for species identification are disclosed. The methods and systems include: obtaining first, second, and third trained artificial intelligence (AI) models; obtaining one or more runtime images including a subject; dete...
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WO/2024/024646A1 |
The present invention provides an expression vector carrying a gene encoding LHFPL6 protein and a gene encoding TM7SF3 protein. The present invention also provides a vector set comprising an expression vector carrying a gene encoding LHF...
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WO/2024/025806A1 |
The presently described techniques relate generally to providing motion feedback (e.g., motion system calibration and/or sample alignment) in the context of an imaging system (such as a time delay and integration (TDI) based imaging syst...
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WO/2024/026509A2 |
The present disclosure provides methods for individualized selection of, and monitoring of treatment using a neurodegenerative therapeutic agent such as Sigma-1 receptor agonist therapy for a subject, based on changes in gene expression ...
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WO/2024/025481A1 |
Provided is a CRISPR RNA (crRNA) applicable in a CRISPR-based ribonucleoprotein (RNP) system for reacting towards one or more genetic materials derived from Burkholderia pseudomallei in a biological sample. The crRNA comprises a spacer r...
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WO/2024/025815A1 |
Described are methods and apparatuses for isolating and purifying mRNA using Immobilized Metal Affinity Chromatography (IMAC). The methods and apparatuses use IMAC matrices and IMAC conditions designed to selectively bind and elute mRNA,...
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WO/2024/026084A2 |
A method for storage of digital information via a biopolymer includes: receiving digital information; designing a target biopolymer sequence; encoding the digital information; synthesizing the target biopolymer sequence via a layered mic...
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WO/2024/023860A1 |
The present invention concerns a method for predicting the development of resistance to BRAF inhibiting drugs, alone or in combination with MEK inhibiting drugs (i.e. MAPK pathway inhibitors or simply MAPKi), in an anti-tumour treatment,...
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WO/2024/023510A1 |
The present invention provides methods for detecting and/or distinguishing one or more single nucleotide polymorphisms (SNPs) in a target nucleic acid sequence in a sample, the method comprising: providing a first oligonucleotide probe c...
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WO/2024/026360A2 |
Disclosed herein is an assay for measuring inhibition of binding between SARS-CoV-2 Spike (S) glycoproteins and hACE2. Also provided herein are methods of using the assay to evaluate the efficacy of COVID-19 vaccines.
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WO/2024/021172A1 |
Provided in the present invention are an SNP molecular marker associated with intramuscular fat traits in pigs and the use thereof, and a method and kit for detecting the molecular marker. The SNP molecular marker is a base at position 1...
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WO/2023/114915A9 |
The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifyi...
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WO/2024/026376A2 |
The present disclosure provides methods and systems for performing experiments and computational methods for generating, analyzing, and using multi-omics data and leveraging such multiomics data and computational analysis for application...
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WO/2024/025247A1 |
The present invention provides an analytic method to provide information needed for the diagnosis of patients with ovarian cancer resistant to cisplatin, which is an anticancer drug widely used in the treatment of ovarian cancer, the met...
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WO/2024/026364A2 |
The present disclosure provides a multiplexed fluorescence in situ hybridization method that enables single-cell and spatial analysis of gene expression in plant tissue in a transgene-free manner. The present disclosure provides methods ...
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