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WO/2024/025536A1 |
We used a powerful longitudinal within-subject design in individuals with psychiatric disorders to discover blood gene expression change between self-reported low anxiety and high anxiety states. We prioritized the list of candidate biom...
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WO/2024/022207A1 |
The methods and compositions disclosed herein relate to preparing libraries to sequence long molecules in their entirety using massively parallel short read sequencing. The methods disclosed herein generate a nested set of nucleic acid c...
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WO/2024/023944A1 |
A genetic testing device 1 further comprises a calculation unit 2d that adds, to the time at which an analyte is put, an available standby time depending on the priority of the analyte and calculates a target time by which dispensation t...
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WO/2024/026441A2 |
The invention provides methods and device for determining the identity and order of units of large biopolymers. Device of the invention use electrical fields to translocate the molecule through the channel and pass the molecule, base-by-...
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WO/2024/024147A1 |
Disclosed are: a method for identifying, by using refractive index distribution data of an observation object containing liver cells, bile canaliculus regions included in the observation object; and a method for evaluating the bile canal...
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WO/2024/026035A2 |
Provided herein are isolated peptides that bind to a phage that infects and lyses the pathogenic bacterium P. aeruginosa. The peptides are useful as in vivo tracers for the real-time analysis of phage therapy.
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WO/2024/026075A1 |
Methods and systems are disclosed for covariate prediction from methylation features. A system identifies a feature set of genomic regions by training one or more regressions to evaluate a covariance score of a genomic region. The system...
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WO/2024/019555A1 |
The present invention relates to a molecular biological composition, kit, and diagnostic method for diagnosing Alzheimer's disease dementia by measuring the methylation level of CpG sites in the promoter of the ATPase secretory pathway C...
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WO/2024/017155A1 |
Provided is a bubble-free lysis composition capable of rapidly lysing and releasing a nucleic acid of a virus and the like, wherein the lysis composition is acidic and does not contain a surfactant and a guanidine salt, and thus has almo...
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WO/2024/017510A1 |
The present invention relates to the field of in vitro methods for identifying a subject suitable for treatment with a combination of immunotherapy and chemotherapy by identifying a specific genetic signature in a biological sample from ...
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WO/2024/020122A1 |
The methods, compositions and kits described herein provide signal amplification approaches for the detection of target biomolecules that significantly increase the sensitivity of detection using target-binding ligand molecules. The meth...
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WO/2024/020543A2 |
The present disclosure features kits and methods for diagnosis and treatment of actinomycetia (e.g., corynebacteriales) infections, e.g., caused by mycobacterial cells. The methods include using a mixture of lytic enzymes to specifically...
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WO/2024/020441A1 |
The present disclosure provides improved breeding methods that allow for the selection of a member or members of a population having a desired phenotype using a limited number of genetic markers. In certain aspects, the methods for selec...
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WO/2024/020348A2 |
The present disclosure provides a device comprising a transducer with adjustable focus. In some examples, the device comprises an acoustic transducer configured to provide an acoustic beam. The device may further comprise a lens mount ac...
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WO/2024/020036A1 |
Methods and systems for segmenting sequencing regions obtained from a sample interval are disclosed, sample contamination detection are disclosed. In particular, an analytics system accesses test sequences from a sample. The test sequenc...
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WO/2024/018485A1 |
Methods and systems for detection and identification of pathogens and antibiotic resistant genes are disclosed herein. The method is a high throughput, rapid comprehensive method for identification of pathogens in a sample or subject. Th...
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WO/2023/158740A9 |
The present invention relates to systems and methods for well planning and management in a field to maximize the production of hydrocarbons. Specifically, the present invention involves identifying microbial compositions (including pheno...
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WO/2024/018188A1 |
The present invention relates to virus-like particle (VLP) that include one or more viral capsid protein heterodimer(s) each comprising a first monomer encoded by a first amino acid sequence and a second monomer encoded by a second amino...
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WO/2024/017382A1 |
The present invention provides a primer pair for detecting porcine genome DNA, a detection reagent or kit containing the primer pair of the present invention, and a method for detecting porcine genome DNA by using the primer pair. The pr...
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WO/2024/020343A1 |
Embodiments of the present disclosure are directed to systems and methods comprising receiving training data comprising training values for a plurality of training input features associated with a gene receptor status in a plurality of t...
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WO/2024/017393A1 |
A primer pair for detecting bovine genomic DNA, a detection reagent or kit containing the primer pair, and a method for detecting bovine genomic DNA by using the primer pair, the primer pair specifically binding to the sequence represent...
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WO/2024/016730A1 |
A method for reducing the off-target rate of a Cas protein (such as CRISPR-Cas12a) specifically cleaving a target nucleic acid by changing the concentration of ions or ions. Specifically, provided is a reaction system comprising a soluti...
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WO/2024/020527A1 |
The present invention provides methods for using waste effluent biofluids in cell culture assays as all or part of the cell culture microenvironment. Methods of the invention contemplate that biofluids typically regarded as waste may be ...
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WO/2024/020395A2 |
Provided herein are compositions, kits, and methods for collection, integration and analysis of various facets of information from tissues at the cellular or subcellular level. Information includes spatial mapping from nucleic acid barco...
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WO/2024/020373A2 |
Various compositions and diagnostic devices for the detection of nucleic acids are provided. Also provided are systems comprising the same, and methods of using the same. In some embodiments, compositions and devices comprise or are conf...
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WO/2024/020364A1 |
Methods and systems to control continuous gas fermentation platforms for improved conversion of gas substrates into products is developed and particularly relates to a control process and system to control feedstock gases and maximize th...
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WO/2024/020412A2 |
Methods and systems for rapid preparation of a nucleic acid sample.
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WO/2024/018266A1 |
The present invention relates to a method for simultaneously detecting and identifying multiple species of mussels of the genus Mytilus and associated oligonucleotides/probes, including their first-generation hybrids and hybrids from oth...
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WO/2024/017263A1 |
Provided is a composition comprising an antibody linked with an oligonucleotide via a disulfide bond, wherein the oligonucleotide is specific for the antibody. Further provided is a kit comprising the same and the method for detecting on...
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WO/2024/019165A1 |
The present invention addresses the problem of providing a method and a kit for easily detecting a microorganism or a cell. Provided are a method for detecting a microorganism or a cell, and a kit for the method. The method comprises a...
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WO/2024/019492A1 |
The present invention relates to a COVID-19 infection model using lung organoids. Lung organoids infected with a respiratory virus, produced according to the present invention, are expected to be effectively used in preclinical or clinic...
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WO/2024/018097A1 |
The present invention relates to a diagnosis method for bladder cancer and a cancer staging method of the tumour that caused it. The method comprises measuring the expression levels of a miRNA group in a sample extracted from a patient. ...
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WO/2024/017613A1 |
The present invention relates to a composition which can be used as spike-in cocktail. Further, the present invention relates to a kit comprising the composition. Furthermore, the present invention relates to a method for examining a sam...
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WO/2024/020398A1 |
The present disclosure is directed to methods for measuring proteomes of single cells. In one aspect, methods comprise disposing cells on a surface, synthesizing hydrogel chambers around each of the cells, lysing the cells to release int...
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WO/2024/018079A1 |
The present invention proposes a method of determining the existence and/or degree of resistance of a microorganism to one or more antimicrobial agents.
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WO/2024/020124A1 |
The methods, compositions and kits described herein provide signal amplification approaches for the detection of target biomolecules that significantly increase the sensitivity of detection using target-binding ligand molecules. The meth...
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WO/2024/019657A1 |
This document describes a system and method for enumerating a concentration of microorganism in a liquid sample. The disclosed system has a filtration medium that has an inlet for receiving the liquid sample and an outlet for removing a ...
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WO/2024/016625A1 |
Provided in the present invention is a rapid next-generation sequencing method, which comprises the following steps: polymerization, involving: a detection complex is linked to a primer hybridized to a nucleic acid molecule to be detecte...
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WO/2023/240611A9 |
The present invention belongs to the field of gene sequencing, and particularly relates to a library construction and sequencing method for a single-stranded nucleic acid cyclic library. In the method, a sequencing primer binding sequenc...
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WO/2024/020166A1 |
Buffer compositions, such as two-part buffer compositions and buffer systems, methods, assays, kits and kits of parts comprising buffers, for rapid, non-hazardous and fully automated extraction of nucleic acids from various samples. The ...
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WO/2024/020325A1 |
The present disclosure provides devices, systems, and methods capable of optimizing in vivo electrochemical measurement of a molecule of interest, for example glucose. Disclosed aspects may include an interference zapping layer, to which...
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WO/2024/019326A1 |
The present disclosure relates to a method and a device for predicting a nucleic acid amount on the basis of a pathological image and proposing the optimal gene test. This method may comprise the steps of: receiving a pathological image ...
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WO/2024/019113A1 |
Provided, with respect to the production of inactivated whole influenza virus particle vaccines using the embryonated chicken egg method, is a method for reducing pyrogenic activity. With respect to the method for producing an inactiva...
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WO/2024/016944A1 |
Disclosed is a novel molecular target through which aspirin exerts a neuroprotective effect on cerebral apoplexy. Aspirin exerts a neuroprotective effect on a mouse model of cerebral apoplexy by means of acetylating calcium ion-calmoduli...
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WO/2024/017763A1 |
The present invention relates to a method for detecting a target nucleic acid in a sample using an optimized SMART method that comprises the use of at least one fluorogenic aptamer for the direct detection of the RNA transcripts. Prefera...
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WO/2024/018971A1 |
The purpose of the present invention is to accurately calculate the number of cells. A cell culture device 1 comprises a sensor 26 for measuring the lactic acid concentration in a medium. The sensor 26 measures the concentration of lacti...
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WO/2024/020573A1 |
The disclosure relates to improved sequencing reactions. Specifically, the disclosure provides methods which allow for the identification of regions of a DNA molecule that were synthesized during an end repair and/or A-tailing reaction. ...
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WO/2024/020414A1 |
Methods and systems for rapid preparation of a nucleic acid sample.
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WO/2024/020578A2 |
Systems and methods for determining an effect regulatory untranslated RNA elements are provided. A plurality of RNA untranslated region (UTR) sequences are designed, subject to a requirement that each UTR RNA sequence includes one or mor...
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WO/2024/016461A1 |
Provided in the present invention is a method for preparing a bispecific-probe-coupled capture magnetic bead, which method comprises: coupling a capture magnetic bead to a bispecific probe, wherein hypoxanthine is introduced into a posit...
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