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WO/2022/082619A1 |
The present invention provides a penicillin refining system and a refining method therefor. The penicillin refining system comprises: a fermentation tank and a control system, wherein the top portion of the fermentation tank is provided ...
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WO/2020/243431A1 |
Described herein are recombinant edible filamentous fungal strain comprising a genetic modification of a gene in a mycotoxin biosynthesis pathway and methods to produce such recombinant edible filamentous fungal strains. Such recombinant...
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WO/2020/156176A1 |
The present application relates to the technical field of antibiotic medicine, and relates to a phenoxyacetic acid derivative and a method for preparing a penicillin V salt by using an enzymatic method of said phenoxyacetic acid derivati...
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WO/2017/186864A1 |
The invention provides an improved process for producing β-lactam antibiotics catalyzed by an enzyme, which is immobilized onto a carrier, wherein the resulting β-lactam antibiotics are poorly soluble in the reaction media. The process...
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WO/2017/178624A1 |
The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with a...
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WO/2016/179464A1 |
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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WO/2016/046055A1 |
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...
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WO/2014/003555A1 |
The invention relates to improved means and methods for producing a compound of interest in fungal host cells. Provided is a method for producing at least one secondary metabolite in a fungal host cell, comprising culturing a fungal host...
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WO/2013/191678A1 |
The invention relates to methods of making compounds useful for production of paclitaxel and analogs or derivatives thereof.
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WO/2013/113646A1 |
The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isop...
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WO/2012/113120A1 |
A new nucleotide sequence of xylose isomerase obtained from the metagenomic library of cattle rumen liquor and the amino acid sequence encoded thereof, vectors and transformants containing the said nucleotide sequence are provided. The s...
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WO/2011/161004A1 |
The present invention relates to an industrial scale fermentation process for the production of valuable compounds using microorganisms wherein ≥50% of the total energy input is delivered by injection of an oxygen containing gas and â‰...
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WO/2010/115838A1 |
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...
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WO/2010/072765A2 |
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...
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WO/2010/055527A1 |
The present invention provides a stable and viable biocatalyst with high activity and operational stability and method of immobilization thereof. The immobilization process is based on the principle of entrapment of partially purified en...
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WO/2010/054319A2 |
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
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WO/2009/133098A2 |
The present invention relates to a method for the identification of one or more genes of a parent microbial strain capable of producing a β-lactam compound and to mutant microbial strains in which the identified genes have been the func...
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WO/2009/092727A1 |
Genetically modified Saccharomyces having the ability to synthesize non-ribosomal peptides and precursors thereof.
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WO/2009/016642A1 |
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIPl and processing of PA into biocatalyst useful...
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WO/2008/110527A1 |
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side ch...
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WO2007030772A9 |
Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (...
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WO/2008/040731A2 |
The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cys...
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WO/2007/138148A1 |
The present invention describes different PGA enzyme mutants prepared by inserting one (1) Cys (in each mutant) in a different region of the surface of the enzyme which was relatively rich in lysine residues as well as immobilized forms ...
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WO/2007/116724A1 |
Disclosed is a novel process for producing a 1β-methylcarbapenem compound by culturing a microorganism. A 1β-methylcarbapenem compound can be produced by culturing a microorganism capable of producing a carbapenem compound, particularl...
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WO/2007/006593A2 |
The present invention relates to a mutant expandase that is a variant of a model polypeptide with expandase activity whereby the mutant expandase has an at least 2.5-fold improved in vitro expandase activity towards adipyl-6-APA in compa...
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WO2006058942B1 |
The invention relates to a method of producing 6-aminopenicillanic acid using the aculeacin A acylase enzyme of Actinoplanes utahensis, which is purified from recombinant bacteria Streptomyces lividans CECT 3377. More specifically, the i...
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WO/2006/089946A2 |
The present invention relates to novel acyltransferase polypeptides, as well as the polynucleotides that encode them, that are particularly useful in the production of beta-lactam intermediates and antibiotic compounds having adipoyl sid...
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WO/2006/089951A1 |
The present invention relates to polypeptides with acyl-CoA:isopenicillin N acyltransferase (AT) activity that are variants of a model polypeptide with AT activity, the variants having a modified specificity for the side chain and/or a m...
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WO/2006/069984A2 |
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...
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WO/2006/061425A2 |
The present invention describes the transformation of a microorganism that does not naturally produce a beta-lactam compound with polynucleotides involved in the biosynthesis of beta-lactam compounds and the use of such transformed micro...
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WO/2006/048886A2 |
A method for performing chemically analyzing samples (e.g. bodily fluids) dispensed with an acoustic ejection device is disclosed. A method preparing a sample for analysis by centrifuging the sample in a sample collection device in fluid...
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WO/2006/025735A2 |
The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein ...
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WO/2005/095624A2 |
The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleot...
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WO/2005/045205A2 |
A combinatorial lubricating oil composition library is provided comprising a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating viscosity and (b) at least one lubricating oil ad...
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WO/2004/111241A1 |
The present invention relates to a novel enzyme having Penicillin G acylase activity, characterised by a. an initial Synthesis/Hydrolysis ratio (S/Hini) of at least 50% above the S/Hini of Penicillin G acylase of E. coli and b. an initia...
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WO/2004/092344A2 |
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to catalyze the decarboxylation of para-hydroxy...
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WO/2004/092392A2 |
Methods are provided for the production and recovery of multifunctional aromatic compounds from a fermentation medium. Preferred multifunctional aromatic compounds include para-hydroxycinnamic acid (pHCA), cinnamic acid (CA), and para-hy...
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WO/2004/062558A2 |
The present invention describes a process for the preparation of β-lactam antibiotics, cephalexin and ampicillin, wherein the β-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyzed by...
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WO/2004/048559A1 |
A metabolically engineered micro-organism has an operative first metabolic pathway in which a first metabolite is transformed into a second metabolite in a reaction in which NAD is a cofactor for a first enzyme, suitably a phosphorylatin...
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WO/2003/104446A1 |
It is intended to provide a highly active β-lactam acylase protein; a gene encoding this β-lactam acylase protein; a recombinant vector having this gene; a transformant containing this recombinant vector; and a process for producing a ...
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WO/2002/085913A1 |
A penicillin and cephalosporin compound having a phenylacetic acid or phenoxyacetic acid content of 100 ppm or lower; and a process for producing a penicillin and cephalosporin compound which comprises extracting two or more times phenyl...
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WO/2002/024865A2 |
Disclosed are methods for the modulation of secondary metabolite production by fungi through genetic manipulation of such fungi. Also disclosed are new commercial processes using ZBC proteins, or variants thereof, to significantly increa...
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WO/2002/020819A2 |
An enzymatic process for the preparation of a semi-synthetic $g(b)-lactam antibiotic compound by reacting an N-substituted $g(b)-lactam with two enzymes, namely a penicillin acylase and an $g(a)-amino acid ester hydrolase or microorganis...
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WO/2002/018618A2 |
The invention relates to a process for the preparation of an aqueous solution or suspension of a $g(b)-lactam nucleus and application thereof. The aqueous solution or suspension of the $g(b)-lactam nucleus is prepared by process wherein ...
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WO/2001/098518A2 |
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicam...
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WO/2001/042426A1 |
The invention relates to a method for obtaining a Penicillium chrysogenum transgenic merodiploid strain in which the activity of the regulating gene controlling the biosynthesis of penicillin has been altered in a targeted manner. Hence,...
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WO/2001/032904A2 |
An method for enhancing the secretion of a $g(b)-lactam compound from a micro-organism is described, together with an isolated polynucleotide encoding the ABC transporter protein responsible for said enhanced secretion. Furthermore an is...
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WO/2001/030977A2 |
The invention relates to organisms producing increased levels of clavulanic acid and other 5R clavams, including those with strong $g(b)-lactamase inhibitory activity, in combination with low or undetectable levels of 5S clavams.
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WO/2001/029073A1 |
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for...
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WO/2001/029202A1 |
Immobilization of penicillin V acylase of Streptomyces lavendulae ATCC 13664 on commercial support Eupergit C has made it possible to obtain biocatalyst ECPVA, a novel acylase immobilized penicillin for obtaining 6-APA from penicillin V....
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