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Matches 1 - 50 out of 430

Document Document Title
WO/2017/186864A1
The invention provides an improved process for producing β-lactam antibiotics catalyzed by an enzyme, which is immobilized onto a carrier, wherein the resulting β-lactam antibiotics are poorly soluble in the reaction media. The process...  
WO/2017/178624A1
The present invention relates to a method to improve the production of a secondary metabolite catalyzed by a non-ribosomal peptide synthetase comprising contacting in a eukaryotic host a eukaryotic non-ribosomal peptide synthetase with a...  
WO/2016/179464A1
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.  
WO/2016/046055A1
The present invention relates to the hemi sulfuric acid salt of D-phenylglycine methyl ester, to a method for the preparation of said salt and to the use of said salt in the enzymatic synthesis of antibiotics and of D-phenylglycine methy...  
WO/2014/003555A1
The invention relates to improved means and methods for producing a compound of interest in fungal host cells. Provided is a method for producing at least one secondary metabolite in a fungal host cell, comprising culturing a fungal host...  
WO/2013/191678A1
The invention relates to methods of making compounds useful for production of paclitaxel and analogs or derivatives thereof.  
WO/2013/113646A1
The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isop...  
WO/2012/113120A1
A new nucleotide sequence of xylose isomerase obtained from the metagenomic library of cattle rumen liquor and the amino acid sequence encoded thereof, vectors and transformants containing the said nucleotide sequence are provided. The s...  
WO/2011/161004A1
The present invention relates to an industrial scale fermentation process for the production of valuable compounds using microorganisms wherein ≥50% of the total energy input is delivered by injection of an oxygen containing gas and ...  
WO/2010/115838A1
The present invention describes a process for the production of a valuable compound comprising a fermentation of a microbial strain on industrial scale comprising a non-repressing C-source and feeding at least one growth rate limiting nu...  
WO/2010/072765A3
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...  
WO/2010/072765A2
The present invention relates to a mutant prokaryotic penicillin G acylase derived from a wild-type penicillin G acylase characterized in that the mutant is having an amino acid substitution at one or more amino acid positions selected f...  
WO/2010/055527A1
The present invention provides a stable and viable biocatalyst with high activity and operational stability and method of immobilization thereof. The immobilization process is based on the principle of entrapment of partially purified en...  
WO/2010/054319A3
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.  
WO/2010/054319A2
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.  
WO/2009/133098A3
The present invention relates to a method for the identification of one or more genes of a parent microbial strain capable of producing a β-lactam compound and to mutant microbial strains in which the identified genes have been the func...  
WO/2009/133098A2
The present invention relates to a method for the identification of one or more genes of a parent microbial strain capable of producing a β-lactam compound and to mutant microbial strains in which the identified genes have been the func...  
WO/2009/092727A1
Genetically modified Saccharomyces having the ability to synthesize non-ribosomal peptides and precursors thereof.  
WO/2009/016642A1
The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIPl and processing of PA into biocatalyst useful...  
WO/2008/110527A1
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side ch...  
WO2007030772A9
Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (...  
WO/2008/040731A2
The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cys...  
WO/2008/040731A3
The present invention describes a process for the production of an N-α-amino-hydroxyphenylacetyl or an N-α-aminophenylacetyl β-lactam antibiotic comprising an IPNS-catalysed conversion of a precursor tripeptide hydroxyphenylglycyl-cys...  
WO/2007/138148A1
The present invention describes different PGA enzyme mutants prepared by inserting one (1) Cys (in each mutant) in a different region of the surface of the enzyme which was relatively rich in lysine residues as well as immobilized forms ...  
WO/2007/116724A1
Disclosed is a novel process for producing a 1β-methylcarbapenem compound by culturing a microorganism. A 1β-methylcarbapenem compound can be produced by culturing a microorganism capable of producing a carbapenem compound, particularl...  
WO/2007/030772A2
Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (...  
WO/2007/006593A3
The present invention relates to a mutant expandase that is a variant of a model polypeptide with expandase activity whereby the mutant expandase has an at least 2.5-fold improved in vitro expandase activity towards adipyl-6-APA in compa...  
WO/2007/006593A2
The present invention relates to a mutant expandase that is a variant of a model polypeptide with expandase activity whereby the mutant expandase has an at least 2.5-fold improved in vitro expandase activity towards adipyl-6-APA in compa...  
WO2006058942B1
The invention relates to a method of producing 6-aminopenicillanic acid using the aculeacin A acylase enzyme of Actinoplanes utahensis, which is purified from recombinant bacteria Streptomyces lividans CECT 3377. More specifically, the i...  
WO/2006/089946A3
The present invention relates to novel acyltransferase polypeptides, as well as the polynucleotides that encode them, that are particularly useful in the production of beta-lactam intermediates and antibiotic compounds having adipoyl sid...  
WO/2006/089946A2
The present invention relates to novel acyltransferase polypeptides, as well as the polynucleotides that encode them, that are particularly useful in the production of beta-lactam intermediates and antibiotic compounds having adipoyl sid...  
WO/2006/089951A1
The present invention relates to polypeptides with acyl-CoA:isopenicillin N acyltransferase (AT) activity that are variants of a model polypeptide with AT activity, the variants having a modified specificity for the side chain and/or a m...  
WO2006058942A3
The invention relates to a method of producing 6-aminopenicillanic acid using the aculeacin A acylase enzyme of Actinoplanes utahensis, which is purified from recombinant bacteria Streptomyces lividans CECT 3377. More specifically, the i...  
WO2006061425A3
The present invention describes the transformation of a microorganism that does not naturally produce a beta-lactam compound with polynucleotides involved in the biosynthesis of beta-lactam compounds and the use of such transformed micro...  
WO/2006/069984A2
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...  
WO/2006/069984A3
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D- phenylglycine in activated form (PGa) in the presence of an enzyme in a rea...  
WO/2006/061425A2
The present invention describes the transformation of a microorganism that does not naturally produce a beta-lactam compound with polynucleotides involved in the biosynthesis of beta-lactam compounds and the use of such transformed micro...  
WO/2006/058942A2
The invention relates to a method of producing 6-aminopenicillanic acid using the aculeacin A acylase enzyme of Actinoplanes utahensis, which is purified from recombinant bacteria Streptomyces lividans CECT 3377. More specifically, the i...  
WO/2006/048886A2
A method for performing chemically analyzing samples (e.g. bodily fluids) dispensed with an acoustic ejection device is disclosed. A method preparing a sample for analysis by centrifuging the sample in a sample collection device in fluid...  
WO2006025735A3
The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein ...  
WO/2006/025735A2
The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein ...  
WO2005095624A3
The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleot...  
WO2005045205A3
A combinatorial lubricating oil composition library is provided comprising a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating viscosity and (b) at least one lubricating oil ad...  
WO/2005/095624A2
The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleot...  
WO2004048559A8
A metabolically engineered micro-organism has an operative first metabolic pathway in which a first metabolite is transformed into a second metabolite in a reaction in which NAD is a cofactor for a first enzyme, suitably a phosphorylatin...  
WO2004092392A3
Methods are provided for the production and recovery of multifunctional aromatic compounds from a fermentation medium. Preferred multifunctional aromatic compounds include para-hydroxycinnamic acid (pHCA), cinnamic acid (CA), and para-hy...  
WO2004062558A3
The present invention describes a process for the preparation of beta-lactam antibiotics, cephalexin and ampicillin, wherein the beta-lactam nucleus is acylated with an acylating agent, D-phenylglycine, by means of a reaction biocatalyze...  
WO/2005/045205A2
A combinatorial lubricating oil composition library is provided comprising a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating viscosity and (b) at least one lubricating oil ad...  
WO/2004/111241A1
The present invention relates to a novel enzyme having Penicillin G acylase activity, characterised by a. an initial Synthesis/Hydrolysis ratio (S/Hini) of at least 50% above the S/Hini of Penicillin G acylase of E. coli and b. an initia...  
WO/2004/092344A2
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to catalyze the decarboxylation of para-hydroxy...  

Matches 1 - 50 out of 430