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WO/2005/080318A1 |
The invention provides a process permitting easy production in high yield of &agr -aminooxyketones, which are equivalents for the synthesis of monosaccharides or pentoses and equivalents of &agr -hydroxyketones serving as intermediates i...
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WO/2005/077122A2 |
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
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WO/2005/063371A2 |
The invention relates to the use, as a dispersant and/or agent for assisting in the grinding of pigments and/or mineral loads in aqueous suspension, of a water-soluble polymer having a controlled structure and obtained by a controlled ra...
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WO/2005/061444A1 |
It is intended to provide a fullerene derivative comprising a site to which a sugar chain can be specifically attached regardless of the sugar chain type and a fullerene nucleus. It is also intended to provide a novel sugar chain analysi...
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WO/2005/058800A1 |
This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, l or 2; R1 and R2, independently of each other, are H, OH or OCH3; R3 is H or CH3; R4 is H, C1-C3 straight or branched alkyl or, together w...
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WO/2005/054174A2 |
The invention relates to compounds for modulating the glycolysis enzyme complex and the transaminase complex, pharmaceutical compositions containing said compounds, and to the uses of said compounds for the production of pharmaceutical c...
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WO/2005/037771A2 |
An O-substituted hydroxylamine having the following general formula : R1-CHX-O-NH2, wherein X is hydrogen or an alkyl; and R1 is an unsubstituted or substituted phenyl, thienyl, furanyl, pyrrolyl or -CR2=C3R4; wherein R2, R3 and R4 are h...
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WO/2005/023757A1 |
Provided is a process by which O-substituted hydroxyl- amines can be produced from industrially available raw materials in high yield, namely, a process for the production of O-substituted hydroxylamines which comprises the step of react...
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WO/2005/020896A2 |
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This spec...
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WO/2005/019159A1 |
A process for producing corresponding &agr -aminooxyketones in high yield and with high enantioselectivity, that is, a process for the production of optically active &agr -aminooxyketone derivatives represented by the general formula (1)...
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WO/2005/014530A2 |
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylhydrazine compounds, hydroxylamine (aminooxy) compounds, and other compounds are disclosed which are inhibitors...
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WO/2004/087650A2 |
A novel process is provided for the preparation of chiral beta-amino acid amide inhibitors of the dipeptidyl peptidase-IV and the useful intermediates obtained therein. The products resulting from the instant process are inhibitors of di...
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WO/2004/087643A1 |
Provided are a novel compound useful for a deformylase inhibitor with excellent antibacterial activity or a pharmaceutically acceptable salt thereof, a process for preparing the same, and an antibacterial composition including the same a...
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WO/2004/080492A1 |
The invention relates to conjugates of formula (V) or (VI): wherein X is -CO-NH-, -NH-, -O-, -NHCONH-, or -NHCSNH-; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
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WO/2004/076053A2 |
Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl&rcub -(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or mor...
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WO/2004/072019A1 |
A method for producing a hydroxylamine compound, characterized in that a nitro compound is contacted with a hydrogen source and optionally a catalyst poisoning agent in the presence of a platinum catalyst fixed on an ion-exchange resin. ...
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WO/2004/066929A2 |
Novel thyroid receptor ligands are provided having the general Formula (I) wherein X, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11, are as defined herein. In addition, a method is provided for preventing, inhibiting or treating diseas...
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WO/2004/062601A2 |
Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infectio...
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WO/2004/058687A1 |
A substance which can specifically interact with sugar chains. Also provided is a method of separating, concentrating, or purifying sugar chains or a sugar chain-containing substance each contained in a sample, which comprises: a) a step...
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WO/2004/052836A1 |
The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in c...
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WO2000061134A9 |
Compounds of formula (I) are antibacterial agents wherein: Z represents a radical of formula -N(OH)CH(=O) of formula -C(=O)NH(OH) and R1-R4 are as defined in the specification.
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WO/2004/024676A1 |
The invention relates to compounds for modulating the glycolysis enzyme complex and transaminase complex, pharmaceutical compositions containing such compounds and the uses of said compounds in the production of pharmaceutical compositio...
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WO/2004/018414A2 |
The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing g...
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WO/2004/011410A1 |
Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11$g(b)HSD1 are described.
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WO/2004/007369A1 |
The invention relates to a method for concentrating an at least partially crystalline solid containing at least one zeolite in a mixture, said mixture containing at least one auxiliary agent, for example a template compound, and the cite...
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WO/2004/007462A1 |
Improved reagents and methods of amination are provided. The reagents are phenyl hydroxylamines containing one nitro and at least one CF3 substituent on the phenyl moiety.
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WO/2003/087040A2 |
The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyshpidemias, dysproteinemias, and glucose metabolism disorders comp...
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WO/2003/087108A2 |
The invention relates to novel Acyl coenzyme-A mimics, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders com...
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WO/2003/082205A2 |
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and so...
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WO/2003/079984A2 |
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms...
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WO/2003/078376A1 |
A NK1 antagonist having the formula (I), with the variables defined herein, which is useful for treating a number of disorders, including emesis, depression, anxiety and cough.
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WO/2003/074475A2 |
The invention relates to novel aryl ketones of formula (I), in which Z represents groupings (II) and (III) and A1, A2, A3, R1, R2, R3, R4, R5, R6, R7, X, Y, and m have the meaning indicated in the description, the use thereof as plant tr...
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WO/2003/074572A1 |
The present invention relates to open chain alkoxyamine compounds, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one open chain alkoxyamine compound. Further aspects of the prese...
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WO/2003/062189A1 |
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.
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WO/2003/053931A1 |
This invention pertains to a novel process for preparing sterically hindered N−substituted alkyloxyamines from alkenes by the transition−metal−catalyzed reaction of a intermediate alkylborane with a sterically hindered nitroxyl rad...
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WO/2003/049690A2 |
The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or ...
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WO/2003/048138A1 |
The invention relates to novel [1.2] oxazin-3,5-dione derivatives of formula (I) in which W, X, Y, Z, G, D, A and B have the meanings given in the description, several methods for production and use thereof as microbicide, pesticide and ...
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WO/2003/045919A2 |
Amine ethers of sterically hindered amines are obtained in good yield from the corresponding N-oxyl hindered amine precursor by reaction with a hydrocarbon in the presence of an organic hydroperoxide and an iodide. The products of presen...
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WO/2003/031330A1 |
A stabilized hydroxylamine solution is disclosed. The stabilized solution comprises a selected stabilizer, which can be added during manufacture and/or storage of the hydroxylamine solution.
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WO/2003/029188A2 |
The present invention describes pesticidal β-substituted nitrostyrene and cyanostyrene compounds having the formula I: wherein A,Ar,R,R1,Y,X,k,l, and m are as defined herein. The present invention is directed to compositions that includ...
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WO/2003/018565A1 |
The invention pertains, at least in part, to methods for synthesizing an oxazinone compound of formula (I). The method includes contacting an aminooxy compound of formula (II) with a cyclizing agent under appropriate conditions, such as ...
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WO/2003/010153A1 |
The present invention provides novel N-alkyl-N-phenylhydroxylamine derivatives containing metal chelating groups, a process for preparing the same, the use of the novel compounds as therapeutics for treating and/or preventing various med...
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WO/2002/100813A2 |
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, -CH¿2?-or-CH¿2?CH¿2?-; W is a substituted or unsubstituted alkylene or a substituted or unsubsti...
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WO/2002/092553A1 |
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels a...
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WO/2002/088126A1 |
The invention relates to novel triazolopyrimidines of formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿ and X have the meanings as cited in the description. The invention also relates to a plurality of methods for producing said novel subs...
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WO/2002/088125A2 |
The invention relates to novel triazolopyrimidines of formula (I), in which R?1¿, R?2¿, R?3¿ and X have the meanings as cited in the description, to acid addition salts thereof, to a number of methods for producing these novel substan...
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WO/2002/088127A2 |
The invention relates to novel triazolopyrimidines of formula (I), wherein R?1¿, R?2¿, R?3¿, R?4¿, X and n have the meaning cited in the description. The invention also relates to several methods for the production of said novel subs...
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WO/2002/079144A1 |
The invention relates to the (p-amino-hydroxyphenyl)-acrylamide derivatives of general formula (I), or the physiologically acceptable, water-soluble salts thereof, and to oxidative dyes for keratin fibers containing said compounds.
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WO/2002/048093A2 |
The invention relates to a method for producing N-substituted hydroxylamines from N-substituted aryloxaziridines or heteroaryloxaziridines by means of acid hydrolysis and isolation of the N-substituted hydroxylamines in the form of the s...
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WO/2002/046150A2 |
Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation.
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