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WO/2021/255737A1 |
The present disclosure pertains to amino cyclohexanone compounds, pharmaceutical compositions containing same and methods of treating depression, pain, inflammation, and other clinical indications.
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WO/2021/133839A1 |
Disclosed herein are methods of preparing N6-((2-azidoethoxy)carbonyl)lysine, N6-((2-azidoethoxy)carbonyl)-L-lysine, and N6-((2-azidoethoxy)carbonyl)-D-lysine. Also disclosed herein are the compounds tert-butyl N2-(tert-butoxycarbonyl)-N...
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WO/2021/119606A1 |
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diis...
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WO/2021/050660A1 |
Phenyl rings provide a robust scaffold for molecular design, given the limited number of ring carbon atoms and the fixed geometry in between. However, it can be difficult to form highly substituted phenyl rings suitable for covalent atta...
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WO/2020/260514A1 |
Bis(2-haloacetamido)- compounds for use as linkers to chemically cross-linking multiple thiol groups, and particularly, although not exclusively, the thiol groups of cysteine amino acids in peptide chains are described, along with their ...
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WO/2020/255425A1 |
This anti-HBV agent contains a compound represented by general formula (I) or a compound represented by general formula (II), or a salt thereof.
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WO/2020/237262A1 |
Embodiments are directed to therapeutic, diagnostic, or functional complexes comprising a kethoxal derivative.
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WO/2020/205470A1 |
The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer.
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WO/2020/163532A1 |
Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits compr...
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WO/2020/146568A1 |
A method for the synthesis of diazabicyclo[6.2.0]decane compounds is provided. The synthesis proceeds by stereoselective synthesis of a chiral lactone followed by azetidine formation via a series of chemoselective reactions. Bicyclizatio...
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WO/2020/104627A1 |
The invention relates to a method for labeling a target compound with a radiometal by photochemically induced conjugation. Furthermore, a chelating compound for use in said method is provided. The chelating compound is characterized by a...
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WO/2020/043997A1 |
The present invention relates to 1,4-dimethyltetrazenes of formula (la), (Ib) and (le): R1-CH2-N(CH3)-N=N-N(CH3)-CH2-R2 (la) R3-CH2-CH2-N(CH3)-N=N-N(CH3)-CH2-CH2-R4 (Ib) R5-CHOH-CH2-N(CH3)-N=N-N(CH3)-CH2-CHOH-R5 (lc), in which RI, R2, R3...
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WO/2020/006340A1 |
The invention relates to chemically reactive and/or biologically active compounds, reagents and compositions thereof. More particularly, the invention provides novel reagents that are useful in chemical synthesis, functionalization, deli...
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WO/2020/002634A1 |
The present invention relates to specific nitrogen containing compounds of formulas (I), (II) and (IV) of the present invention, which are suitable to be used in a method to detect alkyne group containing organic compounds by mass spectr...
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WO/2020/004043A1 |
The present invention provides a method which uses an aniline derivative as a starting material, and which is capable of producing an α-azidoaniline derivative or an α, α'-diazide derivative. The present invention comprises a method f...
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WO/2019/240579A1 |
The invention provides a production process for the production of an aromatic epoxide derived compound, the production process comprising: (i) an epoxidation stage comprising: reacting an aromatic compound and a peroxide in the presence ...
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WO/2019/235493A1 |
The present invention provides a method by which a diaminobenzoic acid ester and a benzimidazole derivative are able to be produced more easily with use of lower cost materials. The present invention includes a method for producing a dia...
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WO/2019/184772A1 |
The present invention discloses a gibberellin-like compound, a preparation method therefor, a pharmaceutical composition, uses and an intermediate thereof, wherein the gibberellin-like compound shown in formula (I) has relatively good in...
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WO/2019/155169A1 |
The present invention relates to difunctional biphenyl compounds according to formula (I): in which Alk, Alk' and R are as defined in the description. Said compounds are suitable for use as curing agents for thermosetting resins, particu...
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WO/2019/152801A1 |
The present disclosure features non-canonical or heavy isotope-containing amino acids, where the alpha-amino terminus and/or carboxvlic acid terminus is modified with molecular cages. The molecular cage-modified amino acids are precluded...
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WO/2019/142614A1 |
This container comprises: a container body having formed therein an internal space in which a liquid can be stored; and partitions that divide the internal space into a plurality of liquid storage sections. Holes are formed in the partit...
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WO/2019/037755A1 |
The present invention relates to a compound represented by general formula (I), as well as a racemate, a stereoisomer, a tautomer, a polymorphic substance, and a solvate thereof, or a pharmaceutically acceptable salt thereof. The present...
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WO/2018/179343A1 |
The present invention provides a pharmaceutical composition for treating or preventing cognitive function disease or disorder, the composition comprising a compound represented by formula (I), an enantiomer thereof, a diastereomer thereo...
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WO/2018/119101A1 |
A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized mol...
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WO/2018/102517A1 |
Disclosed herein are compositions for use in an energy providing devices and methods of preparing such devices. Also included herein is energy providing devices that comprise a charged compound modified substrate or zwitterion-modified s...
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WO/2017/131097A1 |
Provided is a pharmaceutical composition for the treatment or prevention of a cognitive disease or disorder, the composition comprising a compound represented by formula (1), an enantiomer thereof or diasteriomer thereof, or a pharmaceut...
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WO/2017/131236A1 |
The present invention relates to the nucleic acid complex expressed by formula 1. Formula 1: (In formula 1, X is an oligonucleotide, L1 and L2 each independently represents a sugar ligand, and S1, S2 and S3 each independently represents ...
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WO/2017/089492A1 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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WO/2017/081069A1 |
The present invention relates to tri-functional crosslinking reagents carrying (i) a ligand-reactive group for conjugation to a ligand of interest having at least one binding site on a target glycoprotein receptor, (ii) a hydrazone group...
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WO/2017/057461A1 |
A production method for producing an aldehyde compound or a ketone compound by oxidizing a primary or secondary alcohol compound, wherein the alcohol compound has, in the molecule thereof, a group selected from an amino group, an azide g...
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WO/2016/180297A1 |
The present invention relates to the fields of organic chemistry and metal organic chemistry, disclosed are a metal bridge site fused ring compound, and an intermediate, a preparation method and a use thereof, the metal bridge site fused...
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WO/2016/127023A1 |
Neat 4-azidobutylamine and sails of 4-azidobutylamine and processes for producing the same are described herein. Amines represent a large class of organic compounds containing a basic nitrogen atom having a lone pair of electrons and one...
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WO/2016/113764A1 |
The present invention relates to one step room temperature process for the synthesis of azido alcohols from alkenes. More particularly, I2 catalysed a regio and diastereo selective one step room temperature process for the synthesis of 1...
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WO/2016/103283A1 |
The present invention provides bio-based aromatic diisocyanate of formula (I). [Formula should be inserted here] wherein X is –OCH3, Y is selected from -H or –OCH3, and m = 0-12. The present invention further provides a method for pr...
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WO/2016/058056A1 |
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal centre, particularly for the imaging of tumours.
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WO/2016/007726A1 |
By either forming a triaryl acid halide or a triaryl mixed anhydride and subsequently treating with aqueous sodium azide, triaryl acyl azides are prepared in high yield using inexpensive reagents in a process in which by-products are eas...
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WO/2015/122494A1 |
Provided is a novel compound having an excellent suppression action against arrhythmia including atrial fibrillation and being useful as a pharmaceutical product having a separated antiviral effect. A compound indicated by general formul...
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WO/2015/044177A1 |
The present invention refers to compounds of formula: (formula A), wherein R1 is selected from (formula I), (formula II), (formula (III), (formula IV), (formula V), or (formula B), and wherein R2, R3, R4 and R5 are as defined in the clai...
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WO/2015/043493A1 |
The present invention relates to a 5-formylcytosine specific chemical labeling method and related applications in aspects such as sequencing, detection, imaging, and diagnosis. In the method, a condensation reaction occurs between an act...
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WO/2015/004563A1 |
The present invention provides compounds of formula (1) a process for their preparation, a solution comprising these compounds, a process for the preparation of a device using the solution, devices obtainable by the process and the use o...
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WO/2014/197991A1 |
The present application describes amphiphatic compounds like compound Ila below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated...
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WO/2014/158209A1 |
The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C-H bonds and one or more activated C-H bonds in a solvent; adding a phthaloy...
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WO/2014/073001A1 |
The application discloses monomers based on bis phenols with pendent reactive azido groups. The application further provides a process for preparation of bisphenol monomers with pendent reactive azido groups which are used further for pr...
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WO/2014/072992A1 |
The present invention relates to process for preparing triazole compounds used in the treatment of epilepsy. The process comprises of reacting compound of 2, 6 difluoroazide (II) with 2, 3 dihalo compound (III) to form compound of formul...
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WO/2014/044873A1 |
There are provided amino acid derivatives of formula V and VI as defined herein which are pyrrolysine analogs for use in bioconjugation processes.
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WO/2014/036492A1 |
Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified...
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WO/2013/093943A9 |
Disclosed herein is a single step catalytic process for the production of enantiomerically pure α-Aryloxy-α'-Azido/Alkoxy alcohols of formula (A). The invention, in particular discloses phenolytic kinetic resolution of racemic anti and...
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WO/2013/187325A1 |
The present invention provides a method for producing an azide compound. The method is characterized by producing an azide compound in the form of a solution, the azide compound being represented by general formula (I) (wherein, Y repres...
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WO/2013/153873A1 |
A photosensitive compound represented by formula (1) or formula (2). (Chemical formula 1) (In formula (1) and formula (2), n is an integer of 1-3; R1 is a linear or branched alkyl group having 1-6 carbon atoms or an alkylene group having...
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WO/2013/144979A1 |
The present invention relates to an improved process for the preparation of Aliskiren and its pharmaceutically acceptable salts comprising reducing the compound of Formula-Z in presence of catalyst and ammonia. The present invention furt...
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