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JP3838657B2 |
PCT No. PCT/DE94/00756 Sec. 371 Date Feb. 6, 1996 Sec. 102(e) Date Feb. 6, 1996 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01168 PCT Pub. Date Jan. 12, 1995The invention relates to a novel pharmaceutical preparation, containing an active ...
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JP2006523722A |
This invention relates to a compound of Formula (I) and its use in treating hyper-proliferative disorders.
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JP2006523693A |
The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through ...
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JP3834801B2 |
To obtain the subject compound useful as an agrochemical/medicine, esp. agricultural/horticultural germicide, in short process by oximating a benzaldehyde compound followed by amidoximating the reaction product. First, a 2,3-dihalogeno-6...
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JP3828174B2 |
PURPOSE: To safely produce a dye releasing agent in a short process using low-cost starting material by producing 5-substd.-2-acylaminophenol by hydrolysis and partial deacylation of a compd. having a specified structure. CONSTITUTION: A...
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JP2006522054A |
Certain N-formyl hydroxylamine compounds, such as N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylami
no-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes or imidazacyclo4-7alkanes are useful in the treatment of b...
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JP3827324B2 |
Matrix metalloproteinase inhibiting compounds of formula (I) wherein X is a -CO2H or -CONHOH group; R1 is methyl, ethyl, allyl, thienylsulphanylmethyl, thienylsulphinylmethyl, or thienylsulphonylmethyl; R2 is iso-butyl, n-pentyl, n-hexyl...
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JP2006519223A |
The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain.
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JP3811775B2 |
The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters...
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JP2006517960A |
The invention relates to methods of inhibiting HCV viral replication activity comprising contacting an HCV polymerase with a therapeutically effective amount of a hydroxamate MMP inhibitor, and compositions comprising the same.
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JP3803334B2 |
To obtain the subject compound improving preservability of a silver halide photosensitive material emulsion and preservability of a latent image. The hydroxamic acid-based compound is represented by formula (II), [wherein, R1 is a (subst...
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JP3801653B2 |
Hydrazine derivatives of the formulawherein Y is CO or SO2; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-lower alkyl, aryl-lower alk...
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JP3798245B2 |
The invention provides hydrazine derivatives of the formulawherein R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is an acyl group derived from an alpha-, beta-, gamma- or d...
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JP2006516671A |
Novel monoamidine, monoamidoxime and bisamidine curatives, co-curatives and cure accelerators are provided for use with perfluoroelastomeric compositions as well as novel synthesis methods for making monoamidine- and monoamidoxime-based ...
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JP3787821B2 |
To obtain a benzamidoxime compound useful as an intermediate important as an agricultural and horticultural fungicide industrially and extremely advantageously. A compound of formula I (X1 and X5 each a 1-6C alkyl, a halogen, etc.; X2, X...
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JP2002502815A5 |
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JP3759965B2 |
Compounds of formula (I): in which: Ar represents an aromatic or a heteroaromatic radical optionally substituted, in particular, with an alkyl or a carboxyl group, R2 and R3 represent, in particular, H or alkyl, or R2 and R3, taken toget...
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JP2006077019A |
To provide a benzophenone compound (I) useful in treatment of HIV infections.The useful benzophenone compound (I) is, for example, represented by the formula.
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JP2006508986A |
Lung disease, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), asthma or acute and chronic bronchitis, can be treated with an oxyamide-containing compound.
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JP2006056903A |
To provide a pharmaceutical product effective for treatment of skin disease.The pharmaceutical product contains a compound of formula (II) or (III) or a salt, an optical isomer or a geometrical isomer thereof.
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JP2006503053A |
The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use alpha beta-lacta...
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JP2006503090A |
The present invention relates to novel n-hydroxythiourea, urea and amide compounds as a potent vanilloid receptor antagonist and the pharmaceutical compositions comprising the same. The inventive compound can be useful for analgesics to ...
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JP3739704B2 |
The present invention includes benzophenone compounds (I) which are useful in the treatment of HIV infections.
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JP3739618B2 |
To obtain the subject new compounds useful as intermediate compounds for the production of phenylacetic acid derivatives suitable as bactericides, effective for a wide variety of phytopathogens and usable also as leaf and soil disinfecta...
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JP2006501160A |
The present invention relates to the use of amidine compounds in the treatment of amyloid related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising adm...
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JP2006008546A |
To provide a compound having high plant disease injury-controlling efficacy.The compound is an amide compound of formula (1) (wherein, R1 is H, a halogen atom, 1-4C alkyl, 1-4C haloalkyl, 1-4C alkoxy or the like; R2 is H, a halogen atom,...
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JP3712208B2 |
The present invention is related to novel intermediates and processes which are useful in the preparation of certain antihistaminic piperidine derivatives of formula (I) wherein W represents -C(=O)- or -CH(OH)-; R 1 represents hydrogen o...
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JP3710506B2 |
PURPOSE: To obtain a new benzene derivative having an extremely strong insecticidal activity against Hemiptera insect pests such as Nilaparvata lugens or Nephotettix cincticeps and useful for insecticides. CONSTITUTION: The benzene deriv...
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JP3704649B2 |
Compounds of the formula Iin whichY is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen,Z is a group a)R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at m...
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JP2005529973A |
The present invention is related to a process for the preparation of 3-cyano-1-naphthoic acid and some analogues thereof of formula (1), the intermediate 1-halo-3-cyano naphthalene and some analogues thereof used in this process and a pr...
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JP2005527621A |
The present invention is directed to selective LXR modulators, small molecule compounds corresponding to Formula I and is further directed to a process of treating a condition in a mammal that is modulated by LXR using a therapeutically ...
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JP3676236B2 |
The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims, as well as hydrates or solvates and physiologica...
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JP2005189198A |
To prevent the characteristics of an optical device, which has a structure capable of inducing surface plasmon resonance or local plasmon resonance, from being deteriorated by the oxidation of a metal film.An oxidation preventing film co...
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JP3670292B2 |
The present invention is directed to a ketonitrile derivative represented by the following formula (1): (wherein R<1> is a hydrogen atom or a lower alkyl group; each of R<2>, R<3>, R<4>, and R<5>, which may be identical to or different f...
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JP3662941B2 |
Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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JPWO2003070691A1 |
Provided is a novel N-hydroxycarboxamide derivative having excellent physical properties such as stability and solubility and having strong histone deacetylase (HDAC) inhibitory activity. The present inventors have found that a novel N-h...
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JP2005517007A |
The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical c...
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JP2005515253A |
The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.
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JP2005515206A |
The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or ...
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JP2005514418A |
Carboxamidine derivatives (I)-(III) are used for treating or preventing vascular diseases. Carboxamidine derivatives of formula (I)-(III) or their salts are used for treating or preventing vascular diseases. R 1>, R 2>1-6C alkyl (optiona...
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JP3647041B2 |
Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups h...
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JP2005508317A |
A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond = represents a cis-vinylene group or an ethynylene group; Y represents CH<2>, O or S(O)wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive...
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JP2005506949A |
The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
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JP3621884B2 |
Compounds of formula (I):or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix metalloprotease (MMP) inhibitors
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JP2005504021A |
The present invention concerns the generation of hydroxamic acid thrombospondin-peptide analogs that inhibit aggrecanase activity. These analogs are useful in the treatment of diseases characterized by cartilage degradation, such as oste...
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JP2005503412A |
A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond = represents a cis-vinylene group or an ethynylene group; Y represents CH<2>, O or S(O)wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive...
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JP3612082B2 |
Novel oxyalkynes of the general formula I in which the meta or para substituent Y denotes R<1> denotes CH3 or NH2, R<2> denotes H or CH3 and R<3> denotes H, C1-3 -alkyl or COCH3 and Ar represents an aromatic radical from the group consis...
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JP3612737B2 |
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JP2005500259A |
Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase ...
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JP2004359546A |
To provide a hydroxamic acid derivative useful as a prophylactic and/or a therapeutic agent for solid cancer such as cerebral tumor, esophageal cancer, stomach cancer or colon cancer.The hydroxamic acid derivative is represented by gener...
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