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JPH11292837A |
To obtain the subject new compound useful as a fungicide for foliage and soil, etc. This compound is shown by formula I (R1 is F; R2 is a phenyl 1-6C alkyl which may contain one or more substituent groups selected from a halogen, a 1-4C ...
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JPH11286472A |
To obtain the subject new compound having excellent agricultural and horticultural germicidal efficacies, insecticidal and acaricidal efficacies. This compound is represented by the formula {R1 is H, an alkyl, a cycloalkyl or the like; T...
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JP2960965B2 |
This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-
3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for p...
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JPH11269139A |
To simply produce the subject compound under mild conditions at a low cost by using a method for passing a trans-substituted- cyclohexanehydroxamic acid as a starting raw material through a trans- substituted-cyclohexyl isocyanate. A 4-t...
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JPH11511137A |
The present invention relates to the novel use of organic molecules capable of inhibiting C-proteinase activity in order to regulate, modulate and/or inhibit abnormal collagen formation.
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JPH11510697A |
The present invention is directed to the isolation and identification of the nucleic acid sequence encoding C-proteinase, the recognition of such protein's activity and applications, and tools, processes, and methods of use thereof.
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JPH11246436A |
To obtain a medicine for preventing or treating connective tissue diseases, exhibiting more excellent effects than those in a case where the inhibitors against the enzymes are separately used, by allowing to have inhibiting actions again...
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JPH11228956A |
To provide an antioxidant which prevents developing agents from oxidation without hindering developing by incorporating a water-soluble hydroxamic acid into a developer. An aq. compsn. contg. at least 20 wt.% water-soluble compd. of form...
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JP2931410B2 |
PCT No. PCT/EP95/02112 Sec. 371 Date Mar. 28, 1996 Sec. 102(e) Date Mar. 28, 1996 PCT Filed Jun. 3, 1995 PCT Pub. No. WO96/02497 PCT Pub. Date Feb. 1, 1996Compounds of formula (I) and their therapeutic use, inter alia, as LTB4-antagonist...
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JP2932207B2 |
A phenoxycetic acid derivative of the formula: (I) wherein R is a hydroxyl group, an alkoxy group, a group of the formula OM wherein M is an alkali metal ion, an alkaline earth metal ion, a transition metal ion, an ammonium ion or an org...
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JPH11508273A |
Hydroximic acid derivatives have the formula (I), in which the substituents have the following meanings: X stands for CH, CHO or NO; Y stands for O or NH; Z stands for O, S or NR; R stands for hydrogen, alkyl, alkenyl or alkinyl; R<1> st...
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JP2922300B2 |
A method for preparing deferoxamine and a composition of formula (I): X-Ph-CH2-O-C(O)-NH-(CH2)4-CH=NOR, wherein X is a C1-C4 alkyl, -O(C1-C4 alkyl), a halogen or hydrogen; R is X-Ph-CH2- or hydrogen for preparing deferoxamine. In one emb...
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JP2921673B2 |
Compounds of the formula: wherein: n is 0, 1 or 2; Y is hydroxy or XONH-, where X is hydrogen or lower alkyl; R<1> is hydrogen or lower alkyl; R<2> is hydrogen, lower alkyl, heteroalkyl, aryl, aralkyl, arylheteroalkyl, cycloalkyl, cycloa...
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JP2901509B2 |
Acetic acid derivatives of the formula in which L, M, Q and T have the meaning stated in the description, can be used for the treatment or prophylaxis of diseases caused by the binding of adhesive proteins to blood platelets, and by aggr...
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JPH11106371A |
To obtain the subject new compound useful as a Maillard reaction inhibitor, an active oxygen-resistant medicine, a medicine for various kinds of diabetic complications, a medicine for senile diseases and the like. A compound of the formu...
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JPH11504320A |
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as s...
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JP2883677B2 |
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JPH11504015A |
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as st...
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JPH11503746A |
PCT No. PCT/GB96/00930 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33161 PCT Pub. Date Oct. 24, 1996Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; (I) R4 is a group...
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JPH11503748A |
PCT No. PCT/GB96/00930 Sec. 371 Date Oct. 7, 1997 Sec. 102(e) Date Oct. 7, 1997 PCT Filed Apr. 18, 1996 PCT Pub. No. WO96/33161 PCT Pub. Date Oct. 24, 1996Compounds of formula (I), wherein X is a -CO2H or -CONHOH group; (I) R4 is a group...
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JP2873090B2 |
Novel compounds of Formula (I) are described herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the presen...
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JPH11503145A |
Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretio...
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JP2871849B2 |
Compounds of general Formula I: are presented which have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and the promotion of wound healing. Representative diseases involving inclu...
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JP2867165B2 |
Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-inflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid...
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JPH1149737A |
To inexpensively obtain the subject compound useful as a synthetic intermediate for an agrochemical and medicine in good yield by hydrolyzing a specific hydroxamic acid derivative while keeping the configuration thereof. The objective co...
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JP2859350B2 |
Phenylhydrazones of formula I I in which R1 to R6 and m and n have the meanings stated above, and the manufacture thereof. The substances are suitable for combating disease and for cosmetic use.
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JPH11501288A |
PCT No. PCT/GB95/02770 Sec. 371 Date May 21, 1997 Sec. 102(e) Date May 21, 1997 PCT Filed Nov. 27, 1995 PCT Pub. No. WO96/16931 PCT Pub. Date Jun. 6, 1996Compounds of general formula (I), principally characterized in that R4 is a polyeth...
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JPH11501025A |
PCT No. PCT/GB96/00467 Sec. 371 Date Aug. 29, 1997 Sec. 102(e) Date Aug. 29, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/26918 PCT Pub. Date Sep. 6, 1996A method for the preparation of a compound of formula (I) (I) wherein X is hydroge...
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JPH11500716A |
The invention relates to novel substituted heterocyclic compounds, to a plurality of processes for their preparation and to their use as fungicides, and to novel intermediates, to a plurality of processes for their preparation and to the...
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JP2846737B2 |
Compounds of general formula I: (I) wherein: A represents the group -NH2, a substituted acyclic amine or a heterocyclic base; have collagenase inhibition activity and are useful in the management of disease involving tissue degradation a...
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JPH11500413A |
Emulsions of paramagnetic contrast agents, and processes of making and using them are disclosed. The emulsions contain water, a dispersed oil phase and a complex of a paramagnetic metal ion and an organic acid chelator, for example DTPA ...
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JPH111430A |
To obtain the subject medicine having matrix metalloproteinase- inhibiting activities and useful as metastatic infiltration- or growth-inhibiting agents, etc., for various cancer cells, by bringing the medicine to contain a specific hydo...
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JP2839468B2 |
O-Aryl methyl N-acyl or N-thioacyl hydroxylamine derivs. of formula ArCH2ON(R1)C(=X)R2 (I), their enantiomers and diastereoisomers are new. X = O or S; R1 = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, or arylalkyl; R2 = R21 or R22; R21 ...
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JP2836215B2 |
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JP2833647B2 |
PURPOSE: To obtain the subject compound represented by a specific formula, having suppressing actions on collagenases and useful for treating or preventing degenerative joint diseases such as chronic rheumatoid arthritis and osteoarthrit...
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JP2834516B2 |
Process for the preparation of phenyloxadiazolylanilines by reacting a benzonitrile in an aqueous reaction medium firstly with hydroxylamine or its acid addition salts to give a benzamidoxime and then with an isatoic anhydride to give an...
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JP2829599B2 |
A carboxylic acid compound of the formula (I-a) wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R<1>, R<2>, R<3> and R<4> are H, hydroxy and the like. The carboxylic acid co...
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JP2829501B2 |
PURPOSE: To produce the subject compound having excellent inhibition activity against a specific endopeptidase and a suppressing activity against angiotensin- converting enzymes and useful e.g. as an agent for the treatment of cardiovasc...
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JPH10512241A |
The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity of these enzymes. In particular, the pre...
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JPH10511342A |
There is described the use of a compound represented by general formulae (I), (II) or (III), for the inhibition of matrix metalloproteinases (MMP), wherein X1 is oxygen or sulfur, R1 is OH, SH, CH2OH, CH2SH or NHOH, R2 is a residue of 2 ...
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JPH10287634A |
To provide benzene derivatives useful for pharmaceuticals. The compounds are expressed in formula I [R1 is a 5 to 6 membered unsaturated heterocyclic residue, etc.; R2 is a group of formula II (m is an integer of 1 to 3; R8 is H, a halog...
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JP2813462B2 |
Novel substituted beta amino acid derivatives having the general formula: are provided, in which eg. R<2> is selected from the group consisting of hydrogen, lower alkyl radicals, lower alkenyl radicals, lower alkynyl radicals, alicyclic ...
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JP2805649B2 |
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JPH10509719A |
Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviate...
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JPH10509435A |
Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.
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JPH10509157A |
PCT No. PCT/EP95/04428 Sec. 371 Date May 6, 1997 Sec. 102(e) Date May 6, 1997 PCT Filed Nov. 10, 1995 PCT Pub. No. WO96/16030 PCT Pub. Date May 30, 1996Iminooxymethyleneanilides of the formula I where the substituents and the index have ...
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JPH10509158A |
PCT No. PCT/EP95/04429 Sec. 371 Date May 6, 1997 Sec. 102(e) Date May 6, 1997 PCT Filed Nov. 10, 1995 PCT Pub. No. WO96/16029 PCT Pub. Date May 30, 19962-[4-Biphenyloxymethylene]anilides of the formula I I where the indices and the subst...
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JPH10237032A |
To obtain the subject new compound excellent in biodegradability and in metal-making ability and useful as an additive for photographic treatments. A compound of formula I [R1, R2 are each H, an alkyl, an aryl, a heterogeneous ring, carb...
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JPH10218839A |
To obtain the subject new compound having an alkoxy-substituted methylidene group bonded to an acetic acid part and a substituent of a benzene ring bonded through ethylene group, exhibiting excellent herbicidal activity at a reduced rate...
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JPH10218850A |
To provide a method for efficiently producing an N-alkoxy-N- alkylamide compound useful as an intermediate for producing ketones or aldehydes. This N-alkoxy-N-alkylamide compound is obtained from an ester or lactone compound by using an ...
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