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JP2020055841A |
To provide inhibitors of E1 activating enzymes.This invention relates to compounds of the formula (I) that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compo...
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JP6670763B2 |
Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are admi...
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JP6672325B2 |
Process for the production of a diene, preferably a conjugated diene, more preferably 1,3-butadiene, comprising the dehydration of at least one alkenol in the presence of at least one catalytic material comprising at least one acid catal...
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JP6670108B2 |
The present application discloses novel PWNN and PWNWP metal catalysts for organic chemical syntheses including hydrogenation (reduction) of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate com...
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JP2020037545A |
To provide an oxygen isotope-labeled carboxylate compound useful as a supply source of oxygen isotope.There is provided an oxygen isotope-labeled carboxylate compound obtained by reacting pivalonitrile represented by the following formul...
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JP6657043B2 |
Provided is a geometrically selective method for producing (±)-(E)-2-isopropyl-5-methyl-3,5-hexadienyl acetate, which is a sex pheromone of grape pineapple mealybug (GPMB). Specifically provided is a method for producing a an (E)-2-isop...
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JP6653621B2 |
To provide a novel filler for a reaction tube capable of controlling a reaction ratio near reaction tube inlet, reducing loads biased to a catalyst in the reaction band range and dispersing loads over whole catalyst layer in a fixed floo...
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JP2020505357A |
The present disclosure provides compounds and methods for inhibiting or degrading the N-terminal domain of the androgen receptor, as well as methods for treating cancers such as prostate cancer. [Selection diagram] None
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JP6644990B2 |
To provide: guaiazulene derivatives suitable as cancer cell inhibitors, particularly prostate cancer cell inhibitors; and cancer cell inhibitors, particularly prostate cancer cell inhibitors, containing the same.The invention relates to ...
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JP2020504194A |
The present disclosure is directed to the synthesis and application of Undecavertor derivatives with unique and desirable flavor and / or fragrance characteristics. The compounds of the present disclosure can be used alone or mixed with ...
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JP6636871B2 |
To provide a method for manufacturing a catalyst for obtaining a specific allyl type unsaturated alcohol at high conversion ratio and selectivity by a mono-molecule dehydration reaction of diol.A catalyst for manufacturing an unsaturated...
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JP6630789B2 |
To provide novel compounds useful for manufacturing salacinol, a method for manufacturing the compounds, a method for manufacturing salacinol, methods for protecting and deprotecting a diol group, and a protective agent for a diol group....
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JP6632006B2 |
Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.
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JP6628800B2 |
Process for the manufacture of at least one alcohol and/or at least one ketone, which comprises a step during which at least one organic peroxide compound is put into contact with at least one catalyst responding to formula (I) CrNxOy Fo...
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JP6629388B2 |
A copper-based catalyst precursor capable of achieving a high conversion ratio and high selectivity in the isomerization reaction of a ²,³-unsaturated alcohol portion and a method for producing the same and to provide a hydrogenation m...
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JP2020002142A |
To provide complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates, and manufacturing processes for variety of chemicals using the...
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JP6616757B2 |
The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate co...
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JP2019531873A |
Surface hydroxyl groups on porous and non-porous metal oxides such as silica gel and alumina, such as complexes of metals abundant on earth (eg, Fe, Co, Cr, Ni, Cu, Mn and Mg) Metallized with a suitable catalyst precursor. This metallize...
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JP2019532059A |
The present invention relates to a method of hydrogenating an organic compound in the presence of CO and in the presence of a catalyst-fixed bed containing an immobilized structured catalyst molded article.
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JP6602236B2 |
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JP6589233B2 |
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JP6582324B2 |
The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien...
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JP6585605B2 |
A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound...
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JP6578116B2 |
To provide a method of efficiently producing monosubstituted(fluoroalkyl)ethylenes.The method comprises reacting a 1-chloro-2-(fluoroalkyl)ethylene with an organoboron compound under coexistence of an alkylphosphine coordinated palladium...
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JP6570032B2 |
To provide a novel gold-cerium oxide complex catalyst having high catalyst activity, selectivity and durability, which have not been achieved in conventional gold catalysts for use in selective hydrogenation, and a method of using the sa...
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JP2019137630A |
To provide a production method that can synthesize 4-pentyn-1-ol, which is useful as a synthetic raw material of agrochemicals or pharmaceuticals, without using any special reaction facility, in high yields, and in large quantity.A metho...
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JP6563921B2 |
The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-...
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JP6560685B2 |
A process for the hydrogenation of a substrate comprising a carbon heteroatom double bond in the presence of a transition metal complex comprising a tridentate or bisdentate-ligand containing a nitrogen, sulphur and phosphorus atom, of w...
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JP6553553B2 |
Provided are industrial and economical methods for producing 2,6-dimethyl-1,5-heptadien-3-yl acetate (3), which is, for example, a sex pheromone component of Comstock mealybug, and 2,6-dimethyl-1,5-heptadien-3-ol (2), which is an interme...
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JP6551922B2 |
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JP6552355B2 |
To provide a method for selectively manufacturing allyl type unsaturated alcohol form a 1,3-diol type raw material.There is provided a manufacturing method of aimed allyl type unsaturated alcohol by making zirconia having total percentag...
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JP6546926B2 |
The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.
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JP6542234B2 |
A composition comprising 2,3-butanediol is dehydrated to methyl vinyl carbinol and/or 1,3-butadiene by exposure to a catalyst comprising (a) MxOy wherein M is a rare earth metal, a group IIIA metal, Zr, or a combination thereof, and x an...
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JP6531327B2 |
Conventionally, a silver-cerium oxide composite containing a silver particle and cerium oxide covering the surface of the silver particle has been synthesized through a multi-stage process, and is disadvantageous not only in that there i...
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JP6521710B2 |
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JP2019077619A |
To provide a method capable of industrially producing a conjugated diene or a conjugated triene in a short process from a raw material which is easy to obtain and handle.A conjugated diene is produced from a 3-alkenal via reactions of th...
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JP6516837B2 |
The present invention relates to the field of organic synthesis and more specifically it concerns a process for the preparation of homoallylic alcohol derivatives as defined in formula (I) via a reaction of alkene of formula (II) with an...
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JP6511864B2 |
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JP6510848B2 |
The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst,...
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JP6493666B2 |
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JP6493677B2 |
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JP2019043869A |
To provide a manufacturing method of oxide of aromatic hydrocarbon by an oxidation reaction of aromatic hydrocarbon such as toluene, and a catalyst.A product mainly containing oxide of which the methyl group is converted to a carboxyl gr...
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JP2019043883A |
To provide novel alkyl lithium having a functional group or alicyclic group.The present invention provides alkyl lithium represented by formula (1) (Ris a group represented by formula (1-1) or formula (1-2); Ris a group having a function...
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JP6487568B2 |
The present invention relates to kinetic resolution of racemic ´ -hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, race...
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JP6485456B2 |
Provided is a method from which a γ,δ-unsaturated alcohol having a much more smaller amount of inclusion of formic acid and a formic acid ester and having a high purity can be obtained in a high yield. Specifically, provided is a metho...
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JP6481171B2 |
The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in th...
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JP6483134B2 |
The present invention relates to certain iron complexes that have utility in the field of catalytic hydrogenation and, more particularly, to certain iron complexes of tridentate ligands having one amino or imino coordinating groups and t...
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JP6476474B2 |
The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to new specific organic compounds, as well as to flavor and fragrance formulations comprising at l...
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JP6479001B2 |
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JP6472755B2 |
The invention relates to the compounds of the formula I and to a liquid-crystalline medium based on a mixture of polar compounds which contains at least one compound of the formula I in which R1, L1, L2 and L3 and m have the meanings ind...
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