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JP2019525900A |
The present invention relates to a diarylthioether piperazine compound, a method for preparing the same, and its use. Specifically, the compound is a compound of formula (I), where HX is C.10-20It is a fatty acid or pamoic acid. [Chemica...
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JP2019151602A |
To provide a metal imide complexe that can efficiently oxidize a variety of substrates, can be synthesized easily, and have a stable structure.Provided is a metal imide complexe containing a metal and an imide as ligand, and in which, ch...
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JP2019142842A |
To provide a method in which a compound having a hydroxymethyl group is efficiently oxidized to obtain a corresponding carbonyl compound in high yields.The present invention provides a method for producing a carbonyl compound in which: i...
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JP6559394B2 |
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JP6525686B2 |
To provide a porous polymer metal complex utilizable as a gas adsorbent capable of adsorbing oxygen and carbon monoxide selectively in a wide temperature region, and to provide a gas separation apparatus and a gas storage apparatus using...
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JP2019512494A |
The present application a) contacts at least one metal ion with at least one bidentate organic ligand for 20-110 seconds at a temperature of 70-150 ° C in the presence of a solvent, b) step a. ) Is spray-dried under conditions suitable ...
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JP2019509295A |
The present invention has disclosed retinoic acid-based compounds, methods for producing them, intermediates, and applications. The retinoic acid-based compound I of the present invention has an excellent inhibition rate on tumor cells.
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JP2019509262A |
The present invention is a novel compound of the general formula (I):And their use in pharmaceutical compositions intended for use in human or veterinary medicine (particularly skin disorders, rheumatoid disorders, respiratory disorders,...
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JP2019507801A |
The present invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds of formula (I) or salts thereof. These processes and intermediates allow commercial amounts of the compounds to be prepa...
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JP6483674B2 |
The present invention discloses 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-...
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JPWO2017170859A1 |
An object of the present invention is to provide a compound that inhibits the collagen-binding function of HSP47, which is essential for the extracellular secretion of collagen. The present invention provides a bisaryl derivative represe...
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JP6466414B2 |
The present invention relates to metallic zinc cluster compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce carbamates. The invention is also directed towards a method for the alkoxycarbo...
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JP2019014716A |
To provide a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has a superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical co...
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JP6441928B2 |
A compound of formula I, wherein the groups R1, R2, R3, X, m, and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable...
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JP6423821B2 |
Polyarylene oligomers formed from an aromatic dialkyne monomer having a solubility enhancing moiety show improved solubility in certain organic solvents and are useful in forming dielectric material layers in electronics applications.
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JP6395812B2 |
The present invention discloses a process for depolymerization of lignin to yield substituted phenolic monomers using Brönsted ionic liquid as catalyst under mild reaction conditions to obtain an overall yield of monomers up to 97%.
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JP6397818B2 |
Provided is a method for stabilizing DHNA or a vitamin contained in a food, a beverage and or like under an environment which can be subjected to natural light or artificial light, e.g. a transparent container, without requiring the use ...
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JP2018127398A |
To provide a reactor for oxidation capable of oxidizing a hydrocarbon efficiently in terms of both reaction and energy.A reactor for oxidation is equipped with a liquid introduction channel to introduce a liquid containing a hydrocarbon ...
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JP2018515477A |
The present invention relates to a novel solid crystal form of pomalidomide, named co-crystal of foam B, foam M, pomalidomide: gentisic acid, and its production. Advantageously, these solid forms include multiple myeloma, inflammatory di...
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JP6342587B2 |
The present specification discloses methods of purifying one or more cannabinoids from a plant material, including a plant, a plant resin or a plant extract.
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JP6332870B2 |
It is a subject of the present invention to provide a base generator which has high solubility to general-purpose organic solvents, can dissolve directly into a base-reactive compound, such as an epoxy-based compound, further is provided...
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JP6301504B2 |
An object of the present invention is to provide a novel method for producing a thermodynamically more stable clathrate compound comprising at least one compound selected from the group consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)etha...
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JP2018027900A |
To provide an industrially advantageous method for production of aromatic tetracarboxylic acid useful as a raw material of polyimide and the like being a polymeric material.A production method for aromatic tetracarboxylic acid comprises:...
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JPWO2016167225A1 |
An object of the present invention is to provide a method for producing 2-halogenated benzoic acids, which provide high regioselectivity (highly selective) and have a shorter reaction time than conventional reactions. In order to achieve...
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JP6256812B2 |
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JP6254086B2 |
The disclosure relates to metal organic frameworks or isoreticular metal organic frameworks, methods of production thereof, and methods of use thereof.
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JP2017222632A |
To provide a method for preparing a polyalkynyl-substituted arene compound.The method for preparing a polyalkynyl-substituted arene compound comprises: (a) reacting a polyhydroxy-substituted aromatic compound with a fluorosulfonating age...
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JP6215958B2 |
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JP6203746B2 |
Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided...
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JP6205406B2 |
New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1...
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JP6195100B2 |
Disclosed are a compound of Formula I having higher inhibition of protein kinase G (PKG) activity and pharmaceutically acceptable salts thereof. In Formula I, R 1 and R 2 are the same or different, each being independently chosen from th...
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JP2017155008A |
To provide a simple production method capable of obtaining an aromatic monomer such as vanillin and a vanillic acid, which can be used as a raw material of a phenol resin and an epoxy resin, by using wood as a raw material with high yiel...
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JP2017514848A |
The present invention relates to hemipamoart of ivabrazine represented by the formula (I) and a hydrate thereof. The present invention also relates to drugs.
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JP6126440B2 |
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JPWO2015137272A1 |
The present invention is a porous structure containing two or more kinds of metal ions and an organic ligand, and the porous structure is characterized in that two or more kinds of metal ions are uniformly mixed at the atomic level. It p...
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JP6110645B2 |
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JP6104831B2 |
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JP6066355B2 |
A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to f...
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JPWO2014103321A1 |
To provide a novel pyruvate dehydrogenase inhibitor. A pyruvate dehydrogenase inhibitor containing a compound represented by the general formula (I) as an active ingredient (in the formula, ring A has aromaticity which may be substituted...
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JP6055771B2 |
Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R=C(0); -OC(O)- or -CH(OH)-; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B f...
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JP6037838B2 |
The present invention provides a composition comprising a chelating agent and unheated cashew nut shell liquid.
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JP6041396B2 |
The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R 1 represents a C 6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 o...
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JP6035547B2 |
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JP6012055B2 |
A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to f...
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JP2016183260A |
To provide a novel clathrate compound having a different composition ratio from before, using 2-phenyl-4-methyl-5-hydroxymethyl-imidazole as a guest compound, and polyhydroxy benzoic acids as a host compound.Provided is a clathrate compo...
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JP5978137B2 |
A resist composition including: a base component (A) that exhibits changed solubility in a developing solution by the action of acid; a photoreactive quencher (C); and an acid generator component (B) that generates acid upon exposure, wh...
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JP5955333B2 |
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JP2016128388A |
To provide a method for producing 6-benzyloxy-2-naphthoic acid of high purity in high yield with less generation of by-products.After 6-benzyloxy-2-naphthoic acid benzyl (ester-ether body) is produced from 6-hydroxy-2-naphthoic acid, hyd...
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JP5941173B2 |
The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
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JP2016516676A |
The concept of the invention disclosed and / or claimed herein generally relates to an oxidative oxidation reaction product produced by mechanically catalyzed oxidative depolymerization of lignin. More specifically, mechanically catalyze...
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